KEGG   PATHWAY: plop05203
Entry
plop05203                   Pathway                                
Name
Viral carcinogenesis - Perognathus longimembris pacificus (Pacific pocket mouse)
Description
There is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C virus (HCV), human papilloma virus (HPV), human T-cell lymphotropic virus (HTLV-1) and Kaposi's associated sarcoma virus (KSHV) contribute to 10-15% of the cancers worldwide. Via expression of many potent oncoproteins, these tumor viruses promote an aberrant cell-proliferation via modulating cellular cell-signaling pathways and escape from cellular defense system such as blocking apoptosis. Human tumor virus oncoproteins can also disrupt pathways that are necessary for the maintenance of the integrity of host cellular genome. Viruses that encode such activities can contribute to initiation as well as progression of human cancers.
Class
Human Diseases; Cancer: overview
Pathway map
plop05203  Viral carcinogenesis
plop05203

Organism
Perognathus longimembris pacificus (Pacific pocket mouse) [GN:plop]
Gene
125353459  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
125362333  Hras; GTPase HRas isoform X1 [KO:K02833]
125342925  Kras; GTPase KRas isoform X1 [KO:K07827]
125355453  Nras; GTPase NRas [KO:K07828]
125340801  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
125349325  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125350355  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
125350538  Atf2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
125358158  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
125347188  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
125339860  Creb3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
125362185  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
125348600  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
125359105  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
125346776  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
125352747  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
125362345  Ddb1; DNA damage-binding protein 1 isoform X1 [KO:K10610]
125360428  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
125353817  Ywhab; 14-3-3 protein beta/alpha [KO:K16197]
125356548  14-3-3 protein beta/alpha-like [KO:K16197]
125356744  Ywhaq; 14-3-3 protein theta [KO:K16197]
125367231  14-3-3 protein epsilon-like [KO:K06630]
125365431  Ywhae; 14-3-3 protein epsilon [KO:K06630]
125344870  14-3-3 protein epsilon-like [KO:K06630]
125345592  14-3-3 protein epsilon-like [KO:K06630]
125345599  14-3-3 protein epsilon-like [KO:K06630]
125366748  14-3-3 protein epsilon-like [KO:K06630]
125368078  Ywhag; 14-3-3 protein gamma [KO:K16198]
125349313  Ywhah; 14-3-3 protein eta [KO:K16198]
125355256  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
125366353  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
125366352  signal transducer and activator of transcription 5A [KO:K11223]
125365131  Stat5b; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
125339355  Casp3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
125338780  Hpn; serine protease hepsin isoform X1 [KO:K08665] [EC:3.4.21.106]
125354550  Pik3cd; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
125342393  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
125351954  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125367817  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125355095  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
125348916  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
125361933  Rela; transcription factor p65 isoform X1 [KO:K04735]
125356416  Rel; proto-oncogene c-Rel isoform X1 [KO:K09254]
125346119  Nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
125341680  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125365886  Tp53; cellular tumor antigen p53 [KO:K04451]
125338744  Ccne1; G1/S-specific cyclin-E1 [KO:K06626]
125360962  Ccne2; G1/S-specific cyclin-E2 [KO:K06626]
125363256  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
125346366  Egr2; E3 SUMO-protein ligase EGR2 [KO:K12496]
125339449  Egr3; early growth response protein 3 isoform X1 [KO:K12497]
125339434  Vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
125359898  voltage-dependent anion-selective channel protein 3-like [KO:K15041]
125350213  Sp100; nuclear autoantigen Sp-100 isoform X1 [KO:K15413]
125339991  Hnrnpk; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
125352645  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
125361808  ATP-dependent RNA helicase DDX3X-like [KO:K11594] [EC:5.6.2.7]
125343280  Ddx3x; ATP-dependent RNA helicase DDX3X [KO:K11594] [EC:5.6.2.7]
125347887  LOW QUALITY PROTEIN: ATP-dependent RNA helicase DDX3X-like [KO:K11594] [EC:5.6.2.7]
125356561  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
125348811  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
