KEGG   PATHWAY: ssen04020
Entry
ssen04020                   Pathway                                
Name
Calcium signaling pathway - Solea senegalensis (Senegalese sole)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
ssen04020  Calcium signaling pathway
ssen04020

Other DBs
GO: 0019722
Organism
Solea senegalensis (Senegalese sole) [GN:ssen]
Gene
122781596  sodium/calcium exchanger 1-like [KO:K05849]
122762822  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
122782294  sodium/calcium exchanger 1-like [KO:K05849]
122782622  slc8a3; sodium/calcium exchanger 3 [KO:K05849]
122773169  slc8a2b; sodium/calcium exchanger 2b [KO:K05849]
122767277  sodium/calcium exchanger 3-like isoform X1 [KO:K05849]
122780107  slc8a2a; sodium/calcium exchanger 2a [KO:K05849]
122780239  slc8a4a; solute carrier family 8 member 4a [KO:K05849]
122768721  plasma membrane calcium-transporting ATPase 1-like isoform X1 [KO:K05850] [EC:7.2.2.10]
122775848  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
122776930  atp2b3b; plasma membrane calcium-transporting ATPase 3b isoform X1 [KO:K05850] [EC:7.2.2.10]
122766804  atp2b1a; plasma membrane calcium-transporting ATPase 1a isoform X1 [KO:K05850] [EC:7.2.2.10]
122768252  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
122759409  chrm3b; muscarinic acetylcholine receptor M3 [KO:K04129]
122781451  chrm3a; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
122782771  chrm5a; muscarinic acetylcholine receptor M5a [KO:K04133]
122784058  chrm5b; muscarinic acetylcholine receptor M5b [KO:K04133]
122769046  adora2aa; adenosine A2a receptor a [KO:K04266]
122787100  adenosine receptor A2a-like [KO:K04266]
122779715  adora2b; adenosine receptor A2b [KO:K04267]
122774370  adenosine receptor A1-like [KO:K04267]
122759026  adrb1; beta-1 adrenergic receptor [KO:K04141]
122777991  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
122779785  beta-2 adrenergic receptor-like isoform X1 [KO:K04142]
122769054  adrb3a; adrenoceptor beta 3a [KO:K04143]
122770487  D(1) dopamine receptor-like [KO:K04144]
122778405  D(1) dopamine receptor-like [KO:K04144]
122780233  drd1b; dopamine receptor D1b [KO:K04144]
122767718  drd5a; D(1B) dopamine receptor [KO:K05840]
122759583  D(5)-like dopamine receptor [KO:K05840]
122778245  histamine H2 receptor-like [KO:K04150]
122779933  hrh2b; histamine receptor H2b isoform X1 [KO:K04150]
122787046  si:dkey-247m21.3; 5-hydroxytryptamine receptor 4 [KO:K04160]
122770966  5-hydroxytryptamine receptor 4 [KO:K04160]
122778107  htr4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
122765289  htr5ab; 5-hydroxytryptamine (serotonin) receptor 5A, genome duplicate b [KO:K04161]
122777604  htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
122769245  htr7c; 5-hydroxytryptamine receptor 7 [KO:K04163]
122777431  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
122767567  guanine nucleotide-binding protein G(s) subunit alpha-like isoform X1 [KO:K04632]
122781178  guanine nucleotide-binding protein G(olf) subunit alpha-like isoform X1 [KO:K04633]
122772474  guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
122780642  adcy1a; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
122771664  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
122786587  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
122774912  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
122774154  adcy3a; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
122772187  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
122762475  adcy8; LOW QUALITY PROTEIN: adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
122783786  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
122771216  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
122784928  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
122780814  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
122771368  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122772674  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
122785644  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
122785164  pln; cardiac phospholamban [KO:K05852]
122773206  sarcolipin [KO:K22642]
122769318  atp2a2a; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
122770873  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
122758238  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b [KO:K05853] [EC:7.2.2.10]
122785090  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
122779537  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
122759220  atp2a1l; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like isoform X1 [KO:K05853] [EC:7.2.2.10]
