KEGG   PATHWAY: ngi05165
Entry
ngi05165                    Pathway                                
Name
Human papillomavirus infection - Nannospalax galili (Upper Galilee mountains blind mole rat)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
ngi05165  Human papillomavirus infection
ngi05165

Organism
Nannospalax galili (Upper Galilee mountains blind mole rat) [GN:ngi]
Gene
103750567  Wnt1; Wnt family member 1 [KO:K03209]
103734912  Wnt2b; Wnt family member 2B [KO:K00182]
103737375  Wnt2; Wnt family member 2 [KO:K00182]
103739037  Wnt3a; Wnt family member 3A [KO:K00312]
103724772  Wnt3; Wnt family member 3 [KO:K00312]
103746395  Wnt4; Wnt family member 4 [KO:K00408]
103739374  Wnt5b; Wnt family member 5B [KO:K00444]
103749032  Wnt5a; Wnt family member 5A [KO:K00444]
103727729  Wnt6; Wnt family member 6 [KO:K00445]
103743417  Wnt7b; Wnt family member 7B [KO:K00572]
103730373  Wnt7a; Wnt family member 7A [KO:K00572]
103735176  Wnt8a; Wnt family member 8A [KO:K00714]
103743982  Wnt8b; Wnt family member 8B [KO:K00714]
103740409  Wnt9a; Wnt family member 9A [KO:K01064]
103724773  Wnt9b; Wnt family member 9B [KO:K01064]
103750565  Wnt10b; Wnt family member 10B [KO:K01357]
103727730  Wnt10a; Wnt family member 10A [KO:K01357]
103743015  Wnt11; Wnt family member 11 [KO:K01384]
103730604  Wnt16; Wnt family member 16 [KO:K01558]
103736031  Fzd7; frizzled class receptor 7 [KO:K02432]
103725249  Fzd1; frizzled class receptor 1 [KO:K02432]
103738297  Fzd2; frizzled class receptor 2 [KO:K02235]
103729990  Fzd3; frizzled class receptor 3 [KO:K02329]
103742963  Fzd4; frizzled class receptor 4 [KO:K02354]
103744444  Fzd5; frizzled class receptor 5 [KO:K02375]
103748031  Fzd8; frizzled class receptor 8 [KO:K02375]
103748769  Fzd6; frizzled class receptor 6 [KO:K02376]
103746251  Fzd9; frizzled class receptor 9 [KO:K02842]
103750619  Fzd10; frizzled class receptor 10 [KO:K02842]
103732646  Dvl3; dishevelled segment polarity protein 3 [KO:K02353]
103749746  Dvl1; dishevelled segment polarity protein 1 [KO:K02353]
103752158  Dvl2; dishevelled segment polarity protein 2 [KO:K02353]
103741948  Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
103748223  Axin1; axin 1 [KO:K02157]
103742203  Axin2; axin 2 [KO:K04385]
103737324  Apc2; APC2, WNT signaling pathway regulator [KO:K02085]
103735168  Apc; APC, WNT signaling pathway regulator [KO:K02085]
103747127  Ctnnb1; catenin beta 1 [KO:K02105]
103738092  Csnk1a1; casein kinase 1 alpha 1 [KO:K08957] [EC:2.7.11.1]
103749674  Tert; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
103729786  Tcf7; transcription factor 7 (T-cell specific, HMG-box) [KO:K02620]
103739783  Tcf7l1; transcription factor 7 like 1 [KO:K04490]
103731749  Tcf7l2; transcription factor 7 like 2 [KO:K04491]
103734598  Ube3a; ubiquitin protein ligase E3A [KO:K10587] [EC:2.3.2.26]
103750490  Tlr3; toll like receptor 3 [KO:K05401]
103737218  Ticam1; toll like receptor adaptor molecule 1 [KO:K05842]
103727622  Traf3; TNF receptor associated factor 3 [KO:K03174]
103725939  Ikbke; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
103730726  Tbk1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
103743674  Irf3; interferon regulatory factor 3 [KO:K05411]
103743951  Ifnb1; interferon beta 1 [KO:K05415]
103746144  interferon beta-like [KO:K05415]
103743486  Ep300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
103744441  Crebbp; CREB binding protein [KO:K04498] [EC:2.3.1.48]
103751422  Tada3; transcriptional adaptor 3 [KO:K11315]
103752115  Tp53; tumor protein p53 [KO:K04451]
103729135  Magi1; membrane associated guanylate kinase, WW and PDZ domain containing 1 [KO:K05631]
103738044  Pten; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103745649  Pard3; par-3 family cell polarity regulator [KO:K04237]
103738891  Pard6a; par-6 family cell polarity regulator alpha [KO:K06093]
103735770  Pard6b; par-6 family cell polarity regulator beta [KO:K06093]