125355340  Prkacb; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
125367598  histone H2B subacrosomal variant-like [KO:K11252]
125343004  late histone H2B.L4-like [KO:K11252]
125343005  histone H2B-like [KO:K11252]
125352244  histone H2B type 1-A-like [KO:K11252]
125359655  histone H2B type 3-B [KO:K11252]
125352905  histone H2B type 1-C/E/F/G/I [KO:K11252]
125352906  histone H2B type 1-B-like [KO:K11252]
125352907  histone H2B type 1-C/E/F/G/I [KO:K11252]
125352908  histone H2B type 1-C/E/F/G/I [KO:K11252]
125352909  histone H2B type 1-C/E/F/G/I [KO:K11252]
125352910  histone H2B type 1-C/E/F/G/I [KO:K11252]
125352912  histone H2B type 1-C/E/F/G/I [KO:K11252]
125352913  histone H2B type 1-C/E/F/G/I [KO:K11252]
125352914  histone H2B type 1-C/E/F/G/I [KO:K11252]
125352915  histone H2B type 1-C/E/F/G/I [KO:K11252]
125352916  histone H2B type 1-K [KO:K11252]
125352917  histone H2B type 1-C/E/F/G/I [KO:K11252]
125352918  histone H2B type 1-C/E/F/G/I [KO:K11252]
125352957  histone H2B type 1-A [KO:K11252]
125359919  H2B.U histone 2 [KO:K11252]
125360077  histone H2B type 2-F [KO:K11252]
125360078  histone H2B type 2-E [KO:K11252]
125360079  histone H2B type 2-E [KO:K11252]
125352938  histone H3-like [KO:K11254]
125352939  histone H3.1-like [KO:K11254]
125338870  Bax; apoptosis regulator BAX [KO:K02159]
125365698  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
125358313  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
125346357  Cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
125363066  Tbpl2; TATA box-binding protein-like 2 [KO:K03120]
125357302  Tbpl1; TATA box-binding protein-like 1 isoform X1 [KO:K03120]
125357508  TATA-box-binding protein isoform X1 [KO:K03120]
125340325  Usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
125361439  Mdm2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
125365055  Rbpj; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
125352392  Rbpjl; LOW QUALITY PROTEIN: recombining binding protein suppressor of hairless-like protein [KO:K06053]
125362935  Snw1; SNW domain-containing protein 1 [KO:K06063]
125344014  LOW QUALITY PROTEIN: SNW domain-containing protein 1-like [KO:K06063]
125344023  SNW domain-containing protein 1-like [KO:K06063]
125344068  SNW domain-containing protein 1-like [KO:K06063]
125344079  SNW domain-containing protein 1-like [KO:K06063]
125344089  SNW domain-containing protein 1-like [KO:K06063]
125344096  LOW QUALITY PROTEIN: SNW domain-containing protein 1-like [KO:K06063]
125344107  SNW domain-containing protein 1-like [KO:K06063]
125345324  SNW domain-containing protein 1-like [KO:K06063]
125345327  SNW domain-containing protein 1-like [KO:K06063]
125362671  Gtf2h1; general transcription factor IIH subunit 1 [KO:K03141]
125367458  Gtf2h2; general transcription factor IIH subunit 2 isoform X1 [KO:K03142]
125349204  Gtf2h3; general transcription factor IIH subunit 3 isoform X1 [KO:K03143]
125351743  Gtf2e1; general transcription factor IIE subunit 1 [KO:K03136]
125339408  Gtf2e2; transcription initiation factor IIE subunit beta [KO:K03137]
125347103  Snd1; staphylococcal nuclease domain-containing protein 1 [KO:K15979]
125340965  CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
125357982  Ep300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
125355373  Gtf2b; transcription initiation factor IIB [KO:K03124]
125362637  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
125352590  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
125347003  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
125339709  LOW QUALITY PROTEIN: cyclin-A2-like [KO:K06627]
125347890  Ccna1; cyclin-A1 [KO:K06627]
125341412  Ccna2; cyclin-A2 [KO:K06627]
125367687  Skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
125352805  Mrps18b; 28S ribosomal protein S18b, mitochondrial [KO:K16174]
125347818  Traf1; TNF receptor-associated factor 1 [KO:K03172]
125351527  Traf2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
125363299  Traf3; TNF receptor-associated factor 3 [KO:K03174]
125359340  Traf5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
125348908  Jak3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
125360983  Lyn; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
125346974  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
125360442  Atp6v0d2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
125343520  LOW QUALITY PROTEIN: V-type proton ATPase subunit d 1-like [KO:K02146]
125358293  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
125338583  Ube3a; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
125351837  Dlg1; disks large homolog 1 isoform X1 [KO:K12076]
125361016  Scrib; LOW QUALITY PROTEIN: protein scribble homolog [KO:K16175]
125349059  Pxn; paxillin isoform X1 [KO:K05760]
125352692  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
125338811  Irf3; interferon regulatory factor 3 [KO:K05411]
125362974  Psmc1; 26S proteasome regulatory subunit 4 [KO:K03062]
