KEGG   PATHWAY: vlg05165
Entry
vlg05165                    Pathway                                
Name
Human papillomavirus infection - Vulpes lagopus (Arctic fox)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
vlg05165  Human papillomavirus infection
vlg05165

Organism
Vulpes lagopus (Arctic fox) [GN:vlg]
Gene
121480178  WNT1; proto-oncogene Wnt-1 isoform X1 [KO:K03209]
121474438  WNT2; protein Wnt-2 isoform X1 [KO:K00182]
121490731  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
121474007  WNT3; proto-oncogene Wnt-3 [KO:K00312]
121474467  WNT3A; protein Wnt-3a [KO:K00312]
121498205  WNT4; protein Wnt-4 isoform X1 [KO:K00408]
121479913  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
121495641  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
121480717  WNT6; protein Wnt-6 [KO:K00445]
121490476  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
121495152  WNT7A; protein Wnt-7a [KO:K00572]
121476849  WNT8B; protein Wnt-8b [KO:K00714]
121495235  WNT8A; protein Wnt-8a [KO:K00714]
121474006  WNT9B; protein Wnt-9b [KO:K01064]
121475053  WNT9A; protein Wnt-9a isoform X1 [KO:K01064]
121480841  WNT10A; protein Wnt-10a [KO:K01357]
121480042  WNT10B; protein Wnt-10b [KO:K01357]
121475935  WNT11; protein Wnt-11 [KO:K01384]
121474824  WNT16; protein Wnt-16 [KO:K01558]
121480659  FZD7; frizzled-7 isoform X1 [KO:K02432]
121474752  FZD1; frizzled-1 [KO:K02432]
121472594  FZD2; frizzled-2 [KO:K02235]
121498183  FZD3; frizzled-3 isoform X1 [KO:K02329]
121476036  FZD4; frizzled-4 isoform X1 [KO:K02354]
121480532  FZD5; frizzled-5 [KO:K02375]
121498057  FZD8; frizzled-8 [KO:K02375]
121498902  FZD6; frizzled-6 isoform X1 [KO:K02376]
121475662  FZD10; frizzled-10 [KO:K02842]
121486703  FZD9; frizzled-9 [KO:K02842]
121477470  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
121499761  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
121499953  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
121489623  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
121486746  AXIN1; axin-1 isoform X1 [KO:K02157]
121473774  AXIN2; axin-2 isoform X1 [KO:K04385]
121489860  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
121495587  APC2; adenomatous polyposis coli protein 2 isoform X1 [KO:K02085]
121478755  CTNNB1; catenin beta-1 [KO:K02105]
121486399  CSNK1A1; casein kinase I isoform X1 [KO:K08957] [EC:2.7.11.1]
121477440  TERT; telomerase reverse transcriptase isoform X1 [KO:K11126] [EC:2.7.7.49]
121495797  TCF7; transcription factor 7 isoform X1 [KO:K02620]
121490511  TCF7L1; transcription factor 7-like 1 isoform X1 [KO:K04490]
121485032  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
121489012  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
121489930  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
121495956  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
121493392  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
121501599  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
121491543  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
121483963  IRF3; interferon regulatory factor 3 [KO:K05411]
121494639  IFNB1; interferon beta [KO:K05415]
121486664  CREB-binding protein [KO:K04498] [EC:2.3.1.48]
121490691  EP300; histone acetyltransferase p300 isoform X1 [KO:K04498] [EC:2.3.1.48]
121473173  LOW QUALITY PROTEIN: transcriptional adapter 3-like [KO:K11315]
121494461  TADA3; transcriptional adapter 3 [KO:K11315]
121499929  TP53; cellular tumor antigen p53 [KO:K04451]
121494692  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
121475822  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121496593  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
121481909  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
121478163  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
121500588  PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
121477501  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
121499817  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
121484133  cell division control protein 42 homolog [KO:K04393]
121496975  cell division control protein 42 homolog [KO:K04393]
121497282  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
121498672  SCRIB; protein scribble homolog isoform X1 [KO:K16175]
121486853  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
121476318  DLG2; disks large homolog 2 isoform X1 [KO:K12075]
121483376  DLG3; disks large homolog 3 isoform X1 [KO:K21098]
121473797  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
121499619  LLGL1; lethal(2) giant larvae protein homolog 1 isoform X1 [KO:K06094]
121484780  protein crumbs homolog 3 [KO:K06090]
121494378  CRB3; protein crumbs homolog 3 [KO:K06090]
121499695  PATJ; inaD-like protein isoform X1 [KO:K06092]
121492767  PALS1; MAGUK p55 subfamily member 5 isoform X1 [KO:K06091]
121479856  VWF; von Willebrand factor [KO:K03900]
121479866  THBS1; thrombospondin-1 [KO:K16857]
121490137  THBS4; thrombospondin-4 [KO:K04659]
121485307  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
121498105  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
121495334  cartilage oligomeric matrix protein [KO:K04659]
121480523  FN1; fibronectin isoform X1 [KO:K05717]
121473623  COL1A1; collagen alpha-1(I) chain [KO:K06236]
121474775  COL1A2; collagen alpha-2(I) chain [KO:K06236]
121480020  COL2A1; collagen alpha-1(II) chain [KO:K19719]
121482864  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
121483471  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
121477151  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
121477152  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
121497358  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
121497360  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
121478506  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
121478785  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
121478899  collagen alpha-4(VI) chain-like [KO:K06238]
121479427  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
121479461  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
121497053  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
121480927  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
121478210  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
121497279  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
121480664  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
121495728  LAMA1; laminin subunit alpha-1 [KO:K05637]
121477984  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
121498940  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
121496067  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
121501345  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
121494844  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
121492556  LAMB3; laminin subunit beta-3 [KO:K06244]
121471443  LAMB4; laminin subunit beta-4 [KO:K06245]
121491180  LAMC1; laminin subunit gamma-1 [KO:K05635]
121471993  LAMC2; laminin subunit gamma-2 isoform X1 [KO:K06246]
121473681  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
121473553  CHAD; chondroadherin [KO:K06248]
121471407  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
121492441  SPP1; osteopontin isoform X1 [KO:K06250]
121472853  VTN; vitronectin [KO:K06251]
121499751  TNR; tenascin-R [KO:K06252]
121500730  TNXB; tenascin-X isoform X1 [KO:K06252]
121494690  TNN; tenascin-N [KO:K06252]
121495323  TNC; tenascin isoform X1 [KO:K06252]
121493397  bone sialoprotein 2 [KO:K06253]
121486730  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
121486855  ITGA2; integrin alpha-2 [KO:K06481]
121472806  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
121473441  ITGA3; integrin alpha-3 [KO:K06482]
121471988  ITGA4; integrin alpha-4 [KO:K06483]
121479922  ITGA5; integrin alpha-5 [KO:K06484]
121501705  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
121490880  ITGA7; LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
121497862  ITGA8; integrin alpha-8 [KO:K06584]
121478620  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
121491109  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
121485754  ITGA11; integrin alpha-11 [KO:K06587]
121501614  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
121497152  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
121473834  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
121473356  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
121499625  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
121471938  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
121479976  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
121474509  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
121498821  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
121475413  PXN; paxillin isoform X1 [KO:K05760]
121500453  TNF; tumor necrosis factor [KO:K03156]
121480007  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
121499974  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
121498932  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
121475736  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
121471748  FADD; FAS-associated death domain protein [KO:K02373]
121480703  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
121489913  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
121473330  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
121489947  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
121495681  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
121484445  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
121499587  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
121490126  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
121484411  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
121496949  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
121497471  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
121482889  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
121478731  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
121493493  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
121471446  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
121492115  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
121493034  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
121493057  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
121493453  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
121473130  TSC1; hamartin [KO:K07206]
121487228  TSC2; tuberin isoform X1 [KO:K07207]
121489596  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
121496713  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
121489233  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
121471453  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
121472885  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
121497413  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
121501608  BAD; bcl2-associated agonist of cell death [KO:K02158]
121486777  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
121477352  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121478805  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121499678  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121481416  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
121496480  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121494738  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121488903  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121482033  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121482375  LOW QUALITY PROTEIN: RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
121493415  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121496787  FOXO1; forkhead box protein O1 [KO:K07201]
121480271  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
121473591  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
121501724  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
121479990  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
121499073  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
121490703  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
121474633  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
121476479  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
121498848  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
121491263  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
121476853  RB1; retinoblastoma-associated protein [KO:K06618]
121477991  RBL1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
121496541  RBL2; retinoblastoma-like protein 2 [KO:K16332]
121488865  26S proteasome regulatory subunit 4-like [KO:K03062]
121496205  uncharacterized protein LOC121496205 isoform X1 [KO:K03062]
121497986  LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 4-like [KO:K03062]
121493181  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
121478071  E2F1; transcription factor E2F1 [KO:K17454]
121496639  CCNA1; cyclin-A1 isoform X1 [KO:K06627]
121493363  CCNA2; cyclin-A2 [KO:K06627]
121500044  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
121478918  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
121486776  VEGFA; vascular endothelial growth factor A [KO:K05448]
121484113  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
121489510  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
121482779  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
121492781  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
121471268  RELA; transcription factor p65 isoform X1 [KO:K04735]
121491185  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
121495298  NFX1; transcriptional repressor NF-X1 isoform X1 [KO:K12236]
121474770  LOW QUALITY PROTEIN: histone deacetylase 1-like [KO:K06067] [EC:3.5.1.98]
121497459  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
121491330  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
121479715  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X1 [KO:K11643] [EC:5.6.2.-]
121494386  IRF1; interferon regulatory factor 1 [KO:K09444]
121484021  TBPL1; TATA box-binding protein-like 1 isoform X1 [KO:K03120]
121492537  TBPL2; TATA box-binding protein-like 2 [KO:K03120]
121494792  TATA-box-binding protein [KO:K03120]
121489374  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
121489381  DLA class I histocompatibility antigen, A9/A9 alpha chain-like isoform X1 [KO:K06751]
121471640  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
121501728  LOW QUALITY PROTEIN: DLA class I histocompatibility antigen, A9/A9 alpha chain-like [KO:K06751]
121482943  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
121484682  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
121497830  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
121491152  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
121490915  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
121498989  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
121492768  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
121480260  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
121490545  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
121500085  V-type proton ATPase subunit E 1-like isoform X1 [KO:K02150]
121474860  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
121471863  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
121500760  ATP6V1G3; V-type proton ATPase subunit G 3 isoform X1 [KO:K02152]
121494167  V-type proton ATPase subunit G 1-like [KO:K02152]
121495796  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
121498832  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
121489301  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
121475681  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 [KO:K02154]
121472873  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]
121501494  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
121499105  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
121500228  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
121481652  V-type proton ATPase subunit e 1-like [KO:K02153]
121489377  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
121479374  V-type proton ATPase subunit e 2-like [KO:K02153]
121487914  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
121492519  V-type proton ATPase subunit e 1-like [KO:K02153]
121488304  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
121481676  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
121483400  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
121492863  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
121471236  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
121473934  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
121491936  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
121493142  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
121472124  HRAS; GTPase HRas isoform X1 [KO:K02833]
121479900  KRAS; GTPase KRas isoform X1 [KO:K07827]
121491321  NRAS; GTPase NRas [KO:K07828]
121494281  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121484067  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
121495470  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121475510  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121486545  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121497643  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
121488003  PTGER4; LOW QUALITY PROTEIN: prostaglandin E2 receptor EP4 subtype [KO:K04261]
121477898  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
121477899  neuroendocrine secretory protein 55 [KO:K04632]
121486651  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121495416  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
121484229  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
121480493  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
121489094  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
121484743  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
121501517  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
121494424  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
121494648  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
121474745  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
121497300  UBR4; E3 ubiquitin-protein ligase UBR4 isoform X1 [KO:K10691] [EC:2.3.2.27]
121473813  tubulin gamma-2 chain [KO:K10389]
121472815  TUBG1; tubulin gamma-1 chain [KO:K10389]
121484558  PKM; pyruvate kinase PKM isoform X1 [KO:K00873] [EC:2.7.1.40]
121477875  LOW QUALITY PROTEIN: pyruvate kinase PKM-like [KO:K00873] [EC:2.7.1.40]
121496252  interferon alpha-1/2-like [KO:K05414]
121496295  interferon alpha-1/2-like [KO:K05414]
121494194  interferon alpha-1/2 [KO:K05414]
121494460  interferon alpha-2-like [KO:K05414]
121495211  interferon alpha-1/2-like [KO:K05414]
121495363  interferon alpha-1/2-like [KO:K05414]
121495364  interferon alpha-1/2-like [KO:K05414]
121495366  interferon alpha-1/2-like [KO:K05414]
121479467  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
121479519  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
121499401  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
121495696  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
121480638  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
121491356  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
121493250  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
121492020  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
121475257  OASL; 2'-5'-oligoadenylate synthase-like protein [KO:K14608]
121475835  2'-5'-oligoadenylate synthase-like protein 2 isoform X1 [KO:K14608]
121479319  MX2; interferon-induced GTP-binding protein Mx2 isoform X1 [KO:K14754]
121479555  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
121499982  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
121478025  JAG1; protein jagged-1 isoform X1 [KO:K06052]
121472943  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
121490555  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
121495306  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
121492778  NOTCH4; neurogenic locus notch homolog protein 4 isoform X1 [KO:K20996]
121493104  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
121488152  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
121472707  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
121491363  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
121476587  MAML2; mastermind-like protein 2 isoform X1 [KO:K06061]
121492865  MAML3; mastermind-like protein 3 isoform X1 [KO:K06061]
121494333  MAML1; mastermind-like protein 1 [KO:K06061]
121489096  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
121477726  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
121479130  HES1; transcription factor HES-1 [KO:K06054]
121497402  HES6; transcription cofactor HES-6 isoform X1 [KO:K09087]
121500216  HES2; transcription factor HES-2 isoform X1 [KO:K09087]
121500755  HES7; transcription factor HES-7 [KO:K09087]
121499468  HES3; transcription factor HES-3 [KO:K09088]
121500499  HES4; transcription factor HES-4 [KO:K09089]
121500633  HES5; transcription factor HES-5 [KO:K06055]
121481431  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
121484846  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 isoform X1 [KO:K09091]
121499136  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
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Moody CA, Laimins LA
  Title
Human papillomavirus oncoproteins: pathways to transformation.
