KEGG   PATHWAY: mpah04630
mpah04630                   Pathway                                

JAK-STAT signaling pathway - Mus pahari (shrew mouse)
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Environmental Information Processing; Signal transduction
Pathway map
mpah04630  JAK-STAT signaling pathway

Other DBs
GO: 0007259
Mus pahari (shrew mouse) [GN:mpah]
110320556  Il2; interleukin-2 [KO:K05429]
110332758  LOW QUALITY PROTEIN: interleukin-3-like [KO:K04736]
110332760  Il4; interleukin-4 [KO:K05430]
110332614  Il5; interleukin-5 [KO:K05428]
110317140  Il6; interleukin-6 [KO:K05405]
110321006  Il7; interleukin-7 isoform X1 [KO:K05431]
110334313  Il9; interleukin-9 [KO:K05432]
110322547  Il10; interleukin-10 [KO:K05443]
110337120  Il11; interleukin-11 [KO:K05417]
110320680  Il12a; interleukin-12 subunit alpha [KO:K05406]
110332403  Il12b; interleukin-12 subunit beta [KO:K05425]
110332737  Il13; interleukin-13 [KO:K05435]
110337630  Il15; interleukin-15 isoform X1 [KO:K05433]
110325617  Il17d; interleukin-17D [KO:K05492]
110322622  Il19; interleukin-19 [KO:K05444]
110322491  Il20; interleukin-20 isoform X1 [KO:K22667]
110320935  Il21; interleukin-21 isoform X1 [KO:K05434]
110326940  Il22; interleukin-22 [KO:K05445]
110327099  Il23a; interleukin-23 subunit alpha [KO:K05426]
110322551  Il24; interleukin-24 [KO:K22668]
110315179  interferon alpha-4-like [KO:K05414]
110323382  interferon alpha-12-like [KO:K05414]
110323390  interferon alpha-5 [KO:K05414]
110323408  interferon alpha-1-like [KO:K05414]
110322994  interferon alpha-11-like [KO:K05414]
110323165  interferon alpha-5 [KO:K05414]
110315688  interferon alpha-2-like [KO:K05414]
110323303  interferon alpha-1-like [KO:K05414]
110323342  interferon alpha-1-like [KO:K05414]
110323416  interferon alpha-12-like [KO:K05414]
110323424  interferon alpha-7-like [KO:K05414]
110323427  interferon alpha-7-like [KO:K05414]
110323346  Ifnb1; interferon beta [KO:K05415]
110326932  Ifng; interferon gamma [KO:K04687]
110323960  Ifne; interferon epsilon [KO:K05442]
110338822  Ifnk; interferon kappa [KO:K05441]
110330418  Ifnl1; LOW QUALITY PROTEIN: interferon lambda-1 [KO:K05447]
110330430  interferon lambda-2 [KO:K22669]
110330998  Osm; oncostatin-M [KO:K05418]
110330793  Lif; leukemia inhibitory factor isoform X1 [KO:K05419]
110333517  Tslp; thymic stromal lymphopoietin [KO:K05436]
110317740  Ctf1; cardiotrophin-1 isoform X1 [KO:K05422]
110317734  cardiotrophin-2 [KO:K24382]
110332438  Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
110338866  Cntf; LOW QUALITY PROTEIN: ciliary neurotrophic factor [KO:K05420]
110332564  Csf3; granulocyte colony-stimulating factor [KO:K05423]
110313227  Epo; erythropoietin isoform X1 [KO:K05437]
110332223  somatotropin [KO:K05438]
110317099  Lep; leptin [KO:K05424]
110329913  Thpo; thrombopoietin isoform X1 [KO:K06854]
110333863  prolactin-2C2-like isoform X1 [KO:K05439]
110333918  prolactin isoform X1 [KO:K05439]
110334155  prolactin-2A1 [KO:K05439]
110334192  prolactin-5A1 [KO:K05439]
110333583  prolactin-6A1 [KO:K05439]
110320006  Egf; pro-epidermal growth factor isoform X1 [KO:K04357]
110312881  Pdgfa; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110334927  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
110334116  Il2ra; interleukin-2 receptor subunit alpha [KO:K05068]
110335025  Il2rb; interleukin-2 receptor subunit beta [KO:K05069]
110313918  Il2rg; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
110325021  interleukin-3 receptor subunit alpha-like [KO:K04737]
110322992  Il4r; interleukin-4 receptor subunit alpha [KO:K05071]
110317305  Il5ra; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067]
110320682  Il6r; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
110329173  Il7r; interleukin-7 receptor subunit alpha [KO:K05072]
110332526  Il9r; interleukin-9 receptor [KO:K05073]
110327772  Il10ra; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134]
110329837  Il10rb; interleukin-10 receptor subunit beta [KO:K05135]
110338645  Il11ra; interleukin-11 receptor subunit alpha [KO:K05056]
