KEGG   PATHWAY: pviv05165
Entry
pviv05165                   Pathway                                
Name
Human papillomavirus infection - Prionailurus viverrinus (fishing cat)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
pviv05165  Human papillomavirus infection
pviv05165

Organism
Prionailurus viverrinus (fishing cat) [GN:pviv]
Gene
125170971  WNT1; proto-oncogene Wnt-1 [KO:K03209]
125160216  WNT2; protein Wnt-2 [KO:K00182]
125171980  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
125151215  WNT3; proto-oncogene Wnt-3 [KO:K00312]
125160069  WNT3A; protein Wnt-3a [KO:K00312]
125172782  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
125160630  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
125170942  WNT5B; protein Wnt-5b [KO:K00444]
125174071  WNT6; protein Wnt-6 [KO:K00445]
125161015  WNT7A; protein Wnt-7a isoform X1 [KO:K00572]
125171258  WNT7B; protein Wnt-7b [KO:K00572]
125147616  WNT8B; protein Wnt-8b [KO:K00714]
125171462  WNT8A; protein Wnt-8a [KO:K00714]
125152224  WNT9B; protein Wnt-9b isoform X1 [KO:K01064]
125160070  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
125174069  WNT10A; protein Wnt-10a [KO:K01357]
125170371  WNT10B; protein Wnt-10b [KO:K01357]
125176907  WNT11; protein Wnt-11 [KO:K01384]
125161262  WNT16; protein Wnt-16 [KO:K01558]
125172467  FZD7; frizzled-7 isoform X1 [KO:K02432]
125150691  FZD1; frizzled-1 [KO:K02432]
125158384  FZD2; frizzled-2 [KO:K02235]
125164287  FZD3; frizzled-3 isoform X1 [KO:K02329]
125177054  FZD4; frizzled-4 [KO:K02354]
125171085  FZD8; frizzled-8 [KO:K02375]
125172587  FZD5; frizzled-5 [KO:K02375]
125156618  FZD6; frizzled-6 [KO:K02376]
125154616  FZD9; frizzled-9 [KO:K02842]
125149242  FZD10; frizzled-10 [KO:K02842]
125151466  DVL2; LOW QUALITY PROTEIN: segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
125175326  DVL3; segment polarity protein dishevelled homolog DVL-3 [KO:K02353]
125172007  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
125174815  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125154035  AXIN1; axin-1 isoform X1 [KO:K02157]
125151990  AXIN2; axin-2 isoform X1 [KO:K04385]
125159701  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
125146806  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
125174795  CTNNB1; catenin beta-1 [KO:K02105]
125159812  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
125159815  TERT; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
125154231  TCF7; transcription factor 7 isoform X1 [KO:K02620]
125162247  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
125147670  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
125167639  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
125163418  TLR3; toll-like receptor 3 [KO:K05401]
125161093  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
125167483  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
125155367  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
125169650  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
125153270  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
125150775  interferon beta [KO:K05415]
125154001  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
125170911  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
125160742  TADA3; transcriptional adapter 3 [KO:K11315]
125151405  TP53; cellular tumor antigen p53 [KO:K04451]
125160203  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
125147837  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
125169973  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
125152824  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
125162675  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
125149356  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
125175235  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
125172978  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
125172271  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
125156090  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
125174900  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
125176231  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
125157224  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
125151500  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
125151767  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
125151938  CRB3; protein crumbs homolog 3 [KO:K06090]
125172402  PATJ; inaD-like protein isoform X1 [KO:K06092]
125168920  PALS1; protein PALS1 [KO:K06091]
125170119  VWF; von Willebrand factor [KO:K03900]
125168227  THBS1; thrombospondin-1 [KO:K16857]
125166172  THBS2; thrombospondin-2 [KO:K04659]
125173513  THBS4; thrombospondin-4 [KO:K04659]
125155647  THBS3; thrombospondin-3 [KO:K04659]
125156766  COMP; cartilage oligomeric matrix protein [KO:K04659]
125172662  FN1; fibronectin isoform X1 [KO:K05717]
125158627  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
125161150  COL1A2; collagen alpha-2(I) chain [KO:K06236]
125170867  COL2A1; collagen alpha-1(II) chain [KO:K19719]
125162119  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
125162130  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
125157295  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
125157548  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
125173315  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
125173316  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
125158880  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
125159082  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
125159088  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
125174422  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
125175170  collagen alpha-4(VI) chain-like [KO:K06238]
125175500  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
125166320  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
125171769  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
125162329  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
125165961  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
125148766  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
125161630  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
125148702  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
125166189  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
125151448  LAMB1; laminin subunit beta-1 [KO:K05636]
125148915  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
125155428  LAMB3; laminin subunit beta-3 [KO:K06244]
125151455  LAMB4; laminin subunit beta-4 [KO:K06245]
125155356  LAMC1; laminin subunit gamma-1 [KO:K05635]
125155688  LAMC2; laminin subunit gamma-2 [KO:K06246]
125150287  LAMC3; laminin subunit gamma-3 [KO:K06247]
125151926  CHAD; chondroadherin [KO:K06248]
125161025  RELN; reelin [KO:K06249] [EC:3.4.21.-]
125163269  SPP1; osteopontin isoform X1 [KO:K06250]
125152079  VTN; vitronectin [KO:K06251]
125166098  TNXB; tenascin-X isoform X1 [KO:K06252]
125155175  TNN; tenascin-N isoform X1 [KO:K06252]
125155460  TNR; tenascin-R [KO:K06252]
125150097  TNC; tenascin isoform X1 [KO:K06252]
125164694  IBSP; bone sialoprotein 2 [KO:K06253]
125148667  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
125172671  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
125158705  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
125158524  ITGA3; integrin alpha-3 [KO:K06482]
125172067  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
125170000  ITGA5; integrin alpha-5 [KO:K06484]
125171916  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
125170187  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
