KEGG   PATHWAY: mmu05207
Entry
mmu05207                    Pathway                                
Name
Chemical carcinogenesis - receptor activation - Mus musculus (house mouse)
Description
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stages. Chemicals or environmental factors may act at any of these stages to induce and/or enhance the carcinogenic process. Based on their mode-of-action, carcinogens can be classified as genotoxic or non-genotoxic. Genotoxic agent begins their action at the deoxyribonucleic acid (DNA) level, causing DNA damage through several mechanisms. Non-genotoxic carcinogens are chemicals that cause the development of tumors through multiple non-genotoxic events and epigenetic alterations without direct interaction with DNA. One non-genotoxic mechanism involves receptor activation. Biological mechanisms involving receptor activation fall into two broad categories: (i) those that involve cell surface receptors and some intracellular receptors that activate signal transduction pathways, resulting in biological responses, including gene transcription, and (ii) those that involve intracellular receptors that translocate into the nucleus and act as transcription factors regulating gene expression. Both classes of receptors can be involved in mechanisms of carcinogenesis.
Class
Human Diseases; Cancer: overview
Pathway map
mmu05207  Chemical carcinogenesis - receptor activation
mmu05207

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100041375  Cyp3a41b; cytochrome P450, family 3, subfamily a, polypeptide 41B [KO:K07424] [EC:1.14.14.1]
100041449  Cyp3a59; cytochrome P450, family 3, subfamily a, polypeptide 59 [KO:K07424] [EC:1.14.14.1]
100042295  Gsta13; glutathione S-transferase alpha 13 [KO:K00799] [EC:2.5.1.18]
100042314  Gsta5; glutathione S-transferase alpha 5 [KO:K00799] [EC:2.5.1.18]
100043508  Ptges3-ps; prostaglandin E synthase 3, pseudogene [KO:K15730] [EC:5.3.99.3]
100559  Ugt2b38; UDP glucuronosyltransferase 2 family, polypeptide B38 [KO:K00699] [EC:2.4.1.17]
100727  Ugt2b34; UDP glucuronosyltransferase 2 family, polypeptide B34 [KO:K00699] [EC:2.4.1.17]
102465198  Mir7j; microRNA 7j [KO:K16980]
102465309  Mir7k; microRNA 7k [KO:K16980]
103140  Gstt3; glutathione S-transferase, theta 3 [KO:K00799] [EC:2.5.1.18]
104110  Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
104111  Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
108015  Chrnb4; cholinergic receptor, nicotinic, beta polypeptide 4 [KO:K04815]
109689  Arrb1; arrestin, beta 1 [KO:K04439]
110157  Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:2.7.11.1]
110651  Rps6ka3; ribosomal protein S6 kinase polypeptide 3 [KO:K04373] [EC:2.7.11.1]
110834  Chrna3; cholinergic receptor, nicotinic, alpha polypeptide 3 [KO:K04805]
112417  Ugt2b37; UDP glucuronosyltransferase 2 family, polypeptide B37 [KO:K00699] [EC:2.4.1.17]
114230  Aipl1; aryl hydrocarbon receptor-interacting protein-like 1 [KO:K17767]
11438  Chrna4; cholinergic receptor, nicotinic, alpha polypeptide 4 [KO:K04806]
11441  Chrna7; cholinergic receptor, nicotinic, alpha polypeptide 7 [KO:K04809]
11444  Chrnb2; cholinergic receptor nicotinic beta 2 subunit [KO:K04813]
11512  Adcy6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
11513  Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
11514  Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
11515  Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
11554  Adrb1; adrenergic receptor, beta 1 [KO:K04141]
11555  Adrb2; adrenergic receptor, beta 2 [KO:K04142]
11556  Adrb3; adrenergic receptor, beta 3 [KO:K04143]
11622  Ahr; aryl-hydrocarbon receptor [KO:K09093]
11632  Aip; aryl-hydrocarbon receptor-interacting protein [KO:K17767]
11651  Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
11798  Xiap; X-linked inhibitor of apoptosis [KO:K04725] [EC:2.3.2.27]
