KEGG   PATHWAY: pgig04151
Entry
pgig04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Pteropus giganteus (Indian flying fox)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
pgig04151  PI3K-Akt signaling pathway
pgig04151

Other DBs
GO: 0043491
Organism
Pteropus giganteus (Indian flying fox) [GN:pgig]
Gene
120591156  EGF; pro-epidermal growth factor [KO:K04357]
120594411  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
120587961  EREG; proepiregulin [KO:K09784]
120587962  AREG; amphiregulin [KO:K09782]
120581479  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
120616271  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
120591936  FGF16; fibroblast growth factor 16 [KO:K04358]
120602936  FGF9; fibroblast growth factor 9 [KO:K04358]
120614279  FGF10; fibroblast growth factor 10 [KO:K04358]
120614873  FGF18; fibroblast growth factor 18 [KO:K04358]
120583667  FGF22; fibroblast growth factor 22 [KO:K04358]
120583832  FGF20; fibroblast growth factor 20 [KO:K04358]
120606452  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
120584645  FGF4; fibroblast growth factor 4 [KO:K04358]
120607305  FGF6; fibroblast growth factor 6 [KO:K04358]
120588259  FGF5; fibroblast growth factor 5 [KO:K04358]
120609690  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
120623126  FGF7; fibroblast growth factor 7 [KO:K04358]
120584636  FGF19; fibroblast growth factor 19 [KO:K22603]
120606965  FGF21; fibroblast growth factor 21 [KO:K22429]
120607306  FGF23; fibroblast growth factor 23 [KO:K22428]
120585075  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
120605221  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
120611625  NTF3; neurotrophin-3 [KO:K04356]
120606989  NTF4; LOW QUALITY PROTEIN: neurotrophin-4 [KO:K12457]
120584612  INS; insulin [KO:K04526]
120614955  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
120584609  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
120615920  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
120603004  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
120613440  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
120599685  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
120584998  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
120607273  KITLG; kit ligand isoform X1 [KO:K05461]
120615548  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
120596132  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
120600634  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
120619506  PGF; placenta growth factor isoform X1 [KO:K16859]
120618403  VEGFC; vascular endothelial growth factor C [KO:K05449]
120611103  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
120591565  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
120595559  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
120614411  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
120603492  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
120590791  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
120592138  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
120592189  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
120592258  EFNA4; ephrin-A4 [KO:K05462]
120583690  EFNA2; ephrin-A2 [KO:K05462]
120586177  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
120615430  NRTN; neurturin [KO:K25414]
120615468  neurturin-like [KO:K25414]
120619427  ARTN; artemin [KO:K25415]
120615444  PSPN; persephin [KO:K25416]
120602477  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
120611190  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
120604897  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
120587606  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
120595650  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
120608860  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
120582906  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
120616553  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
120588929  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
120606120  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
120612943  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
120599285  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
120587362  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
120588066  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
120581545  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
120581540  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
120588075  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
120602461  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
120602420  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
120592792  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
120616609  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
120588082  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
120601224  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
120617099  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
120585765  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
120594602  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
120600272  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
120604448  SOS2; son of sevenless homolog 2 [KO:K03099]
120621751  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
120584662  HRAS; GTPase HRas isoform X1 [KO:K02833]
120618351  KRAS; GTPase KRas isoform X1 [KO:K07827]
120585069  NRAS; GTPase NRas isoform X1 [KO:K07828]
120621476  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120604492  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
120615382  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
120606851  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
120620121  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
120597107  IRS1; insulin receptor substrate 1 [KO:K16172]
120613273  TLR2; toll-like receptor 2 [KO:K10159]
120605781  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
120616613  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
120594126  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
120620142  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
120609261  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
120599971  somatotropin [KO:K05438]
120605617  PRL; prolactin [KO:K05439]
120601898  OSM; oncostatin-M isoform X1 [KO:K05418]
120616276  IL2; interleukin-2 [KO:K05429]
120616659  interleukin-3-like [KO:K04736]
120602335  IL6; interleukin-6 isoform X1 [KO:K05405]
120616686  IL4; interleukin-4 [KO:K05430]
120585527  IL7; interleukin-7 isoform X1 [KO:K05431]
120605312  interferon alpha-4-like [KO:K05414]
120617124  interferon alpha-1-like [KO:K05414]
120606426  interferon alpha-1-like [KO:K05414]
120589528  interferon alpha-1-like [KO:K05414]
120589531  interferon alpha-5-like [KO:K05414]
120605473  IFNB1; interferon beta [KO:K05415]
120591634  EPO; erythropoietin [KO:K05437]
120611309  CSF3; granulocyte colony-stimulating factor [KO:K05423]
120586151  GHR; growth hormone receptor isoform X1 [KO:K05080]
120586200  PRLR; prolactin receptor [KO:K05081]
120586171  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
120609005  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
120614851  IL2RB; LOW QUALITY PROTEIN: interleukin-2 receptor subunit beta [KO:K05069]
120585387  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
120589517  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
