KEGG   PATHWAY: lww05152
Entry
lww05152                    Pathway                                
Name
Tuberculosis - Leptonychotes weddellii (Weddell seal)
Description
Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
lww05152  Tuberculosis
lww05152

Organism
Leptonychotes weddellii (Weddell seal) [GN:lww]
Gene
102743506  TNF; tumor necrosis factor [KO:K03156]
102739000  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102750365  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
102737084  FADD; FAS-associated death domain protein [KO:K02373]
102733039  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
102735000  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
115943885  BH3-interacting domain death agonist-like [KO:K04726]
102729504  apoptosis regulator BAX-like isoform X1 [KO:K02159]
102725978  cytochrome c 2-like [KO:K08738]
102750923  cytochrome c [KO:K08738]
102726669  cytochrome c [KO:K08738]
102725545  caspase-9-like [KO:K04399] [EC:3.4.22.62]
102729908  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
102747309  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102749871  AKT1; RAC-alpha serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
102734291  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102728568  BAD; bcl2-associated agonist of cell death [KO:K02158]
102744561  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102734245  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
102726493  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
102743812  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
102732377  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
102733689  IFNG; interferon gamma [KO:K04687]
102725692  IFNGR1; LOW QUALITY PROTEIN: interferon gamma receptor 1 [KO:K05132]
102748762  IFNGR2; interferon gamma receptor 2 [KO:K05133]
102736730  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102745262  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
102731818  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
102750916  MHC class II transactivator isoform X1 [KO:K08060] [EC:2.7.11.1]
102740439  RFX5; DNA-binding protein RFX5 isoform X1 [KO:K08061]
102737617  RFXANK; DNA-binding protein RFXANK [KO:K08062]
102736882  RFXAP; regulatory factor X-associated protein [KO:K08063]
102726986  nuclear transcription factor Y subunit alpha [KO:K08064]
102749481  NFYB; nuclear transcription factor Y subunit beta [KO:K08065]
102750980  NFYC; nuclear transcription factor Y subunit gamma isoform X1 [KO:K08066]
102748542  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102733188  HLA class II histocompatibility antigen, DP alpha 1 chain-like isoform X1 [KO:K06752]
102748173  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
102747192  HLA class II histocompatibility antigen, DQ alpha 1 chain-like [KO:K06752]
102734456  HLA class II histocompatibility antigen, DO alpha chain [KO:K06752]
102740784  HLA class II histocompatibility antigen, DR alpha chain [KO:K06752]
102741082  DLA class II histocompatibility antigen, DR-1 beta chain isoform X1 [KO:K06752]
102747485  HLA class II histocompatibility antigen, DQ beta 2 chain isoform X1 [KO:K06752]
102748462  HLA class II histocompatibility antigen, DO beta chain isoform X2 [KO:K06752]
102750166  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
102750454  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
102749776  CD74; HLA class II histocompatibility antigen gamma chain isoform X1 [KO:K06505]
102747427  CREBBP; CREB-binding protein [KO:K04498] [EC:2.3.1.48]
102749228  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
102744308  IL10; interleukin-10 [KO:K05443]
102738815  IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
102734341  IL10RB; interleukin-10 receptor subunit beta [KO:K05135]
102730297  CTSS; cathepsin S isoform X1 [KO:K01368] [EC:3.4.22.27]
102746588  C-type lectin domain family 4 member E-like [KO:K10059]
102733507  FCER1G; high affinity immunoglobulin epsilon receptor subunit gamma [KO:K07983]
102740666  CLEC7A; C-type lectin domain family 7 member A isoform X1 [KO:K10074]
102734775  SRC; proto-oncogene tyrosine-protein kinase Src isoform X3 [KO:K05704] [EC:2.7.10.2]
102734956  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
102745495  CARD9; caspase recruitment domain-containing protein 9 isoform X3 [KO:K12794]