103746967  Pard6g; par-6 family cell polarity regulator gamma [KO:K06093]
103731703  Prkci; protein kinase C iota [KO:K06069] [EC:2.7.11.13]
103749769  Prkcz; protein kinase C zeta [KO:K18952] [EC:2.7.11.13]
103746394  Cdc42; cell division cycle 42 [KO:K04393]
103735277  Scrib; scribbled planar cell polarity protein [KO:K16175]
103738531  Dlg1; discs large MAGUK scaffold protein 1 [KO:K12076]
103742979  Dlg2; discs large MAGUK scaffold protein 2 [KO:K12075]
103743164  Dlg3; discs large MAGUK scaffold protein 3 [KO:K21098]
103732724  Llgl2; LLGL2, scribble cell polarity complex component [KO:K06094]
103724832  Llgl1; LLGL1, scribble cell polarity complex component [KO:K06094]
103737186  Crb3; crumbs 3, cell polarity complex component [KO:K06090]
103729163  inaD-like protein [KO:K06092]
103749284  Mpp5; membrane palmitoylated protein 5 [KO:K06091]
103727534  Vwf; von Willebrand factor [KO:K03900]
103727450  Thbs1; thrombospondin 1 [KO:K16857]
103742336  Thbs2; thrombospondin 2 [KO:K04659]
103750279  Thbs4; thrombospondin 4 [KO:K04659]
103750946  Thbs3; thrombospondin 3 [KO:K04659]
103726858  Comp; cartilage oligomeric matrix protein [KO:K04659]
103727691  Fn1; fibronectin 1 [KO:K05717]
103738382  Col1a1; collagen type I alpha 1 chain [KO:K06236]
103725222  Col1a2; collagen type I alpha 2 chain [KO:K06236]
103740626  Col2a1; collagen type II alpha 1 chain [KO:K19719]
103751683  Col4a2; collagen type IV alpha 2 chain [KO:K06237]
103751684  Col4a1; collagen type IV alpha 1 chain [KO:K06237]
103750063  Col4a5; collagen type IV alpha 5 chain [KO:K06237]
103750029  Col4a6; collagen type IV alpha 6 chain [KO:K06237]
103727826  Col4a4; collagen type IV alpha 4 chain [KO:K06237]
103727827  Col4a3; collagen type IV alpha 3 chain [KO:K06237]
103739960  Col6a2; collagen type VI alpha 2 chain [KO:K06238]
103739958  Col6a1; collagen type VI alpha 1 chain [KO:K06238]
103747522  collagen alpha-4(VI) chain-like [KO:K06238]
103726199  Col6a3; collagen type VI alpha 3 chain [KO:K06238]
103727287  Col6a6; collagen type VI alpha 6 chain [KO:K06238]
103727289  Col6a5; collagen type VI alpha 5 chain [KO:K06238]
103742245  Col9a3; collagen type IX alpha 3 chain [KO:K08131]
103752509  Col9a1; collagen type IX alpha 1 chain [KO:K08131]
103735414  Lama1; laminin subunit alpha 1 [KO:K05637]
103740954  laminin subunit alpha-1-like [KO:K05637]
103729744  Lama2; laminin subunit alpha 2 [KO:K05637]
103742237  Lama5; laminin subunit alpha 5 [KO:K06240]
103745694  Lama3; laminin subunit alpha 3 [KO:K06240]
103749527  Lama4; laminin subunit alpha 4 [KO:K06241]
103732168  Lamb1; laminin subunit beta 1 [KO:K05636]
103750198  Lamb2; laminin subunit beta 2 [KO:K06243]
103727074  Lamb3; laminin subunit beta 3 [KO:K06244]
103732167  Lamb4; laminin subunit beta 4 [KO:K06245]
103726706  Lamc1; laminin subunit gamma 1 [KO:K05635]
103726677  Lamc2; laminin subunit gamma 2 [KO:K06246]
103727706  Lamc3; laminin subunit gamma 3 [KO:K06247]
103738388  Chad; chondroadherin [KO:K06248]
103732198  Reln; reelin [KO:K06249] [EC:3.4.21.-]
103731750  Spp1; secreted phosphoprotein 1 [KO:K06250]
103724488  Vtn; vitronectin [KO:K06251]
103734553  Tnc; tenascin C [KO:K06252]
103727986  Tnn; tenascin N [KO:K06252]
103727988  Tnr; tenascin R [KO:K06252]
103724414  Tnxb; tenascin XB [KO:K06252]
103731762  Ibsp; integrin binding sialoprotein [KO:K06253]
103734043  Itga1; integrin subunit alpha 1 [KO:K06480]
103734059  Itga2; integrin subunit alpha 2 [KO:K06481]
103738294  Itga2b; integrin subunit alpha 2b [KO:K06476]
103738376  Itga3; integrin subunit alpha 3 [KO:K06482]
103729874  Itga4; integrin subunit alpha 4 [KO:K06483]
103738966  Itga5; integrin subunit alpha 5 [KO:K06484]
103751741  Itga6; integrin subunit alpha 6 [KO:K06485]
103738830  Itga7; integrin subunit alpha 7 [KO:K06583]
103734817  Itga8; integrin subunit alpha 8 [KO:K06584]
103752249  Itga9; integrin subunit alpha 9 [KO:K06585]
