KEGG   PATHWAY: lcat05014
Entry
lcat05014                   Pathway                                
Name
Amyotrophic lateral sclerosis - Lemur catta (Ring-tailed lemur)
Description
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive degeneration of motor neurons in the brain and spinal cord. In 90% of patients, ALS is sporadic, with no clear genetic linkage. On the other hand, the remaining 10% of cases show familial inheritance, with mutations in SOD1, TDP43(TARDBP), FUS, or C9orf72 genes being the most frequent causes. In spite of such difference, familial ALS and sporadic ALS have similarities in their pathological features. Proposed disease mechanisms contributing to motor neuron degeneration in ALS are: impaired proteostasis, aberrant RNA processing, mitochondrial disfunction and oxidative stress, microglia activation, and axonal dysfunction.
Class
Human Diseases; Neurodegenerative disease
Pathway map
lcat05014  Amyotrophic lateral sclerosis
lcat05014

Disease
H00058  Amyotrophic lateral sclerosis (ALS)
Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123620171  [KO:K08738]
123620296  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
123620321  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
123620418  [KO:K12741]
123620478  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
123620525  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
123620597  PSMC5; 26S proteasome regulatory subunit 8 isoform X1 [KO:K03066]
123620754  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
123620810  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
123620852  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
123620934  HAP1; huntingtin-associated protein 1 isoform X1 [KO:K04647]
123620977  BECN1; beclin-1 [KO:K08334]
123621103  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
123621235  PSMB6; proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
123621246  PFN1; profilin-1 [KO:K05759]
123621414  ANG; angiogenin [KO:K16631] [EC:3.1.27.-]
123621470  [KO:K02138]
123621509  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
123621514  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
123621547  PSMA8; proteasome subunit alpha-type 8 isoform X1 [KO:K02731] [EC:3.4.25.1]
123621590  [KO:K03948]
123621805  SQSTM1; sequestosome-1 [KO:K14381]
123621824  TUBB6; tubulin beta-6 chain [KO:K07375]
123621842  SEH1L; nucleoporin SEH1 isoform X1 [KO:K14299]
123621881  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
123621883  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
123621919  [KO:K02271]
123621957  SPG11; spatacsin isoform X1 [KO:K19026]
123622324  TUBB1; tubulin beta-1 chain [KO:K07375]
123622325  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
123622419  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
123622513  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
123622599  NXT1; NTF2-related export protein 1 [KO:K14285]
123622686  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
123622846  BCL2L1; bcl-2-like protein 1 [KO:K04570]
123622847  [KO:K02263]
123622897  VAPB; vesicle-associated membrane protein-associated protein B/C [KO:K10707]
123622904  RAE1; mRNA export factor [KO:K14298]
123623040  TUBAL3; LOW QUALITY PROTEIN: tubulin alpha chain-like 3 [KO:K07374]
123623054  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
123623196  DNAH1; dynein axonemal heavy chain 1 [KO:K10408]
123623277  GPX1; glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
123623309  [KO:K00414]
123623368  DNAH12; dynein axonemal heavy chain 12 [KO:K10408]
123623456  PFN3; profilin-3 [KO:K05759]
123623513  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
123623796  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
123623846  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
123623873  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
123623959  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
123623979  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
123624236  [KO:K02128]
123624263  [KO:K02271]
123624276  [KO:K00411] [EC:7.1.1.8]
123624327  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
123624378  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
123624433  [KO:K02270]
123624463  [KO:K02264]
123624466  [KO:K02267]
123624573  [KO:K02738] [EC:3.4.25.1]
123624681  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
123624699  [KO:K02267]
123624741  NUP54; nucleoporin p54 [KO:K14308]
123625148  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
123625208  OPTN; optineurin isoform X1 [KO:K19946]
123625299  NUP93; nuclear pore complex protein Nup93 [KO:K14309]
123625340  [KO:K02263]
123625343  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
123625640  CHCHD10; coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial [KO:K22759]
123625801  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
123625814  NEFH; neurofilament heavy polypeptide isoform X1 [KO:K04574]
123625824  [KO:K00419]
123625931  [KO:K02266]
123625959  ULK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
