KEGG   PATHWAY: pcoq04062
Entry
pcoq04062                   Pathway                                
Name
Chemokine signaling pathway - Propithecus coquereli (Coquerel's sifaka)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
pcoq04062  Chemokine signaling pathway
pcoq04062

Other DBs
GO: 0070098
Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105804907  CCR1; C-C chemokine receptor type 1 [KO:K04176]
105804972  HCK; tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
105805044  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
105805186  CCR9; C-C chemokine receptor type 9 [KO:K04184]
105805194  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
105805204  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
105805796  [KO:K12366]
105805826  CCR5; C-C chemokine receptor type 5 [KO:K04180]
105805835  CCR2; C-C chemokine receptor type 2 [KO:K04177]
105805862  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
105805988  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
105806018  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105806167  PLCB1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105806182  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105806240  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105806301  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105806400  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
105807022  CCL24; C-C motif chemokine 24 [KO:K21097]
105807046  NCF1; neutrophil cytosol factor 1 [KO:K08011]
105807545  KRAS; GTPase KRas [KO:K07827]
105807768  CCL25; C-C motif chemokine 25 [KO:K13072]
105807940  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
105808008  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
105808407  RAP1B; ras-related protein Rap-1b [KO:K07836]
105808527  PARD3; partitioning defective 3 homolog [KO:K04237]
105808688  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
105808707  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
105808759  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
105808764  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
105808769  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
105808775  [KO:K05050]
105808778  [KO:K05050]
105808848  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
105809043  [KO:K04353]
105809543  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
105810179  ADRBK2; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
105810199  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105810397  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105810591  NRAS; GTPase NRas [KO:K07828]
105810783  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105810946  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105811228  SHC2; SHC-transforming protein 2 [KO:K17447]
105811507  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
105811510  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
105811723  FGR; LOW QUALITY PROTEIN: tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
105811845  VAV1; proto-oncogene vav [KO:K05730]
105812430  CCR4; C-C chemokine receptor type 4 [KO:K04179]
105812499  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105812606  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105812764  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
105812876  GRK7; G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
105812945  [KO:K04546]
105813177  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
105813227  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
105813290  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
105813348  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
105813423  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105813491  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
105813510  CCL13; C-C motif chemokine 13 [KO:K16595]
105813511  CCL1; C-C motif chemokine 1 [KO:K05514]
105813535  [KO:K14624]
105813536  CCL7; C-C motif chemokine 7 [KO:K05509]
105813540  CCL11; eotaxin [KO:K16597]
105813541  CCL8; C-C motif chemokine 8 [KO:K16596]
105813715  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105813732  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
105813833  CCL23; LOW QUALITY PROTEIN: C-C motif chemokine 23 [KO:K05511]
105813847  CCL4; C-C motif chemokine 4 [KO:K12964]
105813848  CCL16; C-C motif chemokine 16 [KO:K21093]
105813849  CCL5; C-C motif chemokine 5 [KO:K12499]
105813852  [KO:K05408]
105813858  CCL14; C-C motif chemokine 14 [KO:K21092]
105813862  [KO:K05408]
105814034  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
105814042  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105814299  SHC4; SHC-transforming protein 4 [KO:K17449]
105814456  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105814635  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
105814677  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
105815054  [KO:K05760]
105815179  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
105815218  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
105815233  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
105815381  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
105815495  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
105815695  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
105815725  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
105815749  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
105815750  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
105815753  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
105815931  FOXO3; forkhead box protein O3 [KO:K09408]
105816047  CXCL14; C-X-C motif chemokine 14 isoform X1 [KO:K10033]
105816561  HRAS; GTPase HRas isoform X1 [KO:K02833]
105816581  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
105816606  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
105816642  CCR8; C-C chemokine receptor type 8 [KO:K04183]
105816786  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
105816960  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
105817095  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
105817361  CRK; adapter molecule crk isoform X1 [KO:K04438]
105817505  CCR3; C-C chemokine receptor type 3 [KO:K04178]
105817597  XCR1; chemokine XC receptor 1 [KO:K04193]
105817618  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
105817773  SHC3; SHC-transforming protein 3 [KO:K17448]
105818006  SOS1; son of sevenless homolog 1 [KO:K03099]
105818048  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
105818130  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
105818188  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
105818191  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105818611  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
105818890  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
105819002  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105819191  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105819206  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
105819379  RHOA; transforming protein RhoA [KO:K04513]
105819419  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
105819482  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
105819687  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105819816  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105819845  CCL19; C-C motif chemokine 19 [KO:K05512]
105819855  CCL21; C-C motif chemokine 21 [KO:K16062]
105820016  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
105820211  [KO:K11224]
105820216  CCR10; C-C chemokine receptor type 10 [KO:K04185]
105820249  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
105820360  CCL27; C-C motif chemokine 27 [KO:K16598]
105820573  NFKBIB; NF-kappa-B inhibitor beta [KO:K02581]
105820591  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105820791  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
105820851  CCL17; C-C motif chemokine 17 [KO:K21083]
105820857  CX3CL1; fractalkine [KO:K05508]
105820859  CCL22; C-C motif chemokine 22 [KO:K21095]
105820912  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105820937  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
105821123  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
105821125  [KO:K05507]
105821322  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
105821386  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105821530  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105821872  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
105822028  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
105822091  RAP1A; ras-related protein Rap-1A [KO:K04353]
105822320  CCR6; C-C chemokine receptor type 6 [KO:K04181]
105822386  CRKL; crk-like protein [KO:K04438]
105822815  [KO:K05407]
105822820  CXCL8; interleukin-8 [KO:K10030]
105822825  PPBP; platelet basic protein [KO:K10029]
105822828  [KO:K05506]
105822880  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
105822883  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
105822921  CCR7; C-C chemokine receptor type 7 isoform X1 [KO:K04182]
105823098  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
105823104  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105823509  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
105823839  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105824094  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
105824261  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105824538  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
105824793  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105824997  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105825130  GRK1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
105825274  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
105825853  SOS2; son of sevenless homolog 2 [KO:K03099]
105825893  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
105826540  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105826612  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105826682  [KO:K05730]
105826741  CCL28; C-C motif chemokine 28 [KO:K05513]
105827172  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105827296  BAD; bcl2-associated agonist of cell death [KO:K02158]
105827297  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
105827379  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
105827383  RELA; transcription factor p65 isoform X1 [KO:K04735]
105827405  ADRBK1; beta-adrenergic receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
pcoq04010  MAPK signaling pathway
pcoq04060  Cytokine-cytokine receptor interaction
pcoq04120  Ubiquitin mediated proteolysis
pcoq04630  JAK-STAT signaling pathway
pcoq04670  Leukocyte transendothelial migration
pcoq04810  Regulation of actin cytoskeleton
KO pathway
ko04062   

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