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Nat Rev Cancer 10:550-60 (2010)
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Reference
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Signaling pathways in HPV-associated cancers and therapeutic implications.
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Rev Med Virol 25 Suppl 1:24-53 (2015)
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Reference
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High-risk human papillomavirus targets crossroads in immune signaling.
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Viruses 7:2485-506 (2015)
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Reference
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Molecular mechanisms of human papillomavirus-induced carcinogenesis.
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Reference
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Human papillomavirus proteins as prospective therapeutic targets.
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Reference
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  Title
Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins.
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Rev Med Virol 19:97-113 (2009)
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Reference
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  Title
Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins.
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Reference
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  Title
The molecular biology of cervical cancer.
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Cancer Invest 19:621-9 (2001)
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Reference
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  Authors
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  Title
Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis.
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Reference
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Reference
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McCance DJ
  Title
Human papillomaviruses and cell signaling.
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Sci STKE 2005:pe29 (2005)
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Reference
PMID:15342967
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The role of human papilloma virus in the molecular biology of cervical carcinogenesis.
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Reference
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Tommasino M
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The human papillomavirus family and its role in carcinogenesis.
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Semin Cancer Biol 26:13-21 (2014)
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Reference
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Bello JO, Nieva LO, Paredes AC, Gonzalez AM, Zavaleta LR, Lizano M
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Regulation of the Wnt/beta-Catenin Signaling Pathway by Human Papillomavirus E6 and E7 Oncoproteins.
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Viruses 7:4734-55 (2015)
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Reference
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In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response.
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Sci Rep 5:13446 (2015)
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Reference
PMID:26797638
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James CD, Roberts S
  Title
Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait?
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Pathogens 5:E8 (2016)
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Reference
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Ganti K, Broniarczyk J, Manoubi W, Massimi P, Mittal S, Pim D, Szalmas A, Thatte J, Thomas M, Tomaic V, Banks L
  Title
The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy.
  Journal
Viruses 7:3530-51 (2015)
DOI:10.3390/v7072785
Reference
PMID:21954943
  Authors
Subbaiah VK, Kranjec C, Thomas M, Banks L
  Title
PDZ domains: the building blocks regulating tumorigenesis.
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Biochem J 439:195-205 (2011)
DOI:10.1042/BJ20110903
Reference
PMID:23175122
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Human tumour viruses and the deregulation of cell polarity in cancer.
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Nat Rev Cancer 12:877-86 (2012)
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Reference
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Human papillomaviruses, cervical cancer and cell polarity.
  Journal
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Reference
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Cell intrinsic & extrinsic factors in cervical carcinogenesis.
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Indian J Med Res 130:286-95 (2009)
Reference
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Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.
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Reference
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The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses.
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Reference
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Papillomavirus E5: the smallest oncoprotein with many functions.
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Reference
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Mechanisms of cell transformation by papillomavirus E5 proteins.
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Reference
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Reference
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Reference
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Mol Cell Proteomics 11:M112.016998 (2012)
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Reference
PMID:9990017
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  Title
Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein.
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Reference
PMID:15175323
  Authors
Lu Z, Hu X, Li Y, Zheng L, Zhou Y, Jiang H, Ning T, Basang Z, Zhang C, Ke Y
  Title
Human papillomavirus 16 E6 oncoprotein interferences with insulin signaling pathway by binding to tuberin.
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J Biol Chem 279:35664-70 (2004)
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Reference
PMID:18505829
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Xu M, Luo W, Elzi DJ, Grandori C, Galloway DA
  Title
NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
  Journal
Mol Cell Biol 28:4819-28 (2008)
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Reference
PMID:23536685
  Authors
Raff AB, Woodham AW, Raff LM, Skeate JG, Yan L, Da Silva DM, Schelhaas M, Kast WM
  Title
The evolving field of human papillomavirus receptor research: a review of binding and entry.
  Journal
J Virol 87:6062-72 (2013)
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Related
pathway
vlg04064  NF-kappa B signaling pathway
vlg04110  Cell cycle
vlg04115  p53 signaling pathway
vlg04150  mTOR signaling pathway
vlg04151  PI3K-Akt signaling pathway
vlg04210  Apoptosis
vlg04310  Wnt signaling pathway
vlg04330  Notch signaling pathway
vlg04510  Focal adhesion
vlg04520  Adherens junction
vlg04530  Tight junction
vlg04612  Antigen processing and presentation
vlg04620  Toll-like receptor signaling pathway
vlg04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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