KEGG   PATHWAY: rbb04015
Entry
rbb04015                    Pathway                                
Name
Rap1 signaling pathway - Rhinopithecus bieti (black snub-nosed monkey)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
rbb04015  Rap1 signaling pathway
rbb04015

Other DBs
GO: 0007264
Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:rbb]
Gene
108528085  RAP1A; ras-related protein Rap-1A [KO:K04353]
108525739  ras-related protein Rap-1A [KO:K04353]
108532250  RAP1B; ras-related protein Rap-1b [KO:K07836]
108544611  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
108529323  RAPGEF5; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 5 [KO:K08019]
108533775  DOCK4; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 4 [KO:K17697]
108542864  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
108541249  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
108530279  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
108536001  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
108512653  CALM2; calmodulin [KO:K02183]
108514692  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
108529886  CALML3; calmodulin-like protein 3 [KO:K02183]
108529898  CALML5; calmodulin-like protein 5 [KO:K02183]
108531068  CALM3; calmodulin isoform X1 [KO:K02183]
108533995  calmodulin [KO:K02183]
108535906  CALM1; calmodulin [KO:K02183]
108513076  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
108534255  LOW QUALITY PROTEIN: proteinase-activated receptor 4-like [KO:K04236]
108534287  LOW QUALITY PROTEIN: proteinase-activated receptor 4-like [KO:K04236]
108513163  P2RY1; P2Y purinoceptor 1 [KO:K04270]
108524153  FPR1; fMet-Leu-Phe receptor [KO:K04172]
108513979  lysophosphatidic acid receptor 1 [KO:K04289]
108515641  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
108527700  LPAR3; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 3 [KO:K04294]
108529808  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
108542054  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
108540662  ADORA2A; adenosine receptor A2a [KO:K04266]
108522165  ADORA2B; adenosine receptor A2b [KO:K04267]
108541624  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
108541626  neuroendocrine secretory protein 55 [KO:K04632]
108534793  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
108536960  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
108543021  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
108540946  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
108517430  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
108543933  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
108522948  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
108514094  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
108538326  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
108515949  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
108518542  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
108542641  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
108526885  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
108542252  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
108527553  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
108527564  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
108528680  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
108542853  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
108541026  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
108530219  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
108515579  FGF2; fibroblast growth factor 2 [KO:K18497]
108535339  FGF10; fibroblast growth factor 10 [KO:K04358]
108515073  FGF8; fibroblast growth factor 8 [KO:K04358]
108517319  FGF7; fibroblast growth factor 7 [KO:K04358]
108537873  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
108544577  FGF16; fibroblast growth factor 16 [KO:K04358]
108536494  FGF6; fibroblast growth factor 6 [KO:K04358]
108538230  FGF4; fibroblast growth factor 4 [KO:K04358]
108538240  FGF3; fibroblast growth factor 3 [KO:K04358]
108538283  FGF9; fibroblast growth factor 9 [KO:K04358]
108513599  FGF18; fibroblast growth factor 18 [KO:K04358]
108521318  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
108526452  FGF20; fibroblast growth factor 20 [KO:K04358]
108532456  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
108538219  FGF19; fibroblast growth factor 19 [KO:K22603]
108536498  FGF23; fibroblast growth factor 23 [KO:K22428]
108528126  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
108539226  INS; insulin isoform X1 [KO:K04526]
108543134  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
108542315  PDGFA; LOW QUALITY PROTEIN: platelet-derived growth factor subunit A [KO:K04359]
108520474  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
108534757  PDGFD; platelet-derived growth factor D [KO:K05450]
108529019  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
108528053  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
108528921  KITLG; kit ligand [KO:K05461]
108533452  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
108542677  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
108534920  PGF; placenta growth factor isoform X1 [KO:K16859]
108539697  VEGFD; vascular endothelial growth factor D [KO:K05449]
108534048  VEGFC; vascular endothelial growth factor C [KO:K05449]
108536940  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
108537601  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
108516719  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
108544524  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
108526824  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
108526826  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
108526828  EFNA1; ephrin-A1 [KO:K05462]
108530235  EFNA2; LOW QUALITY PROTEIN: ephrin-A2 [KO:K05462]
108525289  ephrin-A2-like [KO:K05462]
108517608  EFNA5; ephrin-A5 [KO:K05462]
108522039  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
108512401  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
108529768  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
108532286  FGFR3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
108544759  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
108516504  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
108534554  INSR; LOW QUALITY PROTEIN: insulin receptor [KO:K04527] [EC:2.7.10.1]
108538668  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
108533750  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
108532047  PDGFRB; LOW QUALITY PROTEIN: platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
108532049  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
108533749  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
108512923  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
108514173  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
108531591  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
108528695  MET; LOW QUALITY PROTEIN: hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
108527847  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
108524275  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