110336813  Il12rb1; interleukin-12 receptor subunit beta-1 [KO:K05063]
110316620  Il12rb2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064]
110313659  Il13ra1; interleukin-13 receptor subunit alpha-1 [KO:K05076]
110314118  Il13ra2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077]
110333882  Il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
110338370  Il20ra; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136]
110328622  Il20rb; interleukin-20 receptor subunit beta [KO:K05137]
110331013  Il21r; interleukin-21 receptor [KO:K05075]
110323524  Il22ra1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
110338296  Il22ra2; interleukin-22 receptor subunit alpha-2 isoform X1 [KO:K05139]
110316831  Il23r; interleukin-23 receptor [KO:K05065]
110337661  Il27ra; interleukin-27 receptor subunit alpha [KO:K19598]
110328878  Il6st; interleukin-6 receptor subunit beta [KO:K05060]
110329827  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
110329735  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
110338217  Ifngr1; interferon gamma receptor 1 [KO:K05132]
110330069  Ifngr2; interferon gamma receptor 2 [KO:K05133]
110323717  Ifnlr1; interferon lambda receptor 1 isoform X1 [KO:K05140]
110329042  Osmr; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
110328984  Lifr; leukemia inhibitory factor receptor isoform X1 [KO:K05058]
110338678  Cntfr; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
110315436  granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
110334519  cytokine receptor common subunit beta-like [KO:K04738]
110334939  cytokine receptor common subunit beta isoform X1 [KO:K04738]
110323626  Csf3r; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
110328285  Epor; erythropoietin receptor [KO:K05079]
110328813  Ghr; growth hormone receptor isoform X1 [KO:K05080]
110322802  Lepr; leptin receptor isoform X1 [KO:K05062]
110323469  Mpl; thrombopoietin receptor isoform X1 [KO:K05082]
110328981  Prlr; prolactin receptor isoform X1 [KO:K05081]
110330480  Egfr; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:]
110331028  Pdgfra; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:]
110333065  Pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:]
110322912  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:]
110316808  Jak2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:]
110337003  Jak3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:]
110327406  Tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:]
110321139  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
110326622  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
110332765  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
110321473  Stat4; signal transducer and activator of transcription 4 [KO:K11222]
110331871  LOW QUALITY PROTEIN: signal transducer and activator of transcription 5A-like [KO:K11223]
110331105  Stat5b; signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
110326351  Stat6; signal transducer and activator of transcription 6 [KO:K11225]
110327918  Cish; cytokine-inducible SH2-containing protein isoform X1 [KO:K04701]
110329809  Socs1; suppressor of cytokine signaling 1 [KO:K04694]
110326628  Socs2; suppressor of cytokine signaling 2 isoform X1 [KO:K04695]
110332146  Socs3; suppressor of cytokine signaling 3 [KO:K04696]
110325522  Socs4; suppressor of cytokine signaling 4 [KO:K04697]
110335610  Socs5; suppressor of cytokine signaling 5 isoform X1 [KO:K04698]
110333231  Socs6; suppressor of cytokine signaling 6 [KO:K04699]
110332041  Socs7; suppressor of cytokine signaling 7 [KO:K04699]
110321591  Bcl2; apoptosis regulator Bcl-2 [KO:K02161]
110320476  Mcl1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
110318630  Bcl2l1; bcl-2-like protein 1 [KO:K04570]
110338042  Pim1; serine/threonine-protein kinase pim-1 [KO:K04702] [EC:]
110334656  Myc; myc proto-oncogene protein [KO:K04377]
110322378  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
110315929  Ccnd2; G1/S-specific cyclin-D2 [KO:K10151]
110335402  Ccnd3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
