Entry Name Viral protein interaction with cytokine and cytokine receptor - Homo sapiens (human)
Description Viruses have evolved diverse mechanisms to evade detection and destruction by the immune system, including copying and repurposing host cytokine and cytokine receptor genes. Viral cytokines and cytokine receptors, together with a group of structurally unique, soluble, cytokine-binding or cytokine receptor-binding proteins, represent the three major molecular strategies for subversion and modulation of the host cytokine networks mainly in large DNA viruses. Viral cytokines and cytokine receptor homologs, including other binding proteins, may activate or inhibit cytokine signaling and possibly affect different aspects of immunity.
Class Environmental Information Processing; Signaling molecules and interactionBRITE hierarchy
Pathway map hsa04061 Viral protein interaction with cytokine and cytokine receptor
Network Element N00350 HPV E6 to extrinsic apoptotic pathway
N00416 HCMV vIL10 to IL10-JAK-STAT signaling pathway
N00427 HCMV vCXCL to CXCR-GNB/G-PI3K-AKT signaling pathway
N00429 HCMV UL22A to CCR5-GNB/G-PLCB/G-PKC signaling pathway
N00491 HTLV-1 p12 to Jak-STAT signaling pathway
N00560 HSV gD to HVEM-NFKB signaling pathway
Drug D06297 Vicriviroc maleate (USAN)
D06557 Aplaviroc hydrochloride (USAN)
D09878 Cenicriviroc (USAN/INN)
D12648 Quisovalimab (USAN/INN)
Organism Homo sapiens (human) [GN:
hsa ]
Gene 10563 CXCL13; C-X-C motif chemokine ligand 13 [KO:K10032 ]
1230 CCR1; C-C motif chemokine receptor 1 [KO:K04176 ]
1232 CCR3; C-C motif chemokine receptor 3 [KO:K04178 ]
1233 CCR4; C-C motif chemokine receptor 4 [KO:K04179 ]
1234 CCR5; C-C motif chemokine receptor 5 [KO:K04180 ]
1235 CCR6; C-C motif chemokine receptor 6 [KO:K04181 ]
1236 CCR7; C-C motif chemokine receptor 7 [KO:K04182 ]
1237 CCR8; C-C motif chemokine receptor 8 [KO:K04183 ]
1435 CSF1; colony stimulating factor 1 [KO:K05453 ]
1524 CX3CR1; C-X3-C motif chemokine receptor 1 [KO:K04192 ]
2826 CCR10; C-C motif chemokine receptor 10 [KO:K04185 ]
2829 XCR1; X-C motif chemokine receptor 1 [KO:K04193 ]
2833 CXCR3; C-X-C motif chemokine receptor 3 [KO:K04188 ]
2919 CXCL1; C-X-C motif chemokine ligand 1 [KO:K05505 ]
2920 CXCL2; C-X-C motif chemokine ligand 2 [KO:K05505 ]
2921 CXCL3; C-X-C motif chemokine ligand 3 [KO:K05505 ]
3559 IL2RA; interleukin 2 receptor subunit alpha [KO:K05068 ]
3560 IL2RB; interleukin 2 receptor subunit beta [KO:K05069 ]
3561 IL2RG; interleukin 2 receptor subunit gamma [KO:K05070 ]
3572 IL6ST; interleukin 6 cytokine family signal transducer [KO:K05060 ]
3576 CXCL8; C-X-C motif chemokine ligand 8 [KO:K10030 ]
3577 CXCR1; C-X-C motif chemokine receptor 1 [KO:K04175 ]
3579 CXCR2; C-X-C motif chemokine receptor 2 [KO:K05050 ]
3587 IL10RA; interleukin 10 receptor subunit alpha [KO:K05134 ]
3588 IL10RB; interleukin 10 receptor subunit beta [KO:K05135 ]
3627 CXCL10; C-X-C motif chemokine ligand 10 [KO:K12671 ]
388372 CCL4L1; C-C motif chemokine ligand 4 like 1 [KO:K12964 ]
414062 CCL3L3; C-C motif chemokine ligand 3 like 3 [KO:K05408 ]
4283 CXCL9; C-X-C motif chemokine ligand 9 [KO:K05416 ]
5197 PF4V1; platelet factor 4 variant 1 [KO:K05407 ]
53832 IL20RA; interleukin 20 receptor subunit alpha [KO:K05136 ]
53833 IL20RB; interleukin 20 receptor subunit beta [KO:K05137 ]
58985 IL22RA1; interleukin 22 receptor subunit alpha 1 [KO:K05138 ]
6346 CCL1; C-C motif chemokine ligand 1 [KO:K05514 ]
6347 CCL2; C-C motif chemokine ligand 2 [KO:K14624 ]
6348 CCL3; C-C motif chemokine ligand 3 [KO:K05408 ]
6349 CCL3L1; C-C motif chemokine ligand 3 like 1 [KO:K05408 ]
6351 CCL4; C-C motif chemokine ligand 4 [KO:K12964 ]
6352 CCL5; C-C motif chemokine ligand 5 [KO:K12499 ]
6354 CCL7; C-C motif chemokine ligand 7 [KO:K05509 ]
6355 CCL8; C-C motif chemokine ligand 8 [KO:K16596 ]