123626048  ATXN2; ataxin-2 isoform X1 [KO:K23625]
123626088  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
123626129  DNAH10; dynein axonemal heavy chain 10 [KO:K10408]
123626156  [KO:K07374]
123626246  [KO:K07374]
123626251  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
123626307  [KO:K03940] [EC:7.1.1.2]
123626416  DCTN6; dynactin subunit 6 [KO:K10428]
123626484  NRG1; pro-neuregulin-1, membrane-bound isoform isoform X1 [KO:K05455]
123626515  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123626594  [KO:K12741]
123626631  NEFM; neurofilament medium polypeptide isoform X1 [KO:K04573]
123626632  NEFL; neurofilament light polypeptide [KO:K04572]
123626873  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
123626925  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
123626964  [KO:K07374]
123627044  [KO:K00415]
123627290  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123627462  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
123627488  NUP133; nuclear pore complex protein Nup133 isoform X1 [KO:K14300]
123627954  RAB39B; ras-related protein Rab-39B [KO:K07925]
123627957  [KO:K02268]
123628290  NUP62CL; nucleoporin-62 C-terminal-like protein [KO:K14306]
123628370  HDAC6; histone deacetylase 6 isoform X1 [KO:K11407] [EC:3.5.1.98]
123628394  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
123628649  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
123628654  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
123628706  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
123628789  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
123630170  PFN2; profilin-2 isoform X1 [KO:K05759]
123630171  [KO:K02127]
123630288  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
123630330  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
123630502  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
123630631  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
123630658  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
123630679  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
123630707  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
123630777  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
123631474  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
123631520  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
123631525  ACTB; actin, cytoplasmic 1 [KO:K05692]
123631545  [KO:K03938]
123631548  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123631697  TUBB; tubulin beta chain [KO:K07375]
123631724  TNF; tumor necrosis factor [KO:K03156]
123631742  [KO:K03947]
123631832  DAXX; death domain-associated protein 6 [KO:K02308]
123631895  NRG4; pro-neuregulin-4, membrane-bound isoform [KO:K05458]
123631901  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
123631926  PSMA4; proteasome subunit alpha type-4 [KO:K02728] [EC:3.4.25.1]
123631967  DNAH8; LOW QUALITY PROTEIN: dynein axonemal heavy chain 8 [KO:K10408]
123632367  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
123632460  DNAH3; dynein axonemal heavy chain 3 [KO:K10408]
123632466  [KO:K00415]
123632485  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
123632487  DCTN5; dynactin subunit 5 isoform X1 [KO:K10427]
123632527  ATXN2L; ataxin-2-like protein isoform X1 [KO:K23625]
123632601  POM121C; nuclear envelope pore membrane protein POM 121C [KO:K14316]
123632685  [KO:K02266]
123632692  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
123632797  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
123632820  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
123632845  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
123632869  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
123632871  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
123632873  [KO:K00420]
123632881  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
123633005  [KO:K02270]
123633156  FIG4; polyphosphoinositide phosphatase isoform X1 [KO:K22913] [EC:3.1.3.-]
123633303  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
123633365  NUP43; nucleoporin Nup43 [KO:K14305]
123633420  [KO:K03960]
123633441  PRKN; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
123633473  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
123633966  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
123633975  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
123634011  NUP210L; nuclear pore membrane glycoprotein 210-like isoform X1 [KO:K14314]
123634087  UBQLN4; ubiquilin-4 [KO:K04523]
123634125  [KO:K03963]
123634180  [KO:K00416]
123634459  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
123634479  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
123634485  [KO:K23600]
123634820  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
123634994  PSMA5; proteasome subunit alpha type-5 [KO:K02729] [EC:3.4.25.1]
123635033  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial isoform X1 [KO:K02127]
123635220  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
123635223  TOMM40L; mitochondrial import receptor subunit TOM40B isoform X1 [KO:K11518]
