KEGG   PATHWAY: ggo04810
Entry
ggo04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Gorilla gorilla gorilla (western lowland gorilla)
Class
Cellular Processes; Cell motility
Pathway map
ggo04810  Regulation of actin cytoskeleton
ggo04810

Other DBs
GO: 0030036
Organism
Gorilla gorilla gorilla (western lowland gorilla) [GN:ggo]
Gene
101144872  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
101126528  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
101150616  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
101126364  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
101124266  CXCL12; stromal cell-derived factor 1 isoform X2 [KO:K10031]
101137662  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
101149905  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
101144448  F2R; proteinase-activated receptor 1 [KO:K03914]
101132604  INS; insulin isoform X1 [KO:K04526]
101153700  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
101151075  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
101137337  FGF2; fibroblast growth factor 2 [KO:K18497]
101142002  FGF18; fibroblast growth factor 18 [KO:K04358]
101140831  FGF6; fibroblast growth factor 6 [KO:K04358]
101128423  FGF9; fibroblast growth factor 9 [KO:K04358]
101137223  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
101146312  FGF16; fibroblast growth factor 16 [KO:K04358]
101143620  FGF20; fibroblast growth factor 20 [KO:K04358]
101131137  FGF17; fibroblast growth factor 17 isoform X2 [KO:K04358]
101135749  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
101135528  FGF10; fibroblast growth factor 10 [KO:K04358]
101129138  FGF7; fibroblast growth factor 7 [KO:K04358]
101132851  FGF4; fibroblast growth factor 4 [KO:K04358]
101133590  FGF3; fibroblast growth factor 3 [KO:K04358]
101126805  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
101149990  FGF21; fibroblast growth factor 21 [KO:K22429]
101140441  FGF23; fibroblast growth factor 23 [KO:K22428]
101132059  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
101138492  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
101144807  PDGFC; platelet-derived growth factor C [KO:K05450]
101134877  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101125625  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
101126190  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101152179  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
101153046  FGFR2; fibroblast growth factor receptor 2 isoform X11 [KO:K05093] [EC:2.7.10.1]
101139997  FGFR3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
115932714  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
115932715  LOW QUALITY PROTEIN: fibroblast growth factor receptor 3-like [KO:K05094] [EC:2.7.10.1]
101145205  FGFR4; fibroblast growth factor receptor 4 isoform X2 [KO:K05095] [EC:2.7.10.1]
101124928  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
101150577  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101138168  FN1; fibronectin isoform X2 [KO:K05717]
101128466  ITGA1; integrin alpha-1 [KO:K06480]
101127372  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
101136113  ITGA2B; integrin alpha-IIb [KO:K06476]
101147579  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
101139877  ITGA4; integrin alpha-4 isoform X2 [KO:K06483]
101134285  ITGA5; integrin alpha-5 [KO:K06484]
101146479  ITGA6; integrin alpha-6 isoform X3 [KO:K06485]
101154143  ITGA7; integrin alpha-7 isoform X3 [KO:K06583]
101134255  ITGA8; integrin alpha-8 [KO:K06584]
101138424  ITGA9; integrin alpha-9 [KO:K06585]
101134042  ITGA10; integrin alpha-10 [KO:K06586]
101143568  ITGA11; integrin alpha-11 [KO:K06587]
101148851  ITGAV; integrin alpha-V [KO:K06487]
101139540  ITGAL; integrin alpha-L [KO:K05718]
101135400  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
101130485  ITGAX; integrin alpha-X [KO:K06462]
101130856  ITGAD; integrin alpha-D isoform X2 [KO:K06594]
101152981  ITGAE; integrin alpha-E [KO:K06524]
101142683  ITGB1; integrin beta-1 [KO:K05719]
101142773  ITGB2; integrin beta-2 [KO:K06464]
101149719  ITGB3; integrin beta-3 [KO:K06493]
101141382  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
101127698  ITGB5; integrin beta-5 [KO:K06588]
101135367  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101145271  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
101147846  ITGB8; integrin beta-8 [KO:K06591]
101138554  KNG1; kininogen-1 [KO:K03898]
101131912  BDKRB1; B1 bradykinin receptor isoform X1 [KO:K03915]
101132514  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
101131622  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101124976  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101123925  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
101145014  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
101139774  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
101138867  C5; complement C5 isoform X1 [KO:K03994]
101148425  C6; complement component C6 isoform X1 [KO:K03995]
101123977  C7; complement component C7 [KO:K03996]
101138636  C8A; complement component C8 alpha chain [KO:K03997]
101138999  C8B; complement component C8 beta chain isoform X3 [KO:K03998]
101129591  C8G; complement component C8 gamma chain isoform X3 [KO:K03999]
101131679  C9; complement component C9 [KO:K04000]
101147243  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
101152866  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
101147632  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101139427  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101136402  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
101150999  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
101128620  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101132653  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
101127403  CRKL; crk-like protein [KO:K04438]
101127665  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
101153251  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
101130824  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101137539  SOS2; son of sevenless homolog 2 [KO:K03099]
101136425  HRAS; GTPase HRas isoform X1 [KO:K02833]
101144039  KRAS; GTPase KRas isoform X1 [KO:K07827]
101146562  NRAS; GTPase NRas [KO:K07828]
109024246  RRAS; ras-related protein R-Ras [KO:K07829]
101147763  RRAS2; ras-related protein R-Ras2 isoform X3 [KO:K07830]
101146138  MRAS; ras-related protein M-Ras [KO:K07831]
101152069  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
101143811  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101146434  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101152123  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101130978  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
101135298  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101129336  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101124128  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
101142265  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
101139851  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101125464  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
101134493  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101145098  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101136454  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
