KEGG   PATHWAY: bspl05132
Entry
bspl05132                   Pathway                                
Name
Salmonella infection - Betta splendens (Siamese fighting fish)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
bspl05132  Salmonella infection
bspl05132

Organism
Betta splendens (Siamese fighting fish) [GN:bspl]
Gene
114862244  podxl; LOW QUALITY PROTEIN: podocalyxin [KO:K06817]
114852881  ptprc; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
114843335  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
114865393  rab5aa; RAB5A, member RAS oncogene family, a [KO:K07887]
114847336  rab5b; ras-related protein Rab-5B [KO:K07888]
114845616  ras-related protein Rab-5C-like [KO:K07889]
114860715  rab5c; ras-related protein Rab-5C [KO:K07889]
114842811  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2 [KO:K00914] [EC:2.7.1.137]
114855625  si:dkey-13a21.4; ras-related protein rab7 [KO:K07897]
114855873  ras-related protein rab7 [KO:K07897]
114855901  ras-related protein rab7-like [KO:K07897]
114845987  plekhm1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
114868953  vps11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
114851020  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
114849700  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
114861992  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
114848880  vps39; vam6/Vps39-like protein [KO:K20183]
114854325  vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
114867655  rilp; RILP-like protein 1 [KO:K13883]
114848218  dync1h1; cytoplasmic dynein 1 heavy chain 1 isoform X1 [KO:K10413]
114867841  cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414]
114844337  dynein, cytoplasmic 1, intermediate chain 2a-like isoform X1 [KO:K10415]
114865754  cytoplasmic dynein 1 intermediate chain 1 isoform X3 [KO:K10415]
114847143  dynein, cytoplasmic 1, intermediate chain 2a isoform X1 [KO:K10415]
114852175  dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]
114865782  dync1li1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
114842019  dync2li1; cytoplasmic dynein 2 light intermediate chain 1 isoform X1 [KO:K10417]
114868456  dynll2a; dynein, light chain, LC8-type 2a [KO:K10418]
114869025  dynll2b; dynein, light chain, LC8-type 2b [KO:K10418]
114862721  dynll1; dynein light chain 1, cytoplasmic [KO:K10418]
114855542  dynlrb1; dynein light chain roadblock-type 1 [KO:K10419]
114856880  dynein light chain roadblock-type 2 [KO:K10419]
114847532  dynlt3; dynein light chain Tctex-type 3 [KO:K10420]
114849669  dynlt1b; dynein light chain Tctex-type 1 [KO:K10420]
114848055  dctn1b; dynactin subunit 1 isoform X3 [KO:K04648]
114851040  dynactin subunit 1-like isoform X4 [KO:K04648]
114855011  dctn2; dynactin subunit 2 [KO:K10424]
114842692  dctn3; dynactin subunit 3 [KO:K10425]
114864736  dctn4; dynactin subunit 4 isoform X1 [KO:K10426]
114860849  dctn5; dynactin subunit 5 [KO:K10427]
114845061  dynactin subunit 6-like [KO:K10428]
114848519  dynactin subunit 6 [KO:K10428]
114866970  actr1b; actin related protein 1B [KO:K16575]
114849398  actr10; actin-related protein 10 [KO:K16576]
114844824  tubulin alpha chain-like [KO:K07374]
114858462  tubulin alpha-1A chain isoform X1 [KO:K07374]
114858463  tuba1c; tubulin alpha-1C chain [KO:K07374]
114858653  tuba5; tubulin alpha 5 [KO:K07374]
114845917  tubulin alpha-1D chain [KO:K07374]
114859275  tubulin alpha-1B chain [KO:K07374]
114846701  tuba8l3; tubulin alpha chain [KO:K07374]
114846702  tubulin alpha chain-like [KO:K07374]
114846703  tubulin alpha chain-like isoform X1 [KO:K07374]
114869453  tubulin alpha chain-like isoform X2 [KO:K07374]
114869454  tubulin alpha chain-like isoform X2 [KO:K07374]
114850088  tubulin alpha-1B chain-like [KO:K07374]
129602919  si:ch211-114n24.6; tubulin alpha-1A chain [KO:K07374]
114842938  tubb5; tubulin beta-5 chain [KO:K07375]
114844017  tubulin beta-2A chain-like [KO:K07375]
114858378  tubulin beta-4B chain-like [KO:K07375]
114866126  tubulin beta chain-like [KO:K07375]
114845982  tubulin beta-1 chain [KO:K07375]
114854140  tubb6; tubulin, beta 6 class V [KO:K07375]
114860674  tubb4bl; tubulin beta-4B chain [KO:K07375]