122759384  cilia- and flagella-associated protein 251 isoform X1 [KO:K23450]
122780669  stim1a; stromal interaction molecule 1a [KO:K16059]
122779131  stromal interaction molecule 1-like isoform X1 [KO:K16059]
122770423  stromal interaction molecule 2-like isoform X1 [KO:K18196]
122766433  stim2b; stromal interaction molecule 2 isoform X1 [KO:K18196]
122769102  calcium release-activated calcium channel protein 1-like [KO:K16056]
122758731  orai1b; calcium release-activated calcium channel protein 1 [KO:K16056]
122780184  orai2; protein orai-2 [KO:K16057]
122767001  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
122777142  voltage-dependent L-type calcium channel subunit alpha-1D-like isoform X1 [KO:K04851]
122767592  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
122776983  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1 [KO:K04853]
122777519  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
122760459  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
122768110  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like isoform X1 [KO:K04857]
122770849  LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A-like [KO:K04344]
122785004  cacna1aa; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
122769886  cacna1ba; calcium channel, voltage-dependent, N type, alpha 1B subunit, a isoform X1 [KO:K04849]
122758028  voltage-dependent N-type calcium channel subunit alpha-1B-like isoform X1 [KO:K04849]
122780700  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
122777467  LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E-like [KO:K04852]
122760011  voltage-dependent T-type calcium channel subunit alpha-1G-like isoform X1 [KO:K04854]
122785079  cacna1ha; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04855]
122770945  voltage-dependent T-type calcium channel subunit alpha-1I-like [KO:K04856]
122784946  cacna1ia; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
122786577  CHRNA7-FAM7A fusion protein-like [KO:K04809]
122770489  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
122778102  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
122772604  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
122774326  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
122769313  grin1b; glutamate receptor ionotropic, NMDA 1b isoform X1 [KO:K05208]
122758318  grin1a; glutamate receptor ionotropic, NMDA 1a isoform X1 [KO:K05208]
122785109  grin2aa; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
122771497  grin2bb; glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b isoform X1 [KO:K05210]
122785653  glutamate receptor ionotropic, NMDA 2B [KO:K05210]
122784664  grin2ca; glutamate receptor, ionotropic, N-methyl D-aspartate 2Ca [KO:K05211]
122759490  glutamate receptor ionotropic, NMDA 2C-like [KO:K05211]
122786647  grin2da; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
122775037  glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
122757992  grin3a; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
122780457  grin3bb; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
122783311  glutamate receptor ionotropic, NMDA 3B-like [KO:K05214]
122779284  p2rx1; P2X purinoceptor 1 isoform X1 [KO:K05215]
122769846  p2rx2; P2X purinoceptor 2 [KO:K05216]
122770693  p2rx3b; P2X purinoceptor 3b [KO:K05217]
122778955  p2rx3a; P2X purinoceptor 3a [KO:K05217]
122770109  P2X purinoceptor 4-like [KO:K05218]
122773089  P2X purinoceptor 5-like [KO:K05219]
122779539  p2rx5; P2X purinoceptor 5 [KO:K05219]
122773170  ryr1b; ryanodine receptor 1b [KO:K04961]
122779385  ryr1a; ryanodine receptor 1 isoform X1 [KO:K04961]
122782213  ryanodine receptor 2-like [KO:K04962]
122759400  ryr2a; ryanodine receptor 2 isoform X1 [KO:K04962]
122782677  ryanodine receptor 3-like isoform X1 [KO:K04963]
122784057  ryr3; ryanodine receptor 3 [KO:K04963]
122783869  triadin-like isoform X1 [KO:K23449]
122775060  LOW QUALITY PROTEIN: calsequestrin-1-like [KO:K23468]
122765889  casq1b; calsequestrin-1b isoform X1 [KO:K23468]
122762190  calsequestrin-2-like [KO:K23445]
122784789  casq2; calsequestrin-2 [KO:K23445]
122780483  aspartyl/asparaginyl beta-hydroxylase-like [KO:K00476] [EC:1.14.11.16]
122777016  asph; aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
122768290  caldesmon-like [KO:K00476] [EC:1.14.11.16]
122778224  cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
122766904  cysteinyl leukotriene receptor 2-like [KO:K04322]
122776242  muscarinic acetylcholine receptor M2-like [KO:K04130]
