KEGG   PATHWAY: shr04630
Entry
shr04630                    Pathway                                
Name
JAK-STAT signaling pathway - Sarcophilus harrisii (Tasmanian devil)
Description
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class
Environmental Information Processing; Signal transduction
Pathway map
shr04630  JAK-STAT signaling pathway
shr04630

Other DBs
GO: 0007259
Organism
Sarcophilus harrisii (Tasmanian devil) [GN:shr]
Gene
100935068  uncharacterized LOC100935068 precursor [KO:K05429]
100914681  IL4; interleukin-4 [KO:K05430]
116420560  IL7; interleukin-7 [KO:K05431]
105749159  IL9; LOW QUALITY PROTEIN: interleukin-9 [KO:K05432]
100926512  IL15; interleukin-15 isoform X1 [KO:K05433]
105751011  IL21; interleukin-21 [KO:K05434]
105749698  TSLP; LOW QUALITY PROTEIN: thymic stromal lymphopoietin [KO:K05436]
105750698  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
100913275  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
100929781  IL2RG; cytokine receptor common subunit gamma isoform X2 [KO:K05070]
100922104  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
100915478  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
105749532  interleukin-9 receptor [KO:K05073]
105750697  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
100920794  IL21R; interleukin-21 receptor isoform X3 [KO:K05075]
105749996  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
100934043  IL5; interleukin-5 [KO:K05428]
105749995  interleukin-3 receptor subunit alpha [KO:K04737]
100917948  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
100916709  IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067]
105749994  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
105750684  CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738]
105750762  IL6; interleukin-6 [KO:K05405]
111720829  IL13; interleukin-13 [KO:K05435]
100917661  IL27; interleukin-27 subunit alpha [KO:K22629]
105749464  uncharacterized protein LOC105749464 [KO:K05418]
100934326  LIF; leukemia inhibitory factor [KO:K05419]
100918670  CNTF; ciliary neurotrophic factor [KO:K05420]
100928781  cardiotrophin-1 [KO:K05422]
100935199  cardiotrophin-2-like [KO:K24382]
100914334  CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
100924664  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
100913307  IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
100921841  GALT; galactose-1-phosphate uridylyltransferase isoform X1 [KO:K05056]
100930920  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
100923207  IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X2 [KO:K05077]
100922616  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
100935278  IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630]
100934321  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
100934579  LIFR; leukemia inhibitory factor receptor [KO:K05058]
100923143  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
100917955  IL10; LOW QUALITY PROTEIN: interleukin-10 [KO:K05443]
100918216  IL19; interleukin-19 [KO:K05444]
100918476  IL20; interleukin-20 [KO:K22667]
100918737  IL24; interleukin-24 [KO:K22668]
100915178  IL26; interleukin-26 [KO:K05446]
100926905  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
100919327  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
100919001  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
100925684  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
100913243  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
100928138  interleukin-22 receptor subunit alpha-2 isoform X1 [KO:K05139]
100914201  IL12A; interleukin-12 subunit alpha [KO:K05406]
100932486  IL12B; interleukin-12 subunit beta [KO:K05425]
100933427  IL23A; interleukin-23 subunit alpha [KO:K05426]
105749415  IL12RB1; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-1 [KO:K05063]
100931154  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
100930891  IL23R; interleukin-23 receptor [KO:K05065]
100924490  EPO; erythropoietin [KO:K05437]
100922992  somatotropin [KO:K05438]
100932842  PRL; prolactin [KO:K05439]
105750562  THPO; thrombopoietin [KO:K06854]
100925445  CSF3; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor [KO:K05423]
100930199  LEP; leptin [KO:K05424]
100922441  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
100927655  GHR; growth hormone receptor isoform X1 [KO:K05080]
100915999  PRLR; prolactin receptor [KO:K05081]
100928707  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
100914129  LEPR; leptin receptor isoform X2 [KO:K05062]
100914965  interferon tau-like [KO:K05414]
100920968  interferon tau-2-like [KO:K05414]
100914703  interferon tau-2-like [KO:K05414]
116420987  interferon omega-1-like [KO:K05414]
116420989  interferon omega-1-like [KO:K05414]
100914443  interferon beta [KO:K05415]
100914299  interferon lambda-2-like [KO:K22669]
100914565  interferon lambda-2-like [KO:K22669]
116422647  interferon lambda-3-like [KO:K22669]
116422648  interferon lambda-2-like [KO:K22669]
116422649  interferon lambda-3-like [KO:K22669]
116422650  LOW QUALITY PROTEIN: interferon lambda-2-like [KO:K22669]
116422651  interferon lambda-2-like [KO:K22669]
