KEGG   PATHWAY: stru04137
Entry
stru04137                   Pathway                                
Name
Mitophagy - animal - Salmo trutta (river trout)
Description
Mitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process called reactive oxidative species (ROS) lead to mitochondrial dysfunction. If the damage is too excessive to be repaired, such mitochondria are selectively recognized and targeted for degradation by a specific mode of autophagy, termed mitophagy. The loss of the mitochondrial membrane potential can induce mitophagy, involving the kinase PINK1 and the E3 ligase Parkin. PINK1 serves as the sensor for the mitochondrial depolarization and recruits Parkin, followed by ubiquitin-dependent recruitment of mitophagy receptors. There are also several PINK1/Parkin-independent mitophagy pathways, in which a group of LIR-containing receptors are required in response to different stimuli. Mitophagy contributes to the maintenance of a healthy mitochondrial network and the prevention of programmed cell death.
Class
Cellular Processes; Transport and catabolism
Pathway map
stru04137  Mitophagy - animal
stru04137

Other DBs
GO: 0000422
Organism
Salmo trutta (river trout) [GN:stru]
Gene
115152423  activating molecule in BECN1-regulated autophagy protein 1-like isoform X1 [KO:K17985]
115167530  activating molecule in BECN1-regulated autophagy protein 1-like isoform X1 [KO:K17985]
115202872  activating molecule in BECN1-regulated autophagy protein 1-like isoform X1 [KO:K17985]
115197139  activating molecule in BECN1-regulated autophagy protein 1-like [KO:K17985]
115165629  serine/threonine-protein kinase PINK1, mitochondrial-like [KO:K05688] [EC:2.7.11.1]
115173894  mitochondrial import receptor subunit TOM7 homolog [KO:K17771]
115175364  mitochondrial import receptor subunit TOM7 homolog [KO:K17771]
115183322  mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
115177326  mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
115173391  mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
115204706  mitochondrial import receptor subunit TOM40B-like [KO:K11518]
115155394  tomm20; mitochondrial import receptor subunit TOM20 homolog [KO:K17770]
115177829  mitochondrial import receptor subunit TOM20 homolog [KO:K17770]
115200906  mitochondrial import receptor subunit TOM20 homolog B [KO:K17770]
115200907  mitochondrial import receptor subunit TOM20 homolog B [KO:K17770]
115201774  mitochondrial import receptor subunit TOM20 homolog B-like [KO:K17770]
115208540  mitochondrial import receptor subunit TOM20 homolog [KO:K17770]
115158931  mitochondrial import receptor subunit TOM70-like [KO:K17768]
115151409  tomm70; mitochondrial import receptor subunit TOM70 [KO:K17768]
115193909  prkn; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
115193974  E3 ubiquitin-protein ligase MARCH5-like [KO:K10660] [EC:2.3.2.27]
115153040  E3 ubiquitin-protein ligase MARCH5 isoform X1 [KO:K10660] [EC:2.3.2.27]
115159753  E3 ubiquitin-protein ligase MARCH5 [KO:K10660] [EC:2.3.2.27]
115203913  E3 ubiquitin-protein ligase MARCH5-like [KO:K10660] [EC:2.3.2.27]
115159584  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
115159699  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
115164249  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
115203961  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
115204052  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
115183943  E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
115188858  E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
115188928  E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
115171382  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
115178351  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
115201867  E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
115208608  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
115167011  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
115203315  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
115197506  E3 ubiquitin-protein ligase AMFR-like isoform X1 [KO:K10636] [EC:2.3.2.36]
115157580  mitochondrial ubiquitin ligase activator of nfkb 1-A-like [KO:K15688] [EC:2.3.2.27]
115167967  mitochondrial ubiquitin ligase activator of NFKB 1-like [KO:K15688] [EC:2.3.2.27]
115169345  mitochondrial ubiquitin ligase activator of nfkb 1-A-like [KO:K15688] [EC:2.3.2.27]