110338236  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
110321275  aldehyde oxidase 3 isoform X1 [KO:K00157] [EC:]
110321290  Aox1; aldehyde oxidase [KO:K00157] [EC:]
110321921  aldehyde oxidase 4 [KO:K00157] [EC:]
110331730  Gfap; glial fibrillary acidic protein isoform X1 [KO:K05640]
110318348  Stam2; signal transducing adapter molecule 2 isoform X1 [KO:K04705]
110317578  Stam; signal transducing adapter molecule 1 [KO:K04705]
110333049  Ptpn2; tyrosine-protein phosphatase non-receptor type 2 isoform X1 [KO:K18026] [EC:]
110314992  Ptpn6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:]
110325811  Irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
110334526  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:]
110330048  Crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:]
110327437  Pias1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
110332895  Pias2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
110319879  Pias3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064] [EC:2.3.2.-]
110326368  Pias4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:]
110313534  Fhl1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
110339175  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:]
110331195  Grb2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
110335780  Sos1; son of sevenless homolog 1 [KO:K03099]
110324314  Sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
110318967  GTPase HRas-like isoform X1 [KO:K02833]
110319567  Hras; GTPase HRas [KO:K02833]
110338480  GTPase HRas-like [KO:K02833]
110333346  GTPase HRas-like [KO:K02833]
110314893  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:]
110323448  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:]
110319750  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:]
110327251  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:]
110328811  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110336420  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110322865  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
110317258  Akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:]
110324386  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:]
110322284  Akt3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:]
110323363  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:]
Harrison DA
The Jak/STAT pathway.
Cold Spring Harb Perspect Biol 4:a011205 (2012)
Kiu H, Nicholson SE
Biology and significance of the JAK/STAT signalling pathways.
Growth Factors 30:88-106 (2012)
Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Direct effects of type I interferons on cells of the immune system.
Clin Cancer Res 17:2619-27 (2011)
Fish EN, Platanias LC
Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Mol Cancer Res 12:1691-703 (2014)
Ivanenkov YA, Balakin KV, Lavrovsky Y
Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Mini Rev Med Chem 11:55-78 (2011)
O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Annu Rev Med 66:311-28 (2015)
Zoranovic T, Grmai L, Bach EA
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
JAKSTAT 2:e25408 (2013)
Ungureanu D, Silvennoinen O
SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Sci STKE 2005:pe49 (2005)
Richard AJ, Stephens JM
The role of JAK-STAT signaling in adipose tissue function.
Biochim Biophys Acta 1842:431-9 (2014)
Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Neuropathol Appl Neurobiol 41:347-70 (2015)
Hirano T, Ishihara K, Hibi M
Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Oncogene 19:2548-56 (2000)
Rane SG, Reddy EP
Janus kinases: components of multiple signaling pathways.
Oncogene 19:5662-79 (2000)
Heim MH
The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Eur J Clin Invest 26:1-12 (1996)
mpah04010  MAPK signaling pathway
mpah04060  Cytokine-cytokine receptor interaction
mpah04110  Cell cycle
mpah04120  Ubiquitin mediated proteolysis
mpah04151  PI3K-Akt signaling pathway
mpah04210  Apoptosis
KO pathway

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