123635226  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
123635558  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
123635629  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
123635647  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
123635659  [KO:K03948]
123635724  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
123635747  DNALI1; axonemal dynein light intermediate polypeptide 1 [KO:K10410]
123635781  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
123635888  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
123635928  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
123635958  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
123635959  TUBB4A; tubulin beta-4A chain [KO:K07375]
123636458  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
123636664  PFN4; profilin-4 [KO:K05759]
123636788  [KO:K12741]
123636819  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
123636840  [KO:K02270]
123636982  RAB1A; ras-related protein Rab-1A [KO:K07874]
123636996  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
123636997  [KO:K03963]
123637072  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
123637112  DNAH6; dynein axonemal heavy chain 6 [KO:K10408]
123637156  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
123637221  ACTR1B; beta-centractin isoform X1 [KO:K16575]
123637222  [KO:K02265]
123637298  RANBP2; E3 SUMO-protein ligase RanBP2 [KO:K12172] [EC:2.3.2.-]
123637424  [KO:K14295]
123637759  [KO:K00418]
123637772  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
123637830  MATR3; matrin-3 isoform X1 [KO:K13213]
123637849  NRG2; pro-neuregulin-2, membrane-bound isoform isoform X1 [KO:K05456]
123637866  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
123637869  [KO:K03963]
123638010  [KO:K12741]
123638028  [KO:K08738]
123638043  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
123638059  GPX3; glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
123638063  DCTN4; dynactin subunit 4 [KO:K10426]
123638078  [KO:K00416]
123638121  [KO:K14314]
123638178  TUBB2A; tubulin beta-2A chain [KO:K07375]
123638179  [KO:K07375]
123638197  [KO:K08738]
123638210  [KO:K03948]
123638312  NUP153; nuclear pore complex protein Nup153 [KO:K14296]
123638352  POM121L2; LOW QUALITY PROTEIN: POM121-like protein 2 [KO:K14316]
123638412  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
123638436  GPX5; epididymal secretory glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
123638437  GPX6; glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
123638517  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
123638560  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
123638566  [KO:K10428]
123638644  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
123638764  [KO:K07375]
123639225  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
123639242  DNAL4; dynein axonemal light chain 4 [KO:K10412]
123639378  NUP37; nucleoporin Nup37 isoform X1 [KO:K14302]
123639404  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
123639435  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
123639539  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
123639558  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
123639600  KIF5A; kinesin heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
123639604  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
123639606  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
123639613  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
123639636  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
123639645  [KO:K03957]
123639738  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 isoform X1 [KO:K12741]
123639755  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
123639816  ATG101; autophagy-related protein 101 [KO:K19730]
123639881  RAB8A; ras-related protein Rab-8A [KO:K07901]
123639891  KIF5B; kinesin-1 heavy chain [KO:K10396] [EC:5.6.1.3]
123639916  [KO:K08738]
123639979  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
123640135  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
123640141  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
123640169  TUBA8; tubulin alpha-8 chain [KO:K07374]
123640175  BID; BH3-interacting domain death agonist [KO:K04726]
123640204  [KO:K02268]
123640284  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
123640339  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123640418  PRPH; peripherin isoform X1 [KO:K07607]
123640420  TUBA1C; tubulin alpha-1C chain [KO:K07374]
123640422  [KO:K07374]
123640424  [KO:K07374]
123640642  [KO:K02268]
123640770  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
123640771  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
123641096  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
123641287  NXF1; nuclear RNA export factor 1 [KO:K14284]
123641403  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
123641429  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
123641447  [KO:K02273]
123641584  [KO:K02268]
123641604  UBQLN3; ubiquilin-3 [KO:K04523]
