KEGG   PATHWAY: cpla05132
Entry
cpla05132                   Pathway                                
Name
Salmonella infection - Chiloscyllium plagiosum (whitespotted bambooshark)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
cpla05132  Salmonella infection
cpla05132

Disease
H00111  Typhoid fever
Organism
Chiloscyllium plagiosum (whitespotted bambooshark) [GN:cpla]
Gene
122539274  [KO:K10030]
122539315  dctn6; dynactin subunit 6 [KO:K10428]
122539441  [KO:K12753]
122539455  [KO:K10030]
122539462  [KO:K03094]
122539466  lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
122539548  [KO:K02580]
122539558  [KO:K05759]
122539848  rab5c; ras-related protein Rab-5C [KO:K07889]
122539907  [KO:K23649]
122539927  [KO:K07374]
122539997  plekhm1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282]
122540014  [KO:K07937]
122540099  plekhm2; pleckstrin homology domain-containing family M member 2 [KO:K15348]
122540160  dnm2a; dynamin-3 isoform X1 [KO:K23484]
122540222  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
122540242  [KO:K10407]
122540433  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
122540506  [KO:K05482]
122540580  [KO:K05482]
122540718  [KO:K07856]
122540745  [KO:K05403]
122540782  [KO:K07375]
122540861  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
122540870  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122541114  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
122541173  [KO:K03173] [EC:2.3.2.27]
122541180  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
122541496  [KO:K07375]
122541513  [KO:K03173] [EC:2.3.2.27]
122541809  [KO:K04440] [EC:2.7.11.24]
122541851  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122542035  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
122542049  [KO:K07897]
122542066  [KO:K02159]
122542234  [KO:K18441]
122542237  [KO:K04392]
122542238  [KO:K04392]
122542312  [KO:K05759]
122542324  txn2; thioredoxin, mitochondrial [KO:K03671]
122542363  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
122542524  snx33; sorting nexin-33 [KO:K17923]
122542531  fbxo22; F-box only protein 22 [KO:K10302]
122542617  anxa2a; annexin A2a [KO:K17092]
122542778  [KO:K04734]
122542794  klc3; kinesin light chain 3 isoform X1 [KO:K10407]
122542840  [KO:K04456] [EC:2.7.11.1]
122542853  [KO:K03671]
122542854  [KO:K03671]
122542856  [KO:K03671]
122542863  [KO:K07941]
122542947  [KO:K03671]
122542979  [KO:K05759]
122542996  [KO:K04490]
122542999  [KO:K04397] [EC:3.4.22.60]
122543065  [KO:K16575]
122543100  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
122543166  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122543239  il1b; interleukin-1 beta [KO:K04519]
122543305  [KO:K07374]
122543306  [KO:K07374]
122543307  [KO:K07374]
122543337  [KO:K07888]
122543374  [KO:K10415]
122543981  [KO:K23934]
122543990  pfn4; profilin-4 isoform X1 [KO:K05759]
122544333  [KO:K12807]
122544358  [KO:K00922] [EC:2.7.1.153]
122544607  dctn3; dynactin subunit 3 [KO:K10425]
122544975  [KO:K07375]
122545416  [KO:K07856]
122545460  [KO:K10030]
122545707  [KO:K07374]
122545722  [KO:K07374]
122545740  [KO:K07374]
122545763  [KO:K07374]
122546496  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
122546928  [KO:K05692]
122546961  [KO:K07374]
122546976  [KO:K10168]
122547087  [KO:K03156]
122547175  [KO:K07941]
122547269  [KO:K23583]
122547285  [KO:K05692]
122547504  [KO:K10030]
122547519  [KO:K21289] [EC:2.7.1.153]
122547696  [KO:K07374]
122547751  [KO:K10168]
122548121  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
122548201  [KO:K07374]
122548523  acbd3; Golgi resident protein GCP60 [KO:K23935]
122548578  [KO:K04079]
122548799  [KO:K05692]
122548800  [KO:K05692]
122548801  [KO:K05692]
122548802  [KO:K05692]
122548860  [KO:K07375]
122548926  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
122548948  [KO:K05692]
122548949  [KO:K05692]
122549011  [KO:K08846] [EC:2.7.11.1]
122549039  [KO:K12757]
122549154  snx18a; sorting nexin-18a isoform X1 [KO:K17923]
122549176  [KO:K04377]
122549313  [KO:K07834]
