KEGG   PATHWAY: eju04510
Entry
eju04510                    Pathway                                
Name
Focal adhesion - Eumetopias jubatus (Steller sea lion)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
eju04510  Focal adhesion
eju04510

Other DBs
GO: 0005925
Organism
Eumetopias jubatus (Steller sea lion) [GN:eju]
Gene
114196420  COMP; cartilage oligomeric matrix protein [KO:K04659]
114196618  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
114196641  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
114196710  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
114196720  ITGB3; integrin beta-3 [KO:K06493]
114197082  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
114197186  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
114197260  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
114197320  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
114197462  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
114197483  ACTB; actin, cytoplasmic 1 [KO:K05692]
114198341  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
114198363  [KO:K06237]
114198487  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
114198628  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
114198631  THBS3; thrombospondin-3 [KO:K04659]
114198767  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
114198850  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
114198881  LAMC3; laminin subunit gamma-3 [KO:K06247]
114198920  ACTN4; alpha-actinin-4 [KO:K05699]
114198992  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
114199036  CDC42; cell division control protein 42 homolog [KO:K04393]
114199288  LAMA5; laminin subunit alpha-5 [KO:K06240]
114199310  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
114199360  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
114199406  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
114199417  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
114200239  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
114200322  [KO:K12757]
114200324  MYL12B; myosin regulatory light chain 12B [KO:K12757]
114200401  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
114200595  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
114200679  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
114200996  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
114201138  ITGA3; integrin alpha-3 [KO:K06482]
114201157  COL1A1; LOW QUALITY PROTEIN: collagen alpha-1(I) chain [KO:K06236]
114201159  CHAD; chondroadherin [KO:K06248]
114201201  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
114201213  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
114201239  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
114201560  HRAS; GTPase HRas isoform X1 [KO:K02833]
114201601  FLNA; filamin-A isoform X1 [KO:K04437]
114201698  LAMB1; laminin subunit beta-1 [KO:K05636]
114201704  LAMB4; laminin subunit beta-4 [KO:K06245]
114201798  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
114201841  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
114201844  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
114201951  CRKL; crk-like protein [KO:K04438]
114202068  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
114202274  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
114202353  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
114202711  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
114202732  [KO:K06591]
114202735  [KO:K06591]
114202995  [KO:K19662] [EC:2.7.11.13]
114202996  [KO:K19662] [EC:2.7.11.13]
114203023  [KO:K06481]
114203024  [KO:K06481]
114203265  [KO:K04456] [EC:2.7.11.1]
114203268  [KO:K04456] [EC:2.7.11.1]
114203512  [KO:K05704] [EC:2.7.10.2]
114203513  [KO:K05704] [EC:2.7.10.2]
114203793  [KO:K12753]
114203796  [KO:K12753]
114203962  [KO:K04392]
114204469  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
114204569  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
114204633  VEGFA; vascular endothelial growth factor A [KO:K05448]
114204778  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
114205025  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
114205060  PGF; placenta growth factor [KO:K16859]
114205461  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114205549  [KO:K06238]
114205584  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
114205617  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
114205695  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
114205781  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
114205825  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
114206170  VEGFC; vascular endothelial growth factor C [KO:K05449]
114206298  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
114206512  ITGA11; integrin alpha-11 [KO:K06587]
114206514  SHC4; SHC-transforming protein 4 [KO:K17449]
114206518  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114206539  TLN2; talin-2 [KO:K06271]
114206757  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
114206758  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
114206945  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
114206954  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114207692  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
114207761  CAV3; caveolin-3 [KO:K12959]
114207895  RAP1A; ras-related protein Rap-1A [KO:K04353]
114207903  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
114208840  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
114209289  THBS2; thrombospondin-2 [KO:K04659]
114209890  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
114209944  LAMA4; laminin subunit alpha-4 [KO:K06241]
114210095  [KO:K04392]
114210145  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
114210280  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
114210281  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
114210625  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
114210649  CAV1; caveolin-1 [KO:K06278]
114210654  CAV2; caveolin-2 [KO:K12958]
114210819  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
114210852  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
114210864  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
114211055  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
114211152  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