123641691  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
123641767  CASP1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
123641788  [KO:K04741] [EC:3.4.22.-]
123642293  [KO:K03968]
123642474  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
123642582  CAT; catalase [KO:K03781] [EC:1.11.1.6]
123642593  SLC1A2; excitatory amino acid transporter 2 [KO:K05613]
123642652  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
123642654  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
123642678  PSMC3; LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 6A [KO:K03065]
123642684  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
123642690  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
123642737  [KO:K03945]
123642823  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
123642832  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
123642882  CCS; copper chaperone for superoxide dismutase [KO:K04569]
123642897  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
123642988  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
123643313  KIF5C; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
123643439  DNAH7; dynein axonemal heavy chain 7 [KO:K10408]
123643458  NUP35; nucleoporin NUP35 [KO:K14313]
123643488  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
123643524  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
123643576  [KO:K00417]
123643690  [KO:K08738]
123643746  HNRNPA3; heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
123643857  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
123643885  ALS2; alsin isoform X1 [KO:K04575]
123643900  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
123643931  TANK; LOW QUALITY PROTEIN: TRAF family member-associated NF-kappa-B activator [KO:K12650]
123643954  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
123643962  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
123643981  TUBA4A; tubulin alpha-4A chain [KO:K07374]
123644027  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
123644088  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
123644320  [KO:K12741]
123644332  [KO:K02268]
123644357  [KO:K03959]
123644439  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
123644457  DERL1; derlin-1 [KO:K11519]
123644476  [KO:K14295]
123644528  [KO:K00417]
123644587  [KO:K00417]
123644675  [KO:K02268]
123644873  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
123644875  [KO:K00413]
123645117  [KO:K02273]
123645165  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
123645245  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1 [KO:K03957]
123645426  [KO:K08738]
123645581  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
123645603  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
123645645  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
123645738  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
123645740  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
123645765  UBQLN1; ubiquilin-1 isoform X1 [KO:K04523]
123645948  NCBP1; nuclear cap-binding protein subunit 1 isoform X1 [KO:K12882]
123645993  TUBB4B; tubulin beta-4B chain [KO:K07375]
123646042  C9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
123646050  [KO:K12741]
123646178  [KO:K13525]
123646191  SIGMAR1; sigma non-opioid intracellular receptor 1 [KO:K20719]
123646193  DCTN3; dynactin subunit 3 [KO:K10425]
123646197  DNAI1; dynein axonemal intermediate chain 1 isoform X1 [KO:K10409]
123646230  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
123646300  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
123646315  HSPA5; endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
123646379  NUP188; nucleoporin NUP188 isoform X1 [KO:K14311]
123646402  GLE1; mRNA export factor GLE1 isoform X1 [KO:K18723]
123646445  [KO:K03945]
123646570  SETX; probable helicase senataxin isoform X1 [KO:K10706] [EC:5.6.2.5 5.6.2.3]
123646587  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
123646853  SEM1; 26S proteasome complex subunit SEM1 isoform X1 [KO:K10881]
123646985  DNAH11; dynein axonemal heavy chain 11 [KO:K10408]
123646992  DNAL1; dynein axonemal light chain 1 [KO:K10411]
123647075  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
123647215  HNRNPA2B1; heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1 [KO:K13158]
123647253  [KO:K02272]
123647359  [KO:K08738]
123647363  [KO:K12741]
123647452  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
123647466  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
123647646  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
123647696  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
123647735  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
123647736  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
123647968  GPX2; glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
123647977  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
123648126  [KO:K21246]
123648206  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
123648232  DNAH5; dynein axonemal heavy chain 5 [KO:K10408]