125171108  ITGA8; integrin alpha-8 [KO:K06584]
125174963  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
125173824  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
125167533  ITGA11; integrin alpha-11 [KO:K06587]
125172290  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
125170118  ITGB1; integrin beta-1 [KO:K05719]
125152049  ITGB3; integrin beta-3 [KO:K06493]
125151589  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
125174964  ITGB5; integrin beta-5 [KO:K06588]
125173514  ITGB6; integrin beta-6 [KO:K06589]
125169707  ITGB7; integrin beta-7 [KO:K06590]
125160558  ITGB8; integrin beta-8 [KO:K06591]
125156382  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
125149468  PXN; paxillin isoform X1 [KO:K05760]
125165327  TNF; tumor necrosis factor [KO:K03156]
125170769  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
125152758  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
125154937  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
125148091  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
125146980  FADD; FAS-associated death domain protein [KO:K02373]
125172184  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
125163566  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
125151508  NHERF1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
125164370  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
125172646  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
125153770  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
125176421  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
125148417  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
125171565  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
125163831  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
125164262  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
125159266  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
125175047  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
125168935  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
125167344  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
125168560  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
125146761  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
125155472  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
125165614  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
125150812  TSC1; hamartin isoform X1 [KO:K07206]
125154230  TSC2; tuberin isoform X1 [KO:K07207]
125157619  RHEB; GTP-binding protein Rheb [KO:K07208]
125172574  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
125164115  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
125151143  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
125147134  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
125166045  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
125176067  BAD; bcl2-associated agonist of cell death [KO:K02158]
125166177  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
125174838  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
125175184  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125172980  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125161995  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125172124  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
125150373  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
125167750  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125152911  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125155304  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125170819  FOXO1; forkhead box protein O1 [KO:K07201]
125170074  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
125166021  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
125176918  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
125169721  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
125165233  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
125170174  CDK4; cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
125161240  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
125153464  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
125156155  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
125170849  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
125163349  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
125161913  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
125152701  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
125174427  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
125167766  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
125162284  E2F1; transcription factor E2F1 isoform X1 [KO:K17454]
125166102  CCNA1; cyclin-A1 [KO:K06627]
125163539  CCNA2; cyclin-A2 [KO:K06627]
125176182  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
125174791  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
125165878  VEGFA; vascular endothelial growth factor A [KO:K05448]
125147812  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
125163712  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
125159286  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
125163593  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125176511  RELA; transcription factor p65 [KO:K04735]
125170075  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
125150178  NFX1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
125172179  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
125165735  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
125169674  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
125160820  IRF1; interferon regulatory factor 1 [KO:K09444]
125166231  TBP; TATA-box-binding protein [KO:K03120]
125168296  TBPL2; LOW QUALITY PROTEIN: TATA box-binding protein-like 2 [KO:K03120]
125165306  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
125166131  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X1 [KO:K06751]
125166136  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like isoform X1 [KO:K06751]
125166137  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
125160364  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
125165316  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X1 [KO:K06751]
125165372  popy Class I histocompatibility antigen, A-1 alpha chain-like isoform X1 [KO:K06751]
125166132  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
125166134  LOW QUALITY PROTEIN: DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
125166135  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
125159300  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
125174739  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
125162872  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
125163877  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
125156491  ATP6V1C1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
125158280  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
125168922  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
125162834  ATP6V1E2; V-type proton ATPase subunit E 2 isoform X1 [KO:K02150]
125170997  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
125160621  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
125155415  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
125150295  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
125165329  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
125156416  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
125158459  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