103729511  Itga10; integrin subunit alpha 10 [KO:K06586]
103736909  Itga11; integrin subunit alpha 11 [KO:K06587]
103728788  Itgav; integrin subunit alpha V [KO:K06487]
103745645  Itgb1; integrin subunit beta 1 [KO:K05719]
103724762  Itgb3; integrin subunit beta 3 [KO:K06493]
103732717  Itgb4; integrin subunit beta 4 [KO:K06525]
103741999  Itgb5; integrin subunit beta 5 [KO:K06588]
103744081  Itgb6; integrin subunit beta 6 [KO:K06589]
103738472  Itgb7; integrin subunit beta 7 [KO:K06590]
103733702  Itgb8; integrin subunit beta 8 [KO:K06591]
103748419  Ptk2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
103739977  Pxn; paxillin [KO:K05760]
103724452  Tnf; tumor necrosis factor [KO:K03156]
103727530  Tnfrsf1a; TNF receptor superfamily member 1A [KO:K03158]
103738912  Tradd; TNFRSF1A associated via death domain [KO:K03171]
103740694  Faslg; Fas ligand [KO:K04389]
103738053  Fas; Fas cell surface death receptor [KO:K04390]
103751502  Fadd; Fas associated via death domain [KO:K02373]
103738672  Casp8; caspase 8 [KO:K04398] [EC:3.4.22.61]
103744668  caspase-3-like [KO:K02187] [EC:3.4.22.56]
103750475  Casp3; caspase 3 [KO:K02187] [EC:3.4.22.56]
103732759  Slc9a3r1; SLC9A3 regulator 1 [KO:K13365]
103729809  Ppp2ca; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
103743584  Ppp2cb; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
103733889  Ppp2r1b; protein phosphatase 2 scaffold subunit Abeta [KO:K03456]
103745507  Ppp2r1a; protein phosphatase 2 scaffold subunit Aalpha [KO:K03456]
103750638  Ppp2r2c; protein phosphatase 2 regulatory subunit Bgamma [KO:K04354]
103725821  Ppp2r2d; protein phosphatase 2 regulatory subunit Bdelta [KO:K04354]
103724526  Ppp2r2b; protein phosphatase 2 regulatory subunit Bbeta [KO:K04354]
103732390  Ppp2r2a; protein phosphatase 2 regulatory subunit Balpha [KO:K04354]
103740963  Ppp2r3a; protein phosphatase 2 regulatory subunit B''alpha [KO:K11583]
103744720  Ppp2r3c; protein phosphatase 2 regulatory subunit B''gamma [KO:K11583]
103750111  Ppp2r3b; protein phosphatase 2 regulatory subunit B''beta [KO:K11583]
103738772  Ppp2r5b; protein phosphatase 2 regulatory subunit B'beta [KO:K11584]
103747958  Ppp2r5e; protein phosphatase 2 regulatory subunit B'epsilon [KO:K11584]
103727046  Ppp2r5a; protein phosphatase 2 regulatory subunit B'alpha [KO:K11584]
103727634  Ppp2r5c; protein phosphatase 2 regulatory subunit B'gamma [KO:K11584]
103730801  Ppp2r5d; protein phosphatase 2 regulatory subunit B'delta [KO:K11584]
103742835  Tsc1; tuberous sclerosis 1 [KO:K07206]
103752451  Tsc2; tuberous sclerosis 2 [KO:K07207]
103745322  Rheb; Ras homolog enriched in brain [KO:K07208]
103732897  Mtor; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
103741760  Rps6kb1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
103725586  Rps6kb2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
103739733  Bak1; BCL2 antagonist/killer 1 [KO:K14021]
103738795  Bad; BCL2 associated agonist of cell death [KO:K02158]
103747076  Pdgfrb; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103738596  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103733121  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103742946  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103738715  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103726879  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103730305  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103746884  Akt3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103750757  Akt2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103752536  Akt1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103747066  Foxo1; forkhead box O1 [KO:K07201]
103737662  Cdkn1b; cyclin dependent kinase inhibitor 1B [KO:K06624]
103739652  Cdkn1a; cyclin dependent kinase inhibitor 1A [KO:K06625]
103751498  Ccnd1; cyclin D1 [KO:K04503]
103727547  Ccnd2; cyclin D2 [KO:K10151]