102732837  mucosa-associated lymphoid tissue lymphoma translocation protein 1-like [KO:K07369] [EC:3.4.22.-]
102747572  MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [KO:K07369] [EC:3.4.22.-]
102738709  BCL10; B-cell lymphoma/leukemia 10 isoform X1 [KO:K07368]
102747207  NOD2; nucleotide-binding oligomerization domain-containing protein 2 [KO:K10165]
102746338  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
102736787  HSPA9; stress-70 protein, mitochondrial [KO:K04043]
102731829  HSPD1; 60 kDa heat shock protein, mitochondrial [KO:K04077] [EC:5.6.1.7]
102732693  lipopolysaccharide-binding protein [KO:K05399]
102733295  lipopolysaccharide-binding protein-like [KO:K05399]
102737828  TLR2; LOW QUALITY PROTEIN: toll-like receptor 2 [KO:K10159]
102738668  TLR1; toll-like receptor 1 [KO:K05398]
102738975  TLR6; toll-like receptor 6 [KO:K10169]
102749618  TLR4; toll-like receptor 4 [KO:K10160]
102741458  CD14; monocyte differentiation antigen CD14 [KO:K04391]
102732223  TIRAP; toll/interleukin-1 receptor domain-containing adapter protein isoform X3 [KO:K05403]
102737954  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
102741856  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
102726302  interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102739305  IRAK2; interleukin-1 receptor-associated kinase-like 2 [KO:K04731] [EC:2.7.11.1]
102728739  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102732435  nuclear factor NF-kappa-B p105 subunit-like [KO:K02580]
102739707  RELA; transcription factor p65 [KO:K04735]
102746987  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
115942902  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
102738377  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102725695  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
102727849  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102730012  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102739504  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102733548  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
102745902  IL6; interleukin-6 isoform X1 [KO:K05405]
102738603  IL12A; interleukin-12 subunit alpha [KO:K05406]
102740807  IL12B; interleukin-12 subunit beta [KO:K05425]
102742078  IL18; interleukin-18 isoform X1 [KO:K05482]
102739313  IL23A; interleukin-23 subunit alpha isoform X1 [KO:K05426]
102740423  IL1A; interleukin-1 alpha isoform X1 [KO:K04383]
102739919  IL1B; interleukin-1 beta [KO:K04519]
102749933  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
102749108  CEBPG; CCAAT/enhancer-binding protein gamma [KO:K10049]
102729240  LOW QUALITY PROTEIN: CCAAT/enhancer-binding protein gamma-like [KO:K10049]
102743159  toll-like receptor 9 isoform X3 [KO:K10161]
102748540  LOW QUALITY PROTEIN: interferon alpha-14 [KO:K05414]
102747471  interferon alpha-1/2-like [KO:K05414]
102747757  interferon alpha-1/2-like [KO:K05414]
102750324  interferon alpha-2-like [KO:K05414]
102727550  interferon alpha-1/2-like [KO:K05414]
102749740  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
102748842  IFNB1; interferon beta [KO:K05415]
102743181  CD209 antigen-like protein E isoform X1 [KO:K06563]
102744485  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X3 [KO:K07532]
102739474  transforming protein RhoA-like [KO:K04513]
102738654  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
102747926  LSP1; lymphocyte-specific protein 1 isoform X1 [KO:K14957]
102745305  PLK3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
102725959  kinase suppressor of Ras 1-like [KO:K14958]
102726914  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102747528  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
102727105  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
102738835  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
102746290  25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial [KO:K07438] [EC:1.14.15.18]
102739653  VDR; vitamin D3 receptor [KO:K08539]
102742380  CAMP; cathelicidin antimicrobial peptide [KO:K13916]
102735244  C3; complement C3 [KO:K03990]
102740753  ITGAX; integrin alpha-X [KO:K06462]
102725651  ITGB2; integrin beta-2 [KO:K06464]
102728891  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
102728058  secretory phospholipase A2 receptor [KO:K06560]
