KEGG   PATHWAY: epz04810
Entry
epz04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Equus przewalskii (Przewalski's horse)
Class
Cellular Processes; Cell motility
Pathway map
epz04810  Regulation of actin cytoskeleton
epz04810

Other DBs
GO: 0030036
Organism
Equus przewalskii (Przewalski's horse) [GN:epz]
Gene
103539970  PFN3; profilin-3 [KO:K05759]
103540011  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
103540249  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103540309  KNG1; kininogen-1 isoform X1 [KO:K03898]
103540345  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
103540380  VAV1; proto-oncogene vav [KO:K05730]
103540564  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
103540628  PXN; paxillin isoform X4 [KO:K05760]
103540739  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
103540812  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
103541086  BDKRB1; B1 bradykinin receptor isoform X1 [KO:K03915]
103541523  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
103541554  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
103541647  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
103541825  ACTR3B; actin-related protein 3B isoform X8 [KO:K18584]
103542556  FGF4; fibroblast growth factor 4 [KO:K04358]
103542772  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
103542783  FGF18; fibroblast growth factor 18 [KO:K04358]
103542877  FGF19; fibroblast growth factor 19 [KO:K22603]
103542967  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 isoform X1 [KO:K05720]
103543283  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
103543290  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103543333  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
103543384  [KO:K06464]
103543606  FGF16; fibroblast growth factor 16 [KO:K04358]
103543614  CRKL; crk-like protein [KO:K04438]
103543685  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
103544003  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
103544050  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
103544063  FGF3; fibroblast growth factor 3 [KO:K04358]
103544386  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
103544754  FGF22; fibroblast growth factor 22 [KO:K04358]
103544756  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
103545299  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
103545694  [KO:K06464]
103546063  [KO:K06464]
103546217  IQGAP1; ras GTPase-activating-like protein IQGAP1 isoform X1 [KO:K16848]
103546289  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
103546412  CFL2; cofilin-2 isoform X2 [KO:K05765]
103546589  ITGB4; integrin beta-4 isoform X3 [KO:K06525]
103546629  KRAS; GTPase KRas isoform X1 [KO:K07827]
103546686  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
103546835  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
103546845  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X2 [KO:K07532]
103547006  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103547114  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
103547163  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
103547213  MYL11; myosin regulatory light chain 11 [KO:K12758]
103547219  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
103547251  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
103547252  [KO:K06462]
103547254  ITGAD; integrin alpha-D isoform X1 [KO:K06594]
103547261  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103547315  PDGFC; platelet-derived growth factor C isoform X3 [KO:K05450]
103547333  BAIAP2; BAR/IMD domain-containing adapter protein 2 isoform X1 [KO:K05627]
103547465  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
103547475  ITGB5; integrin beta-5 [KO:K06588]
103547531  CRK; adapter molecule crk isoform X3 [KO:K04438]
103547651  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X3 [KO:K05749]
103547657  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
103547830  PFN4; profilin-4 isoform X1 [KO:K05759]
103547895  ACTB; actin, cytoplasmic 1 [KO:K05692]
103548123  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
103548220  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
103548324  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
103548326  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
103548530  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
103548849  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
103548855  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
103548930  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
103549076  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103549125  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
103549223  ABI2; abl interactor 2 isoform X1 [KO:K05751]
103549418  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X3 [KO:K04346]
103549472  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
103549474  VCL; vinculin isoform X1 [KO:K05700]
103549630  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
103549913  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
103549928  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
103550104  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
103550265  FGF1; fibroblast growth factor 1 isoform X3 [KO:K18496]
103550423  C5; complement C5 [KO:K03994]
103550524  WASF2; actin-binding protein WASF2 [KO:K05748]
103550531  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
103550555  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
103550584  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
103550588  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103550692  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
103551055  ITGA3; integrin alpha-3 isoform X2 [KO:K06482]
103551082  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103551104  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
103551192  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
103551206  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
103551341  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
103551394  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
103551430  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103551717  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
103551718  WASF1; actin-binding protein WASF1 isoform X1 [KO:K05753]
103551851  FGF7; fibroblast growth factor 7 [KO:K04358]
103551868  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
103552052  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
103552150  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103552305  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103552510  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
103552675  NRAS; GTPase NRas [KO:K07828]
103552805  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
103552965  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
103553038  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
103553088  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
103553123  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
103553219  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
103553325  FGF21; fibroblast growth factor 21 [KO:K22429]
