KEGG   PATHWAY: sara04060
Entry
sara04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Sorex araneus (European shrew)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
sara04060  Cytokine-cytokine receptor interaction
sara04060

Organism
Sorex araneus (European shrew) [GN:sara]
Gene
101536897  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
101536971  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
101536982  CX3CL1; fractalkine [KO:K05508]
101537204  TNFRSF10B; tumor necrosis factor receptor superfamily member 10B [KO:K04722]
101537237  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
101537248  CCL22; C-C motif chemokine 22 [KO:K21095]
101537499  IL1RL1; interleukin-1 receptor-like 1 [KO:K05171]
101537535  [KO:K05474]
101537675  EBI3; interleukin-27 subunit beta [KO:K24476]
101537676  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
101537767  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
101537997  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
101538205  IL27; interleukin-27 subunit alpha [KO:K22629]
101538411  IL34; interleukin-34 [KO:K22633]
101538806  IL5; interleukin-5 [KO:K05428]
101538809  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
101538871  TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
101538897  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
101538916  PRL; prolactin [KO:K05439]
101538942  IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
101539023  RELT; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 19L [KO:K05156]
101539069  IL13; interleukin-13 [KO:K05435]
101539182  [KO:K05166]
101539189  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
101539198  CCL27; C-C motif chemokine 27 [KO:K16598]
101539338  IL4; interleukin-4 [KO:K05430]
101539403  IL12A; interleukin-12 subunit alpha [KO:K05406]
101539445  [KO:K05507]
101539455  [KO:K05168]
101539467  CCL19; C-C motif chemokine 19 [KO:K05512]
101539626  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
101540080  BMP4; bone morphogenetic protein 4 [KO:K04662]
101540128  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
101540177  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
101540292  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
101540315  CCR8; C-C chemokine receptor type 8 [KO:K04183]
101540340  IL17C; interleukin-17C [KO:K05491]
101540363  IL6; interleukin-6 [KO:K05405]
101540370  GHR; growth hormone receptor [KO:K05080]
101540550  IL23R; interleukin-23 receptor [KO:K05065]
101540574  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
101540596  IL33; interleukin-33 [KO:K12967]
101540691  BMP7; bone morphogenetic protein 7 [KO:K16621]
101540763  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
101540970  IL7; interleukin-7 [KO:K05431]
101540972  IFNG; interferon gamma [KO:K04687]
101541135  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
101541152  ACKR4; atypical chemokine receptor 4 [KO:K04186]
101541156  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
101541229  IL26; interleukin-26 [KO:K05446]
101541261  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101541347  IL19; interleukin-19 [KO:K05444]
101541370  NODAL; nodal homolog [KO:K04666]
101541400  ACVR1B; activin receptor type-1B isoform X1 [KO:K13567] [EC:2.7.11.30]
101541437  INHBB; inhibin beta B chain [KO:K22687]
101541497  IL22; interleukin-22 [KO:K05445]
101541601  LEPR; leptin receptor [KO:K05062]
101541603  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
101541610  IL10; interleukin-10 [KO:K05443]
101541743  GDF6; growth/differentiation factor 6 [KO:K20012]
101541786  CD27; CD27 antigen [KO:K05144]
101541867  ACVR1C; activin receptor type-1C isoform X1 [KO:K13568] [EC:2.7.11.30]
101542043  [KO:K14624]
101542064  IL13RA1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
101542075  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
101542314  [KO:K16597]
101542336  BMP3; bone morphogenetic protein 3 [KO:K05496]
101542348  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
101542581  [KO:K16596]
101542694  BMP5; bone morphogenetic protein 5 [KO:K04663]
101542768  IL12B; interleukin-12 subunit beta [KO:K05425]
101542838  [KO:K16595]
101543141  MPL; thrombopoietin receptor [KO:K05082]