11799  Birc5; baculoviral IAP repeat-containing 5 [KO:K08731]
11835  Ar; androgen receptor [KO:K08557]
11863  Arnt; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
11909  Atf2; activating transcription factor 2 [KO:K04450]
11911  Atf4; activating transcription factor 4 [KO:K04374]
12015  Bad; BCL2-associated agonist of cell death [KO:K02158]
12043  Bcl2; B cell leukemia/lymphoma 2 [KO:K02161]
12053  Bcl6; B cell leukemia/lymphoma 6 [KO:K15618]
12224  Klf5; Kruppel-like transcription factor 5 [KO:K09206]
12286  Cacna1a; calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [KO:K04344]
12287  Cacna1b; calcium channel, voltage-dependent, N type, alpha 1B subunit [KO:K04849]
12288  Cacna1c; calcium channel, voltage-dependent, L type, alpha 1C subunit [KO:K04850]
12289  Cacna1d; calcium channel, voltage-dependent, L type, alpha 1D subunit [KO:K04851]
12292  Cacna1s; calcium channel, voltage-dependent, L type, alpha 1S subunit [KO:K04857]
12355  Nr1i3; nuclear receptor subfamily 1, group I, member 3 [KO:K08541]
12443  Ccnd1; cyclin D1 [KO:K04503]
12445  Ccnd3; cyclin D3 [KO:K10152]
12530  Cdc25a; cell division cycle 25A [KO:K06645] [EC:3.1.3.48]
12912  Creb1; cAMP responsive element binding protein 1 [KO:K05870]
12913  Creb3; cAMP responsive element binding protein 3 [KO:K09048]
12915  Atf6b; activating transcription factor 6 beta [KO:K09049]
13076  Cyp1a1; cytochrome P450, family 1, subfamily a, polypeptide 1 [KO:K07408] [EC:1.14.14.1]
13077  Cyp1a2; cytochrome P450, family 1, subfamily a, polypeptide 2 [KO:K07409] [EC:1.14.14.1]
13078  Cyp1b1; cytochrome P450, family 1, subfamily b, polypeptide 1 [KO:K07410] [EC:1.14.14.1]
13088  Cyp2b10; cytochrome P450, family 2, subfamily b, polypeptide 10 [KO:K07412] [EC:1.14.14.1]
13089  Cyp2b13; cytochrome P450, family 2, subfamily b, polypeptide 13 [KO:K07412] [EC:1.14.14.1]
13090  Cyp2b19; cytochrome P450, family 2, subfamily b, polypeptide 19 [KO:K07412] [EC:1.14.14.1]
13094  Cyp2b9; cytochrome P450, family 2, subfamily b, polypeptide 9 [KO:K07412] [EC:1.14.14.1]
13112  Cyp3a11; cytochrome P450, family 3, subfamily a, polypeptide 11 [KO:K07424] [EC:1.14.14.1]
13113  Cyp3a13; cytochrome P450, family 3, subfamily a, polypeptide 13 [KO:K07424] [EC:1.14.14.1]
13114  Cyp3a16; cytochrome P450, family 3, subfamily a, polypeptide 16 [KO:K07424] [EC:1.14.14.1]
13388  Dll1; delta like canonical Notch ligand 1 [KO:K06051]
13389  Dll3; delta like canonical Notch ligand 3 [KO:K06051]
13555  E2f1; E2F transcription factor 1 [KO:K17454]
13645  Egf; epidermal growth factor [KO:K04357]
13649  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
13685  Eif4ebp1; eukaryotic translation initiation factor 4E binding protein 1 [KO:K07205]
13849  Ephx1; epoxide hydrolase 1, microsomal [KO:K01253] [EC:3.3.2.9]
13850  Ephx2; epoxide hydrolase 2, cytoplasmic [KO:K08726] [EC:3.3.2.10 3.1.3.76]
13982  Esr1; estrogen receptor 1 (alpha) [KO:K08550]
13983  Esr2; estrogen receptor 2 (beta) [KO:K08551]
14165  Fgf10; fibroblast growth factor 10 [KO:K04358]
14171  Fgf17; fibroblast growth factor 17 [KO:K04358]
14172  Fgf18; fibroblast growth factor 18 [KO:K04358]
14173  Fgf2; fibroblast growth factor 2 [KO:K18497]
14174  Fgf3; fibroblast growth factor 3 [KO:K04358]
14175  Fgf4; fibroblast growth factor 4 [KO:K04358]
14176  Fgf5; fibroblast growth factor 5 [KO:K04358]
14177  Fgf6; fibroblast growth factor 6 [KO:K04358]
14178  Fgf7; fibroblast growth factor 7 [KO:K04358]
14179  Fgf8; fibroblast growth factor 8 [KO:K04358]
14180  Fgf9; fibroblast growth factor 9 [KO:K04358]
14281  Fos; FBJ osteosarcoma oncogene [KO:K04379]
14677  Gnai1; G protein subunit alpha i1 [KO:K04630]
14678  Gnai2; G protein subunit alpha i2 [KO:K04630]
14679  Gnai3; G protein subunit alpha i3 [KO:K04630]
14683  Gnas; GNAS complex locus [KO:K04632]