125161106  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 isoform X1 [KO:K02154]
125176257  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 isoform X1 [KO:K02154]
125148693  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
125153038  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
125156454  ATP6V0D2; V-type proton ATPase subunit d 2 isoform X1 [KO:K02146]
125159519  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
125149284  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
125154214  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
125174075  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' isoform X1 [KO:K03661]
125159360  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
125164093  EGF; pro-epidermal growth factor [KO:K04357]
125160878  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
125151442  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
125167677  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
125161831  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
125146782  HRAS; GTPase HRas isoform X1 [KO:K02833]
125170295  KRAS; GTPase KRas [KO:K07827]
125171937  NRAS; GTPase NRas [KO:K07828]
125152491  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125167652  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125149335  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125154521  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
125149069  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125155837  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
125146668  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
125161530  neuroendocrine secretory protein 55 [KO:K04632]
125161813  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
125160305  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
125172461  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
125152529  BAX; apoptosis regulator BAX [KO:K02159]
125173452  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
125160384  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
125146741  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
125148303  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
125155795  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
125150367  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
125161255  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
125171949  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
125158425  tubulin gamma-1 chain [KO:K10389]
125158729  tubulin gamma-2 chain [KO:K10389]
125167271  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
125150359  interferon alpha-like [KO:K05414]
125150391  interferon alpha-like [KO:K05414]
125150421  interferon alpha [KO:K05414]
125150431  interferon alpha [KO:K05414]
125150435  interferon alpha-like [KO:K05414]
125150749  interferon alpha-2-like [KO:K05414]
125150820  interferon alpha-2-like [KO:K05414]
125174560  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
125175082  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
125173198  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
125150147  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
125173414  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
125170213  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
125167371  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
125163061  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
125149378  2'-5'-oligoadenylate synthase-like protein 2 isoform X1 [KO:K14608]
125149379  OASL; 2'-5'-oligoadenylate synthase-like protein [KO:K14608]
125174999  interferon-induced GTP-binding protein Mx1 [KO:K14754]
125172382  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
125161772  JAG1; protein jagged-1 isoform X1 [KO:K06052]
125150308  NOTCH1; neurogenic locus notch homolog protein 1 isoform X1 [KO:K02599]
125171962  NOTCH2; neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
125157539  NOTCH3; neurogenic locus notch homolog protein 3 isoform X1 [KO:K20995]
125165853  LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 4-like [KO:K20996]
125166422  neurogenic locus notch homolog protein 4-like [KO:K20996]
125165840  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
125167696  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
125151658  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
125169770  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe isoform X1 [KO:K05948] [EC:2.4.1.222]
125154755  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
125165995  MAML1; mastermind-like protein 1 isoform X1 [KO:K06061]
125176133  MAML2; mastermind-like protein 2 [KO:K06061]
125164196  MAML3; mastermind-like protein 3 isoform X1 [KO:K06061]
125162056  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
125163917  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
125175686  HES1; transcription factor HES-1 [KO:K06054]
125173760  HES2; transcription factor HES-2 [KO:K09087]
125158902  HES6; transcription cofactor HES-6 [KO:K09087]
125151745  HES7; transcription factor HES-7 isoform X1 [KO:K09087]
125173017  HES3; transcription factor HES-3 isoform X1 [KO:K09088]
125171590  HES4; transcription factor HES-4 [KO:K09089]
125174016  HES5; transcription factor HES-5 [KO:K06055]
125173626  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein [KO:K09091]
125166533  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 [KO:K09091]
125156027  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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Human papillomavirus oncoproteins: pathways to transformation.
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Sci Rep 5:13446 (2015)
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Pathogens 5:E8 (2016)
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Viruses 7:3530-51 (2015)
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PDZ domains: the building blocks regulating tumorigenesis.
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Human tumour viruses and the deregulation of cell polarity in cancer.
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Mol Cell Proteomics 11:M112.016998 (2012)
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Reference
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Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
PMID:15175323
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Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
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Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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J Biol Chem 279:35664-70 (2004)
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Reference
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Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Mol Cell Biol 28:4819-28 (2008)
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Reference
PMID:23536685
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  Title
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Related
pathway
pviv04064  NF-kappa B signaling pathway
pviv04110  Cell cycle
pviv04115  p53 signaling pathway
pviv04150  mTOR signaling pathway
pviv04151  PI3K-Akt signaling pathway
pviv04210  Apoptosis
pviv04310  Wnt signaling pathway
pviv04330  Notch signaling pathway
pviv04510  Focal adhesion
pviv04520  Adherens junction
pviv04530  Tight junction
pviv04612  Antigen processing and presentation
pviv04620  Toll-like receptor signaling pathway
pviv04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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