120592175  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
120620155  interleukin-4 receptor subunit alpha-like isoform X1 [KO:K05071]
120586196  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
120598793  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
120598866  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
120610825  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
120593303  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
120583126  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
120619063  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
120606540  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
120615011  COL1A2; collagen alpha-2(I) chain [KO:K06236]
120588945  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
120618230  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
120616365  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
120616381  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
120605335  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
120605336  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
120597091  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
120597092  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
120582065  collagen alpha-4(VI) chain-like isoform X1 [KO:K06238]
120582066  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
120582067  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
120616395  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
120616409  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
120601689  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
120614012  COL9A2; LOW QUALITY PROTEIN: collagen alpha-2(IX) chain [KO:K08131]
120603980  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
120594914  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
120592323  LAMA2; laminin subunit alpha-2 [KO:K05637]
120588351  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
120603402  LAMA5; laminin subunit alpha-5 [KO:K06240]
120587525  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
120608707  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
120591582  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
120582328  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
120608483  LAMB3; laminin subunit beta-3 [KO:K06244]
120591580  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
120617578  LAMC1; laminin subunit gamma-1 [KO:K05635]
120617572  LAMC2; laminin subunit gamma-2 [KO:K06246]
120602714  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
120588954  CHAD; chondroadherin [KO:K06248]
120591725  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
120587198  THBS1; thrombospondin-1 [KO:K16857]
120592221  THBS3; thrombospondin-3 [KO:K04659]
120606573  cartilage oligomeric matrix protein [KO:K04659]
120617968  THBS2; thrombospondin-2 [KO:K04659]
120612479  THBS4; thrombospondin-4 [KO:K04659]
120587617  FN1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
120588302  SPP1; osteopontin [KO:K06250]
120620949  VTN; vitronectin [KO:K06251]
120605792  TNC; tenascin isoform X1 [KO:K06252]
120617487  TNN; tenascin-N [KO:K06252]
120617638  TNR; tenascin-R [KO:K06252]
120618893  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
120611627  VWF; von Willebrand factor isoform X1 [KO:K03900]
120588299  bone sialoprotein 2 [KO:K06253]
120608161  ITGA1; integrin alpha-1 [KO:K06480]
120608166  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
120589223  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
120588938  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
120596787  ITGA4; integrin alpha-4 [KO:K06483]
120602233  ITGA5; integrin alpha-5 [KO:K06484]
120597205  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
120604874  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
120614631  ITGA8; integrin alpha-8 [KO:K06584]
120586757  ITGA9; integrin alpha-9 [KO:K06585]
120585154  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
120604629  ITGA11; integrin alpha-11 [KO:K06587]
120584269  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
120584124  ITGB1; integrin beta-1 [KO:K05719]
120589273  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
120600356  ITGB4; integrin beta-4 [KO:K06525]
120586723  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
120597015  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
120602246  ITGB7; integrin beta-7 [KO:K06590]
120602322  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
120588751  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
120582132  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120596984  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120585845  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
120606549  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
120608247  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120620206  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
120598929  F2R; proteinase-activated receptor 1 [KO:K03914]
120600782  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
120600967  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
120608747  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
120606604  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
120583282  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
120611645  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
120583849  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
120614112  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
120591822  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
120611665  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
120597058  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
120623087  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
120604431  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
120600851  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1 [KO:K04540]
120592628  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
120583739  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1 [KO:K04543]
120617888  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
120608754  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
120615015  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
120583204  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
120618548  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
120615017  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
120611274  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
120591586  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
120589723  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
120589726  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
120620273  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
120583692  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
120586161  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
120621730  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
120609513  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
120602738  TSC1; hamartin isoform X1 [KO:K07206]
120620251  TSC2; tuberin isoform X1 [KO:K07207]
120601454  RHEB; GTP-binding protein Rheb [KO:K07208]
120620262  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
120585826  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
120600162  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
120595621  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