14784  Grb2; growth factor receptor bound protein 2 [KO:K04364]
14857  Gsta1; glutathione S-transferase, alpha 1 (Ya) [KO:K00799] [EC:2.5.1.18]
14858  Gsta2; glutathione S-transferase, alpha 2 (Yc2) [KO:K00799] [EC:2.5.1.18]
14859  Gsta3; glutathione S-transferase, alpha 3 [KO:K00799] [EC:2.5.1.18]
14860  Gsta4; glutathione S-transferase, alpha 4 [KO:K00799] [EC:2.5.1.18]
14862  Gstm1; glutathione S-transferase, mu 1 [KO:K00799] [EC:2.5.1.18]
14863  Gstm2; glutathione S-transferase, mu 2 [KO:K00799] [EC:2.5.1.18]
14864  Gstm3; glutathione S-transferase, mu 3 [KO:K00799] [EC:2.5.1.18]
14865  Gstm4; glutathione S-transferase, mu 4 [KO:K00799] [EC:2.5.1.18]
14866  Gstm5; glutathione S-transferase, mu 5 [KO:K00799] [EC:2.5.1.18]
14867  Gstm6; glutathione S-transferase, mu 6 [KO:K00799] [EC:2.5.1.18]
14871  Gstt1; glutathione S-transferase, theta 1 [KO:K00799] [EC:2.5.1.18]
14872  Gstt2; glutathione S-transferase, theta 2 [KO:K00799] [EC:2.5.1.18]
14873  Gsto1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
15461  Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
15516  Hsp90ab1; heat shock protein 90 alpha (cytosolic), class B member 1 [KO:K04079]
15519  Hsp90aa1; heat shock protein 90, alpha (cytosolic), class A member 1 [KO:K04079]
16211  Kpnb1; karyopherin subunit beta 1 [KO:K14293]
16449  Jag1; jagged 1 [KO:K06052]
16452  Jak2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
16476  Jun; jun proto-oncogene [KO:K04448]
16600  Klf4; Kruppel-like transcription factor 4 (gut) [KO:K17846]
16646  Kpna1; karyopherin subunit alpha 1 [KO:K23940]
16647  Kpna2; karyopherin subunit alpha 2 [KO:K15043]
16648  Kpna3; karyopherin subunit alpha 3 [KO:K23583]
16649  Kpna4; karyopherin subunit alpha 4 [KO:K23583]
16650  Kpna6; karyopherin subunit alpha 6 [KO:K15042]
16653  Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
17869  Myc; myelocytomatosis oncogene [KO:K04377]
18033  Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
18129  Notch2; notch 2 [KO:K20994]
18176  Nras; neuroblastoma ras oncogene [KO:K07828]
18667  Pgr; progesterone receptor [KO:K08556]
18706  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
18707  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
18708  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
18709  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
18710  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
18747  Prkaca; protein kinase, cAMP dependent, catalytic, alpha [KO:K04345] [EC:2.7.11.11]
18749  Prkacb; protein kinase, cAMP dependent, catalytic, beta [KO:K04345] [EC:2.7.11.11]
18750  Prkca; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
18751  Prkcb; protein kinase C, beta [KO:K19662] [EC:2.7.11.13]
18752  Prkcg; protein kinase C, gamma [KO:K19663] [EC:2.7.11.13]
19013  Ppara; peroxisome proliferator activated receptor alpha [KO:K07294]
19645  Rb1; RB transcriptional corepressor 1 [KO:K06618]
19697  Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
20111  Rps6ka1; ribosomal protein S6 kinase polypeptide 1 [KO:K04373] [EC:2.7.11.1]
20112  Rps6ka2; ribosomal protein S6 kinase, polypeptide 2 [KO:K04373] [EC:2.7.11.1]
20181  Rxra; retinoid X receptor alpha [KO:K08524]
20182  Rxrb; retinoid X receptor beta [KO:K08525]
20183  Rxrg; retinoid X receptor gamma [KO:K08526]
20662  Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
20663  Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
20779  Src; Rous sarcoma oncogene [KO:K05704] [EC:2.7.10.2]
20848  Stat3; signal transducer and activator of transcription 3 [KO:K04692]
20850  Stat5a; signal transducer and activator of transcription 5A [KO:K11223]
20851  Stat5b; signal transducer and activator of transcription 5B [KO:K11224]
208647  Creb3l2; cAMP responsive element binding protein 3-like 2 [KO:K09048]
208677  Creb3l3; cAMP responsive element binding protein 3-like 3 [KO:K09048]
