KEGG   PATHWAY: aamp05160
Entry
aamp05160                   Pathway                                
Name
Hepatitis C - Arvicola amphibius (Eurasian water vole)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
aamp05160  Hepatitis C
aamp05160

Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119809008  Ldlr; low-density lipoprotein receptor [KO:K12473]
119824480  Scarb1; scavenger receptor class B member 1 isoform X1 [KO:K13885]
119811142  Cd81; CD81 antigen [KO:K06508]
119804018  Cldn12; claudin-12 [KO:K06087]
119800358  Cldn10; claudin-10 isoform X1 [KO:K06087]
119808693  Cldn25; putative claudin-25 [KO:K06087]
119810682  Cldn18; claudin-18 isoform X1 [KO:K06087]
119811089  Cldn23; claudin-23 [KO:K06087]
119817503  Cldn19; claudin-19 [KO:K06087]
119804293  claudin-34-like [KO:K06087]
119804295  claudin-34-like [KO:K06087]
119804534  claudin-34-like [KO:K06087]
119824826  Cldn1; claudin-1 [KO:K06087]
119804911  claudin-34-like [KO:K06087]
119804913  claudin-34-like [KO:K06087]
119804914  claudin-34-like [KO:K06087]
119804916  claudin-34-like [KO:K06087]
119804917  claudin-34-like [KO:K06087]
119804919  claudin-34-like [KO:K06087]
119812049  Cldn6; claudin-6 [KO:K06087]
119812050  Cldn9; claudin-9 [KO:K06087]
119825091  claudin-3 [KO:K06087]
119825127  Cldn4; claudin-4 isoform X1 [KO:K06087]
119825276  Cldn8; claudin-8 [KO:K06087]
119825342  Cldn5; claudin-5 [KO:K06087]
119805380  Cldn2; claudin-2 isoform X1 [KO:K06087]
119825584  Cldn15; claudin-15 [KO:K06087]
119825671  Cldn14; claudin-14 [KO:K06087]
119825704  Cldn16; claudin-16 [KO:K06087]
119825783  Cldn17; claudin-17 [KO:K06087]
119812995  Cldn7; claudin-7 [KO:K06087]
119813198  claudin-22 [KO:K06087]
119813487  claudin-22-like [KO:K06087]
119820483  Cldn20; claudin-20 [KO:K06087]
119826848  Cldn11; claudin-11 [KO:K06087]
119809581  Ocln; occludin [KO:K06088]
119824522  Oas3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
119824530  Oas1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
119824811  Oas2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
119824866  2'-5'-oligoadenylate synthase 1A-like [KO:K14216] [EC:2.7.7.84]
119827862  2-5A-dependent ribonuclease-like isoform X1 [KO:K01165]
119827863  2-5A-dependent ribonuclease-like [KO:K01165]
119826628  Ddx58; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
119814914  Mavs; mitochondrial antiviral-signaling protein [KO:K12648]
119818887  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
119803361  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
119827931  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
119802528  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
119821228  Irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
121677052  interferon alpha-12-like [KO:K05414]
121677053  interferon alpha-12-like [KO:K05414]
121677054  interferon alpha-9-like [KO:K05414]
119817047  interferon alpha-12-like [KO:K05414]
119817048  LOW QUALITY PROTEIN: interferon alpha-12-like [KO:K05414]
119817051  interferon alpha-12-like [KO:K05414]
119817054  interferon alpha-12-like [KO:K05414]
119817055  interferon alpha-12-like [KO:K05414]
119817056  interferon alpha-12-like [KO:K05414]
119817057  interferon alpha-12-like [KO:K05414]
119817059  interferon alpha-12-like [KO:K05414]
119817275  interferon alpha-12-like [KO:K05414]
119805874  interferon alpha-12-like [KO:K05414]
119805875  interferon alpha-12-like [KO:K05414]
119805877  interferon alpha-12-like [KO:K05414]
119805879  interferon alpha-12-like [KO:K05414]
119805881  interferon alpha-12-like [KO:K05414]
119805882  interferon alpha-12-like [KO:K05414]
119805887  interferon alpha-12-like [KO:K05414]
119805888  interferon alpha-12-like [KO:K05414]
119805889  interferon alpha-12-like [KO:K05414]
119805892  interferon alpha-9-like [KO:K05414]
119816165  Ifnb1; LOW QUALITY PROTEIN: interferon beta [KO:K05415]
119817276  interferon beta-like [KO:K05415]
119803682  Ifng; interferon gamma [KO:K04687]
119812470  Tlr3; toll-like receptor 3 isoform X1 [KO:K05401]
119804058  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
119814858  Traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
119816683  Ripk1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
119816335  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
119812324  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
119804668  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119818958  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
119801102  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119803437  Rela; transcription factor p65 isoform X1 [KO:K04735]
119822506  Tnf; tumor necrosis factor [KO:K03156]
119810520  Cxcl10; C-X-C motif chemokine 10 [KO:K12671]
119824668  Eif2ak1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
119808127  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
119808167  Eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
119814070  Eif2ak4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
119820997  LOW QUALITY PROTEIN: interferon-induced protein with tetratricopeptide repeats 1-like [KO:K14217]
119806233  interferon-induced protein with tetratricopeptide repeats 1-like [KO:K14217]
119806240  interferon-induced protein with tetratricopeptide repeats 1-like [KO:K14217]
119822355  interferon-induced protein with tetratricopeptide repeats 1-like [KO:K14217]
119803799  interferon-induced protein with tetratricopeptide repeats 1-like [KO:K14217]
119823228  Eif3e; eukaryotic translation initiation factor 3 subunit E [KO:K03250]
119818610  Eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
119811206  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
119812431  Socs3; suppressor of cytokine signaling 3 [KO:K04696]
119825470  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
119824686  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
119816123  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
