Entry
Name
Influenza A - Macaca thibetana thibetana (Pere David's macaque)
Description
Influenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains that cause pandemics arise from avian influenza virus by genetic reassortment among influenza viruses and two surface glycoproteins HA and NA form the basis of serologically distinct virus types. The innate immune system recognizes invaded virus through multiple mechanisms. Viral non-structural NS1 protein is a multifunctional virulence factor that interfere IFN-mediated antiviral response. It inhibits IFN production by blocking activation of transcription factors such as NF-kappa B and IRF3. NS1 further inhibits the activation of IFN-induced antiviral genes. PB1-F2 protein is another virulence factor that induce apoptosis of infected cells, which results in life-threatening bronchiolitis.
Class
Human Diseases; Infectious disease: viral
BRITE hierarchy
Pathway map
Ortholog table
Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:
mthb ]
Gene
126939871 calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348 ]
126948486 myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729 ]
126932637 signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
126931203 signal transducer and activator of transcription 2 isoform X1 [KO:K11221 ]
126952222 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
126952695 mamu class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
126952697 HLA class II histocompatibility antigen, DQ beta 1 chain [KO:K06752 ]
126952698 HLA class II histocompatibility antigen, DO beta chain [KO:K06752 ]
126952699 HLA class II histocompatibility antigen, DRB1 beta chain isoform X1 [KO:K06752 ]
126952700 HLA class II histocompatibility antigen, DRB1 beta chain isoform X1 [KO:K06752 ]
126952701 HLA class II histocompatibility antigen, DQ beta 1 chain isoform X1 [KO:K06752 ]
126952702 HLA class II histocompatibility antigen, DQ alpha 1 chain isoform X1 [KO:K06752 ]
126952777 HLA class II histocompatibility antigen, DP alpha 1 chain isoform X1 [KO:K06752 ]
126952785 HLA class II histocompatibility antigen, DO alpha chain isoform X1 [KO:K06752 ]
126952790 HLA class II histocompatibility antigen, DM beta chain [KO:K06752 ]
126952792 HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752 ]
126952793 HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752 ]
126952833 HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752 ]
126944252 apoptosis-associated speck-like protein containing a CARD [KO:K12799 ]
126961422 phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
126956531 phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
126942202 phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649 ]
126952893 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
126961267 tumor necrosis factor receptor superfamily member 10A isoform X1 [KO:K04722 ]
126961271 tumor necrosis factor receptor superfamily member 10B isoform X1 [KO:K04722 ]
126963192 tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
126930443 tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
126945020 tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171 ]
126950515 cleavage and polyadenylation specificity factor subunit 4 isoform X1 [KO:K14404 ]
126939916 putative cleavage and polyadenylation specificity factor subunit 4-like protein isoform X1 [KO:K14404 ]
126941751 heterogeneous nuclear ribonucleoprotein U-like protein 1 isoform X1 [KO:K15047 ]
126935015 LOW QUALITY PROTEIN: nuclear pore complex protein Nup98-Nup96 [KO:K14297 ]
126934173 radical S-adenosyl methionine domain-containing protein 2 [KO:K15045 ]
Compound
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference
Authors
Edinger TO, Pohl MO, Stertz S
Title
Entry of influenza A virus: host factors and antiviral targets.
Journal
Reference
Authors
Kido H, Okumura Y, Takahashi E, Pan HY, Wang S, Chida J, Le TQ, Yano M
Title
Host envelope glycoprotein processing proteases are indispensable for entry into human cells by seasonal and highly pathogenic avian influenza viruses.
Journal
J Mol Genet Med 3:167-75 (2008)
Reference
Authors
Ramakrishnan B, Viswanathan K, Tharakaraman K, Dancik V, Raman R, Babcock GJ, Shriver Z, Sasisekharan R
Title
A Structural and Mathematical Modeling Analysis of the Likelihood of Antibody-Dependent Enhancement in Influenza.
Journal
Reference
Authors
Thanh TT, van Doorn HR, de Jong MD
Title
Human H5N1 influenza: current insight into pathogenesis.
Journal
Reference
Authors
Michael P, Brabant D, Bleiblo F, Ramana CV, Rutherford M, Khurana S, Tai TC, Kumar A, Kumar A
Title
Influenza A induced cellular signal transduction pathways.
Journal
Reference
Authors
Hale BG, Albrecht RA, Garcia-Sastre A
Title
Innate immune evasion strategies of influenza viruses.
Journal
Reference
Authors
Sharma K, Tripathi S, Ranjan P, Kumar P, Garten R, Deyde V, Katz JM, Cox NJ, Lal RB, Sambhara S, Lal SK
Title
Influenza A virus nucleoprotein exploits Hsp40 to inhibit PKR activation.
Journal
Reference
Authors
Ehrhardt C, Seyer R, Hrincius ER, Eierhoff T, Wolff T, Ludwig S
Title
Interplay between influenza A virus and the innate immune signaling.
Journal
Reference
Authors
van de Sandt CE, Kreijtz JH, Rimmelzwaan GF
Title
Evasion of influenza A viruses from innate and adaptive immune responses.
Journal
Reference
Authors
Long JS, Mistry B, Haslam SM, Barclay WS
Title
Host and viral determinants of influenza A virus species specificity.
Journal
Reference
Authors
Chen X, Liu S, Goraya MU, Maarouf M, Huang S, Chen JL
Title
Host Immune Response to Influenza A Virus Infection.
Journal
Reference
Authors
Lu X, Masic A, Li Y, Shin Y, Liu Q, Zhou Y
Title
The PI3K/Akt pathway inhibits influenza A virus-induced Bax-mediated apoptosis by negatively regulating the JNK pathway via ASK1.
Journal
Reference
Authors
Ichinohe T, Iwasaki A, Hasegawa H
Title
Innate sensors of influenza virus: clues to developing better intranasal vaccines.
Journal
Reference
Authors
Le Sage V, Cinti A, Amorim R, Mouland AJ
Title
Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway.
Journal
Reference
Authors
Fan Y, Sanyal S, Bruzzone R
Title
Breaking Bad: How Viruses Subvert the Cell Cycle.
Journal
Reference
Authors
Varga ZT, Palese P
Title
The influenza A virus protein PB1-F2: killing two birds with one stone?
Journal
Reference
Authors
Atkin-Smith GK, Duan M, Chen W, Poon IKH
Title
The induction and consequences of Influenza A virus-induced cell death.
Journal
Reference
Authors
Nogales A, Martinez-Sobrido L, Topham DJ, DeDiego ML
Title
Modulation of Innate Immune Responses by the Influenza A NS1 and PA-X Proteins.
Journal
Reference
Authors
Dai X, Zhang L, Hong T
Title
Host cellular signaling induced by influenza virus.
Journal
Reference
Authors
Li J, Yu M, Zheng W, Liu W
Title
Nucleocytoplasmic shuttling of influenza A virus proteins.
Journal
Reference
Authors
Dou D, Revol R, Ostbye H, Wang H, Daniels R
Title
Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
Journal
Reference
Authors
Paterson D, Fodor E
Title
Emerging roles for the influenza A virus nuclear export protein (NEP).
Journal
Related pathway
mthb04620 Toll-like receptor signaling pathway
mthb04621 NOD-like receptor signaling pathway
mthb04622 RIG-I-like receptor signaling pathway
KO pathway
LinkDB
All DBs