210044  Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
211666  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
216869  Arrb2; arrestin, beta 2 [KO:K04439]
21943  Tnfsf11; tumor necrosis factor (ligand) superfamily, member 11 [KO:K05473]
22027  Hsp90b1; heat shock protein 90, beta (Grp94), member 1 [KO:K09487]
22236  Ugt1a2; UDP glucuronosyltransferase 1 family, polypeptide A2 [KO:K00699] [EC:2.4.1.17]
22238  Ugt2b5; UDP glucuronosyltransferase 2 family, polypeptide B5 [KO:K00699] [EC:2.4.1.17]
22337  Vdr; vitamin D (1,25-dihydroxyvitamin D3) receptor [KO:K08539]
22339  Vegfa; vascular endothelial growth factor A [KO:K05448]
22408  Wnt1; wingless-type MMTV integration site family, member 1 [KO:K03209]
224129  Adcy5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
231252  Chrna9; cholinergic receptor, nicotinic, alpha polypeptide 9 [KO:K04810]
231396  Ugt2b36; UDP glucuronosyltransferase 2 family, polypeptide B36 [KO:K00699] [EC:2.4.1.17]
231991  Creb5; cAMP responsive element binding protein 5 [KO:K09047]
23797  Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
23834  Cdc6; cell division cycle 6 [KO:K02213]
243085  Ugt2b35; UDP glucuronosyltransferase 2 family, polypeptide B35 [KO:K00699] [EC:2.4.1.17]
243881  Cyp2b23; cytochrome P450, family 2, subfamily b, polypeptide 23 [KO:K07412] [EC:1.14.14.1]
26395  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
26396  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
26427  Creb3l1; cAMP responsive element binding protein 3-like 1 [KO:K09048]
337924  Cyp3a44; cytochrome P450, family 3, subfamily a, polypeptide 44 [KO:K07424] [EC:1.14.14.1]
381686  Kpna7; karyopherin subunit alpha 7 [KO:K15043]
384214  Ephx4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
387159  Mir141; microRNA 141 [KO:K17018]
387222  Mir29a; microRNA 29a [KO:K16995]
387223  Mir29b-1; microRNA 29b-1 [KO:K16996]
387224  Mir29c; microRNA 29c [KO:K16997]
387244  Mirlet7a-1; microRNA let7a-1 [KO:K16980]
387245  Mirlet7b; microRNA let7b [KO:K16980]
387247  Mirlet7d; microRNA let7d [KO:K16980]
387248  Mirlet7e; microRNA let7e [KO:K16980]
387249  Mirlet7g; microRNA let7g [KO:K16980]
387251  Mirlet7i; microRNA let7i [KO:K16980]
387252  Mirlet7f-1; microRNA let7f-1 [KO:K16980]
387253  Mirlet7f-2; microRNA let7f-2 [KO:K16980]
394430  Ugt1a10; UDP glycosyltransferase 1 family, polypeptide A10 [KO:K00699] [EC:2.4.1.17]
394432  Ugt1a7c; UDP glucuronosyltransferase 1 family, polypeptide A7C [KO:K00699] [EC:2.4.1.17]
394433  Ugt1a5; UDP glucuronosyltransferase 1 family, polypeptide A5 [KO:K00699] [EC:2.4.1.17]
394434  Ugt1a9; UDP glucuronosyltransferase 1 family, polypeptide A9 [KO:K00699] [EC:2.4.1.17]
394435  Ugt1a6b; UDP glucuronosyltransferase 1 family, polypeptide A6B [KO:K00699] [EC:2.4.1.17]
394436  Ugt1a1; UDP glucuronosyltransferase 1 family, polypeptide A1 [KO:K00699] [EC:2.4.1.17]
432530  Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
53973  Cyp3a41a; cytochrome P450, family 3, subfamily a, polypeptide 41A [KO:K07424] [EC:1.14.14.1]
54485  Dll4; delta like canonical Notch ligand 4 [KO:K06051]
54652  Cacna1f; calcium channel, voltage-dependent, alpha 1F subunit [KO:K04853]
552899  Ugt2a2; UDP glucuronosyltransferase 2 family, polypeptide A2 [KO:K00699] [EC:2.4.1.17]
56351  Ptges3; prostaglandin E synthase 3 [KO:K15730] [EC:5.3.99.3]
56388  Cyp3a25; cytochrome P450, family 3, subfamily a, polypeptide 25 [KO:K07424] [EC:1.14.14.1]
56489  Ikbke; inhibitor of kappaB kinase epsilon [KO:K07211] [EC:2.7.11.10]
56615  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
56717  Mtor; mechanistic target of rapamycin kinase [KO:K07203] [EC:2.7.11.1]
58988  Rps6kb2; ribosomal protein S6 kinase, polypeptide 2 [KO:K04688] [EC:2.7.11.1]
613123  Ugt1a8; UDP glucuronosyltransferase 1 family, polypeptide A8 [KO:K00699] [EC:2.4.1.17]