114855083  tubb1; tubulin beta-1 chain [KO:K07375]
114848248  tubulin beta-4B chain [KO:K07375]
114844599  FYVE and coiled-coil domain-containing protein 1-like isoform X1 [KO:K21954]
114853928  fyco1a; FYVE and coiled-coil domain-containing protein 1 [KO:K21954]
114858347  ADP-ribosylation factor-like protein 8A isoform X1 [KO:K07955]
114855581  arl8bb; ADP-ribosylation factor-like protein 8B-A [KO:K07955]
114856239  arl8ba; ADP-ribosylation factor-like protein 8B-A [KO:K07955]
114858757  plekhm2; pleckstrin homology domain-containing family M member 2 isoform X1 [KO:K15348]
114844512  kinesin-1 heavy chain [KO:K10396]
114858522  kif5aa; kinesin family member 5Aa [KO:K10396]
114845690  kinesin heavy chain-like [KO:K10396]
114847415  kinesin heavy chain-like isoform X1 [KO:K10396]
114854576  kinesin-1 heavy chain-like isoform X1 [KO:K10396]
114855008  kif5ab; kinesin heavy chain isoform X2 [KO:K10396]
114842594  klc2; kinesin light chain 2 [KO:K10407]
114868449  klc3; kinesin light chain 3 isoform X2 [KO:K10407]
114848989  klc1a; kinesin light chain 1 isoform X1 [KO:K10407]
114870410  klc1b; kinesin light chain 1b isoform X1 [KO:K10407]
114849765  acbd3; Golgi resident protein GCP60 [KO:K23935]
114858233  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
114858620  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
114859320  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
114859359  rhoab; rho-related GTP-binding protein RhoA-B isoform X1 [KO:K04513]
114855843  rho-related GTP-binding protein RhoA-B [KO:K04513]
114856260  rho-related GTP-binding protein RhoA-D [KO:K04513]
114842953  m6pr; cation-dependent mannose-6-phosphate receptor [KO:K10089]
114846781  rab9a; ras-related protein Rab-9A [KO:K07899]
114870606  ras-related protein Rab-9A-like [KO:K07899]
114864137  rab9b; ras-related protein Rab-9B [KO:K07900]
114846876  GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
114853660  syntaxin-10 [KO:K23937]
114844594  profilin-2-like isoform X1 [KO:K05759]
114853208  pfn2b; profilin-2 isoform X1 [KO:K05759]
114858520  flna; filamin-A isoform X1 [KO:K04437]
114845552  exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
114848275  exoc5; exocyst complex component 5 [KO:K19984]
114861964  exoc4; exocyst complex component 4 isoform X1 [KO:K06111]
114854551  exoc2; exocyst complex component 2 isoform X1 [KO:K17637]
114853079  ralaa; ras-related protein Ral-A [KO:K07834]
114860257  actb2; actin, cytoplasmic 2 [KO:K05692]
114854321  actb1; actin, cytoplasmic 1 [KO:K05692]
114861411  actin, cytoplasmic [KO:K05692]
114843193  s100a10b; protein S100-A10b [KO:K17274]
114865494  s100a10a; protein S100-A10a [KO:K17274]
114865706  anxa14; annexin A2 [KO:K17092]
114852711  annexin A2-like [KO:K17092]
114857301  annexin A2-like [KO:K17092]
114860988  si:ch211-69b7.6; neuroblast differentiation-associated protein AHNAK [KO:K23934]
114849010  neuroblast differentiation-associated protein AHNAK-like [KO:K23934]
114864231  ahnak; neuroblast differentiation-associated protein AHNAK [KO:K23934]
114867781  rho guanine nucleotide exchange factor 26-like [KO:K13744]
114869235  rhogb; ras homolog family member Gb [KO:K07863]
114864564  rhogd; ras homolog gene family, member Gd [KO:K07863]
114865749  elmo1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
114856024  elmo2; engulfment and cell motility protein 2 isoform X1 [KO:K18985]
114848338  rock2a; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
114849611  rho-associated protein kinase 1-like isoform X2 [KO:K17388] [EC:2.7.11.39]
114862013  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
114856279  myl2a; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
114867390  LOW QUALITY PROTEIN: myosin light chain 5-like [KO:K12753]
114861736  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
114856293  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
114844925  myl12.2; myosin, light chain 12, genome duplicate 2 [KO:K12757]
114853635  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
114846099  mylpfb; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
114860965  mylpfa; myosin regulatory light chain 2, skeletal muscle [KO:K12758]
