KEGG   PATHWAY: panu04621
Entry
panu04621                   Pathway                                
Name
NOD-like receptor signaling pathway - Papio anubis (olive baboon)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
panu04621  NOD-like receptor signaling pathway
panu04621

Organism
Papio anubis (olive baboon) [GN:panu]
Gene
101000342  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
101006774  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
100998877  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101016447  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5 [KO:K07209] [EC:2.7.11.10]
100998839  NFKBIB; NF-kappa-B inhibitor beta isoform X2 [KO:K02581]
101023751  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101026781  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X6 [KO:K02580]
101017078  RELA; transcription factor p65 isoform X1 [KO:K04735]
101023446  IL1B; interleukin-1 beta [KO:K04519]
101011371  IL18; interleukin-18 isoform X1 [KO:K05482]
100381195  IL6; interleukin-6 precursor [KO:K05405]
100381196  CXCL8; interleukin-8 precursor [KO:K10030]
103884403  growth-regulated alpha protein [KO:K05505]
101022800  growth-regulated alpha protein [KO:K05505]
101024554  growth-regulated alpha protein-like [KO:K05505]
101026663  CXCL1; growth-regulated alpha protein [KO:K05505]
100381197  CCL2; C-C motif chemokine 2 precursor [KO:K14624]
101025455  CCL5; C-C motif chemokine 5 isoform X1 [KO:K12499]
101017082  CAMP; cathelicidin antimicrobial peptide isoform X1 [KO:K13916]
101016942  neutrophil defensin 1 [KO:K05230]
101018347  neutrophil defensin 4 [KO:K05230]
100126731  DEFA1; neutrophil defensin 1 precursor [KO:K05230]
100126732  DEFA1; neutrophil defensin 1 precursor [KO:K05230]
100196939  BTDC; theta defensin subunit C precursor [KO:K05230]
100196940  BTDA; theta defensin subunit A precursor [KO:K05230]
100196941  BTDB; theta defensin subunit B precursor [KO:K05230]
101016209  LOW QUALITY PROTEIN: neutrophil defensin 4 [KO:K05230]
101026945  beta-defensin 4A-like [KO:K21100]
101002463  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
101013055  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
101011339  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
100997900  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
101023277  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
101012041  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101006756  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101005010  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101022320  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101019884  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101001103  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
101002393  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101024189  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101024771  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101010894  JUN; transcription factor AP-1 [KO:K04448]
101005309  ATG16L1; autophagy-related protein 16-1 isoform X2 [KO:K17890]
101010339  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
100997562  ATG12; LOW QUALITY PROTEIN: ubiquitin-like protein ATG12 [KO:K08336]
101011002  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
101020446  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 isoform X4 [KO:K08341]
101025519  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
108582275  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
110740813  MAP1LC3B2; LOW QUALITY PROTEIN: microtubule-associated proteins 1A/1B light chain 3 beta 2 [KO:K10435]
100999213  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B isoform X1 [KO:K10435]
101019892  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A isoform X2 [KO:K10435]
100999024  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
101012693  SUGT1; protein SGT1 homolog [KO:K12795]
101022832  SHARPIN; sharpin isoform X1 [KO:K20894]
101001673  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
101015955  RNF31; E3 ubiquitin-protein ligase RNF31 isoform X2 [KO:K11974] [EC:2.3.2.31]
100998457  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 8 [KO:K04725] [EC:2.3.2.27]
101022825  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
101014875  CARD6; caspase recruitment domain-containing protein 6 isoform X1 [KO:K12797]
101015787  TRIP6; thyroid receptor-interacting protein 6 isoform X1 [KO:K12792]
100998385  ERBIN; erbin isoform X8 [KO:K12796]
101026503  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X2 [KO:K16060]
100997299  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
101017914  TRAF2; LOW QUALITY PROTEIN: TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101024624  TRAF5; TNF receptor-associated factor 5 isoform X4 [KO:K09849]
101002649  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
100997650  CARD9; caspase recruitment domain-containing protein 9 isoform X4 [KO:K12794]
100998710  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X2 [KO:K11859] [EC:3.4.19.12]
101008300  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
101015482  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
100999858  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101001355  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X2 [KO:K07211] [EC:2.7.11.10]
101020486  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
101013579  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
101005316  IRF7; interferon regulatory factor 7 isoform X5 [KO:K09447]
101023828  LOW QUALITY PROTEIN: interferon alpha-21 [KO:K05414]
101016516  interferon alpha-1/13 [KO:K05414]
116270026  interferon alpha-1/13 [KO:K05414]
101019008  LOW QUALITY PROTEIN: interferon alpha-1/13 [KO:K05414]
101018652  LOW QUALITY PROTEIN: interferon alpha-1/13 [KO:K05414]
101017918  interferon alpha-8 [KO:K05414]
101018287  interferon alpha-2 [KO:K05414]
101019380  interferon alpha-6 [KO:K05414]
101021706  interferon alpha-14 [KO:K05414]
101023118  interferon alpha-4 [KO:K05414]
101024523  IFNB1; interferon beta [KO:K05415]
101003220  NLRX1; NLR family member X1 isoform X2 [KO:K12653]
101011593  ANTXR1; anthrax toxin receptor 1 isoform X2 [KO:K20909]
101025474  ANTXR2; anthrax toxin receptor 2 isoform X1 [KO:K20909]
101004175  NLRP1; NACHT, LRR and PYD domains-containing protein 1 isoform X1 [KO:K12798]
100998153  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
101008696  caspase-1-like isoform X1 [KO:K01370] [EC:3.4.22.36]
101006831  CASP1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
101009375  LOW QUALITY PROTEIN: caspase-1-like [KO:K01370] [EC:3.4.22.36]