120615834  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-like [KO:K03259]
120616548  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
120597214  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
120588339  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
120584753  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
120620825  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
120602153  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
120604299  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
120615108  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
120595025  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
120608272  RPS6; 40S ribosomal protein S6 [KO:K02991]
120600384  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
120618473  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
120583308  PKN2; serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
120601737  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692] [EC:2.7.11.13]
120615796  serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
120603683  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
120585461  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
120613959  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120595669  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120619079  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120593799  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
120591721  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
120609356  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
120616858  acyl-coenzyme A thioesterase THEM4-like isoform X1 [KO:K16339] [EC:3.1.2.2]
120581292  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
120589049  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
120583980  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
120621983  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
120581501  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
120613401  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
120582867  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
120582112  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
120620761  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
120610948  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
120603778  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
120617516  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
120596143  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
120619709  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
120600686  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
120596182  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
120619712  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
120614942  HSP90B1; endoplasmin [KO:K09487]
120610868  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
120592226  CRTC2; CREB-regulated transcription coactivator 2 [KO:K16333]
120593874  PHLPP2; LOW QUALITY PROTEIN: PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
120584408  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
120619778  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
120605925  MTCP1; protein p13 MTCP-1 [KO:K16837]
120601518  NOS3; LOW QUALITY PROTEIN: nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
120611051  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
120586669  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
120606948  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
120618372  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
120603862  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
120608500  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
120596847  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
120589204  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
120611062  G6PC1; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
120595433  MYC; myc proto-oncogene protein [KO:K04377]
120584714  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
120597553  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
120613734  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
120604889  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
120604974  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
120615024  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
120607308  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
120596338  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
120605475  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
120617212  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
120608178  FOXO3; forkhead box protein O3 [KO:K09408]
120617273  RBL2; retinoblastoma-like protein 2 [KO:K16332]
120617668  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
120610288  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
120603713  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
120595639  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
120622065  YWHAQ; 14-3-3 protein theta [KO:K16197]
120621032  YWHAE; 14-3-3 protein epsilon [KO:K06630]
120591800  YWHAG; 14-3-3 protein gamma [KO:K16198]
120601857  YWHAH; 14-3-3 protein eta [KO:K16198]
120600645  BAD; bcl2-associated agonist of cell death [KO:K02158]
120603516  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
120584396  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
120585783  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
120587583  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
120597156  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
120602997  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
120592160  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
120615385  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
120606645  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
120601151  CREB3L2; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
120612863  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
120602391  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
120618891  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
120585206  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
120606417  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
120602137  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
120605919  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
120609204  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
120595665  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
120584840  RELA; transcription factor p65 [KO:K04735]
120591230  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
120615791  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
120605043  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
120589680  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
pgig00010  Glycolysis / Gluconeogenesis
pgig04010  MAPK signaling pathway
pgig04012  ErbB signaling pathway
pgig04062  Chemokine signaling pathway
pgig04064  NF-kappa B signaling pathway
pgig04068  FoxO signaling pathway
pgig04110  Cell cycle
pgig04115  p53 signaling pathway
pgig04150  mTOR signaling pathway
pgig04210  Apoptosis
pgig04370  VEGF signaling pathway
pgig04510  Focal adhesion
pgig04620  Toll-like receptor signaling pathway
pgig04630  JAK-STAT signaling pathway
pgig04662  B cell receptor signaling pathway
pgig04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

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