123648345  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
123648577  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
123648613  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
123648620  ACTR10; actin-related protein 10 [KO:K16576]
123648626  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
123648630  [KO:K02272]
123648644  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
123648813  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
123649129  PSMC6; 26S proteasome regulatory subunit 10B [KO:K03064]
123649461  NUP58; nucleoporin p58/p45 isoform X1 [KO:K14307]
123649776  NRG3; pro-neuregulin-3, membrane-bound isoform isoform X1 [KO:K05457]
123649941  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
123649962  [KO:K02135]
123650082  ACTR1A; alpha-centractin [KO:K16575]
123650126  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
123650135  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
123650245  [KO:K12741]
123650296  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123650298  ANXA7; annexin A7 isoform X1 [KO:K17095]
123650345  ANXA11; annexin A11 [KO:K17095]
123650367  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
123650554  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
123650574  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
123650585  [KO:K08738]
123650594  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 [KO:K03035]
123650613  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 [KO:K17908]
123650624  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
123650686  ACTG1; actin, cytoplasmic 2 [KO:K05692]
123650706  ALYREF; THO complex subunit 4 [KO:K12881]
123650747  DNAI2; dynein axonemal intermediate chain 2 [KO:K11143]
123650764  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
123650775  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
123650785  NUP85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
123650827  NUP88; nuclear pore complex protein Nup88 isoform X1 [KO:K14318]
123650900  TP53; cellular tumor antigen p53 [KO:K04451]
123650902  DNAH2; dynein axonemal heavy chain 2 isoform X1 [KO:K10408]
68929161  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
68929162  COX3; cytochrome c oxidase subunit III [KO:K02262]
68929165  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
68929167  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
68929174  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
68929177  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
68929182  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
68929184  COX2; cytochrome c oxidase subunit II [KO:K02261]
68929185  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
68929186  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
68929187  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
68929190  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
68929191  CYTB; cytochrome b [KO:K00412]
Compound
C00001  H2O
C00008  ADP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00039  DNA
C00046  RNA
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C16844  Hydroxyl radical
C16845  Peroxynitrite
Reference
PMID:28700839
  Authors
Brown RH, Al-Chalabi A
  Title
Amyotrophic Lateral Sclerosis.
  Journal
N Engl J Med 377:162-172 (2017)
DOI:10.1056/NEJMra1603471
Reference
PMID:28512398
  Authors
Webster CP, Smith EF, Shaw PJ, De Vos KJ
  Title
Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?
  Journal
Front Mol Neurosci 10:123 (2017)
DOI:10.3389/fnmol.2017.00123
Reference
PMID:30879475
  Authors
Valko K, Ciesla L
  Title
Amyotrophic lateral sclerosis.
  Journal
Prog Med Chem 58:63-117 (2019)
DOI:10.1016/bs.pmch.2018.12.001
Reference
PMID:30870681
  Authors
Mathis S, Goizet C, Soulages A, Vallat JM, Masson GL
  Title
Genetics of amyotrophic lateral sclerosis: A review.
  Journal
J Neurol Sci 399:217-226 (2019)
DOI:10.1016/j.jns.2019.02.030
Reference
PMID:23415570
  Authors
Turner MR, Hardiman O, Benatar M, Brooks BR, Chio A, de Carvalho M, Ince PG, Lin C, Miller RG, Mitsumoto H, Nicholson G, Ravits J, Shaw PJ, Swash M, Talbot K, Traynor BJ, Van den Berg LH, Veldink JH, Vucic S, Kiernan MC
  Title
Controversies and priorities in amyotrophic lateral sclerosis.
  Journal
Lancet Neurol 12:310-22 (2013)
DOI:10.1016/S1474-4422(13)70036-X
Reference
PMID:16924260
  Authors
Pasinelli P, Brown RH
  Title
Molecular biology of amyotrophic lateral sclerosis: insights from genetics.
  Journal
Nat Rev Neurosci 7:710-23 (2006)
DOI:10.1038/nrn1971
Reference
PMID:16723044
  Authors
Goodall EF, Morrison KE
  Title
Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment.
  Journal
Expert Rev Mol Med 8:1-22 (2006)
DOI:10.1017/S1462399406010854
Reference
PMID:28669745
  Authors
Smith EF, Shaw PJ, De Vos KJ
  Title
The role of mitochondria in amyotrophic lateral sclerosis.
  Journal
Neurosci Lett 710:132933 (2019)
DOI:10.1016/j.neulet.2017.06.052
Reference
PMID:32344665
  Authors
Kodavati M, Wang H, Hegde ML
  Title
Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective.