115165623  mitochondrial ubiquitin ligase activator of NFKB 1-like [KO:K15688] [EC:2.3.2.27]
115157452  mitochondrial ubiquitin ligase activator of nfkb 1-A-like [KO:K15688] [EC:2.3.2.27]
115167822  E3 ubiquitin-protein ligase HUWE1-like isoform X1 [KO:K10592] [EC:2.3.2.26]
115165470  E3 ubiquitin-protein ligase HUWE1-like isoform X1 [KO:K10592] [EC:2.3.2.26]
115151925  E3 ubiquitin-protein ligase Siah1-like isoform X1 [KO:K04506] [EC:2.3.2.27]
115196839  siah1; E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
115192976  E3 ubiquitin-protein ligase arih1-like isoform X1 [KO:K11968] [EC:2.3.2.31]
115203616  E3 ubiquitin-protein ligase arih1 isoform X1 [KO:K11968] [EC:2.3.2.31]
115166737  E3 ubiquitin-protein ligase arih1-like isoform X1 [KO:K11968] [EC:2.3.2.31]
115157966  mitofusin-1-like isoform X1 [KO:K21356] [EC:3.6.5.-]
115156562  mitofusin-1-like [KO:K21356] [EC:3.6.5.-]
115151529  mitofusin-1-like [KO:K21356] [EC:3.6.5.-]
115166092  mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
115171730  mitochondrial Rho GTPase 1-A-like isoform X1 [KO:K07870] [EC:3.6.5.-]
115178839  mitochondrial Rho GTPase 1-A-like isoform X1 [KO:K07870] [EC:3.6.5.-]
115208745  mitochondrial Rho GTPase 1-A-like isoform X1 [KO:K07870] [EC:3.6.5.-]
115206035  mitochondrial Rho GTPase 1-A isoform X1 [KO:K07870] [EC:3.6.5.-]
115159709  rhot2; mitochondrial Rho GTPase 2 [KO:K07871] [EC:3.6.5.-]
115200775  mitochondrial Rho GTPase 2-like [KO:K07871] [EC:3.6.5.-]
115158095  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
115169942  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
115156752  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
115151664  ubiquitin-60S ribosomal protein L40 [KO:K02927]
115193648  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
115153309  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
115203878  polyubiquitin-B [KO:K04551]
115154315  polyubiquitin-C isoform X1 [KO:K08770]
115148848  ubc; polyubiquitin-C isoform X1 [KO:K08770]
115187704  tax1bp1; tax1-binding protein 1 [KO:K21347]
115173951  tax1-binding protein 1 homolog A-like isoform X1 [KO:K21347]
115175465  tax1-binding protein 1 homolog B-like [KO:K21347]
115171017  sequestosome-1-like [KO:K14381]
115205128  sqstm1; sequestosome-1 [KO:K14381]
115158672  calcium-binding and coiled-coil domain-containing protein 2-like [KO:K21348]
115180485  optineurin-like isoform X1 [KO:K19946]
115198834  optineurin-like isoform X1 [KO:K19946]
115158311  next to BRCA1 gene 1 protein-like isoform X1 [KO:K17987]
115171261  next to BRCA1 gene 1 protein-like isoform X1 [KO:K17987]
115201067  next to BRCA1 gene 1 protein-like isoform X1 [KO:K17987]
115199564  next to BRCA1 gene 1 protein-like isoform X1 [KO:K17987]
115189789  serine/threonine-protein kinase TBK1-like [KO:K05410] [EC:2.7.11.10]
115189827  serine/threonine-protein kinase TBK1-like isoform X1 [KO:K05410] [EC:2.7.11.10]
115188365  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
115176534  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
115154929  gamma-aminobutyric acid receptor-associated protein [KO:K08341]
115166707  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
115151878  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
115194182  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
115203592  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
115198183  gamma-aminobutyric acid receptor-associated protein-like [KO:K08341]
115168785  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
115178512  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
115151102  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
115151842  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
115208534  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
115196926  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
115204894  microtubule-associated proteins 1A/1B light chain 3C-like isoform X1 [KO:K10435]
115184010  beclin-1-like [KO:K08334]
115160708  beclin-1 isoform X1 [KO:K08334]
115160858  beclin-1-like [KO:K08334]
115160932  beclin-1-like [KO:K08334]
115160956  beclin-1-like isoform X1 [KO:K08334]
115182362  ubiquitin carboxyl-terminal hydrolase 8-like isoform X1 [KO:K11839] [EC:3.4.19.12]
115167432  ubiquitin carboxyl-terminal hydrolase 8-like [KO:K11839] [EC:3.4.19.12]
