KEGG   PATHWAY: rno04022
Entry
rno04022                    Pathway                                
Name
cGMP-PKG signaling pathway - Rattus norvegicus (rat)
Description
Cyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated intracellular cGMP level exerts its physiological action through two forms of cGMP-dependent protein kinase (PKG), cGMP-regulated phosphodiesterases (PDE2, PDE3) and cGMP-gated cation channels, among which PKGs might be the primary mediator. PKG1 isoform-specific activation of established substrates leads to reduction of cytosolic calcium concentration and/or decrease in the sensitivity of myofilaments to Ca2+ (Ca2+-desensitization), resulting in smooth muscle relaxation. In cardiac myocyte, PKG directly phosphorylates a member of the transient potential receptor canonical channel family, TRPC6, suppressing this nonselective ion channel's Ca2+ conductance, G-alpha-q agonist-induced NFAT activation, and myocyte hypertrophic responses. PKG also opens mitochondrial ATP-sensitive K+ (mitoKATP) channels and subsequent release of ROS triggers cardioprotection.
Class
Environmental Information Processing; Signal transduction
Pathway map
rno04022  cGMP-PKG signaling pathway
rno04022

Other DBs
GO: 0070305
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100361818  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 [KO:K04446]
100911165  Mylk4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
100911796  Adora3; adenosine receptor A3 isoform b [KO:K04268]
114493  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
114593  Nppc; C-type natriuretic peptide precursor [KO:K12336]
116564  Npr2; atrial natriuretic peptide receptor 2 precursor [KO:K12324] [EC:4.6.1.2]
116590  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116601  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
116670  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
117273  Rhoa; transforming protein RhoA [KO:K04513]
117558  Mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
140447  Slc8a2; sodium/calcium exchanger 2 precursor [KO:K05849]
140448  Slc8a3; sodium/calcium exchanger 3 precursor [KO:K05849]
170851  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
171115  Pde5a; cGMP-specific 3',5'-cyclic phosphodiesterase [KO:K13762] [EC:3.1.4.35]
171378  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
24173  Adra1b; alpha-1B adrenergic receptor [KO:K04136]
24174  Adra2b; alpha-2B adrenergic receptor [KO:K04139]
24175  Adra2c; alpha-2C adrenergic receptor [KO:K04140]
24176  Adrb2; beta-2 adrenergic receptor [KO:K04142]
24180  Agtr1a; type-1 angiotensin II receptor A [KO:K04166]
24185  Akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
24211  Atp1a1; sodium/potassium-transporting ATPase subunit alpha-1 precursor [KO:K01539] [EC:7.2.2.13]
24212  Atp1a2; sodium/potassium-transporting ATPase subunit alpha-2 precursor [KO:K01539] [EC:7.2.2.13]
24213  Atp1a3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
24214  Atp1b2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
24215  Atp2b2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
24239  Cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
24242  Calm1; calmodulin-1 [KO:K02183]
24244  Calm3; calmodulin-3 [KO:K02183]
24326  Ednra; endothelin-1 receptor precursor [KO:K04197]
24505  Ins1; insulin-1 preproprotein [KO:K04526]
24506  Ins2; insulin-2 preproprotein [KO:K04526]
24600  Nos3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
24602  Nppa; natriuretic peptides A precursor [KO:K12334]
24603  Npr1; atrial natriuretic peptide receptor 1 precursor [KO:K12323] [EC:4.6.1.2]
24613  Oprd1; delta-type opioid receptor [KO:K04213]
24654  Plcb1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
24668  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
24669  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1 [KO:K06269] [EC:3.1.3.16]
24674  Ppp3ca; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
24675  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
24703  Raf1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
24903  Kng2; T-kininogen 1 precursor [KO:K03898]
24925  Adrb1; beta-1 adrenergic receptor [KO:K04141]
24954  Insr; insulin receptor preproprotein [KO:K04527] [EC:2.7.10.1]
25031  Plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
25083  Adra2a; alpha-2A adrenergic receptor [KO:K04138]
25087  Kng2l1; kininogen-1 isoform 1 precursor [KO:K03898]
25105  Nppb; natriuretic peptides B precursor [KO:K12335]
25176  Slc25a5; ADP/ATP translocase 2 [KO:K05863]
25202  Gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
25206  Gucy1b2; guanylate cyclase soluble subunit beta-2 isoform 2 [KO:K12319] [EC:4.6.1.2]
25233  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
25245  Bdkrb2; B2 bradykinin receptor isoform 2 [KO:K03916]