622127  Cyp3a57; cytochrome P450, family 3, subfamily a, polypeptide 57 [KO:K07424] [EC:1.14.14.1]
66447  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
67071  Rps6ka6; ribosomal protein S6 kinase polypeptide 6 [KO:K04373] [EC:2.7.11.1]
67112  Fgf22; fibroblast growth factor 22 [KO:K04358]
68214  Gsto2; glutathione S-transferase omega 2 [KO:K00799] [EC:2.5.1.18]
68312  Gstm7; glutathione S-transferase, mu 7 [KO:K00799] [EC:2.5.1.18]
71773  Ugt2b1; UDP glucuronosyltransferase 2 family, polypeptide B1 [KO:K00699] [EC:2.4.1.17]
71904  Paqr7; progestin and adipoQ receptor family member VII [KO:K25039]
71932  Ephx3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
72094  Ugt2a3; UDP glucuronosyltransferase 2 family, polypeptide A3 [KO:K00699] [EC:2.4.1.17]
723963  Mir29b-2; microRNA 29b-2 [KO:K16996]
723965  Mirlet7a-2; microRNA let7a-2 [KO:K16980]
72508  Rps6kb1; ribosomal protein S6 kinase, polypeptide 1 [KO:K04688] [EC:2.7.11.1]
74090  Paqr5; progestin and adipoQ receptor family member V [KO:K25041]
74229  Paqr8; progestin and adipoQ receptor family member VIII [KO:K25040]
74769  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
75886  Gstt4; glutathione S-transferase, theta 4 [KO:K00799] [EC:2.5.1.18]
78284  Creb3l4; cAMP responsive element binding protein 3-like 4 [KO:K09048]
80857  Fgf20; fibroblast growth factor 20 [KO:K04358]
80903  Fgf16; fibroblast growth factor 16 [KO:K04358]
94215  Ugt2a1; UDP glucuronosyltransferase 2 family, polypeptide A1 [KO:K00699] [EC:2.4.1.17]
94284  Ugt1a6a; UDP glucuronosyltransferase 1 family, polypeptide A6A [KO:K00699] [EC:2.4.1.17]
Compound
C00076  Calcium cation
C00410  Progesterone
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00780  Serotonin
C00788  L-Adrenaline
C00951  Estradiol-17beta
C03690  Bis(2-ethylhexyl)phthalate
C04623  DDT
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06697  Arsenite
C06790  Trichloroethene
C06916  Clofibrate
C07020  Gemfibrozil
C07434  Phenobarbital
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C08150  Medroxyprogesterone acetate
C11042  Hexachlorobenzene
C11150  Trichloroacetate
C11371  Nafenopin
C11906  Sodium arsenite
C13624  Bisphenol A
C14240  Di(2-ethylhexyl) adipate
C14573  3,3',4,4',5-Pentachlorobiphenyl
C15995  Bombesin
C16452  N'-Nitrosonornicotine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Reference
PMID:15660110
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
Reference
PMID:19631282
  Authors
Hernandez LG, van Steeg H, Luijten M, van Benthem J
  Title
Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach.
  Journal
Mutat Res 682:94-109 (2009)
DOI:10.1016/j.mrrev.2009.07.002
Reference
PMID:21444681
  Authors
Wu CH, Lee CH, Ho YS
  Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
  Journal
Clin Cancer Res 17:3533-41 (2011)
DOI:10.1158/1078-0432.CCR-10-2434
Reference
PMID:19194381
  Authors
Schuller HM
  Title
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
  Journal
Nat Rev Cancer 9:195-205 (2009)
DOI:10.1038/nrc2590
Reference
PMID:21541211
  Authors
Singh S, Pillai S, Chellappan S
  Title
Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.
  Journal
J Oncol 2011:456743 (2011)
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Reference
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Related
pathway
mmu00980  Metabolism of xenobiotics by cytochrome P450
mmu03320  PPAR signaling pathway
mmu04010  MAPK signaling pathway
mmu04024  cAMP signaling pathway
mmu04150  mTOR signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04370  VEGF signaling pathway
mmu04915  Estrogen signaling pathway
mmu05204  Chemical carcinogenesis - DNA adducts
mmu05206  MicroRNAs in cancer
mmu05208  Chemical carcinogenesis - reactive oxygen species
KO pathway
ko05207   

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