115180587  ubiquitin carboxyl-terminal hydrolase 15-like isoform X1 [KO:K21343] [EC:3.4.19.12]
115198641  ubiquitin carboxyl-terminal hydrolase 15-like isoform X1 [KO:K21343] [EC:3.4.19.12]
115200219  usp30; ubiquitin carboxyl-terminal hydrolase 30 isoform X1 [KO:K11851] [EC:3.4.19.12]
115168617  bcl-2-like protein 1 [KO:K04570]
115165991  bcl-2-like protein 1 [KO:K04570]
115150840  bcl-2-like protein 1 [KO:K04570]
115207590  bcl-2-like protein 1 [KO:K04570]
115159376  serine/threonine-protein phosphatase PGAM5, mitochondrial-like [KO:K15637] [EC:3.1.3.16]
115164317  serine/threonine-protein phosphatase PGAM5, mitochondrial-like isoform X1 [KO:K15637] [EC:3.1.3.16]
115148324  serine/threonine-protein phosphatase PGAM5, mitochondrial-like [KO:K15637] [EC:3.1.3.16]
115200338  serine/threonine-protein phosphatase PGAM5, mitochondrial-like [KO:K15637] [EC:3.1.3.16]
115185756  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
115174049  casein kinase II subunit alpha-like isoform X1 [KO:K03097] [EC:2.7.11.1]
115175558  casein kinase II subunit alpha [KO:K03097] [EC:2.7.11.1]
115176623  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
115166713  casein kinase II subunit alpha'-like isoform X1 [KO:K03097] [EC:2.7.11.1]
115151855  casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
115150132  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
115208343  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
115196912  casein kinase II subunit alpha'-like isoform X1 [KO:K03097] [EC:2.7.11.1]
115203596  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
115185845  casein kinase II subunit beta-like isoform X1 [KO:K03115]
115176017  casein kinase II subunit beta [KO:K03115]
115176651  casein kinase II subunit beta-like isoform X1 [KO:K03115]
115173331  casein kinase II subunit beta isoform X1 [KO:K03115]
115167934  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
115165589  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
115150079  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
115208382  proto-oncogene tyrosine-protein kinase Src-like isoform X1 [KO:K05704] [EC:2.7.10.2]
115159639  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
115204015  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
115200038  serine/threonine-protein kinase ULK1-like isoform X1 [KO:K21357] [EC:2.7.11.1]
115155922  fundc1; FUN14 domain-containing protein 1 [KO:K17986]
115179162  FUN14 domain-containing protein 1-like isoform X1 [KO:K17986]
115161310  FUN14 domain-containing protein 1-like [KO:K17986]
115196342  FUN14 domain-containing protein 1-like isoform X1 [KO:K17986]
115190205  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1 [KO:K15464]
115193728  bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 isoform X1 [KO:K15464]
115152711  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like isoform X1 [KO:K15464]
115159201  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
115149351  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
115159484  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15465]
115164569  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15465]
115204154  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15465]
115200076  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15465]
115152227  bcl-2-like protein 13 isoform X1 [KO:K15485]
115197427  bcl-2-like protein 13 [KO:K15485]
115192617  fkbp8; peptidyl-prolyl cis-trans isomerase FKBP8 isoform X1 [KO:K09574] [EC:5.2.1.8]
115158265  peptidyl-prolyl cis-trans isomerase FKBP8-like isoform X1 [KO:K09574] [EC:5.2.1.8]
115152022  peptidyl-prolyl cis-trans isomerase FKBP8-like isoform X1 [KO:K09574] [EC:5.2.1.8]
115196724  peptidyl-prolyl cis-trans isomerase FKBP8-like [KO:K09574] [EC:5.2.1.8]
115180288  sorting and assembly machinery component 50 homolog B-like [KO:K07277]
115192835  sorting and assembly machinery component 50 homolog A isoform X1 [KO:K07277]
115197092  sorting and assembly machinery component 50 homolog A-like [KO:K07277]
115198789  sorting and assembly machinery component 50 homolog B isoform X1 [KO:K07277]
115192180  prohibitin-2-like [KO:K17081]
115158804  prohibitin-2-like [KO:K17081]
115156564  prohibitin-2-like isoform X1 [KO:K17081]
115205900  NLR family member X1-like isoform X1 [KO:K12653]
115180206  metaxin-1-like isoform X1 [KO:K17776]
115175789  metaxin-1-like [KO:K17776]
