KEGG   PATHWAY: pcoo04810
Entry
pcoo04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Puma concolor (puma)
Class
Cellular Processes; Cell motility
Pathway map
pcoo04810  Regulation of actin cytoskeleton
pcoo04810

Other DBs
GO: 0030036
Organism
Puma concolor (puma) [GN:pcoo]
Gene
112867216  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
112852987  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
112871167  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
112867719  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
112854348  CXCL12; stromal cell-derived factor 1 [KO:K10031]
112848859  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
112865052  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
112861690  F2R; proteinase-activated receptor 1 [KO:K03914]
112858016  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
112861306  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
112855096  FGF7; fibroblast growth factor 7 [KO:K04358]
112869913  FGF20; fibroblast growth factor 20 [KO:K04358]
112869983  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
112870825  FGF16; fibroblast growth factor 16 [KO:K04358]
112858559  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
112860871  FGF9; fibroblast growth factor 9 [KO:K04358]
112867668  FGF6; fibroblast growth factor 6 [KO:K04358]
112851220  FGF21; fibroblast growth factor 21 [KO:K22429]
112867914  FGF23; fibroblast growth factor 23 [KO:K22428]
112863445  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
112858328  PDGFC; platelet-derived growth factor C [KO:K05450]
112865896  PDGFD; platelet-derived growth factor D [KO:K05450]
112851679  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
112860068  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
112858029  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
112854765  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
112860952  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
112858116  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
112860921  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
112866897  FN1; fibronectin [KO:K05717]
112860928  ITGA1; integrin alpha-1 [KO:K06480]
112860252  ITGA2; integrin alpha-2 [KO:K06481]
112853975  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
112852652  ITGA3; integrin alpha-3 [KO:K06482]
112870107  ITGA4; integrin alpha-4 [KO:K06483]
112867444  ITGA5; integrin alpha-5 [KO:K06484]
112871999  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
112863749  ITGA7; integrin alpha-7 [KO:K06583]
112867980  ITGA8; integrin alpha-8 [KO:K06584]
112850082  ITGA9; integrin alpha-9 [KO:K06585]
112870810  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
112855542  ITGA11; integrin alpha-11 [KO:K06587]
112848575  ITGAV; integrin alpha-V [KO:K06487]
112856284  ITGAL; integrin alpha-L [KO:K05718]
112856162  integrin alpha-M-like [KO:K06461]
112856153  ITGAX; integrin alpha-X [KO:K06462]
112856854  ITGAD; integrin alpha-D isoform X1 [KO:K06594]
112854534  ITGAE; integrin alpha-E [KO:K06524]
112867303  ITGB1; integrin beta-1 [KO:K05719]
112849420  ITGB2; integrin beta-2 [KO:K06464]
112862191  ITGB3; LOW QUALITY PROTEIN: integrin beta-3 [KO:K06493]
112864554  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
112849886  ITGB5; integrin beta-5 [KO:K06588]
112866044  ITGB6; integrin beta-6 [KO:K06589]
112867454  ITGB7; integrin beta-7 [KO:K06590]
112866864  ITGB8; integrin beta-8 [KO:K06591]
112849750  KNG1; kininogen-1 isoform X1 [KO:K03898]
112855876  BDKRB1; B1 bradykinin receptor [KO:K03915]
112856307  BDKRB2; B2 bradykinin receptor [KO:K03916]
112852113  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
112866732  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
112851546  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
112865504  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
112856055  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
112865031  C5; complement C5 [KO:K03994]
112861081  C6; complement component C6 [KO:K03995]
112860462  C7; complement component C7 [KO:K03996]
112848474  C8A; complement component C8 alpha chain [KO:K03997]
112872270  C8B; complement component C8 beta chain [KO:K03998]
112860598  C8G; complement component C8 gamma chain [KO:K03999]
112861565  C9; complement component C9 [KO:K04000]
112864473  GNA13; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
112848961  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
112852984  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
112870870  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
112868524  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
112859711  focal adhesion kinase 1-like [KO:K05725] [EC:2.7.10.2]
112857231  BCAR1; breast cancer anti-estrogen resistance protein 1 [KO:K05726]
112870314  CRKL; crk-like protein [KO:K04438]
112854202  CRK; adapter molecule crk isoform X1 [KO:K04438]
112854745  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
112869273  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
112855446  SOS2; son of sevenless homolog 2 [KO:K03099]
112864130  SOS1; son of sevenless homolog 1 [KO:K03099]
112868012  KRAS; GTPase KRas isoform X1 [KO:K07827]
112848478  NRAS; GTPase NRas [KO:K07828]
112865645  RRAS2; ras-related protein R-Ras2 [KO:K07830]
112866321  LOW QUALITY PROTEIN: ras-related protein R-Ras2-like [KO:K07830]
112849549  MRAS; ras-related protein M-Ras [KO:K07831]
112871320  ARHGEF6; rho guanine nucleotide exchange factor 6 [KO:K05729]
112849397  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112849524  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112848856  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
112861619  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
112868847  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112864658  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
112852876  VAV1; proto-oncogene vav [KO:K05730]
112860360  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
112849321  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
112870575  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
112866443  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
