Entry Name JAK-STAT signaling pathway - Sarcophilus harrisii (Tasmanian devil)
Description The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Sarcophilus harrisii (Tasmanian devil) [GN:
shr ]
Gene 100913307 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
100914432 PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063 ] [EC:2.3.2.-]
100915478 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
100916709 IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067 ]
100917875 PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386 ]
100917948 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
100919064 IFNAR1; LOW QUALITY PROTEIN: interferon alpha/beta receptor 1 [KO:K05130 ]
100920230 FHL1; four and a half LIM domains protein 1 isoform X3 [KO:K14365 ]
100920307 STAT5B; signal transducer and activator of transcription 5B [KO:K11224 ]
100921841 GALT; galactose-1-phosphate uridylyltransferase isoform X1 [KO:K05056 ]
100922104 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
100923143 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
100923207 IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X2 [KO:K05077 ]
100924903 STAM2; signal transducing adapter molecule 2 isoform X1 [KO:K04705 ]
100924976 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
100924985 PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
100925445 CSF3; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor [KO:K05423 ]
100926892 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100926905 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
100928324 PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706 ] [EC:2.3.2.-]
100928648 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539 ]
100928707 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
100929781 IL2RG; cytokine receptor common subunit gamma isoform X2 [KO:K05070 ]
100929811 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
100930901 STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225 ]
100932099 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
100932204 STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705 ]
100933167 STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
100933581 STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
100933645 STAT4; signal transducer and activator of transcription 4 [KO:K11222 ]
100935230 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
100935278 IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630 ]
105749415 IL12RB1; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-1 [KO:K05063 ]
105749698 TSLP; LOW QUALITY PROTEIN: thymic stromal lymphopoietin [KO:K05436 ]
105749862 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
105749979 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
105749994 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
105750684 CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738 ]
105750698 IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068 ]
Reference Authors Harrison DA
Title The Jak/STAT pathway.
Journal Reference Authors Kiu H, Nicholson SE
Title Biology and significance of the JAK/STAT signalling pathways.
Journal Reference Authors Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title Direct effects of type I interferons on cells of the immune system.
Journal Reference Authors Fish EN, Platanias LC
Title Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal Reference Authors Ivanenkov YA, Balakin KV, Lavrovsky Y
Title Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal Reference Authors O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal Reference Authors Zoranovic T, Grmai L, Bach EA
Title Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal Reference Authors Ungureanu D, Silvennoinen O
Title SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal Reference Authors Richard AJ, Stephens JM
Title The role of JAK-STAT signaling in adipose tissue function.
Journal Reference Authors Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal Reference Authors Hirano T, Ishihara K, Hibi M
Title Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal Reference Authors Rane SG, Reddy EP
Title Janus kinases: components of multiple signaling pathways.
Journal Reference Authors Heim MH
Title The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal Reference Authors Morris R, Kershaw NJ, Babon JJ
Title The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal Reference Authors Tzeng HT, Chyuan IT, Lai JH
Title Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal Reference Authors Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal Related shr04060 Cytokine-cytokine receptor interaction
KO pathway
