Entry Name MicroRNAs in cancer - Mirounga leonina (Southern elephant seal)
Description MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article.
Class Human Diseases; Cancer: overviewBRITE hierarchy
Pathway map Ortholog table Organism Mirounga leonina (Southern elephant seal) [GN:
mlx ]
Gene 118000307 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539 ]
117998428 ZEB1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299 ]
118014087 TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
118012474 ZEB2; zinc finger E-box-binding homeobox 2 isoform X1 [KO:K23560 ]
118005041 RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850 ]
118009545 SLC7A1; high affinity cationic amino acid transporter 1 isoform X1 [KO:K13863 ]
118024910 STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
118016863 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
118019468 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
118006042 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
118004424 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
118020028 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
118006556 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
118023315 HNRNPK; heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886 ]
118017952 RECK; reversion-inducing cysteine-rich protein with Kazal motifs isoform X1 [KO:K17461 ]
118017516 NOTCH1; neurogenic locus notch homolog protein 1 isoform X1 [KO:K02599 ]
118000453 NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994 ]
118006072 NOTCH3; neurogenic locus notch homolog protein 3 isoform X1 [KO:K20995 ]
118027299 NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996 ]
118002349 DICER1; endoribonuclease Dicer isoform X1 [KO:K11592 ] [EC:3.1.26.-]
118025052 IGF2BP1; insulin-like growth factor 2 mRNA-binding protein 1 isoform X1 [KO:K17391 ]
118027047 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
118011488 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
117999262 PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
117998664 PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386 ]
118000549 MARCKS; myristoylated alanine-rich C-kinase substrate [KO:K12561 ]
Reference Authors Lee YS, Dutta A
Title MicroRNAs in cancer.
Journal Reference Authors Babashah S, Soleimani M
Title The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis.
Journal Reference Authors Garzon R, Calin GA, Croce CM
Title MicroRNAs in Cancer.
Journal Reference Authors Chen PS, Su JL, Hung MC
Title Dysregulation of microRNAs in cancer.
Journal Reference Authors Ling H, Zhang W, Calin GA
Title Principles of microRNA involvement in human cancers.
Journal Reference Authors Iorio MV, Croce CM
Title MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.
Journal Reference Authors Sayed D, Abdellatif M
Title MicroRNAs in development and disease.
Journal Reference Authors Wang Q, Wang S, Wang H, Li P, Ma Z
Title MicroRNAs: novel biomarkers for lung cancer diagnosis, prediction and treatment.
Journal Reference Authors Song JH, Meltzer SJ
Title MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers.
Journal Reference Authors Chu Y, Zhu H, Lv L, Zhou Y, Huo J
Title MiRNA s in oesophageal squamous cancer.
Journal Neth J Med 71:69-75 (2013)
Reference Authors Kan T, Meltzer SJ
Title MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma.
Journal Reference Authors Smith CM, Watson DI, Michael MZ, Hussey DJ
Title MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma.
Journal Reference Authors Song S, Ajani JA
Title The role of microRNAs in cancers of the upper gastrointestinal tract.
Journal Reference Authors Liu WH, Yeh SH, Chen PJ
Title Role of microRNAs in hepatitis B virus replication and pathogenesis.
Journal Reference Authors Hrasovec S, Glavac D
Title MicroRNAs as Novel Biomarkers in Colorectal Cancer.
Journal Reference Authors Liu H
Title MicroRNAs in breast cancer initiation and progression.
Journal Reference Authors Li SD, Zhang JR, Wang YQ, Wan XP
Title The role of microRNAs in ovarian cancer initiation and progression.
Journal Reference Authors Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA
Title Characteristic patterns of microRNA expression in human bladder cancer.
Journal Reference Authors Saini S, Majid S, Dahiya R
Title Diet, microRNAs and prostate cancer.
Journal Related KO pathway LinkDB All DBs