114211231  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
114211382  [KO:K16060]
114211580  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
114211766  ZYX; zyxin [KO:K06273]
114211897  SOS2; son of sevenless homolog 2 [KO:K03099]
114211916  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
114211921  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
114212152  JUN; transcription factor AP-1 [KO:K04448]
114212231  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
114212343  CTNNB1; catenin beta-1 [KO:K02105]
114212775  TNC; tenascin [KO:K06252]
114213130  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
114213645  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
114213730  VTN; vitronectin [KO:K06251]
114213901  CRK; adapter molecule crk isoform X1 [KO:K04438]
114214126  VCL; vinculin isoform X1 [KO:K05700]
114214373  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
114214409  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114214570  MYL10; myosin regulatory light chain 10 [KO:K12756]
114214590  FLNB; filamin-B isoform X1 [KO:K27392]
114214730  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
114214898  RAP1B; ras-related protein Rap-1b [KO:K07836]
114214976  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
114215523  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114215532  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
114215744  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
114215923  FN1; fibronectin isoform X1 [KO:K05717]
114216053  ACTG1; actin, cytoplasmic 2 [KO:K05692]
114216141  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
114216204  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
114216301  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
114216393  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
114216508  ITGB6; integrin beta-6 [KO:K06589]
114216805  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
114217308  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
114217613  THBS4; thrombospondin-4 [KO:K04659]
114217923  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
114218047  VEGFD; vascular endothelial growth factor D [KO:K05449]
114218273  TLN1; talin-1 isoform X1 [KO:K06271]
114218362  PARVB; beta-parvin isoform X1 [KO:K06275]
114218415  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
114218551  PARVG; gamma-parvin [KO:K06275]
114218556  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
114218686  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
114219061  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
114219135  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
114219196  PXN; paxillin isoform X1 [KO:K05760]
114219330  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
114219346  PARVA; alpha-parvin [KO:K06275]
114219700  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
114219794  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
114219804  SHC3; SHC-transforming protein 3 [KO:K17448]
114219962  EMP2; epithelial membrane protein 2 [KO:K26256]
114220110  IBSP; bone sialoprotein 2 [KO:K06253]
114220121  SPP1; osteopontin isoform X1 [KO:K06250]
114220310  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
114220328  BAD; bcl2-associated agonist of cell death [KO:K02158]
114220332  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
114220523  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
114220642  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
114220729  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
114220766  COL1A2; collagen alpha-2(I) chain [KO:K06236]
114220792  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
114221286  THBS1; thrombospondin-1 [KO:K16857]
114221299  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
114221353  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
114221743  EMP1; epithelial membrane protein 1 [KO:K26255]
114221826  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
114221938  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
114222095  TNXB; tenascin-X [KO:K06252]
114222402  ITGB1; integrin beta-1 [KO:K05719]
114222473  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
114222568  VWF; von Willebrand factor [KO:K03900]
114222658  EGF; pro-epidermal growth factor [KO:K04357]
114222807  LAMC1; laminin subunit gamma-1 [KO:K05635]
114222885  LAMC2; laminin subunit gamma-2 [KO:K06246]
114222977  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
114223322  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
114223458  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
114223713  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
114223793  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
114223891  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
114223943  TNN; LOW QUALITY PROTEIN: tenascin-N [KO:K06252]
114224014  TNR; tenascin-R isoform X1 [KO:K06252]
114224064  COL2A1; collagen alpha-1(II) chain [KO:K19719]
114224260  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
114224308  [KO:K02649]
114224473  [KO:K04393]
114224631  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
114224643  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
114224715  LAMA1; laminin subunit alpha-1 [KO:K05637]
114224898  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114225019  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
114225106  RHOA; transforming protein RhoA [KO:K04513]
114225299  [KO:K19719]
114225654  LAMA2; laminin subunit alpha-2 [KO:K05637]
114225725  ITGB7; integrin beta-7 [KO:K06590]
114225746  ITGA5; integrin alpha-5 [KO:K06484]
114225908  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
114225917  LAMB3; laminin subunit beta-3 [KO:K06244]
114226139  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
114226263  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
114226321  SHC2; SHC-transforming protein 2 [KO:K17447]
114226659  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
eju04010  MAPK signaling pathway
eju04060  Cytokine-cytokine receptor interaction
eju04070  Phosphatidylinositol signaling system
eju04110  Cell cycle
eju04151  PI3K-Akt signaling pathway
eju04310  Wnt signaling pathway
eju04512  ECM-receptor interaction
eju04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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