108536084  CRKL; crk-like protein [KO:K04438]
108524318  CRK; adapter molecule crk isoform X1 [KO:K04438]
108513945  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
108527422  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
108514542  CDH1; LOW QUALITY PROTEIN: cadherin-1 [KO:K05689]
108542618  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
108531541  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
108534860  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
108528107  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
108520366  LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2-like [KO:K08018]
108512577  RAPGEF6; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 6 [KO:K08020]
108523693  LAT; linker for activation of T-cells family member 1 isoform X1 [KO:K07362]
108515993  FYB; FYN-binding protein [KO:K17698]
108513605  LCP2; LOW QUALITY PROTEIN: lymphocyte cytosolic protein 2 [KO:K07361]
108516502  SKAP1; src kinase-associated phosphoprotein 1 isoform X1 [KO:K17699]
108519825  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
108517746  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
108538857  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
108529452  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
108544649  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
108531066  PRKD2; serine/threonine-protein kinase D2 isoform X1 [KO:K06070] [EC:2.7.11.13]
108520878  PRKD3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
108536354  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
108515682  CNR1; cannabinoid receptor 1 isoform X1 [KO:K04277]
108519632  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
108534866  GNAI1; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
108526962  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
108538458  RAP1GAP; rap1 GTPase-activating protein 1 isoform X1 [KO:K17700]
108536206  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701]
108542291  SIPA1; signal-induced proliferation-associated protein 1 [KO:K08013]
108531498  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
108535290  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 [KO:K17703]
108524136  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
108526966  THBS1; thrombospondin-1 [KO:K16857]
108513486  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
108528764  ral-GDS-related protein-like [KO:K08732]
108526577  RALA; ras-related protein Ral-A isoform X1 [KO:K07834]
108542108  RALB; ras-related protein Ral-B [KO:K07835]
108523982  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108515883  ras-related C3 botulinum toxin substrate 1-like isoform X1 [KO:K04392]
108512764  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
108534092  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
108515828  LOW QUALITY PROTEIN: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like [KO:K17704]
108518989  TLN1; talin-1 isoform X1 [KO:K06271]
108527660  TLN2; talin-2 isoform X1 [KO:K06271]
108532191  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
108536294  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
108518278  PFN2; profilin-2 [KO:K05759]
108544776  PFN3; profilin-3 [KO:K05759]
108524810  PFN1; profilin-1 [KO:K05759]
108523453  profilin-2-like [KO:K05759]
108531097  VASP; LOW QUALITY PROTEIN: vasodilator-stimulated phosphoprotein [KO:K06274]
108538743  ENAH; protein enabled homolog isoform X1 [KO:K05746]
108542288  EVL; LOW QUALITY PROTEIN: ena/VASP-like protein [KO:K23487]
108534125  ACTG1; actin, cytoplasmic 2 [KO:K05692]
108538237  ACTB; actin, cytoplasmic 1 [KO:K05692]
108530209  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
108526989  RHOA; transforming protein RhoA [KO:K04513]
108519844  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
108521081  FARP2; FERM, RhoGEF and pleckstrin domain-containing protein 2 [KO:K06082]
108538451  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
108513251  VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
108534558  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
108522647  LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV3-like [KO:K05730]
108536834  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
108529253  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
108539474  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
108515376  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
108522983  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
108536030  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
108513135  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
108544169  AFDN; afadin isoform X1 [KO:K05702]
108514849  CTNND1; catenin delta-1 isoform X1 [KO:K05690]
108528497  KRIT1; krev interaction trapped protein 1 [KO:K17705]
108544808  RGS14; regulator of G-protein signaling 14 isoform X1 [KO:K17706]
108535148  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
108535405  ITGAL; LOW QUALITY PROTEIN: integrin alpha-L [KO:K05718]
108528119  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
108539787  ITGB2; LOW QUALITY PROTEIN: integrin beta-2 [KO:K06464]
108529400  ITGB1; integrin beta-1 [KO:K05719]
108541537  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
108517986  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
108514672  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108512087  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
108523695  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
108536070  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108521513  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
108523215  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
108528326  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
108528327  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
108539403  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
108539422  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
108544591  PIK3CB; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
108532960  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108539355  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108535636  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
108534276  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
108541175  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
108512498  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108539069  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
108521880  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108521233  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
108543525  HRAS; GTPase HRas isoform X1 [KO:K02833]
108523748  KRAS; GTPase KRas isoform X1 [KO:K07827]
108528122  NRAS; GTPase NRas [KO:K07828]
108535827  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
rbb04010  MAPK signaling pathway
rbb04014  Ras signaling pathway
rbb04020  Calcium signaling pathway
rbb04151  PI3K-Akt signaling pathway
rbb04510  Focal adhesion
rbb04520  Adherens junction
rbb04660  T cell receptor signaling pathway
rbb04810  Regulation of actin cytoskeleton
KO pathway
ko04015   
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