112859466  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
112859778  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
112855545  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112852828  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
112856394  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112870302  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112863208  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112851313  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112861152  RGCC; regulator of cell cycle RGCC [KO:K26108]
112851398  ARHGEF1; rho guanine nucleotide exchange factor 1 [KO:K12330]
112865830  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
112850754  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
112853046  RHOA; transforming protein RhoA [KO:K04513]
112859959  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
112863355  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
112872162  CDC42; cell division control protein 42 homolog [KO:K04393]
112865943  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
112850498  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
112871314  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
112868968  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
112855361  serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
112861180  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
112855086  GIT1; ARF GTPase-activating protein GIT1 [KO:K05737]
112868225  ROCK1; LOW QUALITY PROTEIN: rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
112864195  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
112849883  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
112869545  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
112857385  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
112870325  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
112864257  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112851965  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
112863593  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
112857630  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
112870159  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
112858209  MYL5; myosin light chain 5 [KO:K12753]
112868836  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
112859907  MYL10; myosin regulatory light chain 10 [KO:K12756]
112868098  myosin regulatory light polypeptide 9 [KO:K12757]
112868099  myosin regulatory light chain 12B-like [KO:K12757]
112856893  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
112863345  myosin-9-like [KO:K10352]
112857084  MYH10; LOW QUALITY PROTEIN: myosin-10 [KO:K10352]
112853139  MYH11; myosin-11 [KO:K10352]
112860965  DIAPH1; LOW QUALITY PROTEIN: protein diaphanous homolog 1 [KO:K05740]
112870724  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
112871858  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
112868560  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
112865314  PIP5K1A; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
112852821  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
112867967  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
112863505  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
112854099  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
112870457  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
112870101  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
112860280  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
112863169  ENAH; protein enabled homolog [KO:K05746]
112866400  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
112871968  WASF2; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
112856107  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
112860959  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
112867327  NCKAP1L; nck-associated protein 1-like [KO:K05750]
112848770  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
112871222  ABI2; abl interactor 2 isoform X1 [KO:K05751]
112858676  BRK1; protein BRICK1 [KO:K05752]
112862273  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
112869292  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
112871868  ACTR3; actin-related protein 3 [KO:K18584]
112866673  ACTR3B; actin-related protein 3B [KO:K18584]
112860095  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
112872185  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
112870125  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
112858569  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
112863918  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein isoform X1 [KO:K05754]
112857825  ARPC5; actin-related protein 2/3 complex subunit 5 isoform X1 [KO:K05754]
112864619  ACTG1; actin, cytoplasmic 2 [KO:K05692]
112860092  ACTB; actin, cytoplasmic 1 [KO:K05692]
112861515  PFN3; profilin-3 [KO:K05759]
112849669  PFN2; profilin-2 isoform X1 [KO:K05759]
112864340  PFN4; profilin-4 [KO:K05759]
112870752  profilin-1-like [KO:K05759]
112870464  PXN; paxillin [KO:K05760]
112862402  EZR; ezrin isoform X1 [KO:K08007]
112864888  RDX; radixin isoform X1 [KO:K05762]
112870754  MSN; moesin [KO:K05763]
112851932  thymosin beta-4-like [KO:K05764]
112871639  TMSB4X; thymosin beta-4 [KO:K05764]
112856087  CFL2; cofilin-2 [KO:K05765]
112852178  CFL1; cofilin-1 [KO:K05765]
112870454  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
112851962  SSH3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
112852006  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
112854676  VCL; vinculin isoform X1 [KO:K05700]
112855178  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
112860579  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
112859741  GSN; gelsolin isoform X1 [KO:K05768]
112866311  SCIN; LOW QUALITY PROTEIN: adseverin [KO:K05768]
112855807  ACTN1; alpha-actinin-1 [KO:K05699]
112851289  ACTN4; alpha-actinin-4 [KO:K05699]
112860216  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
112871030  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
pcoo04010  MAPK signaling pathway
pcoo04510  Focal adhesion
pcoo04520  Adherens junction
KO pathway
ko04810   
LinkDB

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