6356 CCL11; C-C motif chemokine ligand 11 [KO:K16597 ]
6357 CCL13; C-C motif chemokine ligand 13 [KO:K16595 ]
6358 CCL14; C-C motif chemokine ligand 14 [KO:K21092 ]
6359 CCL15; C-C motif chemokine ligand 15 [KO:K05511 ]
6360 CCL16; C-C motif chemokine ligand 16 [KO:K21093 ]
6361 CCL17; C-C motif chemokine ligand 17 [KO:K21083 ]
6362 CCL18; C-C motif chemokine ligand 18 [KO:K21094 ]
6363 CCL19; C-C motif chemokine ligand 19 [KO:K05512 ]
6364 CCL20; C-C motif chemokine ligand 20 [KO:K14625 ]
6366 CCL21; C-C motif chemokine ligand 21 [KO:K16062 ]
6367 CCL22; C-C motif chemokine ligand 22 [KO:K21095 ]
6368 CCL23; C-C motif chemokine ligand 23 [KO:K05511 ]
6369 CCL24; C-C motif chemokine ligand 24 [KO:K21097 ]
6370 CCL25; C-C motif chemokine ligand 25 [KO:K13072 ]
6372 CXCL6; C-X-C motif chemokine ligand 6 [KO:K05506 ]
6373 CXCL11; C-X-C motif chemokine ligand 11 [KO:K12672 ]
6374 CXCL5; C-X-C motif chemokine ligand 5 [KO:K05506 ]
6375 XCL1; X-C motif chemokine ligand 1 [KO:K05507 ]
6376 CX3CL1; C-X3-C motif chemokine ligand 1 [KO:K05508 ]
6387 CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031 ]
643 CXCR5; C-X-C motif chemokine receptor 5 [KO:K04190 ]
6846 XCL2; X-C motif chemokine ligand 2 [KO:K05507 ]
7132 TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158 ]
7133 TNFRSF1B; TNF receptor superfamily member 1B [KO:K05141 ]
7852 CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189 ]
8740 TNFSF14; TNF superfamily member 14 [KO:K05477 ]
8743 TNFSF10; TNF superfamily member 10 [KO:K04721 ]
8764 TNFRSF14; TNF receptor superfamily member 14 [KO:K05152 ]
8793 TNFRSF10D; TNF receptor superfamily member 10d [KO:K22702 ]
8794 TNFRSF10C; TNF receptor superfamily member 10c [KO:K22701 ]
8795 TNFRSF10B; TNF receptor superfamily member 10b [KO:K04722 ]
8797 TNFRSF10A; TNF receptor superfamily member 10a [KO:K04722 ]
8807 IL18RAP; interleukin 18 receptor accessory protein [KO:K05174 ]
8809 IL18R1; interleukin 18 receptor 1 [KO:K05173 ]
9547 CXCL14; C-X-C motif chemokine ligand 14 [KO:K10033 ]
9560 CCL4L2; C-C motif chemokine ligand 4 like 2 [KO:K12964 ]
Reference Authors Alcami A
Title Viral mimicry of cytokines, chemokines and their receptors.
Journal Reference Authors Pontejo SM, Murphy PM
Title Chemokines encoded by herpesviruses.
Journal Reference Authors de Munnik SM, Smit MJ, Leurs R, Vischer HF
Title Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors.
Journal Reference Authors Vischer HF, Siderius M, Leurs R, Smit MJ
Title Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases?
Journal Reference Authors Smith CA, Smith TD, Smolak PJ, Friend D, Hagen H, Gerhart M, Park L, Pickup DJ, Torrance D, Mohler K, Schooley K, Goodwin RG
Title Poxvirus genomes encode a secreted, soluble protein that preferentially inhibits beta chemokine activity yet lacks sequence homology to known chemokine receptors.
Journal Reference Authors Isegawa Y, Ping Z, Nakano K, Sugimoto N, Yamanishi K
Title Human herpesvirus 6 open reading frame U12 encodes a functional beta-chemokine receptor.
Journal Reference Authors Damon I, Murphy PM, Moss B
Title Broad spectrum chemokine antagonistic activity of a human poxvirus chemokine homolog.
Journal Reference Authors Dewin DR, Catusse J, Gompels UA
Title Identification and characterization of U83A viral chemokine, a broad and potent beta-chemokine agonist for human CCRs with unique selectivity and inhibition by spliced isoform.
Journal Reference Authors Fitzsimons CP, Gompels UA, Verzijl D, Vischer HF, Mattick C, Leurs R, Smit MJ
Title Chemokine-directed trafficking of receptor stimulus to different g proteins: selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor U51.
Journal Reference Authors Wang D, Bresnahan W, Shenk T
Title Human cytomegalovirus encodes a highly specific RANTES decoy receptor.