103725891  Ccnd3; cyclin D3 [KO:K10152]
103742900  Cdk4; cyclin dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
103725210  Cdk6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
103740830  Ccne1; cyclin E1 [KO:K06626]
103745830  Ccne2; cyclin E2 [KO:K06626]
103746495  Cdk2; cyclin dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
103726779  Rb1; RB transcriptional corepressor 1 [KO:K06618]
103736926  Rbl1; RB transcriptional corepressor like 1 [KO:K04681]
103731674  Rbl2; RB transcriptional corepressor like 2 [KO:K16332]
103724618  Psmc1; proteasome 26S subunit, ATPase 1 [KO:K03062]
103751571  E2f1; E2F transcription factor 1 [KO:K17454]
103746957  Ccna2; cyclin A2 [KO:K06627]
103731982  Ccna1; cyclin A1 [KO:K06627]
103731335  Atm; ATM serine/threonine kinase [KO:K04728] [EC:2.7.11.1]
103752518  Atr; ATR serine/threonine kinase [KO:K06640] [EC:2.7.11.1]
103730772  Vegfa; vascular endothelial growth factor A [KO:K05448]
103743976  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
103726621  Ikbkb; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103731232  Ikbkg; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
103728077  Nfkb1; nuclear factor kappa B subunit 1 [KO:K02580]
103724994  Rela; RELA proto-oncogene, NF-kB subunit [KO:K04735]
103745079  Mdm2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
103741589  Nfx1; nuclear transcription factor, X-box binding 1 [KO:K12236]
103733778  Hdac2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
103745919  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
103727520  Chd4; chromodomain helicase DNA binding protein 4 [KO:K11643] [EC:5.6.2.-]
103747025  Irf1; interferon regulatory factor 1 [KO:K09444]
103739216  Tbpl2; TATA-box binding protein like 2 [KO:K03120]
103742347  Tbp; TATA-box binding protein [KO:K03120]
103724914  Tbpl1; TATA-box binding protein like 1 [KO:K03120]
103738688  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
103740578  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like [KO:K06751]
103739356  HLA class I histocompatibility antigen, B-73 alpha chain-like [KO:K06751]
103744250  HLA class I histocompatibility antigen, A-30 alpha chain-like [KO:K06751]
103747894  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103725555  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103752329  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
103752528  patr class I histocompatibility antigen, A-126 alpha chain-like [KO:K06751]
103752527  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
103724463  patr class I histocompatibility antigen, A-126 alpha chain [KO:K06751]
103731142  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
103729790  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103729781  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
103729792  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
103729784  HLA class I histocompatibility antigen, A-23 alpha chain-like [KO:K06751]
103729783  class I histocompatibility antigen, B alpha chain-like [KO:K06751]
103731195  Bcap31; B-cell receptor-associated protein 31 [KO:K14009]
103741925  Atp6v1a; ATPase H+ transporting V1 subunit A [KO:K02145] [EC:7.1.2.2]
103747668  Atp6v1b2; ATPase H+ transporting V1 subunit B2 [KO:K02147]
103726958  Atp6v1b1; ATPase H+ transporting V1 subunit B1 [KO:K02147]
103748771  Atp6v1c1; ATPase H+ transporting V1 subunit C1 [KO:K02148]
103747611  Atp6v1c2; ATPase H+ transporting V1 subunit C2 [KO:K02148]
103749286  Atp6v1d; ATPase H+ transporting V1 subunit D [KO:K02149]
103745895  Atp6v1e1; ATPase H+ transporting V1 subunit E1 [KO:K02150]
103725755  Atp6v1e2; ATPase H+ transporting V1 subunit E2 [KO:K02150]
103744556  Atp6v1f; ATPase H+ transporting V1 subunit F [KO:K02151]
103734513  Atp6v1g1; ATPase H+ transporting V1 subunit G1 [KO:K02152]
103724454  Atp6v1g2; ATPase H+ transporting V1 subunit G2 [KO:K02152]
