KEGG   PATHWAY: lmut04010
Entry
lmut04010                   Pathway                                
Name
MAPK signaling pathway - Lagopus muta (rock ptarmigan)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
lmut04010  MAPK signaling pathway
lmut04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Lagopus muta (rock ptarmigan) [GN:lmut]
Gene
125683997  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
125684010  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
125684015  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
125684016  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
125684039  NGF; beta-nerve growth factor [KO:K02582]
125684074  RAP1A; ras-related protein Rap-1A [KO:K04353]
125684092  NRAS; GTPase NRas [KO:K07828]
125684094  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
125684182  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
125684239  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
125684479  DUSP3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
125684537  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
125684645  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
125684649  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
125684672  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
125684686  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
125684739  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
125684790  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
125684849  NRTN; neurturin isoform X1 [KO:K25414]
125684904  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
125684996  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125685032  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
125685063  EFNA2; ephrin-A2 [KO:K05462]
125685068  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
125685091  JUND; transcription factor JunD [KO:K04449]
125685203  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
125685318  TGFA; protransforming growth factor alpha [KO:K08774]
125685332  [KO:K04519]
125685336  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
125685538  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
125685585  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
125685910  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
125686210  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
125686409  [KO:K04352]
125686479  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
125686599  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
125686609  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
125686624  FGF9; fibroblast growth factor 9 [KO:K04358]
125686631  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
125686640  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
125686702  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
125686761  FGF10; fibroblast growth factor 10 [KO:K04358]
125686865  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
125687160  RASA1; ras GTPase-activating protein 1 [KO:K04352]
125687252  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
125687299  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
125687783  [KO:K04853]
125687811  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125687950  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
125687995  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
125687996  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
125688069  RAP1B; ras-related protein Rap-1b [KO:K07836]
125688091  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
125688094  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
125688190  FGF23; fibroblast growth factor 23 [KO:K22428]
125688191  FGF6; fibroblast growth factor 6 [KO:K04358]
125688322  [KO:K04386]
125688358  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
125688361  KRAS; GTPase KRas isoform X1 [KO:K07827]
125688438  NTF3; neurotrophin-3 [KO:K04356]
125688459  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
125688467  KITLG; kit ligand isoform X1 [KO:K05461]
125688635  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
125688713  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
125688781  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
125688893  SRF; serum response factor isoform X1 [KO:K04378]
125688936  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
125689225  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
125689229  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
125689326  MAP3K21; mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
125689415  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
125689429  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
125689588  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
125689607  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
125689864  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
125689872  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125689969  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
125689987  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
125690024  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
125690056  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
125690192  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
125690581  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
125691012  ANGPT1; angiopoietin-1 [KO:K05465]
125691076  STK3; serine/threonine-protein kinase 3 [KO:K04412]
125691213  MYC; myc proto-oncogene protein [KO:K04377]
125691395  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
125691554  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
125691561  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
125691626  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
125691708  LAMTOR3; ragulator complex protein LAMTOR3 isoform X1 [KO:K04370]
125691715  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
125691815  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
125691861  [KO:K04441] [EC:2.7.11.24]
125691887  AREG; amphiregulin [KO:K09782]
125691900  FGF20; fibroblast growth factor 20 [KO:K04358]
125691943  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
125691946  VEGFC; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
125692121  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
125692196  EGF; pro-epidermal growth factor [KO:K04357]
125692252  FGF5; fibroblast growth factor 5 [KO:K04358]
125692361  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
125692392  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
125692478  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
125692489  EREG; proepiregulin [KO:K09784]
125692512  FGF2; fibroblast growth factor 2 [KO:K18497]
125692539  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
125692551  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125692760  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
125693021  ARTN; artemin isoform X1 [KO:K25415]
125693084  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
125693118  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
125693140  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
125693218  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
125693312  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
125693327  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
125693396  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
125693421  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
125693580  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
125693707  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
125693708  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
125693731  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
