Entry
Name
Cytokine-cytokine receptor interaction - Mus pahari (shrew mouse)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
mpah04060 Cytokine-cytokine receptor interaction
Organism
Mus pahari (shrew mouse) [GN:
mpah ]
Gene
110313918 Il2rg; cytokine receptor common subunit gamma isoform X1 [KO:K05070 ]
110314090 Eda2r; tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
110314118 Il13ra2; interleukin-13 receptor subunit alpha-2 isoform X1 [KO:K05077 ]
110316225 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
110316473 Ltbr; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159 ]
110316620 Il12rb2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
110317305 Il5ra; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067 ]
110318800 Il1rn; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
110318846 Cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
110320682 Il6r; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055 ]
110320972 Tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
110322215 Faslg; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389 ]
110322442 Tnfsf18; tumor necrosis factor ligand superfamily member 18 isoform X1 [KO:K05479 ]
110322494 Tnfrsf11a; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
110322632 Tnfsf4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
110323544 Tnfrsf9; tumor necrosis factor receptor superfamily member 9 isoform X1 [KO:K05146 ]
110323610 Tnfrsf25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
110323617 Tnfrsf14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
110323625 Tnfrsf18; tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154 ]
110323626 Csf3r; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
110323704 Tnfrsf4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
110323711 Tnfsf8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
110323728 Tnfrsf8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
110323744 Tnfrsf1b; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
110323754 Tnfsf15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
110324516 Clcf1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
110325199 Tnfrsf19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
110325778 Tnfsf11; tumor necrosis factor ligand superfamily member 11 isoform X1 [KO:K05473 ]
110325978 Tnfrsf10b; tumor necrosis factor receptor superfamily member 10B [KO:K04722 ]
110326880 Edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
110327438 Relt; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
110327772 Il10ra; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
110329009 Il31ra; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630 ]
110329042 Osmr; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
110329561 Il1rap; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
110330139 Tnfrsf17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
110331904 Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
110332438 Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
110332615 Tnfrsf13b; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
110332797 Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
110333882 Il15ra; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
110335158 Tnfrsf11b; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
110335289 Tnfrsf13c; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151 ]
110335742 Tnfrsf21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
110335940 Tnfsf9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
110336050 Tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
110336856 Tnfsf13b; tumor necrosis factor ligand superfamily member 13B isoform X1 [KO:K05476 ]
110338325 Tnfrsf12a; tumor necrosis factor receptor superfamily member 12A isoform X1 [KO:K05149 ]
110338370 Il20ra; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136 ]
110338678 Cntfr; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
110338866 Cntf; LOW QUALITY PROTEIN: ciliary neurotrophic factor [KO:K05420 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway