KEGG   PATHWAY: ncar04360
Entry
ncar04360                   Pathway                                
Name
Axon guidance - Sciurus carolinensis (gray squirrel)
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
Pathway map
ncar04360  Axon guidance
ncar04360

Other DBs
GO: 0007411
Organism
Sciurus carolinensis (gray squirrel) [GN:ncar]
Gene
124963773  netrin-G1 isoform X1 [KO:K07522]
124964373  netrin-G2 isoform X1 [KO:K16359]
124958800  leucine-rich repeat-containing protein 4C [KO:K07523]
124990582  leucine-rich repeat-containing protein 4 [KO:K16351]
124980436  netrin-1 isoform X1 [KO:K06843]
124970219  netrin-3 [KO:K06844]
124983980  netrin-4 isoform X1 [KO:K06845]
124965531  netrin receptor DCC [KO:K06765]
124977089  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
124966613  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
124993142  short transient receptor potential channel 1 isoform X1 [KO:K04964]
124994631  short transient receptor potential channel 3 isoform X1 [KO:K04966]
124984917  short transient receptor potential channel 4 isoform X1 [KO:K04967]
124972009  short transient receptor potential channel 5 [KO:K04968]
124958780  short transient receptor potential channel 6 isoform X1 [KO:K04969]
124994051  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124984768  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124982403  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
124963548  calcineurin subunit B type 1 [KO:K06268]
124963939  calcineurin subunit B type 2 [KO:K06268]
124977074  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2-like [KO:K17332]
124966545  LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3-like [KO:K17333]
124976754  nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
124964882  focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
124988460  tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
124977049  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
124970154  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
124971456  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
124982630  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
124980331  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
124993558  cell division control protein 42 homolog [KO:K04393]
124990642  cell division control protein 42 homolog [KO:K04393]
124980858  cell division control protein 42 homolog isoform X1 [KO:K04393]
124986640  actin-binding LIM protein 3 isoform X1 [KO:K07520]
124994141  actin-binding LIM protein 2 isoform X1 [KO:K07520]
124985008  actin-binding LIM protein 1 isoform X1 [KO:K07520]
124992992  cytoplasmic protein NCK1 isoform X1 [KO:K07365]
124958584  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
124992680  serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
124992782  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
124993680  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
124993681  serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
124971789  serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
124967383  serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
124977925  serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
124977838  serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
124993416  transforming protein RhoA [KO:K04513]
124989136  transforming protein RhoA-like isoform X1 [KO:K04513]
124976920  transforming protein RhoA-like [KO:K04513]
124965296  rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
124962770  rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
124986674  netrin receptor UNC5A isoform X1 [KO:K07521]
124994855  netrin receptor UNC5C isoform X1 [KO:K07521]
124985069  netrin receptor UNC5B isoform X1 [KO:K07521]
124983769  netrin receptor UNC5D isoform X1 [KO:K07521]
124990645  tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
124977998  repulsive guidance molecule A isoform X1 [KO:K23096]
124976142  neogenin isoform X1 [KO:K06766]
124994326  myosin light chain 5 [KO:K12753]
124977953  myosin regulatory light polypeptide 9 [KO:K12755]
124991004  myosin regulatory light chain 12B-like [KO:K12757]
124985330  myosin regulatory light chain 12B-like [KO:K12757]
124965640  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
124965803  myosin regulatory light chain 12B [KO:K12757]
124958195  rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
124980837  leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1 [KO:K24609]
124992767  ephrin-A3 isoform X1 [KO:K05462]
124992967  ephrin-A4 [KO:K05462]
124987247  ephrin-A5 isoform X1 [KO:K05462]
124990608  ephrin-A1-like [KO:K05462]
124969343  ephrin-A2 isoform X1 [KO:K05462]
124966421  ephrin-A1-like [KO:K05462]
124985103  ephrin-B2 [KO:K05463]
124980243  ephrin-B3 [KO:K05463]
124972625  ephrin-B1 [KO:K05463]
124990383  ephrin type-A receptor 1 isoform X1 [KO:K05102] [EC:2.7.10.1]
124980445  ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
124993201  ephrin type-A receptor 3 isoform X1 [KO:K05104] [EC:2.7.10.1]
124980049  ephrin type-A receptor 4 [KO:K05105] [EC:2.7.10.1]
124994616  ephrin type-A receptor 5 isoform X1 [KO:K05106] [EC:2.7.10.1]
124992511  ephrin type-A receptor 6 isoform X1 [KO:K05107] [EC:2.7.10.1]
124988842  LOW QUALITY PROTEIN: ephrin type-A receptor 7-like [KO:K05108] [EC:2.7.10.1]
124958051  ephrin type-A receptor 8 isoform X1 [KO:K05109] [EC:2.7.10.1]
124992679  ephrin type-B receptor 1 isoform X1 [KO:K05110] [EC:2.7.10.1]
124991090  ephrin type-B receptor 2 isoform X1 [KO:K05111] [EC:2.7.10.1]
124993227  ephrin type-B receptor 3 [KO:K05112] [EC:2.7.10.1]
124970370  LOW QUALITY PROTEIN: ephrin type-B receptor 4-like [KO:K05113] [EC:2.7.10.1]
124990579  ephrin type-B receptor 6 [KO:K05114] [EC:2.7.10.1]
124965033  tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
124961547  protein enabled homolog isoform X1 [KO:K05746]
124987003  ras GTPase-activating protein 1 [KO:K04352]
124981124  ephexin-1 isoform X1 [KO:K07525]
124958599  GTPase HRas isoform X1 [KO:K02833]
124991017  GTPase KRas-like [KO:K07827]
124982118  GTPase KRas isoform X1 [KO:K07827]
124962389  GTPase NRas [KO:K07828]
124990635  LOW QUALITY PROTEIN: mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
124970294  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
124963574  cytoplasmic protein NCK2 [KO:K19862]
124964208  regulator of G-protein signaling 3-like isoform X1 [KO:K07524]
124980050  C-X-C chemokine receptor type 4 [KO:K04189]
124992673  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
124988012  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
124991078  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
124984845  slit homolog 1 protein [KO:K06838]
124994495  slit homolog 2 protein isoform X1 [KO:K06839]
124986565  slit homolog 3 protein isoform X1 [KO:K06850]
124992974  roundabout homolog 1 isoform X1 [KO:K06753]
124993090  roundabout homolog 2 isoform X1 [KO:K06754]
124958830  roundabout homolog 3 [KO:K06755]
124961057  SLIT-ROBO Rho GTPase-activating protein 2 isoform X1 [KO:K07526]
124970974  SLIT-ROBO Rho GTPase-activating protein 3 isoform X1 [KO:K07526]
124982596  SLIT-ROBO Rho GTPase-activating protein 1 isoform X1 [KO:K07526]
124990526  semaphorin-3C [KO:K06840]
124991119  semaphorin-3D [KO:K06840]
124991771  semaphorin-3A isoform X1 [KO:K06840]
124991781  semaphorin-3E isoform X1 [KO:K06840]
124992428  semaphorin-3B [KO:K06840]
124992609  semaphorin-3F isoform X1 [KO:K06840]
124969278  semaphorin-3G isoform X1 [KO:K06840]
124990849  plexin-A4 [KO:K06820]
124961540  LOW QUALITY PROTEIN: plexin-A2-like [KO:K06820]
124971046  plexin-A1 isoform X1 [KO:K06820]
124972392  plexin-A3 isoform X1 [KO:K06820]
124961609  neuropilin-1 isoform X1 [KO:K06724]
124972447  neural cell adhesion molecule L1 isoform X1 [KO:K06550]
124970750  LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
124990701  LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
124988512  cofilin-1-like [KO:K05765]
124992526  cofilin-1 [KO:K05765]
124959853  cofilin-1 [KO:K05765]
124978019  cofilin-2 isoform X1 [KO:K05765]
124963176  cofilin-2-like [KO:K05765]
124983224  cofilin-2-like [KO:K05765]
124958926  rho-related GTP-binding protein RhoD [KO:K07530]
124981884  LOW QUALITY PROTEIN: rho-related GTP-binding protein Rho6-like [KO:K07531]
124975997  tyrosine-protein kinase Fes/Fps isoform X1 [KO:K07527] [EC:2.7.10.2]
124963187  dihydropyrimidinase-related protein 5 [KO:K07529]
124983268  dihydropyrimidinase-related protein 2 [KO:K07528]
124990793  cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
124992642  LOW QUALITY PROTEIN: glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
124958876  semaphorin-4A isoform X1 [KO:K06521]
124984712  semaphorin-4G [KO:K06521]
124977681  semaphorin-4B isoform X1 [KO:K06521]
124963106  semaphorin-4C isoform X1 [KO:K06521]
124963118  semaphorin-4F isoform X1 [KO:K06521]
124965423  semaphorin-4D isoform X1 [KO:K06521]
124993797  semaphorin-5B isoform X1 [KO:K06841]
124987359  LOW QUALITY PROTEIN: semaphorin-5A-like [KO:K06841]
124987211  LOW QUALITY PROTEIN: semaphorin-6A-like [KO:K06842]
124977190  semaphorin-6D isoform X1 [KO:K06842]
124961542  semaphorin-6C isoform X1 [KO:K06842]
124969548  semaphorin-6B isoform X1 [KO:K06842]
124992570  plexin-B1 isoform X1 [KO:K06821]
124972435  plexin-B3 isoform X1 [KO:K06821]
124982514  plexin-B2 isoform X1 [KO:K06821]
124990426  hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
124971006  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
124967072  ras-related protein R-Ras [KO:K07829]
124976174  LOW QUALITY PROTEIN: semaphorin-7A-like [KO:K06529]
124982145  plexin-C1 isoform X1 [KO:K06572]
124961697  integrin beta-1 isoform X1 [KO:K05719]
124991984  sonic hedgehog protein isoform X1 [KO:K11988]
124965298  protein patched homolog 1 isoform X1 [KO:K06225]
124991730  smoothened homolog isoform X1 [KO:K06226]
124979014  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
124958328  LOW QUALITY PROTEIN: integrin-linked protein kinase-like [KO:K06272] [EC:2.7.11.1]
124993274  brother of CDO isoform X1 [KO:K20020]
124969304  protein Wnt-5a isoform X1 [KO:K00444]
124983449  protein Wnt-5b isoform X1 [KO:K00444]
124983712  frizzled-3 isoform X1 [KO:K02329]
124992653  tyrosine-protein kinase RYK isoform X1 [KO:K05128] [EC:2.7.10.1]
124985817  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
124986742  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
124994412  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
124990768  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
124994115  protein Wnt-4 isoform X1 [KO:K00408]
124993166  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
124993330  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
124963509  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
124986648  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
124968815  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
124970168  3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
124962289  partitioning defective 3 homolog isoform X1 [KO:K04237]
124983581  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
124977384  partitioning defective 6 homolog beta [KO:K06093]
124965238  partitioning defective 6 homolog gamma [KO:K06093]
124966637  partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
124990667  LOW QUALITY PROTEIN: protein phosphatase Slingshot homolog 1-like [KO:K05766] [EC:3.1.3.16 3.1.3.48]
124990942  LOW QUALITY PROTEIN: protein phosphatase Slingshot homolog 1-like [KO:K05766] [EC:3.1.3.16 3.1.3.48]
124960486  protein phosphatase Slingshot homolog 3-like isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
124979111  protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
124977828  bone morphogenetic protein 7 [KO:K16621]
124962717  growth/differentiation factor 7-like [KO:K20013]
124979034  bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
124994650  bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
Compound
C00076  Calcium cation
Reference
PMID:14682358
  Authors
Guan KL, Rao Y.
  Title
Signalling mechanisms mediating neuronal responses to guidance cues.
  Journal
Nat Rev Neurosci 4:941-56 (2003)
DOI:10.1038/nrn1254
Reference
PMID:15630019
  Authors
Govek EE, Newey SE, Van Aelst L.
  Title
The role of the Rho GTPases in neuronal development.
  Journal
Genes Dev 19:1-49 (2005)
DOI:10.1101/gad.1256405
Reference
PMID:12677003
  Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
  Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
  Journal
Annu Rev Neurosci 26:509-63 (2003)
DOI:10.1146/annurev.neuro.26.010302.081139
Reference
PMID:15818466
  Authors
Negishi M, Oinuma I, Katoh H.
  Title
Plexins: axon guidance and signal transduction.
  Journal
Cell Mol Life Sci 62:1363-71 (2005)
DOI:10.1007/s00018-005-5018-2
Reference
PMID:15363605
  Authors
Huot J.
  Title
Ephrin signaling in axon guidance.
  Journal
Prog Neuropsychopharmacol Biol Psychiatry 28:813-8 (2004)
DOI:10.1016/j.pnpbp.2004.05.025
Reference
PMID:11891122
  Authors
Patel BN, Van Vactor DL.
  Title
Axon guidance: the cytoplasmic tail.
  Journal
Curr Opin Cell Biol 14:221-9 (2002)
DOI:10.1016/S0955-0674(02)00308-3
Reference
PMID:11687826
  Authors
Yu TW, Bargmann CI.
  Title
Dynamic regulation of axon guidance.
  Journal
Nat Neurosci 4 Suppl:1169-76 (2001)
DOI:10.1038/nn748
Reference
PMID:12471249
  Authors
Dickson BJ.
  Title
Molecular mechanisms of axon guidance.
  Journal
Science 298:1959-64 (2002)
DOI:10.1126/science.1072165
Reference
PMID:15960985
  Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
  Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
  Journal
Brain Res Brain Res Rev 49:22-47 (2005)
DOI:10.1016/j.brainresrev.2004.11.003
Reference
PMID:15084255
  Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
  Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
  Journal
Cell 117:157-69 (2004)
DOI:10.1016/S0092-8674(04)00303-4
Reference
PMID:25374504
  Authors
Fujita Y, Yamashita T
  Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
  Journal
Front Neurosci 8:338 (2014)
DOI:10.3389/fnins.2014.00338
Reference
PMID:17169551
  Authors
Yamashita T, Mueller BK, Hata K
  Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
  Journal
Curr Opin Neurobiol 17:29-34 (2007)
DOI:10.1016/j.conb.2006.12.001
Reference
PMID:26651291
  Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
  Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
  Journal
Dev Cell 35:537-552 (2015)
DOI:10.1016/j.devcel.2015.11.008
Related
pathway
ncar04010  MAPK signaling pathway
ncar04060  Cytokine-cytokine receptor interaction
ncar04310  Wnt signaling pathway
ncar04810  Regulation of actin cytoskeleton
KO pathway
ko04360   
LinkDB

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