KEGG   PATHWAY: ocu04022
Entry
ocu04022                    Pathway                                
Name
cGMP-PKG signaling pathway - Oryctolagus cuniculus (rabbit)
Description
Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated intracellular cGMP level exerts its physiological action through two forms of cGMP-dependent protein kinase (PKG), cGMP-regulated phosphodiesterases (PDE2, PDE3) and cGMP-gated cation channels, among which PKGs might be the primary mediator. PKG1 isoform-specific activation of established substrates leads to reduction of cytosolic calcium concentration and/or decrease in the sensitivity of myofilaments to Ca2+ (Ca2+-desensitization), resulting in smooth muscle relaxation. In cardiac myocyte, PKG directly phosphorylates a member of the transient potential receptor canonical channel family, TRPC6, suppressing this nonselective ion channel's Ca2+ conductance, G-alpha-q agonist-induced NFAT activation, and myocyte hypertrophic responses. PKG also opens mitochondrial ATP-sensitive K+ (mitoKATP) channels and subsequent release of ROS triggers cardioprotection.
Class
Environmental Information Processing; Signal transduction
Pathway map
ocu04022  cGMP-PKG signaling pathway
ocu04022

Other DBs
GO: 0070305
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100009164  AGTR1; type-1 angiotensin II receptor [KO:K04166]
100126073  EDNRA; endothelin-1 receptor precursor [KO:K04197]
100009477  EDNRB; endothelin receptor type B precursor [KO:K04198]
100009237  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
100008731  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
100009398  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
100009424  ADRA2A; alpha-2A adrenergic receptor [KO:K04138]
100352237  alpha-2B adrenergic receptor [KO:K04139]
100340719  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
100347293  guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100352794  guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
100347206  short transient receptor potential channel 6 isoform X1 [KO:K04969]
100356245  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100009423  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
100009487  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
100344533  calcineurin subunit B type 2 [KO:K06268]
100339777  myocyte-specific enhancer factor 2A isoform X1 [KO:K09260]
127485294  myocyte-specific enhancer factor 2B isoform X1 [KO:K09261]
100345167  myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
100340589  myocyte-specific enhancer factor 2D isoform X1 [KO:K09262]
100352378  nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
100353824  nuclear factor of activated T-cells, cytoplasmic 2 isoform X3 [KO:K17332]
100008859  nuclear factor of activated T-cells, cytoplasmic 3 isoform X2 [KO:K17333]
100347003  nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334]
100354695  serum response factor isoform X1 [KO:K04378]
100008858  transcription factor GATA-4 isoform X2 [KO:K09183]
100125987  MYH6; myosin-6 [KO:K17751]
100101566  MYH7; myosin-7 [KO:K17751]
103352511  natriuretic peptides B isoform X1 [KO:K12335]
100009087  NPPA; natriuretic peptides A precursor [KO:K12334]
100343663  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
100344147  C-type natriuretic peptide [KO:K12336]
100356598  atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
100008694  PRKG1; cGMP-dependent protein kinase 1 [KO:K07376] [EC:2.7.11.12]
100008781  cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
100101555  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
100327259  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100357261  voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100009585  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100008745  KCNMA1; calcium-activated potassium channel subunit alpha-1 [KO:K04936]
103346203  potassium channel subfamily U member 1 isoform X1 [KO:K05274]
100009034  KCNMB1; calcium-activated potassium channel subunit beta-1 [KO:K04937]
100344926  calcium-activated potassium channel subunit beta-2 isoform X2 [KO:K04938]
100345697  LOW QUALITY PROTEIN: calcium-activated potassium channel subunit beta-3 [KO:K04939]
100342622  calcium-activated potassium channel subunit beta-4 isoform X2 [KO:K04941]
100339605  sodium/calcium exchanger 3 isoform X1 [KO:K05849]
100328570  SLC8A1; sodium/calcium exchanger 1 precursor [KO:K05849]
100358483  sodium/calcium exchanger 2 [KO:K05849]
100349382  sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
100358269  sodium/potassium-transporting ATPase subunit alpha-4 isoform X1 [KO:K01539] [EC:7.2.2.13]
100008756  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
100302415  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
100009577  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
100008749  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
100008788  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
100350113  protein ATP1B4 isoform X2 [KO:K01540]
103349229  sodium/potassium-transporting ATPase subunit gamma isoform X2 [KO:K01538]