  Journal
Cells 9:E1065 (2020)
DOI:10.3390/cells9041065
Reference
PMID:16372325
  Authors
Hervias I, Beal MF, Manfredi G
  Title
Mitochondrial dysfunction and amyotrophic lateral sclerosis.
  Journal
Muscle Nerve 33:598-608 (2006)
DOI:10.1002/mus.20489
Reference
PMID:16603792
  Authors
Bacman SR, Bradley WG, Moraes CT
  Title
Mitochondrial involvement in amyotrophic lateral sclerosis: trigger or target?
  Journal
Mol Neurobiol 33:113-31 (2006)
DOI:10.1385/MN:33:2:113
Reference
PMID:17051205
  Authors
Lin MT, Beal MF
  Title
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.
  Journal
Nature 443:787-95 (2006)
DOI:10.1038/nature05292
Reference
PMID:16909017
  Authors
Bendotti C, Bao Cutrona M, Cheroni C, Grignaschi G, Lo Coco D, Peviani M, Tortarolo M, Veglianese P, Zennaro E
  Title
Inter- and intracellular signaling in amyotrophic lateral sclerosis: role of p38 mitogen-activated protein kinase.
  Journal
Neurodegener Dis 2:128-34 (2005)
DOI:10.1159/000089617
Reference
PMID:14569202
  Authors
Simpson EP, Yen AA, Appel SH
  Title
Oxidative Stress: a common denominator in the pathogenesis of amyotrophic lateral sclerosis.
  Journal
Curr Opin Rheumatol 15:730-6 (2003)
DOI:10.1097/00002281-200311000-00008
Reference
PMID:15310460
  Authors
Bendotti C, Carri MT
  Title
Lessons from models of SOD1-linked familial ALS.
  Journal
Trends Mol Med 10:393-400 (2004)
DOI:10.1016/j.molmed.2004.06.009
Reference
PMID:12595144
  Authors
Robertson J, Kriz J, Nguyen MD, Julien JP
  Title
Pathways to motor neuron degeneration in transgenic mouse models.
  Journal
Biochimie 84:1151-60 (2002)
DOI:10.1016/S0300-9084(02)00025-1
Reference
PMID:17434459
  Authors
Eve DJ, Dennis JS, Citron BA
  Title
Transcription factor p53 in degenerating spinal cords.
  Journal
Brain Res 1150:174-81 (2007)
DOI:10.1016/j.brainres.2007.02.088
Reference
PMID:27649160
  Authors
Bahar E, Kim H, Yoon H
  Title
ER Stress-Mediated Signaling: Action Potential and Ca(2+) as Key Players.
  Journal
Int J Mol Sci 17:E1558 (2016)
DOI:10.3390/ijms17091558
Reference
PMID:19230774
  Authors
Bezprozvanny I
  Title
Calcium signaling and neurodegenerative diseases.
  Journal
Trends Mol Med 15:89-100 (2009)
DOI:10.1016/j.molmed.2009.01.001
Reference
PMID:16026864
  Authors
von Lewinski F, Keller BU
  Title
Ca2+, mitochondria and selective motoneuron vulnerability: implications for ALS.
  Journal
Trends Neurosci 28:494-500 (2005)
DOI:10.1016/j.tins.2005.07.001
Reference
PMID:11239414
  Authors
Julien JP.
  Title
Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded.
  Journal
Cell 104:581-91 (2001)
DOI:10.1016/S0092-8674(01)00244-6
Reference
PMID:11870681
  Authors
Hand CK, Rouleau GA
  Title
Familial amyotrophic lateral sclerosis.
  Journal
Muscle Nerve 25:135-59 (2002)
DOI:10.1002/mus.10000
Reference
PMID:16713195
  Authors
Barber SC, Mead RJ, Shaw PJ
  Title
Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target.
  Journal
Biochim Biophys Acta 1762:1051-67 (2006)
DOI:10.1016/j.bbadis.2006.03.008
Reference
PMID:30837838
  Authors
Prasad A, Bharathi V, Sivalingam V, Girdhar A, Patel BK
  Title
Molecular Mechanisms of TDP-43 Misfolding and Pathology in Amyotrophic Lateral Sclerosis.