103731799  Atp6v1g3; ATPase H+ transporting V1 subunit G3 [KO:K02152]
103743198  Atp6v1h; ATPase H+ transporting V1 subunit H [KO:K02144]
103735898  Atp6v0a1; ATPase H+ transporting V0 subunit a1 [KO:K02154]
103739020  Atp6v0a2; ATPase H+ transporting V0 subunit a2 [KO:K02154]
103744516  Tcirg1; T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3 [KO:K02154]
103726084  Atp6v0a4; ATPase H+ transporting V0 subunit a4 [KO:K02154]
103738897  Atp6v0d1; ATPase H+ transporting V0 subunit d1 [KO:K02146]
103731150  Atp6v0d2; ATPase H+ transporting V0 subunit d2 [KO:K02146]
103734717  Atp6v0e2; ATPase H+ transporting V0 subunit e2 [KO:K02153]
103748196  Atp6v0e1; ATPase H+ transporting V0 subunit e1 [KO:K02153]
103743931  Atp6v0c; ATPase H+ transporting V0 subunit c [KO:K02155]
103743867  Atp6v0b; ATPase H+ transporting V0 subunit b [KO:K03661]
103731222  Atp6ap1; ATPase H+ transporting accessory protein 1 [KO:K03662]
103742642  Egf; epidermal growth factor [KO:K04357]
103748852  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103732729  Grb2; growth factor receptor bound protein 2 [KO:K04364]
103743944  Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
103731514  Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
103751075  Hras; HRas proto-oncogene, GTPase [KO:K02833]
103736717  Kras; KRAS proto-oncogene, GTPase [KO:K07827]
103734938  Nras; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103751450  Raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103736801  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103737276  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103741442  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103726390  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103726651  Ptgs2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
103741335  Ptger4; prostaglandin E receptor 4 [KO:K04261]
103741475  Gnas; GNAS complex locus [KO:K04632]
103741466  neuroendocrine secretory protein 55 [KO:K04632]
103751850  Prkaca; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
103728095  Prkacb; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103743639  Bax; BCL2 associated X, apoptosis regulator [KO:K02159]
103744440  Creb1; cAMP responsive element binding protein 1 [KO:K05870]
103737277  Creb3l3; cAMP responsive element binding protein 3 like 3 [KO:K09048]
103741536  Creb3; cAMP responsive element binding protein 3 [KO:K09048]
103748795  Creb3l1; cAMP responsive element binding protein 3 like 1 [KO:K09048]
103751688  Creb3l4; cAMP responsive element binding protein 3 like 4 [KO:K09048]
103726130  Creb3l2; cAMP responsive element binding protein 3 like 2 [KO:K09048]
103740829  Creb5; cAMP responsive element binding protein 5 [KO:K09047]
103724709  Ubr4; ubiquitin protein ligase E3 component n-recognin 4 [KO:K10691] [EC:2.3.2.27]
103735906  Tubg1; tubulin gamma 1 [KO:K10389]
103735907  tubulin gamma-2 chain [KO:K10389]
103736842  Pkm; pyruvate kinase, muscle [KO:K00873] [EC:2.7.1.40]
103742632  pyruvate kinase PKM-like [KO:K00873] [EC:2.7.1.40]
103736148  interferon alpha-12-like [KO:K05414]
103746654  interferon alpha-1-like [KO:K05414]
103746653  interferon alpha-12-like [KO:K05414]
103731654  interferon alpha-13-like [KO:K05414]
103732546  interferon alpha-13-like [KO:K05414]
103736454  interferon alpha/beta receptor 1-like [KO:K05130]
103736458  Ifnar2; interferon alpha and beta receptor subunit 2 [KO:K05131]
103732475  Jak1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
103747562  Tyk2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
103736156  Stat1; signal transducer and activator of transcription 1 [KO:K11220]
103746519  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
103739430  Irf9; interferon regulatory factor 9 [KO:K04693]
103725269  Eif2ak2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
103740208  2'-5'-oligoadenylate synthase-like protein 2 [KO:K14608]
108491210  Oasl; 2'-5'-oligoadenylate synthetase like [KO:K14608]
