KEGG    Network variation - TLR signaling
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ENTRYnt06517
NameTLR signaling
CategoryPathway view; Immune system
Pathwayhsa04620 Toll-like receptor signaling pathway
DiseaseH00096 Defects of toll-like receptor signaling
Display drug-target relation   disease type
N00435      (TLR1,TLR2,TLR4)→(TIRAP+MYD88)→(IRAK4+IRAK1)→(TRAF6+TAK1+TAB2)→IKK→NFKBIA→NFKB⇒(TNF,IL6,IL12A,IL1..
    LPRS5   TLR1*
    LPRS3/TB   TLR2*
      TLR4*↗
    TB     TIRAP*
N00556    HBV C⊣TLR2
N00561    HSV   ICP0⊣MYD88
N00692    MV     P→TNFAIP3⊣(TRAF6+TAK1+TAB2)
N00466    EBV       BPLF1⊣(TRAF6+TAK1+(TAB1,..
N00562    HSV       US3⊣(TRAF6+TAK1+TAB2)
N00859    Yersinia       YopP/J⊣(TRAF6+TRAF2+TAK1+..
N00436    HIV             Tat→NFKB⇒(TNF,IFNA,IFNB1)
 
N01543      (TLR7+TLR8+TLR9)→MYD88→(IRAK4+IRAK1)→TRAF6→IRF5⇒(IFNA,IFNB1)
    SLEB17   TLR7*↗
    SLEB10           IRF5*
 
N00690      (TLR7,TLR9)→MYD88→(IRAK4+IRAK1)→IRF7⇒(IFNA,IFNB1)
    IMD74   TLR7*
    IMD67       IRAK4*
    IMD39         IRF7*
N00691    MV       V⊣IRF7
 
N00438      (TLR2,TLR4)→(TIRAP+MYD88)→(IRAK4+IRAK1)→(TRAF6+TAK1+TAB2)→(MEK,MKK3/6,MKK4/7..→(ERK,p38,JNK)→AP1
N00926    Escherichia     Tir→SHP1/2⊣(TRAF6+TAK1+TAB2)
N00862    Yersinia         YopP/J⊣(MEK,MKK3/6,MKK4/7..
N00439    HIV           Nef⊣ERK
N00551    HBV           S⊣JNK
N01283    Shigella           OspF⊣(ERK,p38)
 
N00553      TLR4→TICAM2→TICAM1→TRAF3→(IKBKE+TBK1)→(IRF3,IRF7)⇒IFNB1
N00554    HBV   C⊣TICAM2
 
N00149      TLR3→TICAM1→TRAF3→(IKBKE+TBK1)→IRF3→(CREBBP,EP300)⇒IFNB1
    IIAE2   TLR3*
    IIAE6     TICAM1*
    IIAE5       TRAF3*
    IIAE8         TBK1*
    IIAE7           IRF3*
N00516    HCV   (NS3,NS4A)⊣TICAM1
N00552    HBV     P⊣DDX3X=(IKBKE+TBK1)
N00161    KSHV         (IRF1,IRF2,K8)⊣IRF3
N00346    HPV         E6⊣IRF3
 
N00148      TLR3→TICAM1→TRAF3→(IKBKE+TBK1)→IRF7⇒IFNA
N00162    KSHV         vIRF3⊣IRF7
N00163    KSHV         (KIE1,KIE2)⊣IRF7
 
N01566      TLR5→(MYD88)→(IRAK4+IRAK1)→(TRAF6+TAK1+TAB2)→IKK→NFKBIA→NFKB⇒(TNF,IL6,IL12A,IL1..
    LD/MD   TLR5*
 
N00150      (IFNA,IFNB1)→(IFNAR1+IFNAR2)→(JAK1,TYK2)→(STAT1+STAT2+IRF9)⇒(IRF7,EIF2AK2)
N00471    EBV (LMP2A,LMP2B)⊣(IFNAR1+IFNAR2)
N00577    HSV     UL41⊣JAK1
N00693    MV     (V,P)⊣JAK1
N00472    EBV     LMP1⊣TYK2
N00377    HPV     E6⊣TYK2
N00738    IAV     NS1→SOCS3⊣(STAT1+STAT2+IRF9)
N00694    MV       (V,P,C)⊣(STAT1+STAT2+IRF9)
N00473    EBV       BGLF4⊣(STAT1+STAT2+IRF9)
N00261    KSHV       vIRF2⊣(STAT1+STAT2+IRF9)
N00575    HSV       ICP27⊣(STAT1+STAT2+IRF9)
N00379    HPV       E7⊣(STAT1+STAT2+IRF9)
N00270    HCV       Core⊣(STAT1+STAT2+IRF9)
N00558    HBV       P⊣(STAT1+STAT2)
N01321    SARS-CoV-2       (nsp1,nsp6,nsp13,O..⊣STAT1
N01322    SARS-CoV-2       (nsp6,nsp13,ORF7a,..⊣STAT2

Disease nameDisease category
LPRS5H00344LeprosyBacterial infectious disease
LPRS3/TBH00344LeprosyBacterial infectious disease
H00342TuberculosisBacterial infectious disease
ARMD10H00821Age-related macular degenerationNervous system disease
TBH00342TuberculosisBacterial infectious disease
HBVH00048Hepatocellular carcinomaCancer
HSVH00365Herpes simplex virus infectionViral infectious disease
MVH00394MeaslesViral infectious disease
EBVH00008Burkitt lymphomaCancer
H00007Hodgkin lymphomaCancer
H00054Nasopharyngeal cancerCancer
YersiniaH00297PlagueBacterial infectious disease
H00298YersiniosisBacterial infectious disease
HIVH01563HIV infectionViral infectious disease
SLEB17H00080Systemic lupus erythematosusImmune system disease
SLEB10H00080Systemic lupus erythematosusImmune system disease
IMD74H00096Defects of toll-like receptor signalingPrimary immunodeficiency
IMD67H00096Defects of toll-like receptor signalingPrimary immunodeficiency
IMD39H00096Defects of toll-like receptor signalingPrimary immunodeficiency
EscherichiaH00277Enterohemorrhagic Escherichia coli (EHEC) infectionBacterial infectious disease
H00278Enteropathogenic Escherichia coli (EPEC) infectionBacterial infectious disease
ShigellaH00299ShigellosisBacterial infectious disease
IIAE2H02536Infection-induced acute encephalopathyNervous system disease
IIAE6H02536Infection-induced acute encephalopathyNervous system disease
IIAE5H02536Infection-induced acute encephalopathyNervous system disease
IIAE8H02536Infection-induced acute encephalopathyNervous system disease
IIAE7H02536Infection-induced acute encephalopathyNervous system disease
HCVH00048Hepatocellular carcinomaCancer
KSHVH00041Kaposi sarcomaCancer
HPVH00030Cervical cancerCancer
LD/MDH00311LegionellosisBacterial infectious disease
H00317MelioidosisBacterial infectious disease
IAVH00398InfluenzaViral infectious disease
SARS-CoV-2H02398COVID-19Viral infectious disease