KEGG   PATHWAY: rbb04621
Entry
rbb04621                    Pathway                                
Name
NOD-like receptor signaling pathway - Rhinopithecus bieti (black snub-nosed monkey)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
rbb04621  NOD-like receptor signaling pathway
rbb04621

Organism
Rhinopithecus bieti (black snub-nosed monkey) [GN:rbb]
Gene
108533531  NOD1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
108526904  RIPK2; receptor-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K08846] [EC:2.7.11.1]
108518784  IKBKG; NF-kappa-B essential modulator [KO:K07210]
108535077  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
108540719  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
108539021  NFKBIB; NF-kappa-B inhibitor beta isoform X1 [KO:K02581]
108519636  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
108532817  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
108543519  RELA; transcription factor p65 [KO:K04735]
108541809  IL1B; interleukin-1 beta [KO:K04519]
108536445  IL18; interleukin-18 isoform X1 [KO:K05482]
108529326  IL6; interleukin-6 isoform X1 [KO:K05405]
108520255  TNF; tumor necrosis factor isoform X1 [KO:K03156]
108523449  CXCL8; interleukin-8 [KO:K10030]
108515821  growth-regulated alpha protein-like [KO:K05505]
108523516  growth-regulated alpha protein [KO:K05505]
108539235  growth-regulated alpha protein-like [KO:K05505]
108513563  growth-regulated alpha protein-like [KO:K05505]
108539234  C-X-C motif chemokine 3-like [KO:K05505]
108541409  CCL2; C-C motif chemokine 2 [KO:K14624]
108541464  CCL5; C-C motif chemokine 5 [KO:K12499]
108517622  CAMP; cathelicidin antimicrobial peptide [KO:K13916]
108524614  defensin-7 [KO:K05230]
108516716  theta defensin subunit C [KO:K05230]
108516722  neutrophil defensin 1 [KO:K05230]
108516723  theta defensin subunit A [KO:K05230]
108520649  defensin-6-like [KO:K05230]
108525723  neutrophil defensin 4 [KO:K05230]
108539813  beta-defensin 4A-like [KO:K21100]
108539805  beta-defensin 103 [KO:K23126]
108536321  NOD2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
108539499  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
108520466  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
108536673  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
108539169  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
108523695  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
108536070  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108537794  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
108521141  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108517508  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
108528326  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
108528327  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
108539403  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
108539422  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
108532921  JUN; transcription factor AP-1 [KO:K04448]
108520100  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
108533692  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
108540013  ATG12; LOW QUALITY PROTEIN: ubiquitin-like protein ATG12 [KO:K08336]
108514304  GABARAP; gamma-aminobutyric acid receptor-associated protein isoform X1 [KO:K08341]
108527415  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
108545090  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
108542138  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
108517211  gamma-aminobutyric acid receptor-associated protein-like 3 [KO:K08341]
108520768  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
108512512  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
108533773  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
108517797  SUGT1; protein SGT1 homolog [KO:K12795]
108536591  SHARPIN; sharpin isoform X1 [KO:K20894]
108544535  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
108540921  RNF31; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
108544740  CARD6; LOW QUALITY PROTEIN: caspase recruitment domain-containing protein 6 [KO:K12797]
108538174  TRIP6; thyroid receptor-interacting protein 6 isoform X1 [KO:K12792]
108532832  ERBIN; protein LAP2 isoform X1 [KO:K12796]
108514076  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
108514077  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
108542901  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
108515877  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
108535559  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
108542902  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
108518253  TNFAIP3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
108533499  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
108514953  TRAF3; TNF receptor-associated factor 3 [KO:K03174]
108529966  TBK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
108535149  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
108513559  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
108535826  IRF3; interferon regulatory factor 3 [KO:K05411]
108543524  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
108525122  interferon alpha-10 [KO:K05414]
108538560  interferon alpha-4-like [KO:K05414]
108525752  LOW QUALITY PROTEIN: interferon alpha-21-like [KO:K05414]
108536968  IFNA8; LOW QUALITY PROTEIN: interferon alpha-8 [KO:K05414]
108536996  interferon alpha-14 [KO:K05414]
108537115  LOW QUALITY PROTEIN: interferon alpha-6-like [KO:K05414]
108537124  IFNA6; interferon alpha-6 [KO:K05414]
108538565  IFNB1; interferon beta [KO:K05415]
108528626  NLRX1; NLR family member X1 isoform X1 [KO:K12653]
108516334  ANTXR1; anthrax toxin receptor 1 isoform X1 [KO:K20909]
108532460  ANTXR2; anthrax toxin receptor 2 [KO:K20909]
108514393  NLRP1; NACHT, LRR and PYD domains-containing protein 1 [KO:K12798]
108528384  PYCARD; apoptosis-associated speck-like protein containing a CARD [KO:K12799]
108513176  caspase-1-like [KO:K01370] [EC:3.4.22.36]
108513177  caspase-1-like [KO:K01370] [EC:3.4.22.36]
108513179  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
108526412  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
108524131  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
108536689  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
108544055  NLRP3; NACHT, LRR and PYD domains-containing protein 3 [KO:K12800]
108530688  PANX1; pannexin-1 [KO:K03443]