122767307  chrm2a; muscarinic acetylcholine receptor M2a [KO:K04130]
122769083  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
122758435  alpha-1A adrenergic receptor-like [KO:K04135]
122778936  alpha-1A adrenergic receptor-like [KO:K04136]
122770638  adra1d; alpha-1D adrenergic receptor [KO:K04137]
122773663  agtr1b; type-1 angiotensin II receptor [KO:K04166]
122762523  endothelin receptor type B-like isoform X1 [KO:K04197]
122771089  endothelin receptor type B-like isoform X1 [KO:K04197]
122771469  ednraa; endothelin receptor type Aa [KO:K04197]
122781993  ednrba; endothelin receptor Ba [KO:K04198]
122765441  endothelin receptor type B-like [KO:K04198]
122778644  endothelin receptor type B-like [KO:K04198]
122787083  proteinase-activated receptor 1-like [KO:K03914]
122769783  f2r; proteinase-activated receptor 1 [KO:K03914]
122782935  metabotropic glutamate receptor 1-like [KO:K04603]
122784448  grm1a; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
122765056  metabotropic glutamate receptor 5-like [KO:K04604]
122779547  grm5a; glutamate receptor, metabotropic 5a [KO:K04604]
122765583  gastrin-releasing peptide receptor-like [KO:K04169]
122772719  grpr; gastrin-releasing peptide receptor [KO:K04169]
122768567  hrh1; histamine H1 receptor [KO:K04149]
122780693  htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
122765779  htr2cl1; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 [KO:K04157]
122781549  LOW QUALITY PROTEIN: lutropin-choriogonadotropic hormone receptor-like [KO:K04248]
122782142  lhcgr; lutropin-choriogonadotropic hormone receptor [KO:K04248]
122777596  ntsr1; neurotensin receptor type 1 [KO:K04211]
122768849  isotocin receptor-like [KO:K04229]
122768857  oxtra; oxytocin receptor [KO:K04229]
122775472  arg8-vasotocin receptor-like [KO:K04226]
122766016  arg8-vasotocin receptor-like isoform X1 [KO:K04226]
122781944  ltb4r2b; leukotriene B4 receptor 2b [KO:K04297]
122782450  ptafr; platelet-activating factor receptor [KO:K04279]
122771379  ptger1a; prostaglandin E receptor 1a (subtype EP1) [KO:K04258]
122785571  ptger1c; prostaglandin E receptor 1c (subtype EP1) [KO:K04258]
122785897  ptger1b; prostaglandin E receptor 1b (subtype EP1) [KO:K04258]
122780854  ptger3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
122781329  ptgfr; prostaglandin F2-alpha receptor [KO:K04262]
122762515  si:dkey-63b1.1; B2 bradykinin receptor [KO:K03916]
122783191  bdkrb1; B1 bradykinin receptor [KO:K03916]
122783213  bdkrb2; B2 bradykinin receptor [KO:K03916]
122761463  substance-P receptor-like [KO:K04222]
122770163  tacr1a; tachykinin receptor 1a [KO:K04222]
122772052  tacr2; substance-K receptor isoform X1 [KO:K04223]
122770508  tacr3l; tachykinin receptor 3-like [KO:K04224]
122771241  tacr3a; tachykinin receptor 3a isoform X1 [KO:K04224]
122781343  tbxa2r; thromboxane A2 receptor isoform X1 [KO:K04264]
122775552  trhr2; thyrotropin releasing hormone receptor 2 [KO:K04282]
122777575  thyrotropin-releasing hormone receptor-like [KO:K04282]
122774275  trhra; thyrotropin-releasing hormone receptor [KO:K04282]
122786085  trhrb; thyrotropin-releasing hormone receptor b [KO:K04282]
122783254  cholecystokinin receptor [KO:K04194]
122765466  cholecystokinin receptor-like [KO:K04194]
122765886  cckar; cholecystokinin receptor type A [KO:K04194]
122761245  cxcr4a; C-X-C chemokine receptor type 4a [KO:K04189]
122784942  C-X-C chemokine receptor type 4-like [KO:K04189]
122769267  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
122757985  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
122780589  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04635]
122782615  guanine nucleotide-binding protein G(q) subunit alpha-like isoform X1 [KO:K04635]
122769270  gna14a; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
122780952  guanine nucleotide-binding protein subunit alpha-11-like [KO:K04637]
122778301  egf; pro-epidermal growth factor [KO:K04357]
122768083  tgfa; protransforming growth factor alpha [KO:K08774]
122770440  platelet-derived growth factor subunit A-like [KO:K04359]
122785574  pdgfab; platelet-derived growth factor alpha polypeptide b [KO:K04359]
122771409  si:ch211-79m20.1; bromodomain-containing protein 4 isoform X1 [KO:K17386]
122778939  pdgfc; platelet-derived growth factor C [KO:K05450]
122773477  pdgfd; platelet-derived growth factor D [KO:K05450]
122760023  putative fibroblast growth factor 1 [KO:K18496]
122762527  putative fibroblast growth factor 1 [KO:K18496]
122778971  fgf2; fibroblast growth factor 2 [KO:K18497]
122780497  fgf22; fibroblast growth factor 22 [KO:K04358]