122549315  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
122549711  [KO:K08738]
122549716  [KO:K02161]
122549819  [KO:K10415]
122549941  [KO:K07887]
122549956  [KO:K10416]
122550063  abi1a; abl interactor 1a isoform X1 [KO:K23649]
122550078  [KO:K10396] [EC:5.6.1.3]
122550120  [KO:K18584]
122550242  [KO:K05405]
122550281  il6; interleukin-6 [KO:K05405]
122550418  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
122550676  [KO:K20282]
122550689  [KO:K10414]
122550764  wasf3b; wiskott-Aldrich syndrome protein family member 3b isoform X1 [KO:K06083]
122550845  rps3; 40S ribosomal protein S3 [KO:K02985]
122550892  cyfip1; cytoplasmic FMR1-interacting protein 1 homolog isoform X1 [KO:K05749]
122550933  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
122550983  [KO:K07863]
122551010  rhoh; rho-related GTP-binding protein RhoH [KO:K07873]
122551023  [KO:K12755]
122551183  [KO:K07863]
122551287  tlr1; toll-like receptor 1 isoform X1 [KO:K10169]
122551291  rab5b; ras-related protein Rab-5B [KO:K07888]
122551292  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
122551489  nckap1; nck-associated protein 1 isoform X1 [KO:K05750]
122551568  dync1i2b; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
122551690  actr3; actin-related protein 3 isoform X1 [KO:K18584]
122551741  [KO:K10396] [EC:5.6.1.3]
122551809  [KO:K07374]
122551811  [KO:K07374]
122551812  [KO:K07374]
122551814  [KO:K07374]
122551815  [KO:K07374]
122551852  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
122551950  [KO:K07374]
122552009  [KO:K08738]
122552163  map2k7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
122552291  [KO:K23937]
122552657  [KO:K04456] [EC:2.7.11.1]
122552706  [KO:K12805]
122552728  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
122552873  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122552919  [KO:K17923]
122552928  [KO:K10420]
122552951  [KO:K10358]
122553006  [KO:K07941]
122553035  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
122553041  [KO:K10030]
122553046  [KO:K10030]
122553055  [KO:K10030]
122553124  [KO:K17260]
122553170  si:ch211-125o16.4; neuroblast differentiation-associated protein AHNAK [KO:K23934]
122553453  rhoj; rho-related GTP-binding protein RhoJ [KO:K07864]
122553510  [KO:K04079]
122553512  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
122553549  klc1a; kinesin light chain 1 isoform X1 [KO:K10407]
122553568  akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122553637  actr10; actin-related protein 10 isoform X1 [KO:K16576]
122553671  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
122553856  vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
122553881  [KO:K09487]
122553931  exoc5; exocyst complex component 5 [KO:K19984]
122554025  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
122554377  jun; transcription factor AP-1 [KO:K04448]
122554458  [KO:K05754]
122554467  [KO:K10159]
122554548  ptprc; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
122554772  tlr2; toll-like receptor 2 [KO:K10159]
122554956  kpna3; importin subunit alpha-4 [KO:K23583]
122555011  rab9a; ras-related protein Rab-9A [KO:K07899]
122555075  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
122555121  [KO:K10420]
122555210  [KO:K23940]
122555374  [KO:K17923]
122555597  [KO:K04379]
122555663  [KO:K13744]
122555799  [KO:K10030]
122555808  [KO:K10030]
122555815  [KO:K10030]
122555821  [KO:K10030]
122555841  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122555865  kpna4; importin subunit alpha-3 [KO:K23583]
122555910  [KO:K10419]
122556126  [KO:K04721]
122556207  [KO:K05759]
122556444  dctn4; dynactin subunit 4 isoform X1 [KO:K10426]
122556478  cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
122556583  tcf7; transcription factor 7 isoform X1 [KO:K02620]
122556585  skp1; S-phase kinase-associated protein 1 isoform X1 [KO:K03094]
122556642  [KO:K04440] [EC:2.7.11.24]
122556673  [KO:K02580]
122556917  [KO:K10030]
122557200  [KO:K04721]
122557329  [KO:K06083]
122557344  [KO:K05733] [EC:2.7.11.1]
