KEGG   PATHWAY: mmu05208
Entry
mmu05208                    Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Mus musculus (house mouse)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
mmu05208  Chemical carcinogenesis - reactive oxygen species
mmu05208

Organism
Mus musculus (house mouse) [GN:mmu]
Gene
100041273  Ndufb4c; NADH:ubiquinone oxidoreductase subunit B4C [KO:K03960]
100042295  Gsta13; glutathione S-transferase alpha 13 [KO:K00799] [EC:2.5.1.18]
100042314  Gsta5; glutathione S-transferase alpha 5 [KO:K00799] [EC:2.5.1.18]
100042503  Ndufb4b; NADH:ubiquinone oxidoreductase subunit B4B [KO:K03960]
100502727  Gm19340; predicted gene, 19340 [KO:K03949]
101540  Prkd2; protein kinase D2 [KO:K06070] [EC:2.7.11.13]
102631912  Ndufb1; NADH:ubiquinone oxidoreductase subunit B1 [KO:K03957]
102633050  Gm6293; predicted pseudogene 6293 [KO:K00419]
102633230  Gm11633; predicted gene 11633 [KO:K02264]
102634451  Ndufab1-ps; NADH:ubiquinone oxidoreductase subunit AB1b [KO:K03955]
103140  Gstt3; glutathione S-transferase, theta 3 [KO:K00799] [EC:2.5.1.18]
104130  Ndufb11; NADH:ubiquinone oxidoreductase subunit B11 [KO:K11351]
105675  Ppif; peptidylprolyl isomerase F (cyclophilin F) [KO:K09565] [EC:5.2.1.8]
109880  Braf; Braf transforming gene [KO:K04365] [EC:2.7.11.1]
110157  Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:2.7.11.1]
110323  Cox6b1; cytochrome c oxidase, subunit 6B1 [KO:K02267]
11350  Abl1; c-abl oncogene 1, non-receptor tyrosine kinase [KO:K06619] [EC:2.7.10.2]
11352  Abl2; ABL proto-oncogene 2, non-receptor tyrosine kinase [KO:K08887] [EC:2.7.10.2]
11431  Acp1; acid phosphatase 1, soluble [KO:K14394] [EC:3.1.3.2 3.1.3.48]
11622  Ahr; aryl-hydrocarbon receptor [KO:K09093]
11651  Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
11739  Slc25a4; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 [KO:K05863]
11740  Slc25a5; solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5 [KO:K05863]
11836  Araf; Araf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
11863  Arnt; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
11946  Atp5f1a; ATP synthase F1 subunit alpha [KO:K02132]
11947  Atp5f1b; ATP synthase F1 subunit beta [KO:K02133] [EC:7.1.2.2]
11949  Atp5f1c; ATP synthase F1 subunit gamma [KO:K02136]
11950  Atp5pb; ATP synthase peripheral stalk-membrane subunit b [KO:K02127]
11951  Atp5mc1; ATP synthase membrane subunit c locus 1 [KO:K02128]
11957  Atp5pf; ATP synthase peripheral stalk subunit F6 [KO:K02131]
12015  Bad; BCL2-associated agonist of cell death [KO:K02158]
12359  Cat; catalase [KO:K03781] [EC:1.11.1.6]
12408  Cbr1; carbonyl reductase 1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
12675  Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
12857  Cox4i1; cytochrome c oxidase subunit 4I1 [KO:K02263]
12858  Cox5a; cytochrome c oxidase subunit 5A [KO:K02264]
12859  Cox5b; cytochrome c oxidase subunit 5B [KO:K02265]
12861  Cox6a1; cytochrome c oxidase subunit 6A1 [KO:K02266]
12862  Cox6a2; cytochrome c oxidase subunit 6A2 [KO:K02266]
12864  Cox6c; cytochrome c oxidase subunit 6C [KO:K02268]
12865  Cox7a1; cytochrome c oxidase subunit 7A1 [KO:K02270]
12866  Cox7a2; cytochrome c oxidase subunit 7A2 [KO:K02270]
12867  Cox7c; cytochrome c oxidase subunit 7C [KO:K02272]
12868  Cox8a; cytochrome c oxidase subunit 8A [KO:K02273]
12869  Cox8b; cytochrome c oxidase subunit 8B [KO:K02273]
13057  Cyba; cytochrome b-245, alpha polypeptide [KO:K08009]
13076  Cyp1a1; cytochrome P450, family 1, subfamily a, polypeptide 1 [KO:K07408] [EC:1.14.14.1]
13077  Cyp1a2; cytochrome P450, family 1, subfamily a, polypeptide 2 [KO:K07409] [EC:1.14.14.1]
13078  Cyp1b1; cytochrome P450, family 1, subfamily b, polypeptide 1 [KO:K07410] [EC:1.14.14.1]
13106  Cyp2e1; cytochrome P450, family 2, subfamily e, polypeptide 1 [KO:K07415] [EC:1.14.14.-]
13107  Cyp2f2; cytochrome P450, family 2, subfamily f, polypeptide 2 [KO:K07416] [EC:1.14.14.1]
13521  Slc26a2; solute carrier family 26 (sulfate transporter), member 2 [KO:K14701]
13645  Egf; epidermal growth factor [KO:K04357]
13649  Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
13849  Ephx1; epoxide hydrolase 1, microsomal [KO:K01253] [EC:3.3.2.9]