101543306  IL9; interleukin-9 [KO:K05432]
101543447  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
101543461  [KO:K02583]
101543609  IL17B; interleukin-17B [KO:K05490]
101543811  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
101543926  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
101544069  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
101544258  LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159]
101544428  CCL20; C-C motif chemokine 20 [KO:K14625]
101544435  GDF5; growth/differentiation factor 5 [KO:K04664]
101544543  CTF1; cardiotrophin-1 [KO:K24382]
101544607  LEP; leptin [KO:K05424]
101544753  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
101544827  BMP6; bone morphogenetic protein 6 [KO:K16620]
101544839  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
101544961  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
101544994  [KO:K05505]
101545218  [KO:K14624]
101545219  CCR7; C-C chemokine receptor type 7 [KO:K04182]
101545374  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
101545474  IL17A; interleukin-17A [KO:K05489]
101545664  TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160]
101545736  IL17F; interleukin-17F [KO:K05494]
101545791  [KO:K05505]
101545876  EPOR; erythropoietin receptor [KO:K05079]
101545913  THPO; thrombopoietin [KO:K06854]
101545977  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
101546055  [KO:K05407]
101546061  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
101546290  TGFB3; transforming growth factor beta-3 [KO:K13377]
101546305  TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479]
101546322  PPBP; platelet basic protein [KO:K10029]
101546365  IL15RA; interleukin-15 receptor subunit alpha [KO:K05074]
101546383  RELL2; RELT-like protein 2 [KO:K26541]
101546534  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
101546563  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
101546569  TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469]
101546583  CXCL6; C-X-C motif chemokine 6 [KO:K05506]
101546623  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
101546688  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
101546718  IFNGR1; interferon gamma receptor 1 [KO:K05132]
101546751  EPO; erythropoietin [KO:K05437]
101546769  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
101546859  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
101547054  CCL16; C-C motif chemokine 16 [KO:K21093]
101547080  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
101547089  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
101547090  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
101547182  [KO:K05438]
101547315  CCL14; C-C motif chemokine 14 [KO:K21092]
101547363  CCL21; C-C motif chemokine 21 [KO:K16062]
101547466  LTA; lymphotoxin-alpha [KO:K05468]
101547467  GDF11; growth/differentiation factor 11 [KO:K22679]
101547582  BMP10; bone morphogenetic protein 10 [KO:K22670]
101547770  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
101547814  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101547843  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
101547851  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
101547856  [KO:K05408]
101547946  IL15; interleukin-15 [KO:K05433]
101547976  IL17RB; interleukin-17 receptor B [KO:K05165]
101547978  EDA; ectodysplasin-A isoform X1 [KO:K05480]
101548127  [KO:K05408]
101548268  IFNB1; interferon beta [KO:K05415]
101548395  [KO:K05408]
101548404  BMP2; bone morphogenetic protein 2 [KO:K21283]
101548536  [KO:K05440]
101548610  IL17RA; interleukin-17 receptor A [KO:K05164]
101548656  CXCL12; stromal cell-derived factor 1 isoform X2 [KO:K10031]
101548664  IL1A; interleukin-1 alpha [KO:K04383]
101548814  [KO:K16620]
101548837  CCL28; C-C motif chemokine 28 [KO:K05513]
101548839  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
101548921  CCL5; C-C motif chemokine 5 [KO:K12499]
101548924  IL36RN; interleukin-36 receptor antagonist protein [KO:K05483]
101548978  IL23A; interleukin-23 subunit alpha [KO:K05426]
101549004  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
101549078  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
101549187  [KO:K12964]