122769127  fibroblast growth factor 10-like [KO:K04358]
122775527  fgf4; fibroblast growth factor 4 isoform X1 [KO:K04358]
122769879  fgf17; fibroblast growth factor 17 [KO:K04358]
122776140  fgf3; fibroblast growth factor 3 [KO:K04358]
122782010  fgf8a; fibroblast growth factor 8 [KO:K04358]
122776528  fibroblast growth factor 4B-like [KO:K04358]
122771229  fibroblast growth factor 20-like [KO:K04358]
122765292  fgf9; fibroblast growth factor 4A [KO:K04358]
122771557  fgf8b; fibroblast growth factor 8b [KO:K04358]
122765726  fibroblast growth factor 6-like [KO:K04358]
122772024  fgf7; fibroblast growth factor 7 [KO:K04358]
122778079  fgf18a; fibroblast growth factor 18a isoform X1 [KO:K04358]
122778135  fgf20b; fibroblast growth factor 20b [KO:K04358]
122757989  fgf10a; fibroblast growth factor 10a [KO:K04358]
122778178  fgf16; fibroblast growth factor 16 isoform X1 [KO:K04358]
122778738  fgf24; fibroblast growth factor 24 isoform X1 [KO:K04358]
122776286  fgf19; fibroblast growth factor 19 [KO:K22603]
122759297  fgf21; fibroblast growth factor 21 [KO:K22429]
122775523  fibroblast growth factor 23-like [KO:K22428]
122765723  fgf23; fibroblast growth factor 23 [KO:K22428]
122774919  vegfaa; vascular endothelial growth factor A-A isoform X1 [KO:K05448]
122783992  vegfab; vascular endothelial growth factor Ab [KO:K05448]
122778869  vegfba; vascular endothelial growth factor A isoform X1 [KO:K05448]
122770884  vegfc; vascular endothelial growth factor C [KO:K05449]
122765454  vascular endothelial growth factor C-like [KO:K05449]
122777529  nerve growth factor-like [KO:K02582]
122777552  neurotrophin-7-like [KO:K02582]
122767822  ngfb; nerve growth factor [KO:K02582]
122776532  hepatocyte growth factor isoform X1 [KO:K05460]
122765767  hgfa; hepatocyte growth factor a [KO:K05460]
122767684  mst1; hepatocyte growth factor-like protein [KO:K23441]
122769204  glial cell line-derived neurotrophic factor-like [KO:K05452]
122758006  gdnfa; glial cell line-derived neurotrophic factor [KO:K05452]
122769592  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
122770192  egfra; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
122762905  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
122776600  erbb3b; receptor tyrosine-protein kinase erbB-3b [KO:K05084] [EC:2.7.10.1]
122768406  erbb3a; receptor tyrosine-protein kinase erbB-3a [KO:K05084] [EC:2.7.10.1]
122764218  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
122765406  receptor tyrosine-protein kinase erbB-4-like [KO:K05085] [EC:2.7.10.1]
122780311  pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
122762812  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
122778422  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
122770547  fgfr1a; fibroblast growth factor receptor 1-A isoform X1 [KO:K04362] [EC:2.7.10.1]
122764198  fibroblast growth factor receptor 1-A-like [KO:K04362] [EC:2.7.10.1]
122781540  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122773086  si:ch211-167j9.5; tyrosine kinase receptor Cad96Ca isoform X1 [KO:K05093] [EC:2.7.10.1]
122782744  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122779872  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
122778409  kdrl; vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
122778344  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
122781150  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
122775185  ntrk1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
122770195  ntrk2a; neurotrophic tyrosine kinase, receptor, type 2a [KO:K04360] [EC:2.7.10.1]
122757981  ntrk2b; neurotrophic tyrosine kinase, receptor, type 2b isoform X1 [KO:K04360] [EC:2.7.10.1]
122761896  NT-3 growth factor receptor-like [KO:K05101] [EC:2.7.10.1]
122776392  NT-3 growth factor receptor-like isoform X1 [KO:K05101] [EC:2.7.10.1]
122776525  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
122768575  macrophage-stimulating protein receptor-like isoform X1 [KO:K05100] [EC:2.7.10.1]
122768096  macrophage-stimulating protein receptor-like isoform X1 [KO:K05100] [EC:2.7.10.1]
122782182  ret; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
122783119  T cell receptor beta chain MC.7.G5-like [KO:K10785]
122775745  plcd1a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1a isoform X1 [KO:K05857] [EC:3.1.4.11]
122776474  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1-like [KO:K05857] [EC:3.1.4.11]
122784713  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like isoform X1 [KO:K05857] [EC:3.1.4.11]
122785161  plcd3a; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