103553409  RHOA; transforming protein RhoA [KO:K04513]
103553497  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
103553799  PAK1; serine/threonine-protein kinase PAK 1 isoform X2 [KO:K04409] [EC:2.7.11.1]
103553903  ITGA9; integrin alpha-9 isoform X2 [KO:K06585]
103554091  EZR; ezrin [KO:K08007]
103554541  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
103554650  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
103554805  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
103554819  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
103554942  MYL7; myosin regulatory light chain 2, atrial isoform isoform X2 [KO:K12754]
103555079  C7; complement component C7 isoform X1 [KO:K03996]
103555217  C9; complement component C9 isoform X1 [KO:K04000]
103555338  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
103555421  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103555535  GSN; gelsolin isoform X1 [KO:K05768]
103555780  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
103555840  CYRIA; CYFIP-related Rac1 interactor A [KO:K27976]
103555992  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
103556123  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
103556229  ITGA10; integrin alpha-10 isoform X5 [KO:K06586]
103556271  ENAH; protein enabled homolog isoform X1 [KO:K05746]
103556334  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
103556588  RDX; radixin isoform X1 [KO:K05762]
103556855  FGF20; fibroblast growth factor 20 [KO:K04358]
103556997  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
103557327  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
103557393  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
103557622  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
103557835  FGF6; fibroblast growth factor 6 [KO:K04358]
103557856  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
103558069  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
103558080  ITGA2; integrin alpha-2 [KO:K06481]
103558095  MYH11; myosin-11 isoform X1 [KO:K10352]
103558302  MYH14; myosin-14 isoform X1 [KO:K10352]
103558303  ITGAE; integrin alpha-E isoform X1 [KO:K06524]
103558482  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
103558709  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
103558900  FGF9; fibroblast growth factor 9 [KO:K04358]
103558955  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
103559082  MYH10; myosin-10 isoform X3 [KO:K10352]
103559162  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
103559372  CFL1; cofilin-1 isoform X1 [KO:K05765]
103559421  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
103559616  ITGA8; integrin alpha-8 [KO:K06584]
103559731  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
103559741  FGF10; fibroblast growth factor 10 [KO:K04358]
103559760  ITGB8; integrin beta-8 [KO:K06591]
103559795  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
103559862  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103559943  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
103559953  [KO:K12757]
103559954  [KO:K12757]
103560128  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
103560150  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
103560209  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
103560266  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103560321  RGCC; regulator of cell cycle RGCC isoform X1 [KO:K26108]
103560497  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103560646  WASL; actin nucleation-promoting factor WASL [KO:K23612]
103560657  PFN1; profilin-1 [KO:K05759]
103560716  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
103560746  ITGB3; integrin beta-3 isoform X2 [KO:K06493]
103560803  ACTR2; actin-related protein 2 isoform X3 [KO:K17260]
103560830  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
103560907  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
103561014  ACTR3; actin-related protein 3 [KO:K18584]
103561228  APC; adenomatous polyposis coli protein isoform X3 [KO:K02085]
103561322  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
103561369  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
103561460  BRK1; protein BRICK1 [KO:K05752]
103561550  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
103561631  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
103561655  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
103561848  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
103561874  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
103561896  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103561986  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
103562099  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
103562165  C6; complement component C6 [KO:K03995]
103562408  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103562579  BDKRB2; B2 bradykinin receptor [KO:K03916]
103562875  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X4 [KO:K17457]
103562888  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
103563053  FN1; fibronectin isoform X1 [KO:K05717]
103563237  ITGA5; integrin alpha-5 [KO:K06484]
103563244  NCKAP1L; nck-associated protein 1-like [KO:K05750]
103563312  PFN2; profilin-2 isoform X1 [KO:K05759]
103563388  MYH9; myosin-9 [KO:K10352]
103563986  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
103564042  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
103564147  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
103564394  C8A; complement component C8 alpha chain isoform X1 [KO:K03997]
103564395  C8B; complement component C8 beta chain isoform X1 [KO:K03998]
103564414  SCIN; scinderin isoform X1 [KO:K05768]
103564464  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
103564847  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
103565316  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
103565401  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
103565679  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
103565740  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X6 [KO:K13710]
103565974  LIMK2; LIM domain kinase 2 isoform X4 [KO:K05744] [EC:2.7.11.1]
103566036  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
103566208  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
103566518  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
103566630  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
103566657  MSN; moesin [KO:K05763]
103566907  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
103567332  HRAS; GTPase HRas isoform X1 [KO:K02833]
103567387  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
103567614  INS; insulin [KO:K04526]
103567716  FGF23; fibroblast growth factor 23 [KO:K22428]
103568034  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
139074315  [KO:K05692]
139081820  FGF2; fibroblast growth factor 2 [KO:K18497]
139085032  [KO:K07827]
139085512  RRAS; ras-related protein R-Ras [KO:K07829]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
epz04010  MAPK signaling pathway
epz04510  Focal adhesion
epz04520  Adherens junction
KO pathway
ko04810   

DBGET integrated database retrieval system