KEGG   PATHWAY: hrt04810
Entry
hrt04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Hirundo rustica (Barn swallow)
Class
Cellular Processes; Cell motility
Pathway map
hrt04810  Regulation of actin cytoskeleton
hrt04810

Other DBs
GO: 0030036
Organism
Hirundo rustica (Barn swallow) [GN:hrt]
Gene
120765520  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
120761440  lysophosphatidic acid receptor 3-like [KO:K04291]
120764957  lysophosphatidic acid receptor 4-like [KO:K04275]
120765421  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
120748865  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
120755698  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
120755013  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
120754366  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
120765400  F2R; proteinase-activated receptor 1 [KO:K03914]
120754549  INS; insulin [KO:K04526]
120753452  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
120759139  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
120752523  FGF2; fibroblast growth factor 2 [KO:K18497]
120751939  FGF6; fibroblast growth factor 6 [KO:K04358]
120758896  FGF7; fibroblast growth factor 7 [KO:K04358]
120752929  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
120753076  FGF20; fibroblast growth factor 20 [KO:K04358]
120759260  FGF18; fibroblast growth factor 18 [KO:K04358]
120765767  FGF10; fibroblast growth factor 10 [KO:K04358]
120754511  FGF3; fibroblast growth factor 3 [KO:K04358]
120749413  FGF9; fibroblast growth factor 9 isoform X2 [KO:K04358]
120755844  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
120762120  FGF16; fibroblast growth factor 16 [KO:K04358]
120754258  FGF19; fibroblast growth factor 19 [KO:K22603]
120752329  FGF23; fibroblast growth factor 23 [KO:K22428]
120759459  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
120752068  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
120752838  PDGFC; platelet-derived growth factor C [KO:K05450]
120749255  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
120766131  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
120750050  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
120764055  FGFR1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
120755574  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
120752756  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
120759121  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
120753384  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
120759145  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
120755371  FN1; fibronectin isoform X1 [KO:K05717]
120765242  ITGA1; integrin alpha-1 [KO:K06480]
120765354  ITGA2; integrin alpha-2 [KO:K06481]
120763589  ITGA2B; integrin alpha-IIb [KO:K06476]
120748082  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
120754962  ITGA4; integrin alpha-4 [KO:K06483]
120754919  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
120764404  ITGA7; integrin alpha-7 isoform X2 [KO:K06583]
120759826  ITGA8; integrin alpha-8 [KO:K06584]
120748889  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
120758953  ITGA11; integrin alpha-11 [KO:K06587]
120754943  ITGAV; integrin alpha-V [KO:K06487]
120749084  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
120755000  ITGB2; integrin beta-2 [KO:K06464]
120763837  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
120760928  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
120755010  ITGB5; integrin beta-5 [KO:K06588]
120754992  ITGB6; integrin beta-6 [KO:K06589]
120751760  ITGB8; integrin beta-8 [KO:K06591]
120757225  KNG1; kininogen-1 [KO:K03898]
120754444  BDKRB1; B1 bradykinin receptor [KO:K03915]
120754802  BDKRB2; B2 bradykinin receptor [KO:K03916]
120751470  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
120750327  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
120754184  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
120754306  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
120761704  C5; complement C5 [KO:K03994]
120765576  C6; complement component C6 [KO:K03995]
120765581  C7; complement component C7 isoform X1 [KO:K03996]
120756662  C8A; complement component C8 alpha chain isoform X1 [KO:K03997]
120756565  C8B; complement component C8 beta chain [KO:K03998]
120761876  C8G; complement component C8 gamma chain isoform X2 [KO:K03999]
120765263  C9; complement component C9 [KO:K04000]
120759457  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
120760940  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
120756469  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
120758209  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
120762784  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
120757726  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
120760550  CRKL; crk-like protein isoform X1 [KO:K04438]
120761251  CRK; adapter molecule crk isoform X1 [KO:K04438]
120755744  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
120760123  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
120748297  son of sevenless homolog 2-like [KO:K03099]
120754130  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
120750235  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
120753590  HRAS; GTPase HRas [KO:K02833]
120751789  KRAS; GTPase KRas [KO:K07827]
120762833  NRAS; GTPase NRas [KO:K07828]
120754077  RRAS2; ras-related protein R-Ras2 [KO:K07830]
120755007  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
120764821  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
120757477  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
120762378  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
120756929  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120763569  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
120765192  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120756367  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
120747838  LOW QUALITY PROTEIN: proto-oncogene vav-like [KO:K05730]
120761615  VAV2; guanine nucleotide exchange factor VAV2 isoform X2 [KO:K05730]
120756567  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
120765479  TIAM1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
120751656  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
120758250  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120754417  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
120758598  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
120763546  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
120760754  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
120748068  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120754015  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
120749824  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120748838  RGCC; regulator of cell cycle RGCC [KO:K26108]
