KEGG   PATHWAY: sstn03015
Entry
sstn03015                   Pathway                                
Name
mRNA surveillance pathway - Solanum stenotomum
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
sstn03015  mRNA surveillance pathway
sstn03015

Other DBs
GO: 0071028
Organism
Solanum stenotomum [GN:sstn]
Gene
125864698  nuclear cap-binding protein subunit 1 [KO:K12882]
125846899  nuclear cap-binding protein subunit 2 [KO:K12883]
125864944  regulator of nonsense transcripts UPF3-like isoform X1 [KO:K14328]
125870811  regulator of nonsense transcripts UPF3 [KO:K14328]
125843801  RNA-binding protein Y14A [KO:K12876]
125872669  RNA-binding protein Y14A-like [KO:K12876]
125860338  protein mago nashi homolog [KO:K12877]
125844734  eukaryotic initiation factor 4A-3 [KO:K13025] [EC:5.6.2.7]
125869338  histone deacetylase complex subunit SAP18-like isoform X1 [KO:K14324]
125843905  histone deacetylase complex subunit SAP18-like [KO:K14324]
125873034  uncharacterized protein LOC125873034 [KO:K13114]
125857169  uncharacterized protein LOC125857169 isoform X1 [KO:K12875]
125857170  uncharacterized protein LOC125857170 [KO:K12875]
125865165  LOW QUALITY PROTEIN: serine/arginine-rich splicing factor SR45-like [KO:K14325]
125852022  THO complex subunit 4A-like [KO:K12881]
125856923  THO complex subunit 4D-like [KO:K12881]
125843578  THO complex subunit 4A-like [KO:K12881]
125845362  THO complex subunit 4D-like [KO:K12881]
125865718  DEAD-box ATP-dependent RNA helicase 38 isoform X1 [KO:K18655] [EC:5.6.2.7]
125866730  mRNA export factor GLE1-like isoform X1 [KO:K18723]
125855555  mRNA export factor GLE1-like isoform X1 [KO:K18723]
125841194  DEAD-box ATP-dependent RNA helicase 15 isoform X1 [KO:K12812] [EC:5.6.2.7]
125872720  DEAD-box ATP-dependent RNA helicase 15-like isoform X1 [KO:K12812] [EC:5.6.2.7]
125874664  DEAD-box ATP-dependent RNA helicase 15-like isoform X1 [KO:K12812] [EC:5.6.2.7]
125852026  partner of Y14 and mago [KO:K14294]
125870215  uncharacterized protein LOC125870215 isoform X1 [KO:K13171]
125871586  uncharacterized protein LOC125871586 isoform X1 [KO:K13917] [EC:2.7.7.50 3.6.1.74]
125871577  mRNA cap guanine-N7 methyltransferase 1-like [KO:K00565] [EC:2.1.1.56]
125860562  mRNA cap guanine-N7 methyltransferase 1-like [KO:K00565] [EC:2.1.1.56]
125845420  mRNA cap guanine-N7 methyltransferase 2 isoform X1 [KO:K00565] [EC:2.1.1.56]
125872036  transcription initiation factor TFIID subunit 15b isoform X1 [KO:K13098]
125865926  polyadenylate-binding protein 2-like [KO:K14396]
125867731  polyadenylate-binding protein 2-like [KO:K14396]
125857728  polyadenylate-binding protein 1 isoform X1 [KO:K14396]
125845217  polyadenylate-binding protein 2-like isoform X1 [KO:K14396]
125875976  pre-mRNA cleavage factor Im 25 kDa subunit 1 [KO:K14397]
125858053  pre-mRNA cleavage factor Im 25 kDa subunit 2 [KO:K14397]
125871228  pre-mRNA cleavage factor Im 25 kDa subunit 2-like [KO:K14397]
125871239  pre-mRNA cleavage factor Im 25 kDa subunit 2-like [KO:K14397]
125875554  uncharacterized protein LOC125875554 [KO:K14398]
125865403  uncharacterized protein LOC125865403 [KO:K14398]
125866729  uncharacterized protein LOC125866729 [KO:K14398]
125863211  nuclear poly(A) polymerase 3-like [KO:K14376] [EC:2.7.7.19]
125867495  nuclear poly(A) polymerase 1 [KO:K14376] [EC:2.7.7.19]
125841705  nuclear poly(A) polymerase 4-like isoform X1 [KO:K14376] [EC:2.7.7.19]
125843343  nuclear poly(A) polymerase 3-like [KO:K14376] [EC:2.7.7.19]
125861912  nuclear poly(A) polymerase 4 isoform X1 [KO:K14376] [EC:2.7.7.19]
125874789  nuclear poly(A) polymerase 4-like isoform X1 [KO:K14376] [EC:2.7.7.19]
125847983  protein CLP1 homolog [KO:K14399] [EC:2.7.1.78]
125865668  uncharacterized protein LOC125865668 [KO:K14400]
125870423  polyadenylation and cleavage factor homolog 4 [KO:K14400]
125861950  polyadenylation and cleavage factor homolog 4 [KO:K14400]
125857681  cleavage and polyadenylation specificity factor subunit 1 [KO:K14401]
125859548  cleavage and polyadenylation specificity factor subunit 2 isoform X1 [KO:K14402]
125877095  cleavage and polyadenylation specificity factor subunit 3-I [KO:K14403] [EC:3.1.27.-]
125848089  30-kDa cleavage and polyadenylation specificity factor 30-like [KO:K14404]
125849154  30-kDa cleavage and polyadenylation specificity factor 30-like [KO:K14404]
125844668  uncharacterized protein LOC125844668 isoform X1 [KO:K14404]
125841273  flowering time control protein FY [KO:K15542]
125849170  protein ANTHESIS POMOTING FACTOR 1 isoform X1 [KO:K14962]
125862276  protein ANTHESIS POMOTING FACTOR 1 [KO:K14962]
125848189  serine/threonine-protein phosphatase PP1 [KO:K06269] [EC:3.1.3.16]
125866863  serine/threonine-protein phosphatase PP1-like [KO:K06269] [EC:3.1.3.16]
125871538  serine/threonine-protein phosphatase PP1-like [KO:K06269] [EC:3.1.3.16]
125872410  serine/threonine-protein phosphatase PP1-like [KO:K06269] [EC:3.1.3.16]
125872603  serine/threonine-protein phosphatase PP1 isozyme 2 [KO:K06269] [EC:3.1.3.16]
125872751  serine/threonine-protein phosphatase PP1 isozyme 1 [KO:K06269] [EC:3.1.3.16]
125874740  serine/threonine-protein phosphatase PP1 isozyme 3 [KO:K06269] [EC:3.1.3.16]
