KEGG   PATHWAY: psiu04024
Entry
psiu04024                   Pathway                                
Name
cAMP signaling pathway - Phocoena sinus (vaquita)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
psiu04024  cAMP signaling pathway
psiu04024

Other DBs
GO: 0019933
Organism
Phocoena sinus (vaquita) [GN:psiu]
Gene
116763583  VIP; VIP peptides [KO:K05264]
116742639  CRH; corticoliberin [KO:K05256]
116763528  CGA; glycoprotein hormones alpha chain [KO:K08522]
116744345  LHB; lutropin subunit beta isoform X1 [KO:K08521]
116758684  GPHA2; glycoprotein hormone alpha-2 [KO:K25483]
116746161  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
116762615  TSHB; thyrotropin subunit beta [KO:K05251]
116764385  POMC; pro-opiomelanocortin [KO:K05228]
116756656  GCG; glucagon isoform X1 [KO:K05259]
116746104  GIP; gastric inhibitory polypeptide isoform X1 [KO:K05258]
116758023  follitropin subunit beta [KO:K05250]
116758364  FSHB; follitropin subunit beta [KO:K05250]
116760402  NPPA; natriuretic peptides A [KO:K12334]
116738981  ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262]
116741698  ADRB1; beta-1 adrenergic receptor [KO:K04141]
116752214  ADRB2; beta-2 adrenergic receptor isoform X1 [KO:K04142]
116750400  DRD1; D(1A) dopamine receptor [KO:K04144]
116753925  DRD5; LOW QUALITY PROTEIN: D(1B) dopamine receptor [KO:K05840]
116739170  ADORA2A; adenosine receptor A2a [KO:K04266]
116751337  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
116758365  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
116749424  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
116759836  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
116759037  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X1 [KO:K04590]
116746306  CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
116759357  CRHR2; corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
116764300  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
116750018  TSHR; thyrotropin receptor isoform X1 [KO:K04249]
116738812  MC2R; adrenocorticotropic hormone receptor isoform X1 [KO:K04200]
116762766  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
116744090  GIPR; gastric inhibitory polypeptide receptor [KO:K04580]
116748018  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
116764274  FSHR; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
116763973  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
116740990  neuroendocrine secretory protein 55-like [KO:K04632]
116740988  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
116762788  EDN1; endothelin-1 isoform X1 [KO:K16366]
116744510  EDN2; endothelin-2 [KO:K16367]
116739991  EDN3; LOW QUALITY PROTEIN: endothelin-3 [KO:K05227]
116753174  SST; somatostatin [KO:K05237]
116759444  NPY; pro-neuropeptide Y isoform X1 [KO:K05232]
116740273  OXT; oxytocin-neurophysin 1 [KO:K05243]
116753138  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
116744423  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
116763655  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
116763658  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
116752018  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
116758068  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
116759002  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
116757987  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
116755193  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
116762593  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
116741695  ADORA1; adenosine receptor A1 [KO:K04265]
116754588  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
116754254  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
116748614  SSTR1; somatostatin receptor type 1 [KO:K04217]
116746433  SSTR2; somatostatin receptor type 2 [KO:K04218]
116740619  SSTR5; somatostatin receptor type 5 [KO:K04221]
116738969  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
116764968  hydroxycarboxylic acid receptor 2-like [KO:K08402]
116744611  FFAR2; free fatty acid receptor 2 [KO:K04328]
116753637  SUCNR1; succinate receptor 1 [KO:K10042]
116763919  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
116762711  OXTR; oxytocin receptor [KO:K04229]
116753237  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
116761812  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
116749946  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
116759318  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
116759445  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
116752275  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
116764233  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
116749116  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
116753224  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
116760787  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
116744731  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
116742406  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
116740403  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
116762679  adenylate cyclase type 10-like isoform X1 [KO:K11265] [EC:4.6.1.1]
116759017  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
116754560  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
116747549  CNGA2; LOW QUALITY PROTEIN: cyclic nucleotide-gated olfactory channel [KO:K04949]
116764691  CNGA3; cyclic nucleotide-gated cation channel alpha-3 isoform X1 [KO:K04950]
116757580  CNGA4; LOW QUALITY PROTEIN: cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
116743966  CNGB1; cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
116742487  CNGB3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
116744236  CALM3; calmodulin-3 [KO:K02183]
116748386  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
116748713  CALM1; calmodulin-1 isoform X1 [KO:K02183]
116762110  calmodulin-1-like [KO:K02183]
116749119  calmodulin-like [KO:K02183]
116749952  calmodulin-like protein 3 [KO:K02183]
116764310  CALM2; calmodulin-2 [KO:K02183]
116759635  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
116754119  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
116741278  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
116751381  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
116751210  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
116763749  BVES; blood vessel epicardial substance isoform X1 [KO:K21108]
116753277  POPDC2; popeye domain-containing protein 2 isoform X1 [KO:K26206]
116763758  POPDC3; popeye domain-containing protein 3 [KO:K26207]
116760007  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
116750860  HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
116749097  HCN4; LOW QUALITY PROTEIN: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
116742887  ABCC4; LOW QUALITY PROTEIN: multidrug resistance-associated protein 4 [KO:K05673]
116742970  LOW QUALITY PROTEIN: multidrug resistance-associated protein 4-like [KO:K05673]
116761070  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
116757044  RAPGEF4; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 4 [KO:K04351]
116743409  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
116750736  ras-related protein R-Ras2 [KO:K07830]
116757894  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
116751676  LOW QUALITY PROTEIN: ras-related protein R-Ras2-like [KO:K07830]
116746315  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
116753650  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
116741248  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
116754735  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116741257  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116751302  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116755898  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
116753261  ras-related protein Rap-1b-like isoform X1 [KO:K07836]