122557611  zgc:153993; apoptosis regulator BAX [KO:K02159]
122557741  [KO:K02833]
122557770  casp3b; caspase-3b [KO:K04397] [EC:3.4.22.60]
122557774  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
122557956  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
122558209  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
122558226  [KO:K10419]
122558329  [KO:K07375]
122558488  fhod1; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938]
122558526  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
122558541  [KO:K08849] [EC:2.7.11.1]
122558797  rab7a; ras-related protein Rab-7a [KO:K07897]
122558839  brk1; probable protein BRICK1 isoform X1 [KO:K05752]
122558846  [KO:K04513]
122558886  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
122558898  arpc4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
122558962  raf1b; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
122559177  arl8bb; ADP-ribosylation factor-like 8Bb [KO:K07955]
122559374  [KO:K14021]
122559532  [KO:K07955]
122559534  wasla; WASP like actin nucleation promoting factor a isoform X1 [KO:K23612]
122559653  [KO:K23583]
122559701  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
122559833  hsp90b1; endoplasmin [KO:K09487]
122559944  [KO:K18985]
122559998  [KO:K07375]
122560114  cse1l; exportin-2 [KO:K18423]
122560196  [KO:K12755]
122560272  [KO:K10419]
122560530  [KO:K05757]
122560594  cyth3a; cytohesin-3 isoform X1 [KO:K18441]
122560598  [KO:K04392]
122560725  dctn5; dynactin subunit 5 [KO:K10427]
122560779  [KO:K04432] [EC:2.7.12.2]
122560808  [KO:K05757]
122561195  tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
122561202  casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
122561343  [KO:K16575]
122561603  [KO:K00923] [EC:2.7.1.154]
122561715  [KO:K04441] [EC:2.7.11.24]
122561716  mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
122561827  exoc4; exocyst complex component 4 isoform X1 [KO:K06111]
122561981  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
122561991  [KO:K23583]
122562031  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X1 [KO:K04430] [EC:2.7.12.2]
122562165  [KO:K05692]
122562211  [KO:K04433] [EC:2.7.12.2]
122562215  cyth1b; cytohesin-1b isoform X1 [KO:K18441]
122562306  exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
122562654  [KO:K10351]
122562664  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
122562688  vps33a; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
122562779  [KO:K10418]
122562831  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122562929  [KO:K03671]
122562945  [KO:K03671]
122562967  [KO:K07898]
122563070  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923] [EC:2.7.1.154]
122563201  [KO:K04441] [EC:2.7.11.24]
122563202  [KO:K04441] [EC:2.7.11.24]
122563224  [KO:K07955]
122563274  [KO:K14021]
122563340  [KO:K07374]
122563498  [KO:K07856]
122563532  [KO:K10420]
122563842  [KO:K10351]
122563976  [KO:K10418]
122564041  [KO:K13883]
122564102  [KO:K01370] [EC:3.4.22.36]
122564399  elmo1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
122564432  [KO:K08727]
122564434  [KO:K08727]
122564435  nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
122564462  exoc2; exocyst complex component 2 isoform X1 [KO:K17637]
122564486  fyco1a; FYVE and coiled-coil domain-containing protein 1 isoform X1 [KO:K21954]
122564495  ripk1l; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
122564498  [KO:K07375]
122564524  ctnnb1; catenin beta-1 isoform X1 [KO:K02105]
122564593  [KO:K03173] [EC:2.3.2.27]
122564705  [KO:K07375]
122564706  [KO:K07375]
122564723  [KO:K07375]
122564724  [KO:K07375]
122564846  arpc5lb; actin related protein 2/3 complex, subunit 5-like, b [KO:K05754]
122565176  [KO:K04369] [EC:2.7.12.2]
122565506  [KO:K17274]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
cpla04010  MAPK signaling pathway
cpla04210  Apoptosis
cpla04217  Necroptosis
cpla04621  NOD-like receptor signaling pathway
KO pathway
ko05132   

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