Entry
Name
Cytokine-cytokine receptor interaction - Sarcophilus harrisii (Tasmanian devil)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
shr04060 Cytokine-cytokine receptor interaction
Organism
Sarcophilus harrisii (Tasmanian devil) [GN:
shr ]
Gene
100913307 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
100914374 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141 ]
100914610 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
100914627 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
100914694 TNFRSF11A; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
100915478 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
100916471 TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
100916709 IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067 ]
100917236 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
100917948 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
100918968 IL17RB; LOW QUALITY PROTEIN: interleukin-17 receptor B [KO:K05165 ]
100919064 IFNAR1; LOW QUALITY PROTEIN: interferon alpha/beta receptor 1 [KO:K05130 ]
100919776 FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389 ]
100919788 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
100920316 LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
100921354 TNFRSF21; tumor necrosis factor receptor superfamily member 21 isoform X1 [KO:K05157 ]
100921841 GALT; galactose-1-phosphate uridylyltransferase isoform X1 [KO:K05056 ]
100922104 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
100923143 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
100923154 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
100923207 IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X2 [KO:K05077 ]
100923393 IL36RN; LOW QUALITY PROTEIN: interleukin-36 receptor antagonist protein [KO:K05483 ]
100923594 RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
100924125 TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160 ]
100925305 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
100925445 CSF3; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor [KO:K05423 ]
100926390 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
100926905 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
100927086 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
100927255 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
100928707 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
100929781 IL2RG; cytokine receptor common subunit gamma isoform X2 [KO:K05070 ]
100930278 CSF1; macrophage colony-stimulating factor 1 isoform X2 [KO:K05453 ]
100931461 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
100932342 TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477 ]
100932607 TGFB1; LOW QUALITY PROTEIN: transforming growth factor beta-1 proprotein [KO:K13375 ]
100933140 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
100934473 EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
100935026 TNFRSF17; tumor necrosis factor receptor superfamily member 17 isoform X1 [KO:K05153 ]
100935038 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162 ]
100935278 IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630 ]
100935349 CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160 ]
105749219 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
105749415 IL12RB1; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-1 [KO:K05063 ]
105749505 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
105749698 TSLP; LOW QUALITY PROTEIN: thymic stromal lymphopoietin [KO:K05436 ]
105749994 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
105750026 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
105750042 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
105750684 CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738 ]
105750698 IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068 ]
111719911 TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145 ]
111719928 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
111719929 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
111720388 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
111721210 TNFRSF13C; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
111721697 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway