KEGG   PATHWAY: sdu04510
Entry
sdu04510                    Pathway                                
Name
Focal adhesion - Seriola dumerili (greater amberjack)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
sdu04510  Focal adhesion
sdu04510

Other DBs
GO: 0005925
Organism
Seriola dumerili (greater amberjack) [GN:sdu]
Gene
111219718  collagen alpha-1(I) chain-like [KO:K06236]
111223033  col1a2; collagen alpha-2(I) chain [KO:K06236]
111223728  collagen alpha-1(I) chain-like [KO:K06236]
111217313  collagen alpha-1(II) chain-like [KO:K19719]
111223942  collagen alpha-1(II) chain [KO:K19719]
111216873  collagen alpha-4(IV) chain-like isoform X1 [KO:K06237]
111216864  collagen alpha-5(IV) chain-like isoform X1 [KO:K06237]
111218339  col4a2; collagen alpha-2(IV) chain [KO:K06237]
111218340  col4a1; collagen alpha-1(IV) chain [KO:K06237]
111233472  col4a5; collagen alpha-5(IV) chain [KO:K06237]
111233488  col4a6; collagen alpha-6(IV) chain [KO:K06237]
111229096  collagen alpha-1(IV) chain-like isoform X1 [KO:K06237]
111229098  collagen alpha-4(IV) chain-like [KO:K06237]
111218185  collagen alpha-2(VI) chain-like [KO:K06238]
111218115  col6a3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
111233703  collagen alpha-6(VI) chain-like [KO:K06238]
111233704  collagen alpha-6(VI) chain-like [KO:K06238]
111228854  col6a1; collagen alpha-1(VI) chain [KO:K06238]
111228934  collagen alpha-2(VI) chain-like [KO:K06238]
111217412  col9a3; collagen alpha-3(IX) chain [KO:K08131]
111223002  col9a2; collagen alpha-2(IX) chain [KO:K08131]
111234763  col9a1; collagen alpha-1(IX) chain [KO:K08131]
111235878  collagen alpha-1(IX) chain-like [KO:K08131]
111228183  collagen alpha-1(IX) chain-like [KO:K08131]
111236863  lama1; laminin subunit alpha-1 [KO:K05637]
111237038  lama2; laminin subunit alpha-2 [KO:K05637]
111234903  lama5; laminin subunit alpha-5 [KO:K06240]
111238966  lama3; laminin subunit alpha-3 [KO:K06240]
111240464  lama4; laminin subunit alpha-4 [KO:K06241]
111224756  laminin subunit beta-1-like [KO:K05636]
111239787  laminin subunit beta-1-like [KO:K05636]
111234736  lamb2; laminin subunit beta-2 isoform X1 [KO:K06243]
111234737  laminin subunit beta-2-like [KO:K06243]
111221777  lamb3; laminin subunit beta-3 [KO:K06244]
111239784  laminin subunit beta-4-like [KO:K06245]
111231760  lamc1; laminin subunit gamma-1 [KO:K05635]
111231768  laminin subunit gamma-2-like [KO:K06246]
111231770  laminin subunit gamma-2-like [KO:K06246]
111237378  lamc3; laminin subunit gamma-3 [KO:K06247]
111220044  chad; chondroadherin [KO:K06248]
111229759  reln; reelin [KO:K06249] [EC:3.4.21.-]
111225391  thrombospondin-1-like [KO:K16857]
111236186  LOW QUALITY PROTEIN: thrombospondin-1-like [KO:K16857]
111220103  thrombospondin-2-like [KO:K04659]
111219001  comp; cartilage oligomeric matrix protein [KO:K04659]
111233660  thbs3; thrombospondin-3 [KO:K04659]
111227674  thrombospondin-4-B-like [KO:K04659]
111239880  thrombospondin-4-B [KO:K04659]
111234144  thbs2; thrombospondin-2 [KO:K04659]
111238642  fibronectin-like isoform X1 [KO:K05717]
111218037  fibronectin-like [KO:K05717]
111217133  vitronectin-like [KO:K06251]
111224069  vtn; vitronectin isoform X1 [KO:K06251]
111217856  tenascin-like isoform X1 [KO:K06252]
111230647  tenascin-like [KO:K06252]
111228800  tnn; tenascin-N [KO:K06252]
111228257  tenascin-like [KO:K06252]
111239000  tnr; tenascin-R isoform X1 [KO:K06252]
111228525  vwf; von Willebrand factor isoform X1 [KO:K03900]
111239892  itga1; integrin alpha-1 [KO:K06480]
111236511  itga2; integrin alpha-2 [KO:K06481]
111239798  integrin alpha-IIb-like isoform X1 [KO:K06476]
111220391  itga3; integrin alpha-3 [KO:K06482]
111239795  integrin alpha-3-like [KO:K06482]
111218155  itga4; integrin alpha-4 [KO:K06483]
111221828  integrin alpha-5-like isoform X1 [KO:K06484]
111235100  integrin alpha-5-like [KO:K06484]
111218427  itga6; integrin alpha-6 [KO:K06485]
111232581  integrin alpha-6-like [KO:K06485]
111228974  integrin alpha-6-like isoform X1 [KO:K06485]
111223948  itga7; integrin alpha-7 [KO:K06583]
111236795  itga8; integrin alpha-8 [KO:K06584]
111220590  itga9; integrin alpha-9 [KO:K06585]
111229966  itga10; integrin alpha-10 [KO:K06586]
111223970  itga11; integrin alpha-11 [KO:K06587]
111231888  integrin alpha-11-like [KO:K06587]
111218062  itgav; integrin alpha-V [KO:K06487]
111228213  itgb1; integrin beta-1 isoform X1 [KO:K05719]
111233864  integrin beta-1-like [KO:K05719]
111219935  itgb3; integrin beta-3 [KO:K06493]
111217494  integrin beta-3-like [KO:K06493]
111220033  itgb4; integrin beta-4 isoform X1 [KO:K06525]
111218348  itgb5; integrin beta-5 [KO:K06588]
111238685  itgb6; integrin beta-6 [KO:K06589]
111223210  itgb8; integrin beta-8 [KO:K06591]
111230290  emp2; epithelial membrane protein 2 [KO:K26256]
111216525  platelet-derived growth factor subunit A-like [KO:K04359]
111227111  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
111216519  uncharacterized protein LOC111216519 [KO:K17386]
111224145  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
111232625  pdgfc; platelet-derived growth factor C [KO:K05450]
111232468  egf; pro-epidermal growth factor [KO:K04357]
111225018  igf1; insulin-like growth factor I [KO:K05459]
111233786  insulin-like growth factor I [KO:K05459]
111227814  vascular endothelial growth factor A-A-like isoform X1 [KO:K05448]
111238405  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
111225931  pgf; placenta growth factor [KO:K16859]
111240400  vascular endothelial growth factor A-like isoform X1 [KO:K16859]
111224831  vegfd; vascular endothelial growth factor D [KO:K05449]
111236702  vascular endothelial growth factor C-like [KO:K05449]
111230477  vegfc; vascular endothelial growth factor C [KO:K05449]
111224573  hepatocyte growth factor-like [KO:K05460]
111228480  hgf; hepatocyte growth factor [KO:K05460]
111226338  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
111226471  pdgfrb; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
111239485  platelet-derived growth factor receptor beta-like [KO:K05089] [EC:2.7.10.1]
111217738  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
111228731  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
111226355  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
111237405  melanoma receptor tyrosine-protein kinase-like isoform X1 [KO:K04361] [EC:2.7.10.1]
111231258  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
111221028  flt1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
111232404  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
111226519  flt4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
111220524  met; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
111219739  erbb2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
111223693  epithelial membrane protein 2-like [KO:K26255]
111231517  peripheral myelin protein 22-like [KO:K26255]
111233537  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
111235128  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
111238883  arhgap35; rho GTPase-activating protein 35 [KO:K05732]
111234595  rho GTPase-activating protein 35-like [KO:K05732]
111236116  arhgap5; LOW QUALITY PROTEIN: rho GTPase-activating protein 5 [KO:K13709]
111218956  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
111222939  transforming protein RhoA [KO:K04513]
111230710  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
111233774  rho-related GTP-binding protein RhoA-C [KO:K04513]
111232553  protein diaphanous homolog 1-like [KO:K05740]
111231038  rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
111225444  rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
111239446  rho-associated protein kinase 2-like isoform X1 [KO:K17388] [EC:2.7.11.1]
111221531  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
111226251  myosin regulatory light chain 2, ventricular/cardiac muscle isoform-like [KO:K10351]
111238024  myosin light chain 5-like [KO:K12753]
111236479  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
111221962  myosin regulatory light polypeptide 9 [KO:K12755]
111234328  myosin regulatory light chain 2B, cardiac muscle isoform-like [KO:K12756]
111237802  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
111230984  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
111217468  mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
111219734  myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
111225507  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
111217471  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
111219951  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
111235970  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
111226896  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
111232070  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
111229837  protein phosphatase 1 regulatory subunit 12A-like isoform X1 [KO:K06270]
111224778  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
111238191  protein phosphatase 1 regulatory subunit 12B-like [KO:K12329]
111217994  protein phosphatase 1 regulatory subunit 12C-like [KO:K17457]
111230430  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
111220055  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
111227561  myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
111217682  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
111231110  myosin light chain kinase 2, skeletal/cardiac muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
111221161  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like isoform X1 [KO:K00889] [EC:2.7.1.68]
111223078  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
111228812  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma-like isoform X1 [KO:K00889] [EC:2.7.1.68]
111231959  pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
111237179  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
111226304  phosphatidylinositol 4-phosphate 5-kinase type-1 beta-like [KO:K00889] [EC:2.7.1.68]
111216734  actin, cytoplasmic 2 [KO:K05692]
111230355  actb; actin, cytoplasmic 1 [KO:K05692]
111221017  ras-specific guanine nucleotide-releasing factor 1-like [KO:K04349]
111228529  ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
111220638  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111220639  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111237555  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111237556  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111237557  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
111225279  alpha-actinin-1 isoform X1 [KO:K05699]
111216823  actn4; alpha-actinin-4 isoform X1 [KO:K05699]
111221249  tln1; talin-1 [KO:K06271]
111218754  talin-2 [KO:K06271]
111228411  tln2; talin-2 [KO:K06271]
111237012  filamin-A-like isoform X1 [KO:K04437]
111219449  filamin-B-like [KO:K27392]
111221651  paxillin-like [KO:K05760]
111227470  paxillin-like isoform X1 [KO:K05760]
111232291  integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
111234414  integrin-linked protein kinase-like [KO:K06272] [EC:2.7.11.1]
111230053  zyx; zyxin [KO:K06273]
111222556  vasodilator-stimulated phosphoprotein-like isoform X1 [KO:K06274]
111219856  vinculin isoform X1 [KO:K05700]
111234345  vinculin-like isoform X1 [KO:K05700]
111222518  alpha-parvin [KO:K06275]
111229592  parvg; gamma-parvin isoform X1 [KO:K06275]
111229593  parvb; beta-parvin isoform X1 [KO:K06275]
111220410  pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
111225465  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111238251  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
111235389  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111234315  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
111233400  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111218261  gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
111222989  catenin beta-1-like [KO:K02105]
111227669  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
111227115  protein kinase C alpha type-like [KO:K02677] [EC:2.7.11.13]
111236289  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
111216674  protein kinase C beta type-like isoform X1 [KO:K19662] [EC:2.7.11.13]
111230195  prkcb; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
111230118  protein kinase C gamma type-like [KO:K19663] [EC:2.7.11.13]
111223196  focal adhesion kinase 1-like isoform X1 [KO:K05725] [EC:2.7.10.2]
111216431  pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111219094  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
111236831  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
111232818  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111228886  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111239022  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111227486  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
111236942  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
111228846  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
111228984  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
111235342  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
111220177  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111235327  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111216596  vav1; proto-oncogene vav isoform X1 [KO:K05730]
111231041  guanine nucleotide exchange factor VAV3-like isoform X1 [KO:K05730]
111228218  vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
111237501  vav2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
111220230  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
111227294  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
111235860  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
111237036  ras-related C3 botulinum toxin substrate 3 [KO:K07861]
111216915  pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
111225480  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
111226340  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
111234276  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
111216861  serine/threonine-protein kinase PAK 4-like [KO:K05734] [EC:2.7.11.1]
111216376  pak5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
111231703  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
111225873  serine/threonine-protein kinase PAK 6-like [KO:K05735] [EC:2.7.11.1]
111221873  cell division control protein 42 homolog isoform X1 [KO:K04393]
111234891  cell division control protein 42 homolog isoform X1 [KO:K04393]
111230104  cell division control protein 42 homolog [KO:K04393]
111233205  cell division control protein 42 homolog [KO:K04393]
111234832  bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
111238220  adapter molecule crk-like [KO:K04438]
111233069  crkl; crk-like protein [KO:K04438]
111233089  adapter molecule crk-like [KO:K04438]
111219899  dock1; dedicator of cytokinesis protein 1 [KO:K13708]
111237355  rapgef1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
111237440  rap guanine nucleotide exchange factor 1-like isoform X1 [KO:K06277]
111224024  ras-related protein Rap-1A-like [KO:K04353]
111234902  ras-related protein Rap-1A [KO:K04353]
111225046  rap1b; ras-related protein Rap-1b [KO:K07836]
111219534  mitogen-activated protein kinase 8-like [KO:K04440] [EC:2.7.11.24]
111226417  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
111234720  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111235092  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
111228982  jun; transcription factor AP-1 [KO:K04448]
111231968  transcription factor AP-1-like isoform X1 [KO:K04448]
111224636  braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
111220536  cav1; caveolin-1 [KO:K06278]
111220534  cav2; caveolin-2 [KO:K12958]
111222816  caveolin-2-like [KO:K12958]
111230734  caveolin-2-like [KO:K12958]
111222144  cav3; caveolin-3 [KO:K12959]
111222817  caveolin-3-like [KO:K12959]
111225278  tyrosine-protein kinase fyna [KO:K05703] [EC:2.7.10.2]
111235770  fyn; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
111230117  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
111232138  SHC-transforming protein 2-like isoform X1 [KO:K17447]
111234683  shc3; SHC-transforming protein 3 isoform X1 [KO:K17448]
111238681  shc4; SHC-transforming protein 4 [KO:K17449]
111238087  grb2; growth factor receptor-bound protein 2 [KO:K04364]
111225570  sos2; son of sevenless homolog 2 [KO:K03099]
111237578  sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
111228382  hras; GTPase HRas [KO:K02833]
111217320  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
111228471  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
111236845  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111230214  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
111235429  elk1; ETS domain-containing protein Elk-1 [KO:K04375]
111221119  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
111234824  G1/S-specific cyclin-D1-like [KO:K04503]
111225171  G1/S-specific cyclin-D2-like isoform X1 [KO:K10151]
111224908  G1/S-specific cyclin-D2-like [KO:K10151]
111217717  G1/S-specific cyclin-D2-like [KO:K10151]
111222077  G1/S-specific cyclin-D2-like [KO:K10152]
111234415  inhibitor of apoptosis protein-like [KO:K16060]
111226606  xiap; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
111231315  bad; bcl2-associated agonist of cell death [KO:K02158]
111236887  apoptosis regulator Bcl-2-like isoform X1 [KO:K02161]
111239004  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
sdu04010  MAPK signaling pathway
sdu04060  Cytokine-cytokine receptor interaction
sdu04070  Phosphatidylinositol signaling system
sdu04110  Cell cycle
sdu04310  Wnt signaling pathway
sdu04512  ECM-receptor interaction
sdu04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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