100919064  IFNAR1; LOW QUALITY PROTEIN: interferon alpha/beta receptor 1 [KO:K05130]
105750087  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
100913505  IFNLR1; interferon lambda receptor 1 [KO:K05140]
105750683  IFNG; interferon gamma [KO:K04687]
111720994  IFNGR1; interferon gamma receptor 1 [KO:K05132]
100929576  IFNGR2; interferon gamma receptor 2 [KO:K05133]
100933169  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
100924985  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116422035  platelet-derived growth factor subunit A-like [KO:K04359]
100917875  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
100914017  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100925116  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
100917212  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100916991  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
100927237  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
100920108  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
100927743  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
105749862  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
100933167  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
100933581  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
100933645  STAT4; signal transducer and activator of transcription 4 [KO:K11222]
100920045  LOW QUALITY PROTEIN: signal transducer and activator of transcription 5A [KO:K11223]
100920307  STAT5B; signal transducer and activator of transcription 5B [KO:K11224]
100930901  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
100916853  IRF9; interferon regulatory factor 9 isoform X3 [KO:K04693]
100926286  CISH; cytokine-inducible SH2-containing protein [KO:K04701]
100917658  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
105750824  suppressor of cytokine signaling 1 [KO:K04694]
100925364  SOCS2; suppressor of cytokine signaling 2 [KO:K04695]
100934360  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
100921040  SOCS4; suppressor of cytokine signaling 4 [KO:K04697]
100920946  SOCS5; suppressor of cytokine signaling 5 [KO:K04698]
100931670  SOCS7; suppressor of cytokine signaling 7 isoform X1 [KO:K04699]
100918523  SOCS6; suppressor of cytokine signaling 6 [KO:K04699]
100934666  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
100928648  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
100915548  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
100931060  PIM1; serine/threonine-protein kinase pim-1 isoform X1 [KO:K04702] [EC:2.7.11.1]
100921308  MYC; myc proto-oncogene protein [KO:K04377]
100917462  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
100915359  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
100921166  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100926666  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
100923855  AOX1; aldehyde oxidase [KO:K00157] [EC:1.2.3.1]
100929481  uncharacterized protein LOC100929481 [KO:K00157] [EC:1.2.3.1]
100924119  LOW QUALITY PROTEIN: aldehyde oxidase 4-like [KO:K00157] [EC:1.2.3.1]
100921509  aldehyde oxidase 3-like [KO:K00157] [EC:1.2.3.1]
100933739  GFAP; glial fibrillary acidic protein [KO:K05640]
100924903  STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
100932204  STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705]
100935022  PTPN2; tyrosine-protein phosphatase non-receptor type 2 isoform X1 [KO:K18026] [EC:3.1.3.48]
100916661  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X2 [KO:K05697] [EC:3.1.3.48]
100921187  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
100926283  CREBBP; CREB-binding protein isoform X2 [KO:K04498] [EC:2.3.1.48]
100928324  PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
100914432  PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
100925191  PIAS3; E3 SUMO-protein ligase PIAS3 [KO:K16064] [EC:2.3.2.-]
100914530  PIAS4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
100920230  FHL1; four and a half LIM domains protein 1 isoform X3 [KO:K14365]
100930062  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
100915682  LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
100928380  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
100931009  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
100932999  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100929168  ras-like protein [KO:K02833]
116419913  HRAS; GTPase HRas [KO:K02833]
100935202  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
100929811  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
100932099  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105749979  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100926892  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100924976  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100935230  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
100917987  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100913262  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100925440  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100931480  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
Reference
PMID:22383755
  Authors
Harrison DA
  Title
The Jak/STAT pathway.