13850  Ephx2; epoxide hydrolase 2, cytoplasmic [KO:K08726] [EC:3.3.2.10 3.1.3.76]
14083  Ptk2; PTK2 protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
14281  Fos; FBJ osteosarcoma oncogene [KO:K04379]
14784  Grb2; growth factor receptor bound protein 2 [KO:K04364]
14857  Gsta1; glutathione S-transferase, alpha 1 (Ya) [KO:K00799] [EC:2.5.1.18]
14858  Gsta2; glutathione S-transferase, alpha 2 (Yc2) [KO:K00799] [EC:2.5.1.18]
14859  Gsta3; glutathione S-transferase, alpha 3 [KO:K00799] [EC:2.5.1.18]
14860  Gsta4; glutathione S-transferase, alpha 4 [KO:K00799] [EC:2.5.1.18]
14862  Gstm1; glutathione S-transferase, mu 1 [KO:K00799] [EC:2.5.1.18]
14863  Gstm2; glutathione S-transferase, mu 2 [KO:K00799] [EC:2.5.1.18]
14864  Gstm3; glutathione S-transferase, mu 3 [KO:K00799] [EC:2.5.1.18]
14865  Gstm4; glutathione S-transferase, mu 4 [KO:K00799] [EC:2.5.1.18]
14866  Gstm5; glutathione S-transferase, mu 5 [KO:K00799] [EC:2.5.1.18]
14867  Gstm6; glutathione S-transferase, mu 6 [KO:K00799] [EC:2.5.1.18]
14871  Gstt1; glutathione S-transferase, theta 1 [KO:K00799] [EC:2.5.1.18]
14872  Gstt2; glutathione S-transferase, theta 2 [KO:K00799] [EC:2.5.1.18]
14873  Gsto1; glutathione S-transferase omega 1 [KO:K00799] [EC:2.5.1.18]
15234  Hgf; hepatocyte growth factor [KO:K05460]
15251  Hif1a; hypoxia inducible factor 1, alpha subunit [KO:K08268]
15368  Hmox1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
15461  Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
16150  Ikbkb; inhibitor of kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
16151  Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210]
16476  Jun; jun proto-oncogene [KO:K04448]
16653  Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
171429  Slc26a6; solute carrier family 26, member 6 [KO:K14704]
17295  Met; met proto-oncogene [KO:K05099] [EC:2.7.10.1]
17705  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
17706  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
17708  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
17709  COX2; cytochrome c oxidase subunit II [KO:K02261]
17710  COX3; cytochrome c oxidase subunit III [KO:K02262]
17711  CYTB; cytochrome b [KO:K00412]
17716  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
17717  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
17718  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
17719  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
17720  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
17721  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
17722  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
17969  Ncf1; neutrophil cytosolic factor 1 [KO:K08011]
17970  Ncf2; neutrophil cytosolic factor 2 [KO:K08010]
17991  Ndufa2; NADH:ubiquinone oxidoreductase subunit A2 [KO:K03946]
17992  Ndufa4; Ndufa4, mitochondrial complex associated [KO:K03948]
17993  Ndufs4; NADH:ubiquinone oxidoreductase core subunit S4 [KO:K03937]
17995  Ndufv1; NADH:ubiquinone oxidoreductase core subunit V1 [KO:K03942] [EC:7.1.1.2]
18024  Nfe2l2; nuclear factor, erythroid derived 2, like 2 [KO:K05638]
18033  Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
18035  Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734]
18104  Nqo1; NAD(P)H dehydrogenase, quinone 1 [KO:K00355] [EC:1.6.5.2]
18176  Nras; neuroblastoma ras oncogene [KO:K07828]
18607  Pdpk1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
18706  Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
18707  Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
18708  Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
18709  Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
18710  Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
18753  Prkcd; protein kinase C, delta [KO:K06068] [EC:2.7.11.13]
18760  Prkd1; protein kinase D1 [KO:K06070] [EC:2.7.11.13]
18805  Pld1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
18806  Pld2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
19094  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
19211  Pten; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