115176752  metaxin-1-like isoform X1 [KO:K17776]
115164391  mtx3; metaxin-3 isoform X1 [KO:K17776]
115179865  mtx2; metaxin-2 [KO:K17776]
115161813  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
115162042  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
115174610  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
115172304  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
115170922  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
115178533  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
115147454  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
115196317  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
115194041  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115157756  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
115174527  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115152965  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115159070  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115149487  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
115201108  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
115204538  mitogen-activated protein kinase 9-like [KO:K04440] [EC:2.7.11.24]
115192441  transcription factor AP-1-like [KO:K04448]
115169534  transcription factor AP-1-like [KO:K04448]
115158459  transcription factor AP-1-like [KO:K04448]
115157247  transcription factor AP-1-like [KO:K04448]
115149542  transcription factor AP-1-like [KO:K04448]
115160168  transcription factor AP-1-like [KO:K04448]
115194158  transcription factor p65-like isoform X1 [KO:K04735]
115198165  putative transcription factor p65 homolog [KO:K04735]
115152114  GTPase HRas-like [KO:K02833]
115197299  GTPase HRas isoform X1 [KO:K02833]
115152163  GTPase KRas isoform X1 [KO:K07827]
115171866  GTPase HRas-like [KO:K07827]
115207704  GTPase HRas-like [KO:K07827]
115197360  GTPase KRas isoform X1 [KO:K07827]
115155553  ras-related protein M-Ras-like [KO:K07831]
115160872  ras-related protein M-Ras-like [KO:K07831]
115179161  ras-related protein M-Ras-like isoform X1 [KO:K07831]
115196009  ras-related protein M-Ras [KO:K07831]
115192116  ras-related protein R-Ras-like [KO:K07830]
115170759  rras; ras-related protein R-Ras [KO:K07830]
115167085  ras-related protein R-Ras2-like isoform X1 [KO:K07830]
115203241  ras-related protein R-Ras2 [KO:K07830]
115168160  transcription factor E2F1-like [KO:K17454]
115165830  transcription factor E2F1-like isoform X1 [KO:K17454]
115161803  hypoxia-inducible factor 1-alpha-like [KO:K08268]
115163185  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
115172523  hypoxia-inducible factor 1-alpha [KO:K08268]
115148499  endothelial PAS domain-containing protein 1-like [KO:K08268]
115206129  hypoxia-inducible factor 1-alpha-like isoform X1 [KO:K08268]
115207322  sp1; transcription factor Sp1 isoform X1 [KO:K04684]
115154926  cellular tumor antigen p53 [KO:K04451]
115194175  cellular tumor antigen p53-like [KO:K04451]
115198177  cellular tumor antigen p53-like isoform X1 [KO:K04451]
115161985  forkhead box protein O3-like [KO:K09408]
115174430  forkhead box protein O3-like [KO:K09408]
115176439  foxo3; forkhead box protein O3 [KO:K09408]
115172236  forkhead box protein O3-like [KO:K09408]
115192723  cited2; cbp/p300-interacting transactivator 2 [KO:K21361]
115174794  cbp/p300-interacting transactivator 2-like [KO:K21361]
115168120  microphthalmia-associated transcription factor-like isoform X1 [KO:K09455]
115165791  microphthalmia-associated transcription factor-like isoform X1 [KO:K09455]
115150869  microphthalmia-associated transcription factor-like isoform X1 [KO:K09455]
115207557  microphthalmia-associated transcription factor-like isoform X1 [KO:K09455]
115184956  transcription factor EB-like [KO:K15590]
115188645  transcription factor EB-like isoform X1 [KO:K15590]
115168729  transcription factor E3-like isoform X1 [KO:K09105]
115165274  transcription factor E3-like [KO:K09105]
115150845  transcription factor E3-like isoform X1 [KO:K09105]
115207578  transcription factor E3-like isoform X1 [KO:K09105]
115154263  rab5 GDP/GTP exchange factor-like isoform X1 [KO:K20131]
115163280  rab5 GDP/GTP exchange factor-like [KO:K20131]
115148794  rab5 GDP/GTP exchange factor-like isoform X1 [KO:K20131]
115206219  rab5 GDP/GTP exchange factor-like [KO:K20131]
115200153  rab5 GDP/GTP exchange factor-like isoform X1 [KO:K20131]