125858101  uncharacterized protein LOC125858101 [KO:K15544] [EC:3.1.3.16]
125861878  cleavage stimulation factor subunit 50 isoform X1 [KO:K14406]
125871762  cleavage stimulating factor 64-like [KO:K14407]
125864784  cleavage stimulation factor subunit 77 isoform X1 [KO:K14408]
125857022  uncharacterized protein LOC125857022 [KO:K06100]
125871713  uncharacterized protein LOC125871713 [KO:K06100]
125862544  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
125875740  heterogeneous nuclear ribonucleoprotein 1 isoform X1 [KO:K14411]
125848758  uncharacterized protein LOC125848758 isoform X1 [KO:K14411]
125848912  RNA-binding protein 1-like [KO:K14411]
125864835  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
125851285  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
125854514  RNA-binding protein 1-like [KO:K14411]
125856907  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
125870990  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
125843779  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
125859360  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
125862127  heterogeneous nuclear ribonucleoprotein 1-like [KO:K14411]
125865328  polyadenylate-binding protein 7-like [KO:K13126]
125853493  polyadenylate-binding protein 8-like [KO:K13126]
125855451  polyadenylate-binding protein 3 [KO:K13126]
125871879  polyadenylate-binding protein 7-like [KO:K13126]
125872237  polyadenylate-binding protein 2-like [KO:K13126]
125861204  polyadenylate-binding protein 2-like [KO:K13126]
125876995  eukaryotic peptide chain release factor subunit 1-3-like [KO:K03265]
125850330  eukaryotic peptide chain release factor subunit 1-3 [KO:K03265]
125866858  eukaryotic peptide chain release factor subunit 1-3-like [KO:K03265]
125845355  eukaryotic peptide chain release factor subunit 1-3-like [KO:K03265]
125858013  uncharacterized protein LOC125858013 [KO:K03267]
125874777  uncharacterized protein LOC125874777 isoform X1 [KO:K03267]
125854366  regulator of nonsense transcripts UPF2 [KO:K14327]
125852048  uncharacterized protein LOC125852048 [KO:K08873] [EC:2.7.11.1]
125866331  nonsense-mediated mRNA decay factor SMG7-like [KO:K14409]
125861765  nonsense-mediated mRNA decay factor SMG7-like isoform X1 [KO:K14409]
125867489  serine/threonine-protein phosphatase PP2A-5 catalytic subunit [KO:K04382] [EC:3.1.3.16]
125867856  serine/threonine-protein phosphatase PP2A-2 catalytic subunit-like [KO:K04382] [EC:3.1.3.16]
125867857  serine/threonine-protein phosphatase PP2A-2 catalytic subunit-like [KO:K04382] [EC:3.1.3.16]
125856437  serine/threonine-protein phosphatase PP2A-2 catalytic subunit-like [KO:K04382] [EC:3.1.3.16]
125873981  serine/threonine-protein phosphatase PP2A catalytic subunit [KO:K04382] [EC:3.1.3.16]
125874241  serine/threonine-protein phosphatase PP2A-2 catalytic subunit [KO:K04382] [EC:3.1.3.16]
125847238  serine/threonine-protein phosphatase PP2A catalytic subunit-like [KO:K04382] [EC:3.1.3.16]
125852660  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
125866772  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
125857676  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A gamma isoform-like [KO:K03456]
125873057  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
125862488  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like isoform X1 [KO:K04354]
125872178  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
125872979  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like [KO:K04354]
125860672  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform-like isoform X1 [KO:K04354]
125867274  serine/threonine protein phosphatase 2A regulatory subunit B''beta-like isoform X1 [KO:K11583]
125867457  probable serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit TON2 [KO:K11583]
125854881  serine/threonine protein phosphatase 2A regulatory subunit B''beta-like [KO:K11583]
125876319  serine/threonine protein phosphatase 2A 59 kDa regulatory subunit B' gamma isoform [KO:K11584]
125849294  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584]
125864807  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform-like [KO:K11584]
125852495  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform-like [KO:K11584]
125867245  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform-like [KO:K11584]
125867707  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584]
125871143  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' beta isoform-like [KO:K11584]
125872800  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform [KO:K11584]
125861860  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' kappa isoform-like [KO:K11584]
125846563  serine/threonine protein phosphatase 2A 57 kDa regulatory subunit B' theta isoform-like [KO:K11584]
125862855  uncharacterized protein LOC125862855 [KO:K14416]
125858403  uncharacterized protein LOC125858403 isoform X1 [KO:K14416]
125864235  protein PELOTA 1-like [KO:K06965]
125855607  protein PELOTA 1 [KO:K06965]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
sstn03013  Nucleocytoplasmic transport
sstn03018  RNA degradation
sstn03040  Spliceosome
KO pathway
ko03015   
LinkDB

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