19246  Ptpn1; protein tyrosine phosphatase, non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
19247  Ptpn11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
19271  Ptprj; protein tyrosine phosphatase receptor type J [KO:K05698] [EC:3.1.3.48]
19353  Rac1; Rac family small GTPase 1 [KO:K04392]
19697  Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
20463  Cox7a2l; cytochrome c oxidase subunit 7A2 like [KO:K02270]
20655  Sod1; superoxide dismutase 1, soluble [KO:K04565] [EC:1.15.1.1]
20656  Sod2; superoxide dismutase 2, mitochondrial [KO:K04564] [EC:1.15.1.1]
20662  Sos1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
20663  Sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
20779  Src; Rous sarcoma oncogene [KO:K05704] [EC:2.7.10.2]
211666  Mgst2; microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
22272  Uqcrq; ubiquinol-cytochrome c reductase, complex III subunit VII [KO:K00418]
22273  Uqcrc1; ubiquinol-cytochrome c reductase core protein 1 [KO:K00414]
22333  Vdac1; voltage-dependent anion channel 1 [KO:K05862]
22334  Vdac2; voltage-dependent anion channel 2 [KO:K15040]
22335  Vdac3; voltage-dependent anion channel 3 [KO:K15041]
22339  Vegfa; vascular endothelial growth factor A [KO:K05448]
225887  Ndufs8; NADH:ubiquinone oxidoreductase core subunit S8 [KO:K03941] [EC:7.1.1.2]
226646  Ndufs2; NADH:ubiquinone oxidoreductase core subunit S2 [KO:K03935] [EC:7.1.1.2]
227197  Ndufs1; NADH:ubiquinone oxidoreductase core subunit S1 [KO:K03934] [EC:7.1.1.2]
228033  Atp5mc3; ATP synthase membrane subunit c locus 3 [KO:K02128]
230075  Ndufb6; NADH:ubiquinone oxidoreductase subunit B6 [KO:K03962]
231583  Slc26a1; solute carrier family 26 (sulfate transporter), member 1 [KO:K14700]
237038  Nox1; NADPH oxidase 1 [KO:K08008]
23797  Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
26395  Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
26396  Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
26398  Map2k4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
26400  Map2k7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
26408  Map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
26413  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26414  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
26415  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
26416  Mapk14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
26417  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
26419  Mapk8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
26420  Mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
28080  Atp5po; ATP synthase peripheral stalk subunit OSCP [KO:K02137]
29857  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
320718  Slc26a9; solute carrier family 26, member 9 [KO:K14706]
333182  Cox6b2; cytochrome c oxidase subunit 6B2 [KO:K02267]
384214  Ephx4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
407785  Ndufs6; NADH:ubiquinone oxidoreductase core subunit S6 [KO:K03939]
407790  Ndufa4l2; Ndufa4, mitochondrial complex associated like 2 [KO:K03948]
50490  Nox4; NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
50868  Keap1; kelch-like ECH-associated protein 1 [KO:K10456]
53859  Map3k14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
54405  Ndufa1; NADH:ubiquinone oxidoreductase subunit A1 [KO:K03945]
56484  Foxo3; forkhead box O3 [KO:K09408]
56615  Mgst1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
57344  As3mt; arsenite methyltransferase [KO:K07755] [EC:2.1.1.137]
58810  Akr1a1; aldo-keto reductase family 1, member A1 [KO:K00002] [EC:1.1.1.2]
595136  Ndufs5; NADH:ubiquinone oxidoreductase core subunit S5 [KO:K03938]
623286  Ndufs6b; NADH:ubiquinone oxidoreductase subunit S6B [KO:K03939]
66043  Atp5f1d; ATP synthase F1 subunit delta [KO:K02134]
66046  Ndufb5; NADH:ubiquinone oxidoreductase subunit B5 [KO:K03961]
66052  Sdhc; succinate dehydrogenase complex, subunit C, integral membrane protein [KO:K00236]
66091  Ndufa3; NADH:ubiquinone oxidoreductase subunit A3 [KO:K03947]
66108  Ndufa9; NADH:ubiquinone oxidoreductase subunit A9 [KO:K03953]
66142  Cox7b; cytochrome c oxidase subunit 7B [KO:K02271]