116760187  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
116757757  LOW QUALITY PROTEIN: ras-related protein Rap-1b-like [KO:K07836]
116753482  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
116755111  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
116748371  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
116751236  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
116761737  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
116739565  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116760236  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
116745822  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
116758470  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
116751544  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
116762804  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
116763385  AFDN; LOW QUALITY PROTEIN: afadin [KO:K05702]
116752953  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116752990  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
116751286  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116750604  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116742613  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
116751944  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116743673  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116759669  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116748950  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
116759212  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116761625  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116747589  MAP2K1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116751189  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
116738910  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116740620  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
116754197  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
116751566  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
116744938  PPP1R1B; protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
116739009  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
116764122  PPP1CB; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
116757793  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
116756730  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
116755320  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
116740243  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
116758621  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
116751955  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
116759300  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
116759616  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
116760164  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
116739511  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
116758559  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
116749519  FOS; proto-oncogene c-Fos [KO:K04379]
116761115  JUN; transcription factor AP-1 [KO:K04448]
116759841  GLI3; transcriptional activator GLI3 [KO:K06230]
116760105  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
116755916  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
116754618  HHIP; hedgehog-interacting protein isoform X1 [KO:K06231]
116749797  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
116754222  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
116758150  RELA; transcription factor p65 isoform X1 [KO:K04735]
116746395  SOX9; transcription factor SOX-9 [KO:K18435]
116752063  AMH; muellerian-inhibiting factor [KO:K04665]
116760693  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
116754074  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [KO:K00232] [EC:1.3.3.6]
116744969  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
116765202  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
116751838  F2R; proteinase-activated receptor 1 [KO:K03914]
116758242  BAD; bcl2-associated agonist of cell death [KO:K02158]
116743963  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
116765160  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
116764174  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
116760401  PPP1R12A; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12A [KO:K06270]
116740323  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
116743854  TNNI3; troponin I, cardiac muscle isoform X1 [KO:K12044]
116763505  PLN; cardiac phospholamban [KO:K05852]
116738913  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
116740335  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
116745111  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
116741907  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
116755534  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
116740277  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
116760570  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
116746356  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
116744167  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
116754946  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
116750651  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
116751165  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
116754193  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
116747908  GRIA3; glutamate receptor 3 [KO:K05199]
116757796  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
116759844  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
116744406  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
116738896  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X1 [KO:K01539] [EC:7.2.2.13]
116755861  LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-4-like [KO:K01539] [EC:7.2.2.13]
116742064  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
116753189  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540]
116746443  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
116747669  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
116758266  LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit beta-3-like [KO:K01540]
116758154  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
116761037  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
116738827  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
116760098  ATP2B1; plasma membrane calcium-transporting ATPase 1 [KO:K05850] [EC:7.2.2.10]
116747968  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
116748402  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
116762646  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
116760103  CACNA1C; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
116762723  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
116747382  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
116739924  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
116760961  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A isoform X1 [KO:K19021] [EC:3.1.4.17]
116758554  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
116750878  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
116751251  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
116751469  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
116752088  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
116763464  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
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Related
pathway
psiu00071  Fatty acid degradation
psiu04015  Rap1 signaling pathway
psiu04020  Calcium signaling pathway
psiu04151  PI3K-Akt signaling pathway
psiu04210  Apoptosis
psiu04260  Cardiac muscle contraction
psiu04340  Hedgehog signaling pathway
psiu04720  Long-term potentiation
psiu04740  Olfactory transduction
psiu04972  Pancreatic secretion
psiu04976  Bile secretion
KO pathway
ko04024   
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