114851802  fhod1; FH1/FH2 domain-containing protein 1 [KO:K23938]
114845012  si:ch211-63p21.2; FH1/FH2 domain-containing protein 1 isoform X1 [KO:K23938]
114842974  cdc42l; cell division cycle 42, like [KO:K04393]
114866173  cell division control protein 42 homolog isoform X1 [KO:K04393]
114859401  cell division control protein 42 homolog isoform X1 [KO:K04393]
114855655  cell division control protein 42 homolog isoform X1 [KO:K04393]
114845922  rac1a; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
114860501  rac1b; ras-related C3 botulinum toxin substrate 1b [KO:K04392]
114855246  nckap1l; nck-associated protein 1-like [KO:K05750]
114870358  nckap1; nck-associated protein 1 isoform X1 [KO:K05750]
114853398  cyfip1; cytoplasmic FMR1-interacting protein 1 homolog [KO:K05749]
114864216  cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
114844100  abl interactor 1-like isoform X1 [KO:K23649]
114853703  abi1a; abl interactor 1a isoform X1 [KO:K23649]
114856090  brk1; probable protein BRICK1 [KO:K05752]
114870004  wasf3a; actin-binding protein WASF3 isoform X1 [KO:K06083]
114852983  wasf3b; wiskott-Aldrich syndrome protein family member 3b [KO:K06083]
114857628  actin-binding protein WASF3 isoform X1 [KO:K06083]
114842083  actin-related protein 2-B [KO:K17260]
114842713  zgc:101810; actin-related protein 2 [KO:K17260]
114846809  actin-related protein 3-like [KO:K18584]
114851069  actin-related protein 3 [KO:K18584]
114858454  actin-related protein 2/3 complex subunit 1B-A-like [KO:K05757]
114858468  actin-related protein 2/3 complex subunit 1A [KO:K05757]
114860338  zgc:86896; actin-related protein 2/3 complex subunit 1A-A [KO:K05757]
114846917  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
114866624  arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
114855107  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
114855188  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
114844333  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
114853696  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
114867846  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
114869052  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
114848822  myo6b; myosin VIb isoform X1 [KO:K10358]
114850030  myo6a; myosin VIa isoform X1 [KO:K10358]
114844354  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
114858572  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
114853447  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
114867958  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
114859383  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
114861301  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
114856196  pik3c2b; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923] [EC:2.7.1.154]
114857220  pik3c2a; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1 [KO:K00923] [EC:2.7.1.154]
114857343  pik3c2g; phosphatidylinositol 3-kinase C2 domain-containing subunit gamma [KO:K00923] [EC:2.7.1.154]
114842667  cyth2; cytohesin-2 [KO:K18441]
114845810  cytohesin-1-like isoform X1 [KO:K18441]
114845919  cytohesin-3-like isoform X1 [KO:K18441]
114860341  cyth1a; cytohesin-1a isoform X1 [KO:K18441]
114860486  cyth3b; cytohesin-3 isoform X2 [KO:K18441]
114861038  cytohesin-2-like isoform X1 [KO:K18441]
114861578  cytohesin-4-like isoform X1 [KO:K18441]
114848234  arf6b; ADP-ribosylation factor 6b [KO:K07941]
114849812  arf6a; ADP-ribosylation factor 6a [KO:K07941]
114844799  arf1; ADP-ribosylation factor 1 [KO:K07937]
114845636  arf2b; ADP-ribosylation factor 2b [KO:K07937]
114860612  arf2a; ADP-ribosylation factor 2a [KO:K07937]
114867194  sorting nexin-18-like [KO:K17923]
114861896  snx18a; sorting nexin-18a [KO:K17923]
114849685  snx9b; sorting nexin-9b isoform X2 [KO:K17923]
114857260  snx33; sorting nexin-33 [KO:K17923]
114855187  si:dkey-197j19.6; actin nucleation-promoting factor WAS [KO:K23612]
114861783  waslb; WASP like actin nucleation promoting factor b isoform X1 [KO:K23612]
114857461  wasla; WASP like actin nucleation promoting factor a isoform X1 [KO:K23612]
114851306  dynamin-2-like isoform X1 [KO:K23484] [EC:3.6.5.5]