Journal Reference Authors Viejo-Borbolla A, Martinez-Martin N, Nel HJ, Rueda P, Martin R, Blanco S, Arenzana-Seisdedos F, Thelen M, Fallon PG, Alcami A
Title Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses.
Journal Reference Authors Alejo A, Ruiz-Arguello MB, Ho Y, Smith VP, Saraiva M, Alcami A
Title A chemokine-binding domain in the tumor necrosis factor receptor from variola (smallpox) virus.
Journal Reference Authors Tadagaki K, Nakano K, Yamanishi K
Title Human herpesvirus 7 open reading frames U12 and U51 encode functional beta-chemokine receptors.
Journal Reference Authors Lee C, Liu QH, Tomkowicz B, Yi Y, Freedman BD, Collman RG
Title Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.
Journal Reference Authors Najarro P, Lee HJ, Fox J, Pease J, Smith GL
Title Yaba-like disease virus protein 7L is a cell-surface receptor for chemokine CCL1.
Journal Reference Authors Najarro P, Gubser C, Hollinshead M, Fox J, Pease J, Smith GL
Title Yaba-like disease virus chemokine receptor 7L, a CCR8 orthologue.
Journal Reference Authors Catusse J, Spinks J, Mattick C, Dyer A, Laing K, Fitzsimons C, Smit MJ, Gompels UA
Title Immunomodulation by herpesvirus U51A chemokine receptor via CCL5 and FOG-2 down-regulation plus XCR1 and CCR7 mimicry in human leukocytes.
Journal Reference Authors Liu Y, de Waal Malefyt R, Briere F, Parham C, Bridon JM, Banchereau J, Moore KW, Xu J
Title The EBV IL-10 homologue is a selective agonist with impaired binding to the IL-10 receptor.
Journal J Immunol 158:604-13 (1997)
Reference Authors Yoon SI, Jones BC, Logsdon NJ, Walter MR
Title Same structure, different function crystal structure of the Epstein-Barr virus IL-10 bound to the soluble IL-10R1 chain.
Journal Reference Authors Kotenko SV, Saccani S, Izotova LS, Mirochnitchenko OV, Pestka S
Title Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10).
Journal Reference Authors Chang WL, Baumgarth N, Yu D, Barry PA
Title Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality.
Journal Reference Authors Li H, Wang H, Nicholas J
Title Detection of direct binding of human herpesvirus 8-encoded interleukin-6 (vIL-6) to both gp130 and IL-6 receptor (IL-6R) and identification of amino acid residues of vIL-6 important for IL-6R-dependent and -independent signaling.
Journal Reference Authors Nicot C, Mulloy JC, Ferrari MG, Johnson JM, Fu K, Fukumoto R, Trovato R, Fullen J, Leonard WJ, Franchini G
Title HTLV-1 p12(I) protein enhances STAT5 activation and decreases the interleukin-2 requirement for proliferation of primary human peripheral blood mononuclear cells.
Journal Reference Authors Xiang Y, Moss B
Title IL-18 binding and inhibition of interferon gamma induction by human poxvirus-encoded proteins.
Journal Reference Authors Bartlett NW, Dumoutier L, Renauld JC, Kotenko SV, McVey CE, Lee HJ, Smith GL
Title A new member of the interleukin 10-related cytokine family encoded by a poxvirus.
Journal Reference Authors Strockbine LD, Cohen JI, Farrah T, Lyman SD, Wagener F, DuBose RF, Armitage RJ, Spriggs MK
Title The Epstein-Barr virus BARF1 gene encodes a novel, soluble colony-stimulating factor-1 receptor.
Journal Reference Authors Snow AL, Martinez OM
Title Epstein-Barr virus: evasive maneuvers in the development of PTLD.
Journal Reference Authors Shim AH, Chang RA, Chen X, Longnecker R, He X
Title Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.
Journal Reference Authors Filippova M, Song H, Connolly JL, Dermody TS, Duerksen-Hughes PJ
Title The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis.
Journal Reference Authors Brunetti CR, Paulose-Murphy M, Singh R, Qin J, Barrett JW, Tardivel A, Schneider P, Essani K, McFadden G
Title A secreted high-affinity inhibitor of human TNF from Tanapox virus.
Journal Reference Authors Sciortino MT, Medici MA, Marino-Merlo F, Zaccaria D, Giuffre-Cuculletto M, Venuti A, Grelli S, Bramanti P, Mastino A
Title Involvement of gD/HVEM interaction in NF-kB-dependent inhibition of apoptosis by HSV-1 gD.
Journal Reference Authors Smith W, Tomasec P, Aicheler R, Loewendorf A, Nemcovicova I, Wang EC, Stanton RJ, Macauley M, Norris P, Willen L, Ruckova E, Nomoto A, Schneider P, Hahn G, Zajonc DM, Ware CF, Wilkinson GW, Benedict CA
Title Human cytomegalovirus glycoprotein UL141 targets the TRAIL death receptors to thwart host innate antiviral defenses.
Journal KO pathway