102734757  C-type mannose receptor 2 [KO:K06560]
102727922  MRC1; macrophage mannose receptor 1 [KO:K06560]
102750390  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
102742615  SPHK2; sphingosine kinase 2 isoform X4 [KO:K04718] [EC:2.7.1.91]
102730620  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
102738071  calmodulin-like [KO:K02183]
102736921  calmodulin-like [KO:K02183]
102731712  CALM3; calmodulin-3 [KO:K02183]
102738351  calmodulin-like [KO:K02183]
102736922  calmodulin-like [KO:K02183]
102738889  CALM2; calmodulin-2 [KO:K02183]
102732458  CALML6; calmodulin-like protein 6 [KO:K02183]
102735924  CALM1; calmodulin-1 [KO:K02183]
102726280  CALML5; calmodulin-like protein 5 [KO:K02183]
102750042  calmodulin-like protein 3 [KO:K02183]
102726108  calmodulin-like [KO:K02183]
102740754  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
102744182  RAB5A; ras-related protein Rab-5A [KO:K07887]
102733719  RAB5B; ras-related protein Rab-5B [KO:K07888]
102749069  RAB5C; ras-related protein Rab-5C [KO:K07889]
102726284  early endosome antigen 1 [KO:K12478]
102739018  RAB7A; ras-related protein Rab-7a [KO:K07897]
102728100  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
102749956  ATP6V0A1; V-type proton ATPase 116 kDa subunit a [KO:K02154]
102728770  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]
102743875  V-type proton ATPase 116 kDa subunit a [KO:K02154]
102745898  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
102743194  V-type proton ATPase subunit d 2-like [KO:K02146]
102737727  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
102749001  ATP6V1H; V-type proton ATPase subunit H [KO:K02144]
102745472  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
102749071  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
102734147  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661]
102740624  LAMP2; lysosome-associated membrane glycoprotein 2 [KO:K06528]
102734931  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
102739246  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
102743467  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
102747867  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102732630  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102749914  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102734567  CORO1A; coronin-1A [KO:K13882]
102742870  high affinity immunoglobulin gamma Fc receptor I-like [KO:K06498]
102736172  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560]
102735873  low affinity immunoglobulin gamma Fc region receptor III-like [KO:K06463]
Compound
C00076  Calcium cation
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C01561  Calcidiol
C01673  Calcitriol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C06124  Sphingosine 1-phosphate
C19190  Trehalose-6,6'-dibehenate
C21790  Mycobacterial trehalose dimycolate
G13101  Lipomannan
G13105  Triacylated phosphatidyl-myo-inositol pentamannoside
G13106  Triacylated phosphatidyl-myo-inositol hexamannoside
G13108  Triacylated phosphatidyl-myo-inositol dimannoside
G13109  Tetraacylated phosphatidyl-myo-inositol dimannoside
G13112  Tetraacylated phosphatidyl-myo-inositol hexamannoside
G13113  Tetraacylated phosphatidyl-myo-inositol pentamannoside
G13114  Lipoarabinomannan
G13115  Mannose-capped lipoarabinomannan
Reference
PMID:21274449
  Authors
Saiga H, Shimada Y, Takeda K
  Title
Innate immune effectors in mycobacterial infection.
  Journal
Clin Dev Immunol 2011:347594 (2011)
DOI:10.1155/2011/347594
Reference
PMID:20415982
  Authors
Dheda K, Schwander SK, Zhu B, van Zyl-Smit RN, Zhang Y
  Title
The immunology of tuberculosis: from bench to bedside.
  Journal
Respirology 15:433-50 (2010)
DOI:10.1111/j.1440-1843.2010.01739.x
Reference
PMID:11932234
  Authors
van Crevel R, Ottenhoff TH, van der Meer JW
  Title
Innate immunity to Mycobacterium tuberculosis.
  Journal
Clin Microbiol Rev 15:294-309 (2002)
DOI:10.1128/CMR.15.2.294-309.2002
Reference
PMID:18288961
  Authors
Torrelles JB, Azad AK, Henning LN, Carlson TK, Schlesinger LS
  Title
Role of C-type lectins in mycobacterial infections.
  Journal
Curr Drug Targets 9:102-12 (2008)
DOI:10.2174/138945008783502467
Reference
PMID:17359235
  Authors
Jo EK, Yang CS, Choi CH, Harding CV
  Title
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.