114861087  dnm2a; dynamin-3 isoform X5 [KO:K23484] [EC:3.6.5.5]
114843048  tlr18; toll-like receptor 18 [KO:K10159]
114851239  tlr2; toll-like receptor 2 [KO:K10159]
114867801  tirap; toll/interleukin-1 receptor domain-containing adapter protein isoform X2 [KO:K05403]
114854334  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
114849590  toll-like receptor 5 [KO:K10168]
114850172  toll-like receptor 5 [KO:K10168]
114858597  irak1; interleukin-1 receptor-associated kinase 1 isoform X2 [KO:K04730] [EC:2.7.11.1]
114857648  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
114852159  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
114848301  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
114849393  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
114859929  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
114849544  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
114854441  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
114858847  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114845361  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
114870842  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
114861862  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114848588  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
114849518  NF-kappa-B inhibitor alpha-like [KO:K04734]
114864181  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114851349  rela; transcription factor p65 isoform X1 [KO:K04735]
114843085  nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
114849323  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
114849324  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
114849876  hsp90ab1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
114856846  hsp90b1; endoplasmin [KO:K09487]
114845064  receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
114855932  cse1l; exportin-2 [KO:K18423]
114853535  kpna1; importin subunit alpha-5 [KO:K23940]
114846691  kpna3; importin subunit alpha-4 [KO:K23583]
114868361  kpna4; importin subunit alpha-3 [KO:K23583]
114868527  rps3; 40S ribosomal protein S3 [KO:K02985]
114857388  GTPase HRas [KO:K02833]
114858281  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
114857278  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
114853520  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
114845208  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
114860359  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114861888  mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
114846339  map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
114860381  dual specificity mitogen-activated protein kinase kinase 6-like isoform X1 [KO:K04433] [EC:2.7.12.2]
114858494  mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
114859152  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
114859326  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
114861856  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
114861857  mapk11; mitogen-activated protein kinase 11 isoform X6 [KO:K04441] [EC:2.7.11.24]
114855788  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
114857567  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
114845946  map2k4b; dual specificity mitogen-activated protein kinase kinase 4b isoform X1 [KO:K04430] [EC:2.7.12.2]
114860625  map2k4a; dual specificity mitogen-activated protein kinase kinase 4a isoform X2 [KO:K04430] [EC:2.7.12.2]
114863852  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
114841906  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114845408  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114867198  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114864012  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
114849092  fosaa; protein c-Fos [KO:K04379]
114849947  protein c-Fos-like isoform X1 [KO:K04379]
114849948  protein c-Fos-like [KO:K04379]
114844877  transcription factor Jun-like [KO:K04448]
114867319  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
114854282  jun; transcription factor AP-1 isoform X2 [KO:K04448]
114865591  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