127482585  sodium/potassium-transporting ATPase subunit gamma-like isoform X1 [KO:K01538]
100356760  plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
100355180  plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
103351031  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 4-like [KO:K05850] [EC:7.2.2.10]
100339414  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 4-like [KO:K05850] [EC:7.2.2.10]
100356734  plasma membrane calcium-transporting ATPase 4 isoform X3 [KO:K05850] [EC:7.2.2.10]
100353865  plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
103351001  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
100009543  ATP2B1; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
100345200  regulator of G-protein signaling 2 [KO:K18154]
100349268  regulator of G-protein signaling 2 [KO:K18154]
127486775  regulator of G-protein signaling 2-like [KO:K18154]
100339683  general transcription factor II-I isoform X1 [KO:K03121]
127488037  general transcription factor II-I-like [KO:K03121]
100348672  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4 [KO:K05858] [EC:3.1.4.11]
100350395  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100341512  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
103347536  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100009505  inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
100356806  inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
100008939  inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
100008940  IRAG1; inositol 1,4,5-triphosphate receptor associated 1 isoform X3 [KO:K12337]
100009299  PLN; cardiac phospholamban [KO:K05852]
100037716  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
100354976  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2 [KO:K05853] [EC:7.2.2.10]
100038308  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100356250  transforming protein RhoA [KO:K04513]
100348967  transforming protein RhoA-like [KO:K04513]
100340661  transforming protein RhoA [KO:K04513]
100346856  LOW QUALITY PROTEIN: transforming protein RhoA [KO:K04513]
100343368  transforming protein RhoA-like [KO:K04513]
100343680  transforming protein RhoA-like [KO:K04513]
127489660  transforming protein RhoA-like [KO:K04513]
100009220  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100346837  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100350558  protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
100009587  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100009298  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100353054  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
103345165  LOW QUALITY PROTEIN: calmodulin-like protein 3 [KO:K02183]
100347856  calmodulin-like protein 3 [KO:K02183]
100354905  calmodulin-3 [KO:K02183]
100352392  CALM2; calmodulin [KO:K02183]
100350107  calmodulin-1 [KO:K02183]
100345526  calmodulin-like protein 4 isoform X1 [KO:K02183]
100009051  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100353972  myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
100348694  myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
127493971  myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
100343384  myosin regulatory light polypeptide 9 [KO:K12755]
100009524  cGMP-gated cation channel alpha-1 [KO:K04948]
100359123  cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
103347035  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100009201  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
100343958  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100346742  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100009315  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100354934  adenylate cyclase type 6 isoform X8 [KO:K08046] [EC:4.6.1.1]
100357357  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100337882  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100340877  adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100337951  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
100009330  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1 [KO:K19021] [EC:3.1.4.17]
100352820  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
100354625  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
100350099  GUCY1A1; guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
100357621  guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
100349851  GUCY1B1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
100101602  kininogen-1 isoform X1 [KO:K03898]
100338359  B2 bradykinin receptor isoform X1 [KO:K03916]
100351268  delta-type opioid receptor [KO:K04213]
100328615  ADORA1; adenosine receptor A1 [KO:K04265]
100008725  ADORA3; adenosine receptor A3 [KO:K04268]
100338391  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100359147  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
100339066  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100008911  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100339981  insulin receptor substrate 1 [KO:K16172]
103349113  insulin receptor substrate 2 [KO:K07187]
