KEGG    Network variation - Kaposi sarcoma-associated herpesvirus (KSHV)
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ENTRYnt06164
NameKaposi sarcoma-associated herpesvirus (KSHV)
CategoryDisease view; Viral infection
Pathwayhsa05167 Kaposi sarcoma-associated herpesvirus infection
GenomeT40081
DiseaseH00041 Kaposi sarcoma
Display drug-target relation   disease type
ERK signaling
N00216    HGF→MET→GRB2→SOS→RAS→RAF→MEK→ERK
N00160          K1→RAS
N00188    IL1→IL1R→MYD88→IRAK1/4→TRAF6→TAB1/2/3→TAK1→MKK4/7→JNK→AP1
N00189                K15→MKK4/7
N00186    IL1→IL1R→MYD88→IRAK1/4→TRAF6→TAB1/2/3→TAK1→MKK3/6→MAPK14→MK2⊣TTP
N00187                    MAPK14→(MK2+K12)⊣TTP
 
PI3K signaling
N00182          IGF1→IGF1R→PI3K→PIP3→AKT→IKK→NFKBIA→NFKB
N00179            K1→PI3K
N00030    EGF→EGFR→GRB2→SOS→RAS→PI3K→PIP3→AKT⊣BAD
N00159            K1→PI3K
 
WNT signaling
N00056    WNT→(FZD+LRP5/6)→(DVL+FRAT)⊣(GSK3B+AXIN+APC)⊣CTNNB1→TCF/LEF⇒(MYC,CCND1)
N00175        LANA⊣GSK3B⊣CTNNB1→TCF/LEF⇒CCND1
 
JAK-STAT signaling
N00053    Cytokine→Receptor→JAK→STAT⇒PIM1
N00181    vIL6→IL6ST→JAK2→STAT3
 
Calcium signaling
N00147    EGF→EGFR→PLCG→IP3→Ca2+→CALM=CN→NFAT
N00180      K1→PLCG2
N00172      K15→PLCG1
 
TLR signaling
N00148    TLR3→TICAM1→TRAF3→(IKBKE+TBK1)→IRF7⇒IFNA
N00162          vIRF3⊣IRF7
N00163          (KIE1,KIE2)⊣IRF7
N00149    TLR3→TICAM1→TRAF3→(IKBKE+TBK1)→IRF3→(CREBBP,EP300)⇒IFNB1
N00161          (IRF1,IRF2,K8)⊣IRF3
 
Complement cascade
N01487    [C4,C2]−((C1QA,C1QB,C1QC)+..→[C4b,C2a]→(C4b+C2a)
N00213      KCP⊣C4b
 
IFN signaling
N00150    (IFNA,IFNB1)→(IFNAR1+IFNAR2)→(JAK1,TYK2)→(STAT1+STAT2+IRF9)⇒(IRF7,EIF2AK2)
N00261        vIRF2⊣(STAT1+STAT2+IRF9)
 
TNF signaling
N00151    TNF→TNFRSF1A→(RIPK1+TRADD+TRAF2..→(TAB1/2/3+TAK1)→IKK→NFKBIA→NFKB
N00174      vFLIP→TRAF2→IKK→NFKBIA→NFKB
N00173      K15→TRAF2→TAK1→IKK→NFKBIA→NFKB
N00171          vFLIP→IKK→NFKBIA→NFKB
 
Chemokine signaling
N00152    CXCL8→CXCR2→GNB/G→RAS→RAF1→MEK→ERK
N00157      vGPCR→GNB/G
N00153    (CC,CXC)→(CCR,CXCR)→GNB/G→PI3Kgamma→PREX1→RAC1
N00462    (vCCL1,vCCL2,vCCL3..→(CCR3,CCR4,CCR8)
N00212    vCCL2⊣(CCR1,CCR5)
N00178      vGPCR→GNB/G
N00154    CXCL8→CXCR2→GNB/G→PI3Kgamma→PIP3→AKT→MTOR
N00158      vGPCR→GNB/G
 
MHC presentation
N00363    TAP1/2=TAPBP=(PDIA3+CALR)→(MHCI+B2M)
N00184        (MIR1,MIR2)⊣MHCI
N00185        MIR2⊣(ICAM1,CD86,MICA,M..
 
Autophagy
N00155    mTORC1→ULK1_complex→PI3KC3-C1
N00177      vBCL2⊣(BECN1+PIK3C3+ATG1..
N00156    LC3−ATG4⇉ATG7⇉ATG3⇉(ATG12+ATG5+ATG16L..→LC3-II
N00176        vFLIP⊣ATG3
 
Cell cycle
N00066    CDKN2A⊣MDM2⊣TP53⇒CDKN1A⊣(CCND+CDK4/6)→RB1⌿E2F
N00167      (vIRF1,vIRF3)⊣TP53
N00169      LANA⊣TP53
N00168          vCyclin→CDK4/6→RB1⌿E2F
N00170            LANA→RB1⌿E2F
 
Apoptosis
N00146    (FASLG,TNFSF10)→(FAS,TNFRSF10B)→FADD→(CASP8,CASP10)→BID→(BAX,BAK1)→CYCS=APAF1→CASP9→(CASP3,CASP7)
N00166        vFLIP⊣CASP8P3
N00164            vBCL2⊣(BAX,BAK1)
N00165                    vIAP⊣CASP3