KEGG   PATHWAY: cclu04371
Entry
cclu04371                   Pathway                                
Name
Apelin signaling pathway - Coregonus clupeaformis (lake whitefish)
Description
Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various tissues and organ systems. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, cell proliferation and energy metabolism regulation. On the other hand, this ligand receptor couple is also involved in several pathologies including diabetes, obesity, cardiovascular disease and cancer.
Class
Environmental Information Processing; Signal transduction
Pathway map
cclu04371  Apelin signaling pathway
cclu04371

Other DBs
GO: 0060183
Organism
Coregonus clupeaformis (lake whitefish) [GN:cclu]
Gene
121530742  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121530778  [KO:K13240] [EC:1.14.13.39]
121531644  [KO:K04503]
121531768  [KO:K10435]
121531893  [KO:K09260]
121532106  [KO:K02183]
121532188  [KO:K02833]
121532236  [KO:K04630]
121532244  kras; GTPase KRas isoform X1 [KO:K07827]
121532247  [KO:K04959]
121532654  [KO:K04718] [EC:2.7.1.91]
121532721  [KO:K09261]
121532733  [KO:K17845]
121533168  [KO:K04456] [EC:2.7.11.1]
121533289  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
121533332  [KO:K07198] [EC:2.7.11.31]
121533487  [KO:K10435]
121533527  [KO:K04369] [EC:2.7.12.2]
121533711  [KO:K05869] [EC:2.7.11.17]
121533749  [KO:K12313]
121533764  [KO:K04538]
121533872  adcy1a; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
121533886  mylk4b; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
121533913  gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
121534350  si:ch211-286b5.5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
121534442  mylk4a; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
121534524  [KO:K08047] [EC:4.6.1.1]
121534674  [KO:K17845]
121534863  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
121535037  [KO:K04347]
121535203  apln; apelin [KO:K05225]
121535276  [KO:K04674] [EC:2.7.11.30]
121535291  [KO:K07200]
121535312  [KO:K08041] [EC:4.6.1.1]
121535328  [KO:K04345] [EC:2.7.11.11]
121535366  [KO:K12749]
121535471  [KO:K07199]
121535511  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
121535562  [KO:K04542]
121535959  [KO:K11265] [EC:4.6.1.1]
121536646  [KO:K11406] [EC:3.5.1.98]
121536678  [KO:K00907] [EC:2.7.11.18]
121536694  [KO:K07831]
121537021  [KO:K08045] [EC:4.6.1.1]
121537247  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
121537723  [KO:K04630]
121537863  [KO:K08046] [EC:4.6.1.1]
121538102  [KO:K08046] [EC:4.6.1.1]
121538333  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
121538342  [KO:K04960]
121538443  [KO:K04536]
121538562  [KO:K04366] [EC:2.7.11.1]
121538660  [KO:K04547]
121539230  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121539250  [KO:K04963]
121539477  [KO:K02183]
121539623  [KO:K07826]
121539945  [KO:K04347]
121540038  [KO:K00907] [EC:2.7.11.18]
121540184  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
121540361  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
121540386  [KO:K04345] [EC:2.7.11.11]
121540730  [KO:K04539]
121541171  [KO:K12750]
121541196  [KO:K04174]
121541228  [KO:K04544]
121541495  [KO:K07198] [EC:2.7.11.31]
121541524  mef2ca; myocyte enhancer factor 2ca isoform X1 [KO:K04454]
121541829  [KO:K02183]
121541831  [KO:K05849]
121541839  [KO:K04540]
121541906  [KO:K04961]
121541975  [KO:K04456] [EC:2.7.11.1]
121543111  mef2d; myocyte-specific enhancer factor 2D isoform X1 [KO:K09262]
121543270  [KO:K08333] [EC:2.7.11.1]
121543382  [KO:K11831]
121543494  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
121543601  [KO:K04630]
121543663  [KO:K21289] [EC:2.7.1.153]
121543826  sphk2; LOW QUALITY PROTEIN: sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
121544287  [KO:K05858] [EC:3.1.4.11]
121544381  [KO:K05858] [EC:3.1.4.11]
121544557  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
121544568  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
121544618  [KO:K07826]
121544751  [KO:K02183]
121544942  [KO:K04963]
121544961  [KO:K04456] [EC:2.7.11.1]
121545208  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
121545408  [KO:K04366] [EC:2.7.11.1]
121545441  [KO:K08046] [EC:4.6.1.1]
