KEGG   PATHWAY: mcal04810
Entry
mcal04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Mus caroli (Ryukyu mouse)
Class
Cellular Processes; Cell motility
Pathway map
mcal04810  Regulation of actin cytoskeleton
mcal04810

Other DBs
GO: 0030036
Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110292580  Lpar1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
110300387  Lpar2; lysophosphatidic acid receptor 2 [KO:K04291]
110287196  Lpar4; lysophosphatidic acid receptor 4 [KO:K04275]
110297038  Lpar5; lysophosphatidic acid receptor 5 [KO:K08390]
110296032  Cxcl12; stromal cell-derived factor 1 isoform X2 [KO:K10031]
110299256  Cxcr4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
110311945  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
110308051  F2r; proteinase-activated receptor 1 [KO:K03914]
110299132  insulin-2 [KO:K04526]
110286053  insulin-1 [KO:K04526]
110291005  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
110284837  Fgf1; fibroblast growth factor 1 isoform X1 [KO:K18496]
110291557  Fgf2; fibroblast growth factor 2 [KO:K18497]
110300580  Fgf20; fibroblast growth factor 20 [KO:K04358]
110295342  Fgf5; fibroblast growth factor 5 isoform X1 [KO:K04358]
110285629  Fgf8; fibroblast growth factor 8 isoform X1 [KO:K04358]
110287226  Fgf16; fibroblast growth factor 16 [KO:K04358]
110305760  Fgf18; fibroblast growth factor 18 [KO:K04358]
110308847  Fgf17; fibroblast growth factor 17 isoform X1 [KO:K04358]
110303818  Fgf22; fibroblast growth factor 22 isoform X1 [KO:K04358]
110309422  Fgf9; fibroblast growth factor 9 [KO:K04358]
110289950  Fgf7; fibroblast growth factor 7 [KO:K04358]
110296943  Fgf6; fibroblast growth factor 6 [KO:K04358]
110299316  Fgf4; fibroblast growth factor 4 [KO:K04358]
110299386  Fgf3; fibroblast growth factor 3 [KO:K04358]
110308330  Fgf10; fibroblast growth factor 10 [KO:K04358]
110299450  Fgf19; fibroblast growth factor 19 [KO:K22603]
110299358  Fgf21; fibroblast growth factor 21 [KO:K22429]
110297028  Fgf23; fibroblast growth factor 23 [KO:K22428]
110294651  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110310626  Pdgfb; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110290924  Pdgfc; platelet-derived growth factor C [KO:K05450]
110301590  Pdgfd; platelet-derived growth factor D isoform X2 [KO:K05450]
110290874  Insrr; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
110304228  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
110299550  Fgfr1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
110299396  Fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
110293909  Fgfr3; fibroblast growth factor receptor 3 isoform X8 [KO:K05094] [EC:2.7.10.1]
110307648  Fgfr4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
110295292  Pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110284880  Pdgfrb; platelet-derived growth factor receptor beta isoform X2 [KO:K05089] [EC:2.7.10.1]
110283623  Fn1; fibronectin isoform X1 [KO:K05717]
110307562  Itga1; integrin alpha-1 [KO:K06480]
110308074  Itga2; integrin alpha-2 isoform X2 [KO:K06481]
110304761  Itga2b; integrin alpha-IIb [KO:K06476]
110304308  Itga3; integrin alpha-3 [KO:K06482]
110289008  Itga4; integrin alpha-4 [KO:K06483]
110310456  Itga5; integrin alpha-5 [KO:K06484]
110285509  Itga6; integrin alpha-6 isoform X2 [KO:K06485]
110302898  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
110289369  Itga8; integrin alpha-8 [KO:K06584]
110301527  Itga9; integrin alpha-9 [KO:K06585]
110291521  Itga10; integrin alpha-10 isoform X1 [KO:K06586]
110301610  Itga11; integrin alpha-11 [KO:K06587]
110311058  Itgav; integrin alpha-V isoform X1 [KO:K06487]
110299482  Itgal; integrin alpha-L isoform X1 [KO:K05718]
110298307  Itgam; integrin alpha-M isoform X2 [KO:K06461]
110298506  integrin alpha-X isoform X1 [KO:K06462]
110297916  integrin alpha-D [KO:K06594]
110304940  Itgae; integrin alpha-E [KO:K06524]
110299930  Itgb1; integrin beta-1 isoform X2 [KO:K05719]
110311769  integrin beta-2-like protein [KO:K06464]
110303281  Itgb2; integrin beta-2 [KO:K06464]
110305072  Itgb3; integrin beta-3 [KO:K06493]
110304271  Itgb4; integrin beta-4 isoform X2 [KO:K06525]
110311493  Itgb5; integrin beta-5 [KO:K06588]
110289784  Itgb6; integrin beta-6 [KO:K06589]
110310547  Itgb7; integrin beta-7 [KO:K06590]
110307232  Itgb8; integrin beta-8 [KO:K06591]
110311183  kininogen-1 isoform X1 [KO:K03898]
110307526  Bdkrb1; B1 bradykinin receptor [KO:K03915]
110307378  Bdkrb2; B2 bradykinin receptor [KO:K03916]
110285542  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
110296617  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
110308311  Chrm3; muscarinic acetylcholine receptor M3 [KO:K04131]
110288551  Chrm4; muscarinic acetylcholine receptor M4 isoform X2 [KO:K04132]
110289866  Chrm5; muscarinic acetylcholine receptor M5 [KO:K04133]
110285518  C5; complement C5 [KO:K03994]
110310600  C6; complement component C6 [KO:K03995]