114863211  interleukin-1 beta-like [KO:K04519]
114851355  growth-regulated alpha protein-like [KO:K10030]
114844587  cxcl8a; C-X-C motif chemokine 2 [KO:K10030]
114850070  cxcl19; interleukin-8 [KO:K10030]
114843004  ctnnb1; catenin beta-1 [KO:K02105]
114865743  catenin beta-1-like [KO:K02105]
114869348  tcf7; transcription factor 7 isoform X1 [KO:K02620]
114866425  transcription factor 7-like 1-B [KO:K04490]
114861532  tcf7l1b; transcription factor 7-like 1-B isoform X1 [KO:K04490]
114846309  tcf7l2; transcription factor 7-like 2 isoform X3 [KO:K04491]
114862393  lef1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
114854531  myca; transcriptional regulator Myc-A isoform X1 [KO:K04377]
114855486  mych; myelocytomatosis oncogene homolog [KO:K04377]
114863826  pkn1a; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
114851740  fbxo22; F-box only protein 22 [KO:K10302]
114869350  skp1; S-phase kinase-associated protein 1 [KO:K03094]
114842944  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
114858902  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
114845605  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
114866528  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
114866591  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
114852268  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
114869611  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
114845086  ripk1l; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
114842950  gapdh; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
114866152  glyceraldehyde-3-phosphate dehydrogenase-like isoform X1 [KO:K00134] [EC:1.2.1.12]
114853377  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
114848365  tumor necrosis factor ligand superfamily member 10-like [KO:K04721]
114845540  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
114866892  tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722]
114852435  fadd; protein FADD [KO:K02373]
114844036  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
114844038  caspase-3-like [KO:K04398] [EC:3.4.22.61]
114847689  casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]
114857396  receptor-interacting serine/threonine-protein kinase 3-like isoform X1 [KO:K08847] [EC:2.7.11.1]
114847805  ripk3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
114852574  zgc:153993; apoptosis regulator BAX [KO:K02159]
114860604  apoptosis regulator BAX-like isoform X2 [KO:K02159]
114870705  cytochrome c iso-1/iso-2 [KO:K08738]
114844269  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
114853980  apoptosis regulator Bcl-2-like [KO:K02161]
114858837  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
114864529  casp3b; caspase-3b isoform X1 [KO:K02187] [EC:3.4.22.56]
114866430  caspase-3-like isoform X1 [KO:K04397] [EC:3.4.22.60]
114866431  caspase-3-like isoform X1 [KO:K04397] [EC:3.4.22.60]
114846324  casp7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
114849319  rho-related GTP-binding protein RhoB [KO:K07856]
114856731  rhoh; rho-related GTP-binding protein RhoH [KO:K07873]
114841965  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
114868391  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114848934  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114869279  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
114862981  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
114857529  mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
114857530  mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
114857531  mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
114860311  txn2; thioredoxin, mitochondrial [KO:K03671]
114867580  txn; thioredoxin isoform X2 [KO:K03671]
114867589  thioredoxin-like [KO:K03671]
114843270  pycard; apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
114868518  caspase a-like isoform X1 [KO:K01370] [EC:3.4.22.36]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
bspl04010  MAPK signaling pathway
bspl04210  Apoptosis
bspl04217  Necroptosis
bspl04621  NOD-like receptor signaling pathway
KO pathway
ko05132   
LinkDB

DBGET integrated database retrieval system