121545524  [KO:K00907] [EC:2.7.11.18]
121545580  [KO:K04536]
121545889  [KO:K08046] [EC:4.6.1.1]
121545914  [KO:K10435]
121546039  [KO:K04960]
121546142  [KO:K04630]
121546225  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
121546902  [KO:K09203]
121547132  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
121547181  [KO:K08334]
121547331  [KO:K12313]
121547367  [KO:K18050] [EC:2.7.11.13]
121547385  [KO:K04639]
121547648  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121547663  [KO:K18050] [EC:2.7.11.13]
121547849  [KO:K11406] [EC:3.5.1.98]
121548010  gngt2b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2b [KO:K04549]
121548165  [KO:K02183]
121548320  [KO:K00907] [EC:2.7.11.18]
121548501  [KO:K02183]
121548540  [KO:K04963]
121548687  [KO:K05858] [EC:3.1.4.11]
121548707  [KO:K05858] [EC:3.1.4.11]
121548712  [KO:K08043] [EC:4.6.1.1]
121548808  si:dkey-206f10.1; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
121548848  [KO:K04456] [EC:2.7.11.1]
121548985  [KO:K06827]
121549044  [KO:K04630]
121549503  [KO:K04166]
121549724  [KO:K04674] [EC:2.7.11.30]
121549886  prkag2a; 5'-AMP-activated protein kinase subunit gamma-2a isoform X1 [KO:K07200]
121550047  [KO:K11831]
121550213  [KO:K04500]
121550217  [KO:K04454]
121550297  rras; ras-related protein R-Ras [KO:K07830]
121550312  [KO:K04174]
121550334  [KO:K04371] [EC:2.7.11.24]
121550445  hdac4; histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
121550472  [KO:K04549]
121550496  [KO:K12750]
121550867  [KO:K20995]
121550889  [KO:K11406] [EC:3.5.1.98]
121550898  [KO:K21290]
121551044  [KO:K04718] [EC:2.7.1.91]
121551276  [KO:K04634]
121551300  [KO:K04345] [EC:2.7.11.11]
121551334  [KO:K04542]
121551447  [KO:K04347]
121551455  [KO:K04639]
121551578  [KO:K07827]
121551681  [KO:K00907] [EC:2.7.11.18]
121551734  [KO:K00907] [EC:2.7.11.18]
121551797  [KO:K08049] [EC:4.6.1.1]
121552067  [KO:K02183]
121552187  [KO:K05858] [EC:3.1.4.11]
121552196  [KO:K04456] [EC:2.7.11.1]
121552358  [KO:K04963]
121552683  [KO:K05858] [EC:3.1.4.11]
121552959  [KO:K06827]
121553321  [KO:K04962]
121553329  [KO:K05849]
121553593  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
121553641  tfam; transcription factor A, mitochondrial [KO:K11830]
121553820  [KO:K04345] [EC:2.7.11.11]
121553821  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
121553987  [KO:K21290]
121553991  [KO:K21290]
121554349  [KO:K05858] [EC:3.1.4.11]
121554350  [KO:K05849]
121554508  [KO:K07202]
121554620  [KO:K03982]
121555052  [KO:K07831]
121555085  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b isoform X1 [KO:K07200]
121555154  [KO:K08045] [EC:4.6.1.1]
121555975  gng13b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13b [KO:K04547]
121556187  [KO:K07830]
121556192  [KO:K13296] [EC:3.1.4.17]
121556241  [KO:K18050] [EC:2.7.11.13]
121557494  [KO:K08334]
121557691  [KO:K04174]
121557697  [KO:K04503]
121558701  [KO:K06052]
121559072  [KO:K04688] [EC:2.7.11.1]
121559214  [KO:K05689]
121559224  [KO:K05689]
121559390  [KO:K04688] [EC:2.7.11.1]
121559744  [KO:K05689]
121559754  [KO:K05689]
121559874  [KO:K05858] [EC:3.1.4.11]
121560363  [KO:K02183]
121560771  [KO:K00907] [EC:2.7.11.18]
121562225  rps6; 40S ribosomal protein S6 [KO:K02991]
121562328  [KO:K08047] [EC:4.6.1.1]
121563437  [KO:K04962]
121564074  [KO:K05849]
121564969  gnb3a; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3a isoform X1 [KO:K07825]
121565780  [KO:K04544]
121566954  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121567369  [KO:K06052]
121567381  [KO:K02183]
121567519  [KO:K05849]
121567780  [KO:K04456] [EC:2.7.11.1]
121567835  ryr1b; ryanodine receptor 1b isoform X4 [KO:K04961]
121568011  [KO:K04688] [EC:2.7.11.1]
121568060  [KO:K04539]
121568339  nos2b; nitric oxide synthase 2b, inducible [KO:K13241] [EC:1.14.13.39]
121568770  [KO:K04347]
121569042  [KO:K11406] [EC:3.5.1.98]
121569060  [KO:K20995]
121569133  [KO:K04674] [EC:2.7.11.30]
121569204  [KO:K07200]
121569347  [KO:K02183]
121569987  [KO:K04639]
121570091  [KO:K04501]
121570393  [KO:K21290]
121570394  [KO:K21290]
121570397  [KO:K04718] [EC:2.7.1.91]
121570556  [KO:K04549]
121570581  myl4; myosin light chain 4 [KO:K12750]
121570729  [KO:K08049] [EC:4.6.1.1]