119809989  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
119803912  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
119803231  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
119799968  Irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
119824623  Mx1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
119825258  interferon-induced GTP-binding protein Mx1-like isoform X1 [KO:K14754]
119807552  Rsad2; radical S-adenosyl methionine domain-containing protein 2 [KO:K15045]
119810133  Ppp2r1b; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
119820863  Ppp2r1a; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
119814870  Ppp2r2b; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
119823069  Ppp2r2c; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
119803585  Ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
119799986  Ppp2r2a; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
119811275  Ppp2cb; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
119812170  Ppp2ca; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
119808753  Pias1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
119800992  Egf; pro-epidermal growth factor [KO:K04357]
119812357  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119813014  Grb2; growth factor receptor-bound protein 2 [KO:K04364]
119818434  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
119806329  Sos1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
119800249  Hras; GTPase HRas isoform X1 [KO:K02833]
119804230  GTPase KRas-like [KO:K07827]
119806318  Kras; GTPase KRas isoform X1 [KO:K07827]
119801497  Nras; GTPase NRas [KO:K07828]
119806667  Braf; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
119808272  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
119805902  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
119805132  Araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
119808319  Ywhaq; 14-3-3 protein theta [KO:K16197]
119815003  Ywhab; LOW QUALITY PROTEIN: 14-3-3 protein beta/alpha [KO:K16197]
119823278  Ywhaz; 14-3-3 protein zeta/delta [KO:K16197]
119804234  14-3-3 protein theta-like [KO:K16197]
119826292  14-3-3 protein zeta/delta [KO:K16197]
119812405  Ywhae; 14-3-3 protein epsilon [KO:K06630]
119804628  Ywhah; 14-3-3 protein eta [KO:K16198]
119825607  Ywhag; 14-3-3 protein gamma [KO:K16198]
119809903  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119827491  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
119824680  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119813356  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119808979  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119817743  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119812102  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119816315  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119810503  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119826317  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119818643  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119820487  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119827246  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119824224  Gsk3b; LOW QUALITY PROTEIN: glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
119808978  Ctnnb1; catenin beta-1 [KO:K02105]
119820525  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
119823049  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
119818608  cellular tumor antigen p53-like [KO:K04451]
119813419  Tp53; cellular tumor antigen p53 [KO:K04451]
119803337  Cdk2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
119803317  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
119807882  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
119800094  Rb1; retinoblastoma-associated protein [KO:K06618]
119815142  E2f1; transcription factor E2F1 [KO:K17454]
119816691  E2f2; transcription factor E2F2 [KO:K09389]
119817711  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
119808154  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119801899  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
119818726  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
119827881  Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119804936  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
119802203  Fadd; FAS-associated death domain protein [KO:K02373]
119803862  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
119812861  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
119803853  Cflar; LOW QUALITY PROTEIN: CASP8 and FADD-like apoptosis regulator [KO:K04724]
119806482  Bid; BH3-interacting domain death agonist [KO:K04726]
119802627  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
119823918  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
119807948  cytochrome c, somatic-like [KO:K08738]
119827640  cytochrome c, somatic-like [KO:K08738]
119812378  cytochrome c, somatic [KO:K08738]
119812503  cytochrome c, somatic-like [KO:K08738]
119819008  cytochrome c, testis-specific [KO:K08738]
119807481  cytochrome c, somatic [KO:K08738]
119803346  Apaf1; apoptotic protease-activating factor 1 [KO:K02084]
119817619  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
119821481  LOW QUALITY PROTEIN: proteasome activator complex subunit 3-like [KO:K06698]
119813453  Psme3; proteasome activator complex subunit 3 [KO:K06698]
119818907  Rxra; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
119822872  Ppara; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
119815699  Nr1h3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
119827335  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
119822940  Myc; myc proto-oncogene protein [KO:K04377]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20935  2-5A
Reference
PMID:24520529
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
Reference
PMID:23641066
  Authors
Yamauchi Y, Helenius A
  Title
Virus entry at a glance.