  Journal
Front Mol Neurosci 12:25 (2019)
DOI:10.3389/fnmol.2019.00025
Reference
PMID:29626651
  Authors
Nguyen DKH, Thombre R, Wang J
  Title
Autophagy as a common pathway in amyotrophic lateral sclerosis.
  Journal
Neurosci Lett 697:34-48 (2019)
DOI:10.1016/j.neulet.2018.04.006
Reference
PMID:26264610
  Authors
Lee JK, Shin JH, Lee JE, Choi EJ
  Title
Role of autophagy in the pathogenesis of amyotrophic lateral sclerosis.
  Journal
Biochim Biophys Acta 1852:2517-24 (2015)
DOI:10.1016/j.bbadis.2015.08.005
Reference
PMID:28148298
  Authors
Oakes JA, Davies MC, Collins MO
  Title
TBK1: a new player in ALS linking autophagy and neuroinflammation.
  Journal
Mol Brain 10:5 (2017)
DOI:10.1186/s13041-017-0287-x
Reference
PMID:28878620
  Authors
Ramesh N, Pandey UB
  Title
Autophagy Dysregulation in ALS: When Protein Aggregates Get Out of Hand.
  Journal
Front Mol Neurosci 10:263 (2017)
DOI:10.3389/fnmol.2017.00263
Reference
PMID:17409386
  Authors
Kunita R, Otomo A, Mizumura H, Suzuki-Utsunomiya K, Hadano S, Ikeda JE
  Title
The Rab5 activator ALS2/alsin acts as a novel Rac1 effector through Rac1-activated endocytosis.
  Journal
J Biol Chem 282:16599-611 (2007)
DOI:10.1074/jbc.M610682200
Reference
PMID:17566607
  Authors
Hadano S, Kunita R, Otomo A, Suzuki-Utsunomiya K, Ikeda JE
  Title
Molecular and cellular function of ALS2/alsin: implication of membrane dynamics in neuronal development and degeneration.
  Journal
Neurochem Int 51:74-84 (2007)
DOI:10.1016/j.neuint.2007.04.010
Reference
PMID:26388731
  Authors
Ruffoli R, Bartalucci A, Frati A, Fornai F
  Title
Ultrastructural studies of ALS mitochondria connect altered function and permeability with defects of mitophagy and mitochondriogenesis.
  Journal
Front Cell Neurosci 9:341 (2015)
DOI:10.3389/fncel.2015.00341
Reference
PMID:25991442
  Authors
Menzies FM, Fleming A, Rubinsztein DC
  Title
Compromised autophagy and neurodegenerative diseases.
  Journal
Nat Rev Neurosci 16:345-57 (2015)
DOI:10.1038/nrn3961
Reference
PMID:32119873
  Authors
Casterton RL, Hunt RJ, Fanto M
  Title
Pathomechanism Heterogeneity in the Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Disease Spectrum: Providing Focus Through the Lens of Autophagy.
  Journal
J Mol Biol 432:2692-2713 (2020)
DOI:10.1016/j.jmb.2020.02.018
Reference
PMID:28057298
  Authors
Lin G, Mao D, Bellen HJ
  Title
Amyotrophic Lateral Sclerosis Pathogenesis Converges on Defects in Protein Homeostasis Associated with TDP-43 Mislocalization and Proteasome-Mediated Degradation Overload.
  Journal
Curr Top Dev Biol 121:111-171 (2017)
DOI:10.1016/bs.ctdb.2016.07.004
Reference
PMID:24619348
  Authors
Hetz C, Mollereau B
  Title
Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases.
  Journal
Nat Rev Neurosci 15:233-49 (2014)
DOI:10.1038/nrn3689
Reference
PMID:27815720
  Authors
Xiang C, Wang Y, Zhang H, Han F
  Title
The role of endoplasmic reticulum stress in neurodegenerative disease.