101026183  BCL2; apoptosis regulator Bcl-2 isoform X3 [KO:K02161]
101019436  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
101007225  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
101007974  NLRP3; NACHT, LRR and PYD domains-containing protein 3 isoform X1 [KO:K12800]
101005908  PANX1; pannexin-1 [KO:K03443]
101017411  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
100999167  TRPM2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
101025161  transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
116268503  transient receptor potential cation channel subfamily M member 7-like isoform X1 [KO:K04982] [EC:2.7.11.1]
100998582  TRPV2; transient receptor potential cation channel subfamily V member 2 isoform X3 [KO:K04971]
116272421  transient receptor potential cation channel subfamily V member 2-like isoform X1 [KO:K04971]
101006482  CASR; extracellular calcium-sensing receptor isoform X1 [KO:K04612]
101014037  GPRC6A; LOW QUALITY PROTEIN: G-protein coupled receptor family C group 6 member A [KO:K04622]
101012903  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100998763  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100999120  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X5 [KO:K05858] [EC:3.1.4.11]
101010000  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4 [KO:K05858] [EC:3.1.4.11]
101017317  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
101023200  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
101001272  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
101020566  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
101009552  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
101019427  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
101002958  MCU; calcium uniporter protein, mitochondrial isoform X2 [KO:K20858]
101010639  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
101010277  OAS1; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
101015624  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
101012661  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
101001970  DHX33; ATP-dependent RNA helicase DHX33 [KO:K17820] [EC:5.6.2.6]
101006371  MFN1; mitofusin-1 isoform X1 [KO:K21356] [EC:3.6.5.-]
101024137  MFN2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
101011511  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X2 [KO:K02861] [EC:2.7.11.1]
101027042  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
101017170  DNM1L; dynamin-1-like protein isoform X4 [KO:K17065] [EC:3.6.5.5]
101017456  NAMPT; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
101006760  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
101005729  cytochrome b-245 light chain isoform X2 [KO:K08009]
101010923  TXN; thioredoxin [KO:K03671]
103888348  TXN2; thioredoxin, mitochondrial [KO:K03671]
101005789  NEK7; serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
101005739  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X4 [KO:K11864] [EC:3.4.19.-]
101000592  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
101008161  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
101004899  CARD8; caspase recruitment domain-containing protein 8 isoform X1 [KO:K12801]
101005491  LOW QUALITY PROTEIN: caspase recruitment domain-containing protein 8 [KO:K12801]
108583505  PYDC1; LOW QUALITY PROTEIN: pyrin domain-containing protein 1 [KO:K12802]
103882479  PYDC2; pyrin domain-containing protein 2 [KO:K20911]
101025488  MEFV; pyrin isoform X1 [KO:K12803]
101022104  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 isoform X7 [KO:K12804]
101009470  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101017433  FADD; FAS-associated death domain protein [KO:K02373]
101005329  LOW QUALITY PROTEIN: caspase-12 [KO:K04741] [EC:3.4.22.-]
103881450  caspase recruitment domain-containing protein 18 isoform X1 [KO:K12806]
101008343  CARD16; caspase recruitment domain-containing protein 16 [KO:K12806]
100997631  NLRP6; NACHT, LRR and PYD domains-containing protein 6 [KO:K20863]
101011080  NLRP7; NACHT, LRR and PYD domains-containing protein 7 isoform X1 [KO:K20864]
100137561  NLRP12; NACHT, LRR and PYD domains-containing protein 12 [KO:K20865]
101014161  NAIP; baculoviral IAP repeat-containing protein 1 isoform X1 [KO:K12807]
100998325  NLRC4; NLR family CARD domain-containing protein 4 isoform X1 [KO:K12805]
101003920  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
101017772  guanylate-binding protein 2 [KO:K20897]
101001122  AIM2; interferon-inducible protein AIM2 isoform X1 [KO:K12966]
101000203  IFI16; gamma-interferon-inducible protein 16 isoform X1 [KO:K20914]
100137429  TP53BP1; TP53-binding protein 1 [KO:K20915]
108581889  PYDC5; LOW QUALITY PROTEIN: pyrin domain-containing protein 5 [KO:K20916]
101023586  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
101024204  PKN1; serine/threonine-protein kinase N1 isoform X2 [KO:K06071] [EC:2.7.11.13]
101014456  PKN2; serine/threonine-protein kinase N2 isoform X2 [KO:K23691] [EC:2.7.11.13]
101010193  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
101016354  GBP1; LOW QUALITY PROTEIN: guanylate-binding protein 1 [KO:K20899]
101016723  guanylate-binding protein 3 [KO:K20899]
101017417  guanylate-binding protein 7 [KO:K20899]
101022121  LOW QUALITY PROTEIN: guanylate-binding protein 4 [KO:K20899]
101006261  CASP5; caspase-5 isoform X2 [KO:K04395] [EC:3.4.22.58]
101005674  caspase-4 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
101011806  GSDMD; gasdermin-D isoform X3 [KO:K20917]
100137245  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
100137545  IFNAR2; interferon alpha/beta receptor 2 precursor [KO:K05131]
101002872  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
101020681  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
101005886  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101011342  STAT2; LOW QUALITY PROTEIN: signal transducer and activator of transcription 2 [KO:K11221]
101020807  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
101009041  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
101015106  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
101005327  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
101007351  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
100997804  STING1; stimulator of interferon genes protein isoform X1 [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
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pathway
panu04010  MAPK signaling pathway
panu04064  NF-kappa B signaling pathway
panu04140  Autophagy - animal
panu04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
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