101549189  IL1F10; interleukin-1 family member 10 [KO:K05488]
101549205  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
101549371  CSF3; granulocyte colony-stimulating factor [KO:K05423]
101549410  CLCF1; cardiotrophin-like cytokine factor 1 [KO:K05421]
101549463  IL1RN; interleukin-1 receptor antagonist protein [KO:K05481]
101549593  [KO:K05414]
101549920  CCR2; C-C chemokine receptor type 2 [KO:K04177]
101550017  GDF15; growth/differentiation factor 15 [KO:K05504]
101550075  IL1B; interleukin-1 beta [KO:K04519]
101550176  CCR3; C-C chemokine receptor type 3 [KO:K04178]
101550332  IL37; interleukin-37 [KO:K05485]
101550376  [KO:K05440]
101550594  [KO:K05487]
101550636  IFNE; interferon epsilon [KO:K05442]
101550758  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
101550764  GDF7; growth/differentiation factor 7 [KO:K20013]
101550783  [KO:K16622]
101550852  [KO:K05484]
101550947  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101551027  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
101551199  EDAR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
101551254  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
101551332  IL1RL2; interleukin-1 receptor-like 2 [KO:K05172]
101551346  TGFB1; transforming growth factor beta-1 [KO:K13375]
101551521  CD70; CD70 antigen [KO:K05470]
101551600  IL18R1; interleukin-18 receptor 1 [KO:K05173]
101551722  [KO:K05510]
101551851  [KO:K16622]
101551921  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
101552082  CD40LG; CD40 ligand [KO:K03161]
101552175  BMP15; bone morphogenetic protein 15 [KO:K05498]
101552448  LIFR; leukemia inhibitory factor receptor [KO:K05058]
101552607  IFNLR1; interferon lambda receptor 1 [KO:K05140]
101552662  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
101552677  CCL26; C-C motif chemokine 26 [KO:K21096]
101552740  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
101552752  [KO:K22669]
101552948  CCL24; C-C motif chemokine 24 [KO:K21097]
101552971  IL9R; interleukin-9 receptor [KO:K05073]
101553020  IFNL3; interferon lambda-3 [KO:K22669]
101553092  CCR5; C-C chemokine receptor type 5 [KO:K04180]
101553285  [KO:K22669]
101553361  CCR1; C-C chemokine receptor type 1 [KO:K04176]
101553389  MSTN; growth/differentiation factor 8 [KO:K05497]
101553403  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
101553430  GDF3; growth/differentiation factor 3 [KO:K22672]
101553495  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
101553507  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
101553622  XCR1; chemokine XC receptor 1 [KO:K04193]
101553829  CCR6; C-C chemokine receptor type 6 [KO:K04181]
101553868  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
101553885  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
101553975  OSM; oncostatin-M [KO:K05418]
101554072  [KO:K22669]
101554411  CCR9; C-C chemokine receptor type 9 [KO:K04184]
101554607  IL16; pro-interleukin-16 [KO:K22628]
101554650  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
101554763  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
101555037  LIF; leukemia inhibitory factor [KO:K05419]
101555192  PRLR; prolactin receptor [KO:K05081]
101555340  INHBC; inhibin beta C chain [KO:K22688]
101555428  IFNK; interferon kappa [KO:K05441]
101555439  INHBE; inhibin beta E chain [KO:K22689]
101555452  CCR4; C-C chemokine receptor type 4 [KO:K04179]
101555492  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
101555581  [KO:K05050]
101555808  GDF9; growth/differentiation factor 9 [KO:K22673]
101555829  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
101556153  IL21; interleukin-21 [KO:K05434]
101556429  IL2; interleukin-2 [KO:K05429]
101556516  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
101556532  CCR10; C-C chemokine receptor type 10 [KO:K04185]
101556969  INHBA; inhibin beta A chain [KO:K04667]
101557148  GDF10; growth/differentiation factor 10 [KO:K22674]
101557190  NGF; beta-nerve growth factor [KO:K02582]
101557426  GDF2; growth/differentiation factor 2 [KO:K05503]
101557469  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
101557640  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
101557842  CNTF; ciliary neurotrophic factor [KO:K05420]
101557874  TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