103728256  interferon-induced GTP-binding protein Mx2-like [KO:K14754]
103748455  Mx1; MX dynamin like GTPase 1 [KO:K14754]
103749728  Isg15; ISG15 ubiquitin-like modifier [KO:K12159]
103729189  Jag1; jagged 1 [KO:K06052]
103741215  Notch1; notch 1 [KO:K02599]
103732001  Notch2; notch 2 [KO:K20994]
103731622  Notch3; notch 3 [KO:K20995]
103724403  Notch4; notch 4 [KO:K20996]
103747390  Psen1; presenilin 1 [KO:K04505] [EC:3.4.23.-]
103730070  Rfng; RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [KO:K05948] [EC:2.4.1.222]
103748675  Lfng; LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [KO:K05948] [EC:2.4.1.222]
103748612  Mfng; MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [KO:K05948] [EC:2.4.1.222]
103742373  Maml3; mastermind like transcriptional coactivator 3 [KO:K06061]
103748245  Maml2; mastermind like transcriptional coactivator 2 [KO:K06061]
103749376  Maml1; mastermind like transcriptional coactivator 1 [KO:K06061]
103736666  Rbpjl; recombination signal binding protein for immunoglobulin kappa J region like [KO:K06053]
103737516  Rbpj; recombination signal binding protein for immunoglobulin kappa J region [KO:K06053]
103738854  Hes1; hes family bHLH transcription factor 1 [KO:K06054]
103733601  Hes6; hes family bHLH transcription factor 6 [KO:K09087]
103752099  Hes7; hes family bHLH transcription factor 7 [KO:K09087]
103725125  Hes2; hes family bHLH transcription factor 2 [KO:K09087]
103725123  Hes3; hes family bHLH transcription factor 3 [KO:K09088]
103749777  Hes5; hes family bHLH transcription factor 5 [KO:K06055]
103736697  Heyl; hes related family bHLH transcription factor with YRPW motif-like [KO:K09091]
103746526  Hey2; hes related family bHLH transcription factor with YRPW motif 2 [KO:K09091]
103727947  Hey1; hes related family bHLH transcription factor with YRPW motif 1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Human papillomavirus proteins as prospective therapeutic targets.
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Sci Rep 5:13446 (2015)
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James CD, Roberts S
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Pathogens 5:E8 (2016)
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Viruses 7:3530-51 (2015)
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Reference
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PDZ domains: the building blocks regulating tumorigenesis.
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Human tumour viruses and the deregulation of cell polarity in cancer.
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Mol Cell Proteomics 11:M112.016998 (2012)
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
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Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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J Biol Chem 279:35664-70 (2004)
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Reference
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Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
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Reference
PMID:23536685
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The evolving field of human papillomavirus receptor research: a review of binding and entry.
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Related
pathway
ngi04064  NF-kappa B signaling pathway
ngi04110  Cell cycle
ngi04115  p53 signaling pathway
ngi04150  mTOR signaling pathway
ngi04151  PI3K-Akt signaling pathway
ngi04210  Apoptosis
ngi04310  Wnt signaling pathway
ngi04330  Notch signaling pathway
ngi04510  Focal adhesion
ngi04520  Adherens junction
ngi04530  Tight junction
ngi04612  Antigen processing and presentation
ngi04620  Toll-like receptor signaling pathway
ngi04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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