25262  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform 3 [KO:K04958]
25289  Adcy6; adenylate cyclase type 6 isoform 2 [KO:K08046] [EC:4.6.1.1]
25390  Atp1b3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
25391  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
25467  Irs1; insulin receptor substrate 1 [KO:K16172]
25472  Kcnj8; ATP-sensitive inward rectifier potassium channel 8 [KO:K05001]
25523  Prkg2; cGMP-dependent protein kinase 2 [KO:K19477] [EC:2.7.11.12]
25537  Rock2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
25594  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
25643  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
25645  Adrb3; beta-3 adrenergic receptor [KO:K04143]
25650  Atp1b1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
25679  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
25686  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
282819  Ppif; peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor [KO:K09565] [EC:5.2.1.8]
288001  Kng1; T-kininogen 2 precursor [KO:K03898]
288057  Mylk; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
29132  Atp1a4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
291926  Mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
29241  Adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
29290  Adora1; adenosine receptor A1 [KO:K04265]
29322  Plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
29340  Prkce; protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
29376  Irs2; insulin receptor substrate 2 [KO:K07187]
29412  Adra1a; alpha-1A adrenergic receptor [KO:K04135]
29413  Adra1d; alpha-1D adrenergic receptor [KO:K04137]
29414  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
294961  Kcnmb2; calcium-activated potassium channel subunit beta-2 [KO:K04938]
29516  Pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
29556  Myh6; myosin-6 [KO:K17751]
29557  Myh7; myosin-7 [KO:K17751]
29598  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform 3 [KO:K05850] [EC:7.2.2.10]
29599  Atp2b3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
29600  Atp2b4; plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
296313  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
29639  Fxyd2; sodium/potassium-transporting ATPase subunit gamma isoform a [KO:K01538]
29693  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b [KO:K05853] [EC:7.2.2.10]
29715  Slc8a1; sodium/calcium exchanger 1 isoform 6 precursor [KO:K05849]
29716  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
297173  RSA-14-44; ras homolog gene family, member A [KO:K04513]
29747  Kcnmb1; calcium-activated potassium channel subunit beta-1 [KO:K04937]
29748  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
29749  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
298400  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
298947  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
302950  Adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
303634  Gna13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
305509  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
305897  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
307100  Calml3; calmodulin-like protein 3 [KO:K02183]
308899  Irag1; inositol 1,4,5-triphosphate receptor associated 1 isoform b [KO:K12337]
309957  Mef2a; myocyte-specific enhancer factor 2A [KO:K09260]
310303  Kcnmb3; calcium-activated potassium channel subunit beta-3 [KO:K04939]
310616  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1 [KO:K09048]
311658  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
314638  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
315350  Irs4; insulin receptor substrate 4 [KO:K17446]
353256  Gtf2i; general transcription factor II-I isoform 1 [KO:K03121]
361400  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
361517  Vasp; vasodilator-stimulated phosphoprotein [KO:K06274]
362165  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
362339  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
364774  Calml5; calmodulin-like protein 5 [KO:K02183]
406169  Atf6b; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
497757  Gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
497931  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
497932  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
498607  Mef2b; myocyte-specific enhancer factor 2B [KO:K09261]
498885  Slc25a6; solute carrier family 25 member 6 [KO:K05863]
499497  Mef2c; myocyte-specific enhancer factor 2C isoform 1 [KO:K04454]
500131  Creb5; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
500871  Slc25a5l1; ADP/ATP translocase 2-like [KO:K05863]
501099  Srf; serum response factor [KO:K04378]
50663  Calm2; calmodulin-2 [KO:K02183]
50672  Ednrb; endothelin receptor type B precursor [KO:K04198]