120762063  regulator of cell cycle RGCC-like [KO:K26108]
120747768  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
120762502  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
120758077  RHOA; transforming protein RhoA [KO:K04513]
120759467  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
120751425  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
120760855  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
120762393  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
120748427  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
120757077  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
120764542  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
120764589  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
120765810  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
120765811  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
120765814  serine/threonine-protein kinase PAK 1-like [KO:K05733] [EC:2.7.11.1]
120765826  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
120765827  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
120765828  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
120765834  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
120765835  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
120765841  serine/threonine-protein kinase PAK 1-like [KO:K05733] [EC:2.7.11.1]
120761930  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
120750162  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
120761941  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
120762161  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
120747832  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
120753710  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
120765597  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
120761383  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
120750173  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
120750590  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
120757561  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
120760151  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
120763591  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
120754873  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
120749980  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
120748088  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
120760480  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
120749759  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
120752392  PPP1R12A; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12A [KO:K06270]
120762862  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
120760725  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
120760134  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
120761219  MYL10; myosin regulatory light chain 10 [KO:K12756]
120758110  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
120758125  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
120752177  MYH9; myosin-9 [KO:K10352]
120759740  MYH11; myosin-11 isoform X1 [KO:K10352]
120760999  MYH10; myosin-10 isoform X1 [KO:K10352]
120764822  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
120763167  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
120763506  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
120765128  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
120748162  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2 [KO:K00889] [EC:2.7.1.68]
120763864  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
120753641  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
120755019  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
120761305  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
120760370  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
120748568  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
120760826  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
120749935  ENAH; protein enabled homolog isoform X1 [KO:K05746]
120751784  WASL; actin nucleation-promoting factor WASL isoform X1 [KO:K23612]
120763199  WASF2; LOW QUALITY PROTEIN: actin-binding protein WASF2 [KO:K05748]
120759146  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
120749382  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X2 [KO:K05749]
120755464  NCKAP1; nck-associated protein 1 [KO:K05750]
120754880  ABI2; abl interactor 2 isoform X1 [KO:K05751]
120758478  BRK1; protein BRICK1 [KO:K05752]
120751123  WASF1; actin-binding protein WASF1 isoform X1 [KO:K05753]
120749920  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
120754994  ACTR3B; actin-related protein 3B [KO:K18584]
120755166  ACTR3; actin-related protein 3 [KO:K18584]
120759547  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
120759548  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
120755490  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X1 [KO:K05758]
120760594  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
120758167  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
120756693  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
120761661  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
120758534  actin, cytoplasmic type 5 [KO:K05692]
120759701  ACTB; actin, cytoplasmic 1 [KO:K05692]
120760819  ACTG1; actin, cytoplasmic 2 [KO:K05692]
120756996  PFN2; profilin-2 isoform X1 [KO:K05759]
120760535  PXN; paxillin isoform X1 [KO:K05760]
120749813  EZR; ezrin [KO:K08007]
120747727  RDX; radixin isoform X1 [KO:K05762]
120764832  MSN; moesin isoform X1 [KO:K05763]
120759254  thymosin beta-12-like [KO:K05764]
120748552  TMSB4X; thymosin beta-4 [KO:K05764]
120754141  CFL2; cofilin-2 [KO:K05765]
120753704  SSH3; LOW QUALITY PROTEIN: protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
120760448  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
120761198  SSH2; protein phosphatase Slingshot homolog 2 isoform X3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
120755582  VCL; vinculin isoform X1 [KO:K05700]
120758594  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
120764290  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
120765150  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
120755357  SCIN; scinderin [KO:K05768]
120761849  GSN; gelsolin isoform X2 [KO:K05768]
120753895  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
120763476  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
120765635  APC; adenomatous polyposis coli protein [KO:K02085]
120748077  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
120757018  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
hrt04010  MAPK signaling pathway
hrt04510  Focal adhesion
hrt04520  Adherens junction
KO pathway
ko04810   
LinkDB

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