KEGG   PATHWAY: lmut04020
Entry
lmut04020                   Pathway                                
Name
Calcium signaling pathway - Lagopus muta (rock ptarmigan)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
lmut04020  Calcium signaling pathway
lmut04020

Other DBs
GO: 0019722
Organism
Lagopus muta (rock ptarmigan) [GN:lmut]
Gene
125689936  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
125695407  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
125684077  plasma membrane calcium-transporting ATPase 4-like isoform X1 [KO:K05850] [EC:7.2.2.10]
125698904  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
125688452  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
125689566  CHRM3; muscarinic acetylcholine receptor M3 isoform X1 [KO:K04131]
125695289  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
125701555  ADORA2A; adenosine receptor A2a [KO:K04266]
125703140  ADORA2B; adenosine receptor A2b [KO:K04267]
125693191  ADRB1; beta-1 adrenergic receptor [KO:K04141]
125700281  ADRB2; beta-2 adrenergic receptor [KO:K04142]
125685210  ADRB3; beta-3 adrenergic receptor [KO:K04143]
125700013  DRD1; D(1A) dopamine receptor [KO:K04144]
125692060  DRD5; D(1B) dopamine receptor [KO:K05840]
125694118  D(1) dopamine receptor-like [KO:K05840]
125692077  octopamine receptor-like isoform X1 [KO:K04150]
125700160  HRH2; histamine H2 receptor [KO:K04150]
125700197  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
125695965  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
125703338  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
125692734  5-hydroxytryptamine receptor 7-like isoform X1 [KO:K04163]
125694163  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
125701503  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
125690613  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
125690968  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
125690720  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
125689755  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
125699136  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
125690991  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
125700673  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
125694172  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
125688591  PLN; cardiac phospholamban [KO:K05852]
125688918  SLN; sarcolipin [KO:K22642]
125701873  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
125702910  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
125695607  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
125691781  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
125701772  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
125703026  ORAI2; protein orai-2 [KO:K16057]
125693421  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
125698969  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
125687783  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F-like [KO:K04853]
125683997  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
125702742  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
125693396  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
125702036  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
125700537  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
125685585  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
125697973  neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
125687391  neuronal acetylcholine receptor subunit alpha-7-like [KO:K04809]
125702650  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
125700669  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
125692371  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
125702103  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
125687329  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
125684987  GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
125702913  P2RX1; P2X purinoceptor 1 [KO:K05215]
125701698  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
125694703  LOW QUALITY PROTEIN: bone marrow proteoglycan-like [KO:K05217]
125694721  P2RX3; P2X purinoceptor 3 [KO:K05217]
125701877  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
125703142  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
125701956  P2RX6; P2X purinoceptor 6 [KO:K05221]
125701875  P2RX7; LOW QUALITY PROTEIN: P2X purinoceptor 7 [KO:K05220]
125689502  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
125695288  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
125689637  TRDN; triadin isoform X1 [KO:K23449]
125693227  CASQ2; calsequestrin-2 [KO:K23445]
125690433  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
125699669  CYSLTR1; cysteinyl leukotriene receptor 1 isoform X1 [KO:K04322]
125698834  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
125690697  CHRM2; muscarinic acetylcholine receptor M2 isoform X1 [KO:K04130]
125685329  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
125700443  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
125692733  ADRA1D; alpha-1D adrenergic receptor isoform X1 [KO:K04137]
125697883  AGTR1; type-1 angiotensin II receptor [KO:K04166]
125692309  EDNRA; endothelin-1 receptor [KO:K04197]
125693838  EDNRB; endothelin receptor type B [KO:K04198]
125699786  endothelin receptor type B-like [KO:K04198]
125687036  F2R; proteinase-activated receptor 1 [KO:K03914]
125689387  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
125690973  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
125685668  GRPR; gastrin-releasing peptide receptor isoform X1 [KO:K04169]
125698931  HRH1; histamine H1 receptor [KO:K04149]
125697422  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
125698768  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
125699567  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
125689538  lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
125701327  NTSR1; neurotensin receptor type 1 [KO:K04211]
125698675  OXTR; oxytocin receptor [KO:K04229]
125694558  AVPR1A; vasopressin V1a receptor [KO:K04226]
125684180  AVPR1B; vasopressin V1b receptor [KO:K04227]
125703876  PTAFR; platelet-activating factor receptor [KO:K04279]
125694051  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
125693364  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
125694636  BDKRB1; B1 bradykinin receptor [KO:K03915]
125694635  BDKRB2; B2 bradykinin receptor [KO:K03916]
125685163  TACR1; substance-P receptor [KO:K04222]
125693659  TACR2; substance-K receptor isoform X1 [KO:K04223]
125692097  TACR3; neuromedin-K receptor [KO:K04224]
125684942  TBXA2R; thromboxane A2 receptor [KO:K04264]
125690726  TRHR; thyrotropin-releasing hormone receptor isoform X1 [KO:K04282]
125701196  thyrotropin-releasing hormone receptor-like [KO:K04282]
125692157  CCKAR; cholecystokinin receptor type A [KO:K04194]
125695717  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
125696554  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
125686805  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
125685047  guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
125692196  EGF; pro-epidermal growth factor [KO:K04357]
125685318  TGFA; protransforming growth factor alpha [KO:K08774]
125700597  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
125685068  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
125689229  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
125691815  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
125700187  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
125692512  FGF2; fibroblast growth factor 2 [KO:K18497]