50678  Pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
50689  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
54223  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
54254  Gata4; transcription factor GATA-4 [KO:K09183]
54286  Prkg1; cGMP-dependent protein kinase 1 [KO:K07376] [EC:2.7.11.12]
58960  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
64508  Adcy3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
64532  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
64639  Bad; bcl2-associated agonist of cell death [KO:K02158]
64672  Pln; cardiac phospholamban [KO:K05852]
66012  Gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
66016  Kcnmb4; calcium-activated potassium channel subunit beta-4 [KO:K04941]
680912  Kcnu1; potassium channel subfamily U member 1 isoform X6 [KO:K05274]
682930  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
689108  Slc25a31; ADP/ATP translocase 4 [KO:K05863]
691455  Calml4; calmodulin-like protein 4 [KO:K02183]
79255  Atf4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
81518  Mef2d; myocyte-specific enhancer factor 2D [KO:K09262]
81636  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
81638  Agtr1b; type-1 angiotensin II receptor B [KO:K04166]
81646  Creb1; cyclic AMP-responsive element-binding protein 1 isoform A [KO:K05870]
81647  Atf2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
81662  Gna11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
81663  Gna12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
81664  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
81666  Gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
81678  Itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
81743  Pde2a; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor [KO:K18283] [EC:3.1.4.17]
81762  Rock1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.39]
83529  Vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
83531  Vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
83532  Vdac3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
83731  Kcnma1; calcium-activated potassium channel subunit alpha-1 isoform 1 [KO:K04936]
84021  Irs3; insulin receptor substrate 3 [KO:K17445]
84396  Atp1b4; protein ATP1B4 [KO:K01540]
84420  Adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
84583  Rgs2; regulator of G-protein signaling 2 [KO:K18154]
85240  Plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
85259  Cnga1; cGMP-gated cation channel alpha-1 [KO:K04948]
85333  Slc25a4; ADP/ATP translocase 1 [KO:K05863]
89823  Trpc6; short transient receptor potential channel 6 [KO:K04969]
Compound
C00020  AMP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00144  GMP
C00212  Adenosine
C00238  Potassium cation
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:20716671
  Authors
Francis SH, Busch JL, Corbin JD, Sibley D
  Title
cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action.
  Journal
Pharmacol Rev 62:525-63 (2010)
DOI:10.1124/pr.110.002907
Reference
PMID:16439998
  Authors
Feil R, Kemp-Harper B
  Title
cGMP signalling: from bench to bedside. Conference on cGMP generators, effectors and therapeutic implications.
  Journal
EMBO Rep 7:149-53 (2006)
DOI:10.1038/sj.embor.7400627
Reference
PMID:22785374
  Authors
Takimoto E
  Title
Cyclic GMP-dependent signaling in cardiac myocytes.
  Journal
Circ J 76:1819-25 (2012)
DOI:10.1253/circj.CJ-12-0664
Reference
PMID:16371594
  Authors
Hofmann F, Feil R, Kleppisch T, Schlossmann J
  Title
Function of cGMP-dependent protein kinases as revealed by gene deletion.
  Journal
Physiol Rev 86:1-23 (2006)
DOI:10.1152/physrev.00015.2005
Reference
PMID:21685243
  Authors
Kuebler WM
  Title
The Janus-faced regulation of endothelial permeability by cyclic GMP.
  Journal
Am J Physiol Lung Cell Mol Physiol 301:L157-60 (2011)
DOI:10.1152/ajplung.00192.2011
Reference
PMID:21666108
  Authors
Schlossmann J, Desch M
  Title
IRAG and novel PKG targeting in the cardiovascular system.
  Journal
Am J Physiol Heart Circ Physiol 301:H672-82 (2011)
DOI:10.1152/ajpheart.00198.2011
Reference
PMID:16460276
  Authors
Murthy KS
  Title
Signaling for contraction and relaxation in smooth muscle of the gut.
  Journal
Annu Rev Physiol 68:345-74 (2006)
DOI:10.1146/annurev.physiol.68.040504.094707
Reference
PMID:22965426
  Authors
Sanders KM, Koh SD, Ro S, Ward SM
  Title
Regulation of gastrointestinal motility--insights from smooth muscle biology.
  Journal
Nat Rev Gastroenterol Hepatol 9:633-45 (2012)
DOI:10.1038/nrgastro.2012.168
Reference
PMID:20024580
  Authors
Gao Y
  Title
The multiple actions of NO.
  Journal
Pflugers Arch 459:829-39 (2010)
DOI:10.1007/s00424-009-0773-9
Reference
PMID:9003029
  Authors
Wang X, Robinson PJ
  Title
Cyclic GMP-dependent protein kinase and cellular signaling in the nervous system.