  Journal
Cell Microbiol 9:1087-98 (2007)
DOI:10.1111/j.1462-5822.2007.00914.x
Reference
PMID:21274433
  Authors
Marakalala MJ, Graham LM, Brown GD
  Title
The role of Syk/CARD9-coupled C-type lectin receptors in immunity to Mycobacterium tuberculosis infections.
  Journal
Clin Dev Immunol 2010:567571 (2010)
DOI:10.1155/2010/567571
Reference
PMID:15083155
  Authors
Koul A, Herget T, Klebl B, Ullrich A
  Title
Interplay between mycobacteria and host signalling pathways.
  Journal
Nat Rev Microbiol 2:189-202 (2004)
DOI:10.1038/nrmicro840
Reference
PMID:20199890
  Authors
Torrelles JB, Schlesinger LS
  Title
Diversity in Mycobacterium tuberculosis mannosylated cell wall determinants impacts adaptation to the host.
  Journal
Tuberculosis (Edinb) 90:84-93 (2010)
DOI:10.1016/j.tube.2010.02.003
Reference
PMID:15228522
  Authors
Briken V, Porcelli SA, Besra GS, Kremer L
  Title
Mycobacterial lipoarabinomannan and related lipoglycans: from biogenesis to modulation of the immune response.
  Journal
Mol Microbiol 53:391-403 (2004)
DOI:10.1111/j.1365-2958.2004.04183.x
Reference
PMID:19563525
  Authors
Baena A, Porcelli SA
  Title
Evasion and subversion of antigen presentation by Mycobacterium tuberculosis.
  Journal
Tissue Antigens 74:189-204 (2009)
DOI:10.1111/j.1399-0039.2009.01301.x
Reference
PMID:19369951
  Authors
Flannagan RS, Cosio G, Grinstein S
  Title
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies.
  Journal
Nat Rev Microbiol 7:355-66 (2009)
DOI:10.1038/nrmicro2128
Reference
PMID:18541216
  Authors
Pieters J
  Title
Mycobacterium tuberculosis and the macrophage: maintaining a balance.
  Journal
Cell Host Microbe 3:399-407 (2008)
DOI:10.1016/j.chom.2008.05.006
Reference
PMID:19634703
  Authors
Scherr N, Jayachandran R, Mueller P, Pieters J
  Title
Interference of Mycobacterium tuberculosis with macrophage responses.
  Journal
Indian J Exp Biol 47:401-6 (2009)
Reference
PMID:16200082
  Authors
Reith W, LeibundGut-Landmann S, Waldburger JM.
  Title
Regulation of MHC class II gene expression by the class II transactivator.
  Journal
Nat Rev Immunol 5:793-806 (2005)
DOI:10.1038/nri1708
Reference
PMID:17785780
  Authors
Rothfuchs AG, Bafica A, Feng CG, Egen JG, Williams DL, Brown GD, Sher A
  Title
Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells.
  Journal
J Immunol 179:3463-71 (2007)
DOI:10.4049/jimmunol.179.6.3463
Reference
PMID:18407066
  Authors
Master SS, Rampini SK, Davis AS, Keller C, Ehlers S, Springer B, Timmins GS, Sander P, Deretic V
  Title
Mycobacterium tuberculosis prevents inflammasome activation.
  Journal
Cell Host Microbe 3:224-32 (2008)
DOI:10.1016/j.chom.2008.03.003
Reference
PMID:11378475
  Authors
Shtrichman R, Samuel CE
  Title
The role of gamma interferon in antimicrobial immunity.
  Journal
Curr Opin Microbiol 4:251-9 (2001)
DOI:10.1016/S1369-5274(00)00199-5
Related
pathway
lww04010  MAPK signaling pathway
lww04210  Apoptosis
lww04612  Antigen processing and presentation
lww04620  Toll-like receptor signaling pathway
lww04621  NOD-like receptor signaling pathway
lww04630  JAK-STAT signaling pathway
KO pathway
ko05152   
LinkDB

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