125685032  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
125691900  FGF20; fibroblast growth factor 20 [KO:K04358]
125692252  FGF5; fibroblast growth factor 5 [KO:K04358]
125698409  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
125693218  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
125686624  FGF9; fibroblast growth factor 9 [KO:K04358]
125686761  FGF10; fibroblast growth factor 10 [KO:K04358]
125699869  FGF16; fibroblast growth factor 16 isoform X1 [KO:K04358]
125694333  FGF3; fibroblast growth factor 3 [KO:K04358]
125694334  FGF4; fibroblast growth factor 4 [KO:K04358]
125700122  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
125688191  FGF6; fibroblast growth factor 6 [KO:K04358]
125694832  FGF19; fibroblast growth factor 19 [KO:K22603]
125688190  FGF23; fibroblast growth factor 23 [KO:K22428]
125689415  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
125691946  VEGFC; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
125700947  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
125684039  NGF; beta-nerve growth factor [KO:K02582]
125687996  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
125698809  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
125686599  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
125696492  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
125684537  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
125685538  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
125697184  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
125692539  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
125700002  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
125685203  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
125693327  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
125692392  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
125700326  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
125699943  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
125688091  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
125700265  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
125692121  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
125685910  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
125686640  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
125698223  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
125694049  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
125698627  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
125693140  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
125690572  M1-specific T cell receptor beta chain-like [KO:K10785]
125696260  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
125697172  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
125684552  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
125690171  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
125690172  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
125694452  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
125690472  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1-like [KO:K01116] [EC:3.1.4.11]
125701080  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
125699039  PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
125694243  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
125699315  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
125698895  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
125688029  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
125684288  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
125691786  ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1-like isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
125701578  TPCN1; two pore channel protein 1 isoform X1 [KO:K16896]
125695582  TPCN2; two pore channel protein 2 [KO:K14077]
125686293  MCOLN1; LOW QUALITY PROTEIN: mucolipin-1 [KO:K04992]
125693796  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
125694010  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
125702048  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
125694179  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
125700064  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
125693517  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
125685344  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
125692099  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
125699833  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
125688413  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
125693903  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
125698714  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
125701384  TNNC2; troponin C, skeletal muscle [KO:K12042]
125689139  CALM2; calmodulin-2 [KO:K02183]
125698103  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
125688231  calmodulin, striated muscle [KO:K02183]
125694720  CALM1; calmodulin-1 [KO:K02183]
125702957  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
125690787  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
125699314  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
125699764  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
125690974  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
125697246  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
125699316  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
125701390  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
125684560  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
125684156  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
125698596  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
125701300  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
125685190  CAMK2B; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
125692621  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
125693507  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
125700173  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
125685071  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
125686863  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
125692478  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
125687811  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125694065  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125690056  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
125684217  TFEB; LOW QUALITY PROTEIN: transcription factor EB [KO:K15590]
125690581  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
125701402  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
125699022  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
125701757  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
125702893  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
125696090  NOS3; LOW QUALITY PROTEIN: nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
125695811  dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like isoform X1 [KO:K13755] [EC:3.1.4.17]
125696761  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
125689756  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
125689525  inositol-trisphosphate 3-kinase B-like [KO:K00911] [EC:2.7.1.127]
125695496  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
125702349  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
125700557  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
lmut04010  MAPK signaling pathway
lmut04070  Phosphatidylinositol signaling system
lmut04210  Apoptosis
KO pathway
ko04020   
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