  Journal
J Neurochem 68:443-56 (1997)
DOI:10.1046/j.1471-4159.1997.68020443.x
Reference
PMID:19306895
  Authors
Tsai EJ, Kass DA
  Title
Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics.
  Journal
Pharmacol Ther 122:216-38 (2009)
DOI:10.1016/j.pharmthera.2009.02.009
Reference
PMID:20388537
  Authors
Villanueva C, Giulivi C
  Title
Subcellular and cellular locations of nitric oxide synthase isoforms as determinants of health and disease.
  Journal
Free Radic Biol Med 49:307-16 (2010)
DOI:10.1016/j.freeradbiomed.2010.04.004
Reference
PMID:15894227
  Authors
Schlossmann J, Hofmann F
  Title
cGMP-dependent protein kinases in drug discovery.
  Journal
Drug Discov Today 10:627-34 (2005)
DOI:10.1016/S1359-6446(05)03406-9
Reference
PMID:18040025
  Authors
Kass DA, Champion HC, Beavo JA
  Title
Phosphodiesterase type 5: expanding roles in cardiovascular regulation.
  Journal
Circ Res 101:1084-95 (2007)
DOI:10.1161/CIRCRESAHA.107.162511
Reference
PMID:16815627
  Authors
Uckert S, Hedlund P, Andersson KE, Truss MC, Jonas U, Stief CG
  Title
Update on phosphodiesterase (PDE) isoenzymes as pharmacologic targets in urology: present and future.
  Journal
Eur Urol 50:1194-207; discussion 1207 (2006)
DOI:10.1016/j.eururo.2006.05.025
Reference
PMID:12524221
  Authors
Yan C, Kim D, Aizawa T, Berk BC
  Title
Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator.
  Journal
Arterioscler Thromb Vasc Biol 23:26-36 (2003)
DOI:10.1161/01.ATV.0000046231.17365.9D
Reference
PMID:17643091
  Authors
McKinsey TA, Kass DA
  Title
Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface.
  Journal
Nat Rev Drug Discov 6:617-35 (2007)
DOI:10.1038/nrd2193
Reference
PMID:19961855
  Authors
Koitabashi N, Aiba T, Hesketh GG, Rowell J, Zhang M, Takimoto E, Tomaselli GF, Kass DA
  Title
Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition.
  Journal
J Mol Cell Cardiol 48:713-24 (2010)
DOI:10.1016/j.yjmcc.2009.11.015
Reference
PMID:18006449
  Authors
Costa AD, Pierre SV, Cohen MV, Downey JM, Garlid KD
  Title
cGMP signalling in pre- and post-conditioning: the role of mitochondria.
  Journal
Cardiovasc Res 77:344-52 (2008)
DOI:10.1093/cvr/cvm050
Reference
PMID:19176601
  Authors
Boengler K, Schulz R, Heusch G
  Title
Loss of cardioprotection with ageing.
  Journal
Cardiovasc Res 83:247-61 (2009)
DOI:10.1093/cvr/cvp033
Reference
PMID:18757523
  Authors
Gao Y, Portugal AD, Liu J, Negash S, Zhou W, Tian J, Xiang R, Longo LD, Raj JU
  Title
Preservation of cGMP-induced relaxation of pulmonary veins of fetal lambs exposed to chronic high altitude hypoxia: role of PKG and Rho kinase.
  Journal
Am J Physiol Lung Cell Mol Physiol 295:L889-96 (2008)
DOI:10.1152/ajplung.00463.2007
Reference
PMID:11522789
  Authors
Li Z, Xi X, Du X
  Title
A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3.
  Journal
J Biol Chem 276:42226-32 (2001)
DOI:10.1074/jbc.M106129200
Reference
PMID:23212367
  Authors
Xie J, Cha SK, An SW, Kuro-O M, Birnbaumer L, Huang CL
  Title
Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart.
  Journal
Nat Commun 3:1238 (2012)
DOI:10.1038/ncomms2240
Related
pathway
rno04010  MAPK signaling pathway
rno04020  Calcium signaling pathway
rno04151  PI3K-Akt signaling pathway
rno04210  Apoptosis
rno04270  Vascular smooth muscle contraction
rno04744  Phototransduction
KO pathway
ko04022   

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