  Journal
Apoptosis 22:1-26 (2017)
DOI:10.1007/s10495-016-1296-4
Reference
PMID:29476642
  Authors
Hughes D, Mallucci GR
  Title
The unfolded protein response in neurodegenerative disorders - therapeutic modulation of the PERK pathway.
  Journal
FEBS J 286:342-355 (2019)
DOI:10.1111/febs.14422
Reference
PMID:21722302
  Authors
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A
  Title
Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
  Journal
J Cell Mol Med 15:2025-39 (2011)
DOI:10.1111/j.1582-4934.2011.01374.x
Reference
PMID:16472115
  Authors
Turner BJ, Atkin JD
  Title
ER stress and UPR in familial amyotrophic lateral sclerosis.
  Journal
Curr Mol Med 6:79-86 (2006)
DOI:10.2174/156652406775574550
Reference
PMID:18519638
  Authors
Nishitoh H, Kadowaki H, Nagai A, Maruyama T, Yokota T, Fukutomi H, Noguchi T, Matsuzawa A, Takeda K, Ichijo H
  Title
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1.
  Journal
Genes Dev 22:1451-64 (2008)
DOI:10.1101/gad.1640108
Reference
PMID:21834058
  Authors
Walker AK, Atkin JD
  Title
Stress signaling from the endoplasmic reticulum: A central player in the pathogenesis of amyotrophic lateral sclerosis.
  Journal
IUBMB Life 63:754-63 (2011)
DOI:10.1002/iub.520
Reference
PMID:31319884
  Authors
Renaud L, Picher-Martel V, Codron P, Julien JP
  Title
Key role of UBQLN2 in pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia.
  Journal
Acta Neuropathol Commun 7:103 (2019)
DOI:10.1186/s40478-019-0758-7
Reference
PMID:29605155
  Authors
Nguyen HP, Van Broeckhoven C, van der Zee J
  Title
ALS Genes in the Genomic Era and their Implications for FTD.
  Journal
Trends Genet 34:404-423 (2018)
DOI:10.1016/j.tig.2018.03.001
Reference
PMID:25071440
  Authors
Atkin G, Paulson H
  Title
Ubiquitin pathways in neurodegenerative disease.
  Journal
Front Mol Neurosci 7:63 (2014)
DOI:10.3389/fnmol.2014.00063
Reference
PMID:29299811
  Authors
Kim JM, Billington E, Reyes A, Notarianni T, Sage J, Agbas E, Taylor M, Monast I, Stanford JA, Agbas A
  Title
Impaired Cu-Zn Superoxide Dismutase (SOD1) and Calcineurin (Cn) Interaction in ALS: A Presumed Consequence for TDP-43 and Zinc Aggregation in Tg SOD1(G93A) Rodent Spinal Cord Tissue.
  Journal
Neurochem Res 44:228-233 (2019)
DOI:10.1007/s11064-017-2461-z
Reference
PMID:30242016
  Authors
Benarroch EE
  Title
Sigma-1 receptor and amyotrophic lateral sclerosis.
  Journal
Neurology 91:743-747 (2018)
DOI:10.1212/WNL.0000000000006347
Reference
PMID:23361386
  Authors
Millecamps S, Julien JP
  Title
Axonal transport deficits and neurodegenerative diseases.
  Journal
Nat Rev Neurosci 14:161-76 (2013)
DOI:10.1038/nrn3380
Related
pathway
lcat00190  Oxidative phosphorylation
lcat03013  Nucleocytoplasmic transport
lcat03050  Proteasome
lcat04010  MAPK signaling pathway
lcat04012  ErbB signaling pathway
lcat04020  Calcium signaling pathway
lcat04115  p53 signaling pathway
lcat04137  Mitophagy - animal
lcat04140  Autophagy - animal
lcat04141  Protein processing in endoplasmic reticulum
lcat04210  Apoptosis
lcat04724  Glutamatergic synapse
lcat04810  Regulation of actin cytoskeleton
KO pathway
ko05014   

DBGET integrated database retrieval system