125348277  Rb1; retinoblastoma-associated protein isoform X1 [KO:K06618]
125353433  Rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
125358458  Rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
125342836  Cdkn1b; cyclin-dependent kinase inhibitor 1B [KO:K06624]
125354649  Ubr4; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
125355221  Jun; transcription factor Jun [KO:K04448]
125344890  Chd4; LOW QUALITY PROTEIN: chromodomain-helicase-DNA-binding protein 4 [KO:K11643] [EC:5.6.2.-]
125354859  Hdac1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
125357200  Hdac2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
125359756  LOW QUALITY PROTEIN: histone deacetylase 2-like [KO:K06067] [EC:3.5.1.98]
125339784  Hdac3; histone deacetylase 3 isoform X1 [KO:K11404] [EC:3.5.1.98]
125350137  Hdac4; histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
125366369  Hdac5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
125343330  Hdac6; LOW QUALITY PROTEIN: histone deacetylase 6 [KO:K11407] [EC:3.5.1.98]
125365535  Hdac7; histone deacetylase 7 isoform X1 [KO:K11408] [EC:3.5.1.98]
125343574  Hdac8; histone deacetylase 8 [KO:K11405] [EC:3.5.1.98]
125346842  Hdac9; histone deacetylase 9 isoform X1 [KO:K11409] [EC:3.5.1.98]
125357051  Hdac10; polyamine deacetylase HDAC10 isoform X1 [KO:K18671] [EC:3.5.1.98]
125358853  Hdac11; histone deacetylase 11 [KO:K11418] [EC:3.5.1.98]
125367909  Pkm; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
125363490  Irf9; interferon regulatory factor 9 [KO:K04693]
125340712  Dnaja3; dnaJ homolog subfamily A member 3, mitochondrial isoform X1 [KO:K09504]
125358646  Kat2b; histone acetyltransferase KAT2B [KO:K06062] [EC:2.3.1.48]
125365898  Kat2a; histone acetyltransferase KAT2A isoform X1 [KO:K06062] [EC:2.3.1.48]
125362949  Gtf2a1; transcription initiation factor IIA subunit 1 isoform X1 [KO:K03122]
125356461  Gtf2a1l; TFIIA-alpha and beta-like factor isoform X1 [KO:K03122]
125347078  transcription initiation factor IIA subunit 2-like [KO:K03123]
125340915  Gtf2a2; transcription initiation factor IIA subunit 2 [KO:K03123]
125364197  transcription initiation factor IIA subunit 2-like [KO:K03123]
125352568  Srf; serum response factor [KO:K04378]
125343265  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
125363243  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
125342631  Rasa2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
125354689  Cdc42; cell division control protein 42 homolog [KO:K04393]
125345861  cell division control protein 42 homolog [KO:K04393]
125343037  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
125366701  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
125367464  transforming protein RhoA-like [KO:K04513]
125347858  transforming protein RhoA-like [KO:K04513]
125342586  Rhoa; transforming protein RhoA [KO:K04513]
125346862  Scin; scinderin isoform X1 [KO:K05768]
125347942  Gsn; gelsolin isoform X1 [KO:K05768]
125339037  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
125362857  Actn1; alpha-actinin-1 isoform X1 [KO:K05699]
125362060  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
125360604  cyclin-dependent kinase inhibitor 2A-like [KO:K06621]
125360741  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
125349506  Chek1; serine/threonine-protein kinase Chk1 isoform X1 [KO:K02216] [EC:2.7.11.1]
125355022  Cdc20; cell division cycle protein 20 homolog [KO:K03363]
125339280  Mad1l1; mitotic spindle assembly checkpoint protein MAD1 isoform X1 [KO:K06679]
125358202  Vac14; protein VAC14 homolog isoform X1 [KO:K15305]
125349397  Ranbp1; ran-specific GTPase-activating protein isoform X1 [KO:K15306]
125339359  Polb; DNA polymerase beta isoform X1 [KO:K02330] [EC:2.7.7.7 4.2.99.-]
125363317  DNA polymerase beta-like [KO:K02330] [EC:2.7.7.7 4.2.99.-]
125361218  Irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
125367391  Il6st; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
125342292  C-C chemokine receptor type 5-like [KO:K04180]
125342291  Ccr3; C-C chemokine receptor type 3 [KO:K04178]
125352297  Ccr4; C-C chemokine receptor type 4 [KO:K04179]
125359327  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
125350403  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
125362685  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
125363917  Pmaip1; phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
125348555  C3; complement C3 [KO:K03990]
125352790  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like [KO:K06751]
125352791  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
125352794  saoe class I histocompatibility antigen, A alpha chain-like isoform X1 [KO:K06751]
125352795  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like [KO:K06751]
125352797  HLA class I histocompatibility antigen, B alpha chain-like [KO:K06751]
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Viruses associated with human cancer.