110310957  C7; complement component C7 [KO:K03996]
110292511  C8a; complement component C8 alpha chain isoform X1 [KO:K03997]
110292205  C8b; complement component C8 beta chain isoform X2 [KO:K03998]
110284736  C8g; complement component C8 gamma chain [KO:K03999]
110310523  C9; complement component C9 [KO:K04000]
110295092  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
110304818  Gna13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
110300627  Gng14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
110296551  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110286658  Fgd1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
110308185  Fgd3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
110310271  Ptk2; focal adhesion kinase 1 isoform X6 [KO:K05725] [EC:2.7.10.2]
110299902  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
110305233  Crk; adapter molecule crk isoform X1 [KO:K04438]
110311596  Crkl; crk-like protein [KO:K04438]
110298899  Dock1; dedicator of cytokinesis protein 1 [KO:K13708]
110310031  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
110306968  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110312423  Sos1; son of sevenless homolog 1 [KO:K03099]
110297313  Hras; GTPase HRas isoform X2 [KO:K02833]
110296194  Kras; GTPase KRas isoform X1 [KO:K07827]
110290873  Nras; GTPase NRas [KO:K07828]
110298333  Rras; ras-related protein R-Ras [KO:K07829]
110297889  Rras2; ras-related protein R-Ras2 [KO:K07830]
110300983  Mras; ras-related protein M-Ras isoform X1 [KO:K07831]
110286540  Arhgef6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
110290798  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110292183  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110301355  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110308009  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110299855  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
110292624  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110310431  Vav2; guanine nucleotide exchange factor VAV2 isoform X2 [KO:K05730]
110312346  Vav1; proto-oncogene vav isoform X1 [KO:K05730]
110290661  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
110311394  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
110287540  Araf; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
110295945  Braf; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
110296919  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110293761  Mos; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
110301502  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110303196  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110297836  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110311382  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110297609  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110294471  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110307022  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110309425  Rgcc; regulator of cell cycle RGCC [KO:K26108]
110297443  Arhgef1; rho guanine nucleotide exchange factor 1 isoform X3 [KO:K12330]
110301221  Arhgef12; rho guanine nucleotide exchange factor 12 isoform X2 [KO:K07532]
110297432  Arhgap35; rho GTPase-activating protein 35 [KO:K05732]
110292411  transforming protein RhoA [KO:K04513]
110302438  Rhoa; transforming protein RhoA [KO:K04513]
110293965  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
110310226  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110305163  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
110292517  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
110298300  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
110311434  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
110286479  Pak3; serine/threonine-protein kinase PAK 3 isoform X3 [KO:K05733] [EC:2.7.11.1]
110297818  Pak4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
110289454  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
110288173  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
110300086  Arhgef7; rho guanine nucleotide exchange factor 7 [KO:K13710]
110304344  Git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
110284478  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
110306686  Rock2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
110308670  myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
110290127  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
110300419  Mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
110311174  Mylk; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
110285541  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
110294013  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
110294931  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
110288037  serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
110302933  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X4 [KO:K06270]