115173975  ras-related protein Rab-5A [KO:K07887]
115175487  ras-related protein Rab-5A-like [KO:K07887]
115176952  ras-related protein Rab-5A [KO:K07887]
115178119  rab5a; ras-related protein Rab-5A [KO:K07887]
115155571  ras-related protein Rab-5B-like [KO:K07888]
115160896  ras-related protein Rab-5B-like [KO:K07888]
115150454  ras-related protein Rab-5B-like [KO:K07888]
115171112  ras-related protein Rab-5C-like [KO:K07889]
115161258  rab5c; ras-related protein Rab-5C [KO:K07889]
115200986  ras-related protein Rab-5C-like [KO:K07889]
115197954  ras-related protein Rab-5C-like [KO:K07889]
115150930  vacuolar fusion protein MON1 homolog B-like isoform X1 [KO:K20195]
115207493  vacuolar fusion protein MON1 homolog B-like [KO:K20195]
115207571  mon1a; vacuolar fusion protein MON1 homolog A [KO:K20195]
115201384  vacuolar fusion protein CCZ1 homolog [KO:K27045]
115159759  ras-related protein rab7-like [KO:K07897]
115150549  ras-related protein rab7-like [KO:K07897]
115150796  ras-related protein rab7-like isoform X1 [KO:K07897]
115207635  ras-related protein rab7 [KO:K07897]
115207860  ras-related protein rab7-like [KO:K07897]
115203908  ras-related protein Rab-7a-like [KO:K07897]
115200108  ras-related protein Rab-7a-like [KO:K07897]
115152312  TBC1 domain family member 15-like [KO:K20168]
115189702  TBC1 domain family member 15-like [KO:K20168]
115189703  TBC1 domain family member 15-like [KO:K20168]
115197530  TBC1 domain family member 15-like [KO:K20168]
115171486  TBC1 domain family member 17-like [KO:K19945]
115203072  TBC1 domain family member 17-like [KO:K19945]
115154979  mitochondrial fission 1 protein-like [KO:K17969]
115194288  mitochondrial fission 1 protein-like [KO:K17969]
115198291  mitochondrial fission 1 protein-like [KO:K17969]
115169589  autophagy-related protein 9A-like [KO:K17907]
115179113  autophagy-related protein 9A-like [KO:K17907]
115157188  autophagy-related protein 9A-like [KO:K17907]
115196136  autophagy-related protein 9A-like [KO:K17907]
115157980  dynamin-like 120 kDa protein, mitochondrial isoform X1 [KO:K17079] [EC:3.6.5.5]
115151541  dynamin-like 120 kDa protein, mitochondrial isoform X1 [KO:K17079] [EC:3.6.5.5]
115159870  transitional endoplasmic reticulum ATPase-like [KO:K13525]
115177879  transitional endoplasmic reticulum ATPase-like isoform X1 [KO:K13525]
115164401  transitional endoplasmic reticulum ATPase-like [KO:K13525]
115203811  transitional endoplasmic reticulum ATPase-like [KO:K13525]
115200242  transitional endoplasmic reticulum ATPase [KO:K13525]
Compound
C00035  GDP
C00044  GTP
Reference
PMID:25611507
  Authors
Pickrell AM, Youle RJ
  Title
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
  Journal
Neuron 85:257-73 (2015)
DOI:10.1016/j.neuron.2014.12.007
Reference
PMID:25995186
  Authors
Durcan TM, Fon EA
  Title
The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
  Journal
Genes Dev 29:989-99 (2015)
DOI:10.1101/gad.262758.115
Reference
PMID:25999423
  Authors
Shirihai OS, Song M, Dorn GW 2nd
  Title
How mitochondrial dynamism orchestrates mitophagy.
  Journal
Circ Res 116:1835-49 (2015)
DOI:10.1161/CIRCRESAHA.116.306374
Reference
PMID:26611876
  Authors
Hamacher-Brady A, Brady NR
  Title
Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy.
  Journal
Cell Mol Life Sci 73:775-95 (2016)
DOI:10.1007/s00018-015-2087-8
Reference
PMID:26882551
  Authors
Yamano K, Matsuda N, Tanaka K
  Title
The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation.
  Journal
EMBO Rep 17:300-16 (2016)
DOI:10.15252/embr.201541486
Reference
PMID:27021519
  Authors
Yamaguchi O, Murakawa T, Nishida K, Otsu K
  Title
Receptor-mediated mitophagy.
  Journal
J Mol Cell Cardiol 95:50-6 (2016)
DOI:10.1016/j.yjmcc.2016.03.010
Reference
PMID:27443527
  Authors
Roberts RF, Tang MY, Fon EA, Durcan TM
  Title
Defending the mitochondria: The pathways of mitophagy and mitochondrial-derived vesicles.
  Journal
Int J Biochem Cell Biol 79:427-436 (2016)
DOI:10.1016/j.biocel.2016.07.020
Reference
PMID:27701735
  Authors
Arena G, Valente EM
  Title
PINK1 in the limelight: multiple functions of an eclectic protein in human health and disease.
  Journal
J Pathol 241:251-263 (2017)
DOI:10.1002/path.4815
Related
pathway
stru04140  Autophagy - animal
stru04210  Apoptosis
KO pathway
ko04137   
LinkDB

DBGET integrated database retrieval system