66152  Uqcr10; ubiquinol-cytochrome c reductase, complex III subunit X [KO:K00419]
66218  Ndufb9; NADH:ubiquinone oxidoreductase subunit B9 [KO:K03965]
66377  Ndufc1; NADH:ubiquinone oxidoreductase subunit C1 [KO:K03967]
66414  Ndufa12; NADH:ubiquinone oxidoreductase subunit A12 [KO:K11352]
66416  Ndufa7; NADH:ubiquinone oxidoreductase subunit A7 [KO:K03951]
66445  Cyc1; cytochrome c-1 [KO:K00413]
66447  Mgst3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
66495  Ndufb3; NADH:ubiquinone oxidoreductase subunit B3 [KO:K03959]
66576  Uqcrh; ubiquinol-cytochrome c reductase hinge protein [KO:K00416]
66594  Uqcr11; ubiquinol-cytochrome c reductase, complex III subunit XI [KO:K00420]
66694  Uqcrfs1; ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [KO:K00411] [EC:7.1.1.8]
66916  Ndufb7; NADH:ubiquinone oxidoreductase subunit B7 [KO:K03963]
66925  Sdhd; succinate dehydrogenase complex, subunit D, integral membrane protein [KO:K00237]
66945  Sdha; succinate dehydrogenase complex, subunit A, flavoprotein (Fp) [KO:K00234] [EC:1.3.5.1]
67003  Uqcrc2; ubiquinol cytochrome c reductase core protein 2 [KO:K00415]
67126  Atp5f1e; ATP synthase F1 subunit epsilon [KO:K02135]
67130  Ndufa6; NADH:ubiquinone oxidoreductase subunit A6 [KO:K03950]
67184  Ndufa13; NADH:ubiquinone oxidoreductase subunit A13 [KO:K11353]
67264  Ndufb8; NADH:ubiquinone oxidoreductase subunit B8 [KO:K03964]
67273  Ndufa10; NADH:ubiquinone oxidoreductase subunit A10 [KO:K03954]
67530  Uqcrb; ubiquinol-cytochrome c reductase binding protein [KO:K00417]
67680  Sdhb; succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [KO:K00235] [EC:1.3.5.1]
67942  Atp5mc2; ATP synthase membrane subunit c locus 2 [KO:K02128]
68194  Ndufb4; NADH:ubiquinone oxidoreductase subunit B4 [KO:K03960]
68197  Ndufc2; NADH:ubiquinone oxidoreductase subunit C2 [KO:K03968]
68198  Ndufb2; NADH:ubiquinone oxidoreductase subunit B2 [KO:K03958]
68202  Ndufa5; NADH:ubiquinone oxidoreductase subunit A5 [KO:K03949]
68214  Gsto2; glutathione S-transferase omega 2 [KO:K00799] [EC:2.5.1.18]
68312  Gstm7; glutathione S-transferase, mu 7 [KO:K00799] [EC:2.5.1.18]
68342  Ndufb10; NADH:ubiquinone oxidoreductase subunit B10 [KO:K03966]
68349  Ndufs3; NADH:ubiquinone oxidoreductase core subunit S3 [KO:K03936] [EC:7.1.1.2]
68375  Ndufa8; NADH:ubiquinone oxidoreductase subunit A8 [KO:K03952]
69875  Ndufa11; NADH:ubiquinone oxidoreductase subunit A11 [KO:K03956]
70316  Ndufab1; NADH:ubiquinone oxidoreductase subunit AB1 [KO:K03955]
71679  Atp5pd; ATP synthase peripheral stalk subunit d [KO:K02138]
71932  Ephx3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
72900  Ndufv2; NADH:ubiquinone oxidoreductase core subunit V2 [KO:K03943] [EC:7.1.1.2]
73333  Slc25a31; solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 [KO:K05863]
74769  Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
75292  Prkd3; protein kinase D3 [KO:K06070] [EC:2.7.11.13]
75406  Ndufs7; NADH:ubiquinone oxidoreductase core subunit S7 [KO:K03940] [EC:7.1.1.2]
75483  Cox8c; cytochrome c oxidase subunit 8C [KO:K02273]
75886  Gstt4; glutathione S-transferase, theta 4 [KO:K00799] [EC:2.5.1.18]
76113  Lpo; lactoperoxidase [KO:K12550] [EC:1.11.1.7]
77337  Akr1c21; aldo-keto reductase family 1, member C21 [KO:K00212] [EC:1.1.1.149 1.1.1.357 1.3.1.20]
78174  Cox7b2; cytochrome c oxidase subunit 7B2 [KO:K02271]
78330  Ndufv3; NADH:ubiquinone oxidoreductase core subunit V3 [KO:K03944]
84682  Cox4i2; cytochrome c oxidase subunit 4I2 [KO:K02263]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Related
pathway
mmu00190  Oxidative phosphorylation
mmu00980  Metabolism of xenobiotics by cytochrome P450
mmu04010  MAPK signaling pathway
mmu04064  NF-kappa B signaling pathway
mmu04066  HIF-1 signaling pathway
mmu04151  PI3K-Akt signaling pathway
mmu04370  VEGF signaling pathway
mmu05207  Chemical carcinogenesis - receptor activation
mmu05211  Renal cell carcinoma
mmu05215  Prostate cancer
mmu05219  Bladder cancer
mmu05221  Acute myeloid leukemia
mmu05222  Small cell lung cancer
mmu05223  Non-small cell lung cancer
mmu05224  Breast cancer
mmu05225  Hepatocellular carcinoma
KO pathway
ko05208   

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