122759017  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4-like isoform X1 [KO:K05857] [EC:3.1.4.11]
122759331  plcd3b; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3-A [KO:K05857] [EC:3.1.4.11]
122774430  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1-like isoform X1 [KO:K05857] [EC:3.1.4.11]
122781695  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
122765502  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
122765902  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
122783981  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
122784068  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
122781292  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like [KO:K01116] [EC:3.1.4.11]
122777504  plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
122758993  plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
122768001  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
122768475  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
122775623  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
122777265  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
122766606  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
122766860  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like [KO:K01242] [EC:3.2.2.6 2.4.99.20]
122769562  tpcn1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
122760585  tpcn2; two pore calcium channel protein 2 [KO:K14077]
122771639  mucolipin-1-like [KO:K04992]
122785781  mucolipin-1-like [KO:K04992]
122780793  mcoln2; mucolipin-2 [KO:K04993]
122759985  mucolipin-3-like [KO:K04994]
122780887  mcoln3b; mucolipin-3 isoform X1 [KO:K04994]
122779503  mcoln3a; mucolipin-3 [KO:K04994]
122774804  sphk2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
122770984  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
122785854  sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
122781930  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
122780041  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
122781732  voltage-dependent anion-selective channel protein 2 [KO:K15040]
122781733  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
122759048  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
122768947  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
122784259  voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
122771188  slc25a4; ADP/ATP translocase 1 [KO:K05863]
122778089  slc25a5; ADP/ATP translocase 2 [KO:K05863]
122766319  ADP/ATP translocase 3 [KO:K05863]
122779536  si:dkey-251i10.1; ADP/ATP translocase 2 [KO:K05863]
122760012  peptidyl-prolyl cis-trans isomerase A-like [KO:K09565] [EC:5.2.1.8]
122781702  peptidyl-prolyl cis-trans isomerase A-like [KO:K09565] [EC:5.2.1.8]
122765017  peptidyl-prolyl cis-trans isomerase-like [KO:K09565] [EC:5.2.1.8]
122759368  peptidyl-prolyl cis-trans isomerase A-like [KO:K09565] [EC:5.2.1.8]
122785705  peptidyl-prolyl cis-trans isomerase-like [KO:K09565] [EC:5.2.1.8]
122776664  tnnc1a; troponin C type 1a (slow) [KO:K05865]
122776713  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
122777316  troponin C, skeletal muscle isoform X1 [KO:K12042]
122777320  tnnc2.2; troponin C, skeletal muscle [KO:K12042]
122760288  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
122768619  calglandulin-like [KO:K02183]
122775840  calmodulin-like protein 4 [KO:K02183]
122782973  calmodulin-1 [KO:K02183]
122772211  calml4a; calmodulin-like protein 4a [KO:K02183]
122783960  calmodulin-1 [KO:K02183]
122778620  calmodulin-like [KO:K02183]
122773594  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
122760604  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like [KO:K00871] [EC:2.7.11.19]
122759311  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
122772125  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
122772703  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
122767121  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
122759250  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
122780933  mylk4b; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122786945  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
122767287  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122785605  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122768651  camk1a; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
122777763  calcium/calmodulin-dependent protein kinase type 1D-like isoform X1 [KO:K08794] [EC:2.7.11.17]
122766258  camk1da; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