  Journal
Cold Spring Harb Perspect Biol 4:a011205 (2012)
DOI:10.1101/cshperspect.a011205
Reference
PMID:22339650
  Authors
Kiu H, Nicholson SE
  Title
Biology and significance of the JAK/STAT signalling pathways.
  Journal
Growth Factors 30:88-106 (2012)
DOI:10.3109/08977194.2012.660936
Reference
PMID:21372217
  Authors
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
  Title
Direct effects of type I interferons on cells of the immune system.
  Journal
Clin Cancer Res 17:2619-27 (2011)
DOI:10.1158/1078-0432.CCR-10-1114
Reference
PMID:25217450
  Authors
Fish EN, Platanias LC
  Title
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
  Journal
Mol Cancer Res 12:1691-703 (2014)
DOI:10.1158/1541-7786.MCR-14-0450
Reference
PMID:21034406
  Authors
Ivanenkov YA, Balakin KV, Lavrovsky Y
  Title
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
  Journal
Mini Rev Med Chem 11:55-78 (2011)
DOI:10.2174/138955711793564079
Reference
PMID:25587654
  Authors
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
  Title
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
  Journal
Annu Rev Med 66:311-28 (2015)
DOI:10.1146/annurev-med-051113-024537
Reference
PMID:24069565
  Authors
Zoranovic T, Grmai L, Bach EA
  Title
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
  Journal
JAKSTAT 2:e25408 (2013)
DOI:10.4161/jkst.25408
Reference
PMID:16204702
  Authors
Ungureanu D, Silvennoinen O
  Title
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
  Journal
Sci STKE 2005:pe49 (2005)
DOI:10.1126/stke.3042005pe49
Reference
PMID:23735217
  Authors
Richard AJ, Stephens JM
  Title
The role of JAK-STAT signaling in adipose tissue function.
  Journal
Biochim Biophys Acta 1842:431-9 (2014)
DOI:10.1016/j.bbadis.2013.05.030
Reference
PMID:24606160
  Authors
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
  Title
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
  Journal
Neuropathol Appl Neurobiol 41:347-70 (2015)
DOI:10.1111/nan.12133
Reference
PMID:10851053
  Authors
Hirano T, Ishihara K, Hibi M
  Title
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
  Journal
Oncogene 19:2548-56 (2000)
DOI:10.1038/sj.onc.1203551
Reference
PMID:11114747
  Authors
Rane SG, Reddy EP
  Title
Janus kinases: components of multiple signaling pathways.
  Journal
Oncogene 19:5662-79 (2000)
DOI:10.1038/sj.onc.1203925
Reference
PMID:8682149
  Authors
Heim MH
  Title
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
  Journal
Eur J Clin Invest 26:1-12 (1996)
DOI:10.1046/j.1365-2362.1996.103248.x
Reference
PMID:30267440
  Authors
Morris R, Kershaw NJ, Babon JJ
  Title
The molecular details of cytokine signaling via the JAK/STAT pathway.
  Journal
Protein Sci 27:1984-2009 (2018)
DOI:10.1002/pro.3519
Reference
PMID:34492272
  Authors
Tzeng HT, Chyuan IT, Lai JH
  Title
Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
  Journal
Biochem Pharmacol 193:114760 (2021)
DOI:10.1016/j.bcp.2021.114760
Reference
PMID:32203403
  Authors
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
  Title
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
  Journal
Nat Rev Gastroenterol Hepatol 17:323-337 (2020)
DOI:10.1038/s41575-020-0273-0
Related
pathway
shr04010  MAPK signaling pathway
shr04060  Cytokine-cytokine receptor interaction
shr04110  Cell cycle
shr04120  Ubiquitin mediated proteolysis
shr04151  PI3K-Akt signaling pathway
shr04210  Apoptosis
KO pathway
ko04630   
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