110293509  Ppp1r12b; protein phosphatase 1 regulatory subunit 12B isoform X4 [KO:K12329]
110297840  Ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
110294798  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
110305591  Myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
110285279  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
110295174  Myl10; myosin regulatory light chain 10 [KO:K12756]
110312338  myosin regulatory light chain RLC-A isoform X1 [KO:K12757]
110312339  Myl12b; myosin regulatory light chain 12B [KO:K12757]
110297590  Mylpf; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758]
110297781  Myh14; myosin-14 isoform X1 [KO:K10352]
110304509  Myh10; myosin-10 [KO:K10352]
110310114  Myh9; myosin-9 [KO:K10352]
110311849  Myh11; myosin-11 isoform X2 [KO:K10352]
110284518  Diaph1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
110286471  Diaph2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
110292287  Slc9a1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
110291192  Pip5k1a; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
110285491  Pip5k1b; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
110302948  Pip5k1c; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2 [KO:K00889] [EC:2.7.1.68]
110305410  Pip4k2b; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
110285089  Pip4k2a; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
110302794  Pip4k2c; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
110293039  Pikfyve; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X3 [KO:K00921] [EC:2.7.1.150]
110294671  Limk1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
110304738  Limk2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
110309434  Diaph3; protein diaphanous homolog 3 isoform X2 [KO:K05745]
110304964  Baiap2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
110291342  Enah; protein enabled homolog isoform X2 [KO:K05746]
110296116  Wasl; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
110292514  Wasf2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
110304334  Cyfip2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
110297607  Cyfip1; cytoplasmic FMR1-interacting protein 1 isoform X2 [KO:K05749]
110309310  Nckap1; nck-associated protein 1 isoform X3 [KO:K05750]
110310183  Nckap1l; nck-associated protein 1-like [KO:K05750]
110289993  Abi2; abl interactor 2 isoform X7 [KO:K05751]
110296220  Brk1; protein BRICK1 [KO:K05752]
110303189  Wasf1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
110305500  Actr2; actin-related protein 2 isoform X2 [KO:K17260]
110290273  Actr3; actin-related protein 3 [KO:K18584]
110294128  Arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
110294284  Arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
110290663  Arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
110294933  Arpc3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
110295988  Arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
110288098  Arpc5l; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
110289494  Arpc5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
110304283  Actg1; actin, cytoplasmic 2 [KO:K05692]
110295381  Actb; actin, cytoplasmic 1 [KO:K05692]
110307436  Pfn4; profilin-4 [KO:K05759]
110308017  Pfn3; profilin-3 [KO:K05759]
110287579  Pfn2; profilin-2 [KO:K05759]
110305574  Pfn1; profilin-1 [KO:K05759]
115030076  profilin-1-like [KO:K05759]
110293855  Pxn; paxillin isoform X1 [KO:K05760]
110312486  Ezr; ezrin [KO:K08007]
110300986  Rdx; radixin isoform X1 [KO:K05762]
110286791  Msn; moesin [KO:K05763]
110286700  Tmsb4x; thymosin beta-4 [KO:K05764]
110285390  Cfl1; cofilin-1 [KO:K05765]
110306732  Cfl2; cofilin-2 [KO:K05765]
110305902  Ssh2; protein phosphatase Slingshot homolog 2 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
110285524  Ssh3; protein phosphatase Slingshot homolog 3 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
110294703  Ssh1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
110309685  Vcl; vinculin isoform X2 [KO:K05700]
110299257  Iqgap1; ras GTPase-activating-like protein IQGAP1 isoform X1 [KO:K16848]
110290953  Iqgap3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
110308367  Iqgap2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
110306680  Scin; adseverin [KO:K05768]
110290215  Gsn; gelsolin isoform X1 [KO:K05768]
110298906  Actn4; alpha-actinin-4 isoform X1 [KO:K05699]
110306555  Actn1; alpha-actinin-1 [KO:K05699]
110284455  Apc; adenomatous polyposis coli protein isoform X4 [KO:K02085]
110303367  Apc2; adenomatous polyposis coli protein 2 isoform X2 [KO:K02085]
110309852  Spata13; spermatogenesis-associated protein 13 isoform X3 [KO:K05769]
110304799  Arhgef4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
mcal04010  MAPK signaling pathway
mcal04510  Focal adhesion
mcal04520  Adherens junction
KO pathway
ko04810   
LinkDB

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