100339305  insulin receptor substrate 1 [KO:K17445]
103351932  insulin receptor substrate 4 [KO:K17446]
100344144  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
100337757  phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
100340526  LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
100342852  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100353706  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
127486116  RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100009498  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
127493711  nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
100338084  beta-1 adrenergic receptor [KO:K04141]
100340821  beta-2 adrenergic receptor [KO:K04142]
100339100  LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
100009103  PRKCE; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
100008881  KCNJ8; ATP-sensitive inward rectifier potassium channel 8 [KO:K05001]
100008751  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100349506  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
100009473  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100008752  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100346477  ADP/ATP translocase 4 isoform X1 [KO:K05863]
100009414  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100349768  ADP/ATP translocase 1 [KO:K05863]
100356326  ADP/ATP translocase 2 [KO:K05863]
100337764  ADP/ATP translocase 2 [KO:K05863]
100342972  ADP/ATP translocase 2-like [KO:K05863]
100348057  ADP/ATP translocase 2-like [KO:K05863]
100354802  ADP/ATP translocase 2-like [KO:K05863]
100338362  peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100351999  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100355367  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
100339383  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
100358175  cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
100343130  cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X2 [KO:K09048]
100345475  cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100357876  cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
100357483  cyclic AMP-responsive element-binding protein 5 isoform X3 [KO:K09047]
100357489  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
127493063  cyclic AMP-dependent transcription factor ATF-6 beta-like isoform X1 [KO:K09049]
100358587  bcl2-associated agonist of cell death [KO:K02158]
100349467  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
127486002  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100347407  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100009316  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
127489461  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
100347345  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100348561  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
Compound
C00020  AMP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00144  GMP
C00212  Adenosine
C00238  Potassium cation
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:20716671
  Authors
Francis SH, Busch JL, Corbin JD, Sibley D
  Title
cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.
  Journal
Pharmacol Rev 62:525-63 (2010)
DOI:10.1124/pr.110.002907
Reference
PMID:16439998
  Authors
Feil R, Kemp-Harper B
  Title
cGMP signalling: from bench to bedside. Conference on cGMP generators, effectors and therapeutic implications.
  Journal
EMBO Rep 7:149-53 (2006)
DOI:10.1038/sj.embor.7400627
Reference
PMID:22785374
  Authors
Takimoto E
  Title
Cyclic GMP-dependent signaling in cardiac myocytes.
  Journal
Circ J 76:1819-25 (2012)
DOI:10.1253/circj.CJ-12-0664
Reference
PMID:16371594
  Authors
Hofmann F, Feil R, Kleppisch T, Schlossmann J
  Title
Function of cGMP-dependent protein kinases as revealed by gene deletion.
  Journal
Physiol Rev 86:1-23 (2006)
DOI:10.1152/physrev.00015.2005
Reference
PMID:21685243
  Authors
Kuebler WM
  Title
The Janus-faced regulation of endothelial permeability by cyclic GMP.
  Journal
Am J Physiol Lung Cell Mol Physiol 301:L157-60 (2011)
DOI:10.1152/ajplung.00192.2011
Reference
PMID:21666108
  Authors
Schlossmann J, Desch M
  Title
IRAG and novel PKG targeting in the cardiovascular system.
  Journal
Am J Physiol Heart Circ Physiol 301:H672-82 (2011)
DOI:10.1152/ajpheart.00198.2011
Reference
PMID:16460276
  Authors
Murthy KS
  Title
Signaling for contraction and relaxation in smooth muscle of the gut.
  Journal
Annu Rev Physiol 68:345-74 (2006)
DOI:10.1146/annurev.physiol.68.040504.094707
Reference
PMID:22965426
  Authors
Sanders KM, Koh SD, Ro S, Ward SM
  Title
Regulation of gastrointestinal motility--insights from smooth muscle biology.
  Journal
Nat Rev Gastroenterol Hepatol 9:633-45 (2012)
DOI:10.1038/nrgastro.2012.168
Reference
PMID:20024580
  Authors
Gao Y
  Title
The multiple actions of NO.
  Journal
Pflugers Arch 459:829-39 (2010)
DOI:10.1007/s00424-009-0773-9
Reference
PMID:9003029
  Authors
Wang X, Robinson PJ
  Title
Cyclic GMP-dependent protein kinase and cellular signaling in the nervous system.