108529640  P2RX7; P2X purinoceptor 7 [KO:K05220]
108539793  TRPM2; transient receptor potential cation channel subfamily M member 2 isoform X1 [KO:K04977] [EC:3.6.1.13]
108544826  TRPM7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
108541446  CASR; extracellular calcium-sensing receptor isoform X1 [KO:K04612]
108517481  GPRC6A; G-protein coupled receptor family C group 6 member A isoform X1 [KO:K04622]
108526885  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
108542252  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
108527553  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
108527564  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
108528737  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
108523739  ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
108516255  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
108529563  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
108529513  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
108540717  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
108516879  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
108540456  OAS3; 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
108540457  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
108540462  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
108512746  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
108514387  DHX33; putative ATP-dependent RNA helicase DHX33 isoform X1 [KO:K17820] [EC:5.6.2.6]
108532919  MFN1; LOW QUALITY PROTEIN: mitofusin-1 [KO:K21356] [EC:3.6.5.-]
108539352  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
108514229  RIPK1; LOW QUALITY PROTEIN: receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
108540959  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
108538193  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
108531301  NAMPT; LOW QUALITY PROTEIN: nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
108522897  LOW QUALITY PROTEIN: cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
108520444  cytochrome b-245 light chain [KO:K08009]
108531376  TXNIP; thioredoxin-interacting protein [KO:K20910]
108519953  TXN; thioredoxin [KO:K03671]
108513861  thioredoxin-like [KO:K03671]
108518472  TXN2; thioredoxin, mitochondrial [KO:K03671]
108545093  NEK7; LOW QUALITY PROTEIN: serine/threonine-protein kinase Nek7 [KO:K20876] [EC:2.7.11.34]
108538182  lys-63-specific deubiquitinase BRCC36-like [KO:K11864] [EC:3.4.19.-]
108517087  BRCC3; lys-63-specific deubiquitinase BRCC36 isoform X1 [KO:K11864] [EC:3.4.19.-]
108542298  HSP90AA1; LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha [KO:K04079]
108533442  HSP90AB1; LOW QUALITY PROTEIN: heat shock protein HSP 90-beta [KO:K04079]
108537061  LOW QUALITY PROTEIN: heat shock protein HSP 90-alpha-like [KO:K04079]
108540104  CARD8; caspase recruitment domain-containing protein 8 [KO:K12801]
108539882  caspase recruitment domain-containing protein 8-like [KO:K12801]
108519895  GPSM3; G-protein-signaling modulator 3 isoform X1 [KO:K15838]
108532077  IRGM; LOW QUALITY PROTEIN: immunity-related GTPase family M protein [KO:K14139] [EC:3.6.5.-]
108526501  PYDC1; LOW QUALITY PROTEIN: pyrin domain-containing protein 1 [KO:K12802]
108530481  PYDC2; pyrin domain-containing protein 2 [KO:K20911]
108538309  MEFV; pyrin [KO:K12803]
108528518  PSTPIP1; proline-serine-threonine phosphatase-interacting protein 1 isoform X1 [KO:K12804]
108532002  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
108538801  FADD; FAS-associated death domain protein [KO:K02373]
108513174  LOW QUALITY PROTEIN: inactive caspase-12-like [KO:K04741] [EC:3.4.22.-]
108513169  CARD18; caspase recruitment domain-containing protein 18 [KO:K12806]
108513178  CARD16; caspase recruitment domain-containing protein 16 isoform X1 [KO:K12806]
108531418  caspase recruitment domain-containing protein 18 [KO:K12806]
108537998  NLRP6; NACHT, LRR and PYD domains-containing protein 6 isoform X1 [KO:K20863]
108529451  NLRP12; NACHT, LRR and PYD domains-containing protein 12 isoform X1 [KO:K20865]
108541156  NAIP; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 1 [KO:K12807]
108528685  NLRC4; LOW QUALITY PROTEIN: NLR family CARD domain-containing protein 4 [KO:K12805]
108515204  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
108514464  LOW QUALITY PROTEIN: guanylate-binding protein 2-like [KO:K20897]
108531891  AIM2; interferon-inducible protein AIM2 isoform X1 [KO:K12966]
108531892  IFI16; gamma-interferon-inducible protein 16 [KO:K20914]
108517997  TP53BP1; tumor suppressor p53-binding protein 1 [KO:K20915]
108531899  LOW QUALITY PROTEIN: pyrin domain-only protein 3 [KO:K20916]
108526989  RHOA; transforming protein RhoA [KO:K04513]
108514770  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
108514488  PKN2; LOW QUALITY PROTEIN: serine/threonine-protein kinase N2 [KO:K23691] [EC:2.7.11.13]
108524248  YWHAE; 14-3-3 protein epsilon [KO:K06630]
108514541  GBP7; LOW QUALITY PROTEIN: guanylate-binding protein 7 [KO:K20899]
108514558  GBP3; guanylate-binding protein 3 [KO:K20899]
108514550  LOW QUALITY PROTEIN: guanylate-binding protein 1-like [KO:K20899]
108513170  CASP5; caspase-5 [KO:K04395] [EC:3.4.22.58]
108513171  caspase-4-like [KO:K04394] [EC:3.4.22.57 3.4.22.64]
108536565  GSDMD; gasdermin-D isoform X1 [KO:K20917]
108536856  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
108536852  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
108532886  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
108517816  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
108527866  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
108516059  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
108540930  IRF9; interferon regulatory factor 9 isoform X1 [KO:K04693]
108530054  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
108512106  TICAM1; LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1 [KO:K05842]
108512239  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
108539989  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
108544077  TMEM173; stimulator of interferon genes protein [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
rbb04010  MAPK signaling pathway
rbb04064  NF-kappa B signaling pathway
rbb04140  Autophagy - animal
rbb04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
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