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Nat Rev Cancer 10:878-89 (2010)
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APMIS 117:382-99 (2009)
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Oncogene 27 Suppl 2:S31-42 (2008)
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Zhang X, Zhang H, Ye L
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Effects of hepatitis B virus X protein on the development of liver cancer.
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J Lab Clin Med 147:58-66 (2006)
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PMID:12686421
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Hepatitis viruses and the MAPK pathway: is this a survival strategy?
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Virus Res 92:131-40 (2003)
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PMID:21647825
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Hepatitis B virus X gene and hepatocarcinogenesis.
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J Gastroenterol 46:974-90 (2011)
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PMID:21966251
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Genetic and epigenetic signatures in human hepatocellular carcinoma: a systematic review.
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Curr Genomics 12:130-7 (2011)
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PMID:19854353
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Benhenda S, Cougot D, Buendia MA, Neuveut C
  Title
Hepatitis B virus X protein molecular functions and its role in virus life cycle and pathogenesis.
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Adv Cancer Res 103:75-109 (2009)
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PMID:18251977
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Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
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Viral hepatocarcinogenesis: from infection to cancer.
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Liver Int 28:175-88 (2008)
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PMID:9343405
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Klein NP, Schneider RJ
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Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.
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Mol Cell Biol 17:6427-36 (1997)
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Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
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Mol Cell 19:159-70 (2005)
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Benhenda S, Cougot D, Neuveut C, Buendia MA
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Liver cell transformation in chronic HBV infection.
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Viruses 1:630-46 (2009)
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  Journal
Cancer Lett 289:140-50 (2010)
DOI:10.1016/j.canlet.2009.07.004
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:12770701
  Authors
Verma SC, Robertson ES
  Title
Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
  Journal
FEMS Microbiol Lett 222:155-63 (2003)
DOI:10.1016/S0378-1097(03)00261-1
Reference
PMID:10354594
  Authors
Schulz TF, Moore PS
  Title
Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
  Journal
Trends Microbiol 7:196-200 (1999)
DOI:10.1016/S0966-842X(99)01495-X
Reference
PMID:10855768
  Authors
Schulz TF
  Title
Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8): epidemiology and pathogenesis.
  Journal
J Antimicrob Chemother 45 Suppl T3:15-27 (2000)
DOI:10.1093/jac/45.suppl_4.15
Reference
PMID:9594662
  Authors
Moore PS, Chang Y
  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
  Journal
Trends Genet 14:144-50 (1998)
DOI:10.1016/S0168-9525(98)01408-5
Reference
PMID:20534855
  Authors
Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Havemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF
  Title
Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.
  Journal
J Virol 84:8231-40 (2010)
DOI:10.1128/JVI.01696-09
Reference
PMID:21421561
  Authors
Bagneris C, Briggs LC, Savva R, Ebrahimi B, Barrett TE
  Title
Crystal structure of a KSHV-SOX-DNA complex: insights into the molecular mechanisms underlying DNase activity and host shutoff.
  Journal
Nucleic Acids Res 39:5744-56 (2011)
DOI:10.1093/nar/gkr111
Reference
PMID:15919895
  Authors
Glaunsinger B, Chavez L, Ganem D
  Title
The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable.
  Journal
J Virol 79:7396-401 (2005)
DOI:10.1128/JVI.79.12.7396-7401.2005
Related
pathway
plop03022  Basal transcription factors
plop03320  PPAR signaling pathway
plop04010  MAPK signaling pathway
plop04062  Chemokine signaling pathway
plop04064  NF-kappa B signaling pathway
plop04110  Cell cycle
plop04115  p53 signaling pathway
plop04142  Lysosome
plop04151  PI3K-Akt signaling pathway
plop04210  Apoptosis
plop04630  JAK-STAT signaling pathway
plop04662  B cell receptor signaling pathway
plop04810  Regulation of actin cytoskeleton
plop05160  Hepatitis C
plop05161  Hepatitis B
plop05165  Human papillomavirus infection
plop05166  Human T-cell leukemia virus 1 infection
plop05167  Kaposi sarcoma-associated herpesvirus infection
plop05169  Epstein-Barr virus infection
KO pathway
ko05203   
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