125693785  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125693821  DUSP5; dual specificity protein phosphatase 5 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125693900  JUN; transcription factor Jun [KO:K04448]
125693944  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
125694020  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
125694049  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
125694065  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125694172  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
125694333  FGF3; fibroblast growth factor 3 [KO:K04358]
125694334  FGF4; fibroblast growth factor 4 [KO:K04358]
125694438  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
125694448  HRAS; GTPase HRas [KO:K02833]
125694458  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
125694561  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
125694568  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125694573  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
125694668  [KO:K16342] [EC:3.1.1.4]
125694695  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
125694730  [KO:K16342] [EC:3.1.1.4]
125694734  [KO:K16342] [EC:3.1.1.4]
125694751  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
125694788  [KO:K16342] [EC:3.1.1.4]
125694832  FGF19; fibroblast growth factor 19 [KO:K22603]
125694841  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
125694948  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125694998  IGF2; insulin-like growth factor II [KO:K13769]
125695063  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
125695152  [KO:K16342] [EC:3.1.1.4]
125695153  [KO:K16342] [EC:3.1.1.4]
125695154  [KO:K16342] [EC:3.1.1.4]
125695229  INS; insulin [KO:K04526]
125695237  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
125695245  FOS; protein c-Fos [KO:K04379]
125695248  PGF; placenta growth factor isoform X1 [KO:K16859]
125695346  MAX; protein max [KO:K04453]
125695467  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
125695503  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
125695521  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
125695540  [KO:K16342] [EC:3.1.1.4]
125695556  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
125695684  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
125695751  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
125695837  [KO:K04421] [EC:2.7.11.25]
125696109  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
125696192  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
125696289  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X1 [KO:K04415] [EC:2.7.11.25]
125696492  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
125696606  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
125696699  [KO:K04388] [EC:2.7.11.30]
125696772  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125696956  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
125697107  MRAS; ras-related protein M-Ras [KO:K07831]
125697180  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
125697184  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
125697327  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
125697448  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
125697492  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
125697532  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
125697589  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
125697713  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
125697777  [KO:K04723]
125698024  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
125698098  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
125698355  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
125698369  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
125698389  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
125698409  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
125698548  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
125698554  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
125698712  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125698855  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125698969  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
125698970  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
125699022  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
125699220  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
125699633  ARRB1; beta-arrestin-1 [KO:K04439]
125699667  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
125699869  FGF16; fibroblast growth factor 16 isoform X1 [KO:K04358]
125699938  NRK; nik-related protein kinase [KO:K04407] [EC:2.7.11.1]
125699943  [KO:K05096] [EC:2.7.10.1]
125700002  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
125700003  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
125700042  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
125700122  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
125700187  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
125700265  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
125700313  CD14; monocyte differentiation antigen CD14 [KO:K04391]
125700326  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
125700329  IGF1; insulin-like growth factor I [KO:K05459]
125700380  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
125700537  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
125700551  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
125700553  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
125700557  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125700558  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
125700597  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
125700804  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
125700897  CACNG3; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
125700947  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
125701263  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
125701329  ANGPT4; angiopoietin-4 [KO:K05467]
125701521  CRKL; crk-like protein [KO:K04438]
125701530  [KO:K04429] [EC:2.7.11.1]
125701613  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
125701926  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125702013  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
125702036  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
125702133  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
125702186  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
125702281  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
125702300  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
125702318  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
125702319  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
125702349  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
125702608  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
125702742  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
125702807  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
125702829  CRK; adapter molecule crk isoform X1 [KO:K04438]
125702892  NF1; neurofibromin isoform X1 [KO:K08052]
125702894  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
125702907  HSPB1; heat shock protein beta-1 [KO:K04455]
125703287  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
125703361  EPHA2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
125703699  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
125703799  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
125703921  STMN1; stathmin isoform X1 [KO:K04381]
125703925  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
lmut04070  Phosphatidylinositol signaling system
lmut04110  Cell cycle
lmut04115  p53 signaling pathway
lmut04210  Apoptosis
lmut04310  Wnt signaling pathway
KO pathway
ko04010   

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