  Journal
J Cell Sci 126:1289-95 (2013)
DOI:10.1242/jcs.119685
Reference
PMID:24509809
  Authors
Feneant L, Levy S, Cocquerel L
  Title
CD81 and hepatitis C virus (HCV) infection.
  Journal
Viruses 6:535-72 (2014)
DOI:10.3390/v6020535
Reference
PMID:18081727
  Authors
Dubuisson J, Helle F, Cocquerel L
  Title
Early steps of the hepatitis C virus life cycle.
  Journal
Cell Microbiol 10:821-7 (2008)
DOI:10.1111/j.1462-5822.2007.01107.x
Reference
PMID:23675659
  Authors
Liang TJ, Ghany MG
  Title
Current and future therapies for hepatitis C virus infection.
  Journal
N Engl J Med 368:1907-17 (2013)
DOI:10.1056/NEJMra1213651
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
Reference
PMID:26586968
  Authors
Holmes JA, Thompson AJ
  Title
Interferon-free combination therapies for the treatment of hepatitis C: current insights.
  Journal
Hepat Med 7:51-70 (2015)
DOI:10.2147/HMER.S55864
Reference
PMID:15039538
  Authors
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
  Title
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
  Journal
J Gen Virol 85:959-69 (2004)
DOI:10.1099/vir.0.19513-0
Reference
PMID:19708811
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
DOI:10.1089/jir.2009.0063
Reference
PMID:20457596
  Authors
Lemon SM
  Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
  Journal
J Biol Chem 285:22741-7 (2010)
DOI:10.1074/jbc.R109.099556
Reference
PMID:23836238
  Authors
Horner SM, Gale M Jr
  Title
Regulation of hepatic innate immunity by hepatitis C virus.
  Journal
Nat Med 19:879-88 (2013)
DOI:10.1038/nm.3253
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:25852264
  Authors
Yang DR, Zhu HZ
  Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
  Journal
World J Gastroenterol 21:3786-800 (2015)
DOI:10.3748/wjg.v21.i13.3786
Reference
PMID:16107833
  Authors
Gale M Jr, Foy EM
  Title
Evasion of intracellular host defence by hepatitis C virus.
  Journal
Nature 436:939-45 (2005)
DOI:10.1038/nature04078
Reference
PMID:17467654
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
DOI:10.1016/j.abb.2007.03.033
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:16239065
  Authors
Pang R, Tse E, Poon RT
  Title
Molecular pathways in hepatocellular carcinoma.
  Journal
Cancer Lett 240:157-69 (2006)
DOI:10.1016/j.canlet.2005.08.031
Reference
PMID:15302943
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0
Reference
PMID:21250384
  Authors
He Y, Staschke KA, Tan SL
  Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
  Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
PMID:12101418
  Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
  Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
  Journal
Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589
Reference
PMID:11886269
  Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
  Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
  Journal
Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309
Reference
PMID:15381253
  Authors
Hassan M, Ghozlan H, Abdel-Kader O
  Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
  Journal
Cell Signal 16:1375-85 (2004)
DOI:10.1016/j.cellsig.2004.04.005
Reference
PMID:11514734
  Authors
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
  Title
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
  Journal
J Gen Virol 82:2235-41 (2001)
DOI:10.1099/0022-1317-82-9-2235
Reference
PMID:12056797
  Authors
Yamanaka T, Uchida M, Doi T
  Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
  Journal
Biochem Biophys Res Commun 294:521-7 (2002)
DOI:10.1016/S0006-291X(02)00507-7
Reference
PMID:22611309
  Authors
Lim EJ, Chin R, Angus PW, Torresi J
  Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
  Journal
World J Gastroenterol 18:2172-9 (2012)
DOI:10.3748/wjg.v18.i18.2172
Reference
PMID:17828818
  Authors
Fischer R, Baumert T, Blum HE
  Title
Hepatitis C virus infection and apoptosis.
  Journal
World J Gastroenterol 13:4865-72 (2007)
DOI:10.3748/wjg.v13.i36.4865
Reference
PMID:16611896
  Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
  Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
  Journal
J Virol 80:4372-9 (2006)
DOI:10.1128/JVI.80.9.4372-4379.2006
Reference
PMID:19148799
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
  Journal
J Gastroenterol 44 Suppl 19:82-8 (2009)
DOI:10.1007/s00535-008-2276-4
Reference
PMID:17764115
  Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
  Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
  Journal
Int J Cancer 122:124-31 (2008)
DOI:10.1002/ijc.23056
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Related
pathway
aamp03320  PPAR signaling pathway
aamp04010  MAPK signaling pathway
aamp04144  Endocytosis
aamp04210  Apoptosis
aamp04514  Cell adhesion molecules
aamp04620  Toll-like receptor signaling pathway
aamp04622  RIG-I-like receptor signaling pathway
aamp04630  JAK-STAT signaling pathway
aamp04668  TNF signaling pathway
KO pathway
ko05160   
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