  Journal
J Neurochem 68:443-56 (1997)
DOI:10.1046/j.1471-4159.1997.68020443.x
Reference
PMID:19306895
  Authors
Tsai EJ, Kass DA
  Title
Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics.
  Journal
Pharmacol Ther 122:216-38 (2009)
DOI:10.1016/j.pharmthera.2009.02.009
Reference
PMID:20388537
  Authors
Villanueva C, Giulivi C
  Title
Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease.
  Journal
Free Radic Biol Med 49:307-16 (2010)
DOI:10.1016/j.freeradbiomed.2010.04.004
Reference
PMID:15894227
  Authors
Schlossmann J, Hofmann F
  Title
cGMP-dependent protein kinases in drug discovery.
  Journal
Drug Discov Today 10:627-34 (2005)
DOI:10.1016/S1359-6446(05)03406-9
Reference
PMID:18040025
  Authors
Kass DA, Champion HC, Beavo JA
  Title
Phosphodiesterase type 5: expanding roles in cardiovascular regulation.
  Journal
Circ Res 101:1084-95 (2007)
DOI:10.1161/CIRCRESAHA.107.162511
Reference
PMID:16815627
  Authors
Uckert S, Hedlund P, Andersson KE, Truss MC, Jonas U, Stief CG
  Title
Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: present and future.
  Journal
Eur Urol 50:1194-207; discussion 1207 (2006)
DOI:10.1016/j.eururo.2006.05.025
Reference
PMID:12524221
  Authors
Yan C, Kim D, Aizawa T, Berk BC
  Title
Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator.
  Journal
Arterioscler Thromb Vasc Biol 23:26-36 (2003)
DOI:10.1161/01.ATV.0000046231.17365.9D
Reference
PMID:17643091
  Authors
McKinsey TA, Kass DA
  Title
Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface.
  Journal
Nat Rev Drug Discov 6:617-35 (2007)
DOI:10.1038/nrd2193
Reference
PMID:19961855
  Authors
Koitabashi N, Aiba T, Hesketh GG, Rowell J, Zhang M, Takimoto E, Tomaselli GF, Kass DA
  Title
Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition.
  Journal
J Mol Cell Cardiol 48:713-24 (2010)
DOI:10.1016/j.yjmcc.2009.11.015
Reference
PMID:18006449
  Authors
Costa AD, Pierre SV, Cohen MV, Downey JM, Garlid KD
  Title
cGMP signalling in pre- and post-conditioning: the role of mitochondria.
  Journal
Cardiovasc Res 77:344-52 (2008)
DOI:10.1093/cvr/cvm050
Reference
PMID:19176601
  Authors
Boengler K, Schulz R, Heusch G
  Title
Loss of cardioprotection with ageing.
  Journal
Cardiovasc Res 83:247-61 (2009)
DOI:10.1093/cvr/cvp033
Reference
PMID:18757523
  Authors
Gao Y, Portugal AD, Liu J, Negash S, Zhou W, Tian J, Xiang R, Longo LD, Raj JU
  Title
Preservation of cGMP-induced relaxation of pulmonary veins of fetal lambs exposed to chronic high altitude hypoxia: role of PKG and Rho kinase.
  Journal
Am J Physiol Lung Cell Mol Physiol 295:L889-96 (2008)
DOI:10.1152/ajplung.00463.2007
Reference
PMID:11522789
  Authors
Li Z, Xi X, Du X
  Title
A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3.
  Journal
J Biol Chem 276:42226-32 (2001)
DOI:10.1074/jbc.M106129200
Reference
PMID:23212367
  Authors
Xie J, Cha SK, An SW, Kuro-O M, Birnbaumer L, Huang CL
  Title
Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart.
  Journal
Nat Commun 3:1238 (2012)
DOI:10.1038/ncomms2240
Related
pathway
ocu04010  MAPK signaling pathway
ocu04020  Calcium signaling pathway
ocu04151  PI3K-Akt signaling pathway
ocu04210  Apoptosis
ocu04270  Vascular smooth muscle contraction
ocu04744  Phototransduction
KO pathway
ko04022   
LinkDB

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