101557905  IL21R; interleukin-21 receptor [KO:K05075]
101558275  INHA; inhibin alpha chain [KO:K05500]
101558386  IFNGR2; interferon gamma receptor 2 [KO:K05133]
101558405  [KO:K05447]
101558539  IL11; interleukin-11 [KO:K05417]
101558600  IL25; interleukin-25 [KO:K05493]
101558656  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101558664  TNF; tumor necrosis factor [KO:K03156]
101558678  IL17D; interleukin-17D [KO:K05492]
101558830  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
101558845  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
101558876  ACKR3; atypical chemokine receptor 3 [KO:K04304]
101558927  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
101558934  LTB; lymphotoxin-beta [KO:K03157]
101558963  RELL1; RELT-like protein 1 [KO:K26541]
101559035  IL18; interleukin-18 [KO:K05482]
101559190  IFNAR2; interferon alpha/beta receptor 2 [KO:K05131]
101559224  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
101559441  CXCL8; interleukin-8 [KO:K10030]
105942722  [KO:K05475]
105943012  [KO:K05510]
105943238  AMH; muellerian-inhibiting factor [KO:K04665]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Reference
PMID:21106488
  Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
  Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
  Journal
Hum Genomics 5:30-55 (2010)
DOI:10.1186/1479-7364-5-1-30
Reference
PMID:27577879
  Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
  Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
  Journal
J Allergy Clin Immunol 138:984-1010 (2016)
DOI:10.1016/j.jaci.2016.06.033
Reference
PMID:15500860
  Authors
Boulanger MJ, Garcia KC
  Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
  Journal
Adv Protein Chem 68:107-46 (2004)
DOI:10.1016/S0065-3233(04)68004-1
Reference
PMID:16034365
  Authors
Allan SM, Tyrrell PJ, Rothwell NJ
  Title
Interleukin-1 and neuronal injury.
  Journal
Nat Rev Immunol 5:629-40 (2005)
DOI:10.1038/nri1664
Reference
PMID:23847622
  Authors
Lopetuso LR, Chowdhry S, Pizarro TT
  Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
  Journal
Front Immunol 4:181 (2013)
DOI:10.3389/fimmu.2013.00181
Reference
PMID:21349428
  Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
  Title
Functional specialization of interleukin-17 family members.
  Journal
Immunity 34:149-62 (2011)
DOI:10.1016/j.immuni.2011.02.012
Reference
PMID:17530315
  Authors
Fischer P, Hilfiker-Kleiner D
  Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
  Journal
Basic Res Cardiol 102:279-97 (2007)
DOI:10.1007/s00395-007-0658-z
Reference
PMID:24381786
  Authors
Richards CD
  Title
The enigmatic cytokine oncostatin m and roles in disease.
  Journal
ISRN Inflamm 2013:512103 (2013)
DOI:10.1155/2013/512103
Reference
PMID:18926762
  Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
  Title
Structures and biological functions of IL-31 and IL-31 receptors.
  Journal
Cytokine Growth Factor Rev 19:347-56 (2008)
DOI:10.1016/j.cytogfr.2008.08.003
Reference
PMID:21155715
  Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
  Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
  Journal
Biochem J 434:343-51 (2011)
DOI:10.1042/BJ20101628
Reference
PMID:22410872
  Authors
de Weerd NA, Nguyen T
  Title
The interferons and their receptors--distribution and regulation.
  Journal
Immunol Cell Biol 90:483-91 (2012)
DOI:10.1038/icb.2012.9
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:12189384
  Authors
Ashkenazi A
  Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
  Journal
Nat Rev Cancer 2:420-30 (2002)
DOI:10.1038/nrc821
Reference
PMID:26115564
  Authors
Seeger P, Musso T, Sozzani S
  Title
The TGF-beta superfamily in dendritic cell biology.
  Journal
Cytokine Growth Factor Rev 26:647-57 (2015)
DOI:10.1016/j.cytogfr.2015.06.002
Reference
PMID:23612460
  Authors
Wakefield LM, Hill CS
  Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
  Journal
Nat Rev Cancer 13:328-41 (2013)
DOI:10.1038/nrc3500
Reference
PMID:22710174
  Authors
Mueller TD, Nickel J
  Title
Promiscuity and specificity in BMP receptor activation.
  Journal
FEBS Lett 586:1846-59 (2012)
DOI:10.1016/j.febslet.2012.02.043
KO pathway
ko04060   

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