122767817  calcium/calmodulin-dependent protein kinase type 1D-like [KO:K08794] [EC:2.7.11.17]
122768294  camk1b; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
122769541  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
122781651  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
122770769  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
122783734  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
122766468  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
122759364  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
122780179  calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
122780873  si:ch73-60h1.1; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
122769512  ppp3cca; protein phosphatase 3, catalytic subunit, gamma isozyme, a isoform X1 [KO:K04348] [EC:3.1.3.16]
122765879  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122778400  ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
122758340  ppp3ccb; protein phosphatase 3, catalytic subunit, gamma isozyme, b isoform X1 [KO:K04348] [EC:3.1.3.16]
122780171  ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
122781544  calcineurin subunit B type 1 [KO:K06268]
122770844  ppp3r1b; calcineurin subunit B type 1b [KO:K06268]
122768441  tfeb; transcription factor EB isoform X1 [KO:K15590]
122775063  nuclear factor of activated T-cells, cytoplasmic 1-like isoform X1 [KO:K04446]
122786202  nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
122777768  nfatc2a; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
122767575  nuclear factor of activated T-cells, cytoplasmic 2-like isoform X1 [KO:K17332]
122762476  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
122764778  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
122772618  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
122778828  nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
122770718  nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
122769681  nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
122768743  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B-like isoform X1 [KO:K13755] [EC:3.1.4.17]
122760832  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A-like [KO:K13755] [EC:3.1.4.17]
122769367  pde1ca; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
122765028  pde1cb; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
122784027  ptk2bb; protein tyrosine kinase 2 beta, b isoform X1 [KO:K05871] [EC:2.7.10.2]
122782754  itpka; inositol-trisphosphate 3-kinase A isoform X1 [KO:K00911] [EC:2.7.1.127]
122784150  itpkb; inositol-trisphosphate 3-kinase B isoform X1 [KO:K00911] [EC:2.7.1.127]
122773215  itpkcb; inositol-trisphosphate 3-kinase Cb [KO:K00911] [EC:2.7.1.127]
122778965  si:ch73-22a13.3; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
122771238  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
122785514  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
122770953  LOW QUALITY PROTEIN: protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
122784934  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
122774138  prkcg; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
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Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
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Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
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J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
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J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
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Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
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Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
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Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
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J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
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Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
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Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
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Baba Y, Kurosaki T
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[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
ssen04010  MAPK signaling pathway
ssen04070  Phosphatidylinositol signaling system
ssen04210  Apoptosis
KO pathway
ko04020   
LinkDB

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