101149643  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
101132391  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101126885  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101140164  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101135988  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101137723  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101138019  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101128197  RGCC; regulator of cell cycle RGCC isoform X2 [KO:K26108]
101131951  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
101150763  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
101153846  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
101134778  RHOA; transforming protein RhoA [KO:K04513]
101135430  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101141534  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101124029  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101138276  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
101130725  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101141425  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101127864  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
101124352  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
101140999  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
101126018  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X8 [KO:K13710]
101148050  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
101154194  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
101134988  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101142619  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
101143745  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101151517  MYLK; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
101151667  MYLK4; myosin light chain kinase family member 4 isoform X2 [KO:K00907] [EC:2.7.11.18]
101143438  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101129953  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101139376  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
101136268  PPP1R12C; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C [KO:K17457]
115933218  LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C-like [KO:K17457]
101146701  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
101125422  MYL5; myosin light chain 5 [KO:K12753]
101139698  MYL7; myosin regulatory light chain 2, atrial isoform isoform X2 [KO:K12754]
101138103  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
101126168  MYL12B; myosin regulatory light chain 12B [KO:K12757]
101127500  myosin regulatory light chain 12A isoform X1 [KO:K12757]
109028042  myosin regulatory light chain 12B-like [KO:K12757]
115934314  myosin regulatory light chain 12B-like isoform X1 [KO:K12757]
101154067  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758]
101137114  MYH14; myosin-14 isoform X1 [KO:K10352]
101153220  MYH10; myosin-10 isoform X1 [KO:K10352]
101148459  MYH9; myosin-9 isoform X1 [KO:K10352]
101127489  MYH11; myosin-11 isoform X1 [KO:K10352]
101148057  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
101152796  protein diaphanous homolog 2 [KO:K05741]
101134383  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
101132548  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
101150370  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
101132245  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
101149662  LOW QUALITY PROTEIN: putative PIP5K1A and PSMD4-like protein [KO:K00889] [EC:2.7.1.68]
101148420  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
101142708  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
101129094  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
101152226  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
101152288  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
101133437  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
101144182  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
101134448  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
101129354  ENAH; protein enabled homolog isoform X1 [KO:K05746]
101150121  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
101154359  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
101139707  LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 2-like [KO:K05748]
101130377  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X2 [KO:K05749]
101148152  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
101141959  NCKAP1; nck-associated protein 1 isoform X3 [KO:K05750]
101139875  NCKAP1L; nck-associated protein 1-like [KO:K05750]
101127082  ABI2; abl interactor 2 isoform X1 [KO:K05751]
101148625  BRK1; protein BRICK1 [KO:K05752]
101131112  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
101146117  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
101135299  LOW QUALITY PROTEIN: actin-related protein 2-like [KO:K17260]
101144040  ACTR3; actin-related protein 3 [KO:K18584]
101135917  ACTR3B; actin-related protein 3B isoform X3 [KO:K18584]
101148075  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
101140396  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
101123806  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
101141348  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
101143188  ARPC4; actin-related protein 2/3 complex subunit 4 isoform X1 [KO:K05755]
101124873  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
101136325  ARPC5; actin-related protein 2/3 complex subunit 5 isoform X2 [KO:K05754]
101125802  ACTG1; actin, cytoplasmic 2 [KO:K05692]
101127752  actin, cytoplasmic 1 [KO:K05692]
101141207  PFN4; profilin-4 [KO:K05759]
101141125  PFN1; profilin-1 [KO:K05759]
101123856  PFN3; profilin-3 [KO:K05759]
101139387  PFN2; profilin-2 isoform X1 [KO:K05759]
101127935  PXN; paxillin isoform X9 [KO:K05760]
101134827  EZR; ezrin isoform X1 [KO:K08007]
101126000  RDX; radixin isoform X2 [KO:K05762]
101135451  MSN; moesin [KO:K05763]
101131259  thymosin beta-4 [KO:K05764]
109024295  thymosin beta-4 [KO:K05764]
101152912  TMSB4X; thymosin beta-4 [KO:K05764]
101152594  CFL2; cofilin-2 isoform X1 [KO:K05765]
101153774  CFL1; cofilin-1 isoform X1 [KO:K05765]
101127085  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101131623  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101153484  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
101139107  VCL; vinculin isoform X1 [KO:K05700]
101133145  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
101144088  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
101150753  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
101128150  GSN; gelsolin isoform X2 [KO:K05768]
101127633  SCIN; adseverin [KO:K05768]
101144840  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
101138551  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
101137098  APC; adenomatous polyposis coli protein isoform X2 [KO:K02085]
101130129  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
101141215  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
109025496  SPATA13; spermatogenesis-associated protein 13 isoform X2 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
ggo04010  MAPK signaling pathway
ggo04510  Focal adhesion
ggo04520  Adherens junction
KO pathway
ko04810   
LinkDB

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