121571183  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
121571248  [KO:K05858] [EC:3.1.4.11]
121571555  [KO:K07825]
121571774  [KO:K04501]
121571853  [KO:K05742]
121571883  [KO:K08042] [EC:4.6.1.1]
121572000  [KO:K05849]
121572210  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
121572245  [KO:K06827]
121572361  [KO:K05849]
121572391  [KO:K10435]
121572434  [KO:K04501]
121572739  [KO:K03982]
121572968  [KO:K04548]
121573292  [KO:K01343] [EC:3.4.21.68]
121573328  [KO:K04503]
121573359  gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
121573520  [KO:K04634]
121573561  [KO:K04688] [EC:2.7.11.1]
121573631  [KO:K04537]
121573846  [KO:K04501]
121574067  [KO:K09203]
121574276  [KO:K04174]
121574862  [KO:K04536]
121574883  [KO:K04630]
121575032  [KO:K04958]
121575199  [KO:K04958]
121575227  [KO:K04630]
121575256  [KO:K07200]
121575280  [KO:K04630]
121575665  [KO:K07188] [EC:3.1.1.79]
121575888  [KO:K10351]
121576390  [KO:K02833]
121576450  [KO:K05869] [EC:2.7.11.17]
121576523  [KO:K04538]
121576617  plin1; perilipin-1 isoform X1 [KO:K08768]
121576626  [KO:K09260]
121576743  [KO:K10435]
121576774  [KO:K09261]
121577003  [KO:K04959]
121577009  [KO:K07827]
121577016  [KO:K04630]
121577046  [KO:K04503]
121577313  [KO:K17845]
121577563  [KO:K04958]
121577586  [KO:K04630]
121577615  [KO:K07200]
121577636  [KO:K04630]
121578264  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121578386  [KO:K04630]
121578404  gnb1b; guanine nucleotide binding protein (G protein), beta polypeptide 1b [KO:K04536]
121578496  [KO:K02183]
121578563  [KO:K10351]
121579163  [KO:K09203]
121579284  slc8a2a; sodium/calcium exchanger 2a [KO:K05849]
121579285  [KO:K05849]
121579478  [KO:K02183]
121579483  [KO:K05849]
121579490  [KO:K04540]
121579541  [KO:K04961]
121579671  [KO:K04456] [EC:2.7.11.1]
121579764  [KO:K04688] [EC:2.7.11.1]
121579830  [KO:K04537]
121579923  gnb5b; guanine nucleotide-binding protein subunit beta-5b isoform X1 [KO:K04539]
121580567  [KO:K04541]
121580743  [KO:K04347]
121580966  [KO:K04674] [EC:2.7.11.30]
121580982  [KO:K07200]
121581006  [KO:K08041] [EC:4.6.1.1]
121581015  [KO:K04345] [EC:2.7.11.11]
121581054  [KO:K12749]
121581074  [KO:K04542]
121581220  [KO:K07199]
121581322  [KO:K00907] [EC:2.7.11.18]
121581348  [KO:K04369] [EC:2.7.12.2]
121581604  [KO:K17845]
121581754  [KO:K12750]
121582175  [KO:K04501]
121582329  [KO:K00907] [EC:2.7.11.18]
121582397  [KO:K04174]
121582432  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a isoform X1 [KO:K07199]
121582673  [KO:K04454]
121582705  [KO:K07198] [EC:2.7.11.31]
121582810  [KO:K04634]
121582910  [KO:K13296] [EC:3.1.4.17]
121582913  [KO:K07830]
121583405  [KO:K05869] [EC:2.7.11.17]
121584142  [KO:K07199]
121584147  [KO:K04174]
121584339  [KO:K04371] [EC:2.7.11.24]
121584357  [KO:K04639]
121584382  smad4; mothers against decapentaplegic homolog 4 [KO:K04501]
121584492  [KO:K04454]
121584547  [KO:K04634]
121584577  [KO:K12750]
121584646  [KO:K04500]
121584981  plat; tissue-type plasminogen activator isoform X1 [KO:K01343] [EC:3.4.21.68]
121585214  nos1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
121585671  gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
121585784  [KO:K08042] [EC:4.6.1.1]
121585903  [KO:K08043] [EC:4.6.1.1]
121586170  [KO:K07188] [EC:3.1.1.79]
121586434  [KO:K07825]
121586801  [KO:K06827]
121586915  [KO:K09262]
121586923  [KO:K18050] [EC:2.7.11.13]
121586955  [KO:K07831]
121587415  [KO:K04543]
123480992  [KO:K06052]
123481092  [KO:K21290]
123481094  [KO:K11830]
123481415  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123481863  [KO:K05849]
123482290  egr1; early growth response protein 1 [KO:K09203]
123482505  [KO:K04542]
123482642  [KO:K07827]
123483067  [KO:K10435]
123486315  [KO:K21290]
123487330  [KO:K05742]
123490770  [KO:K04166]
123491220  [KO:K04371] [EC:2.7.11.24]
123491302  [KO:K04542]
123491321  [KO:K07830]
123491382  [KO:K09262]
123491562  [KO:K05869] [EC:2.7.11.17]
123492058  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
123492728  [KO:K08333] [EC:2.7.11.1]
123493066  [KO:K05849]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00290  Fibrin
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
Reference
PMID:26143239
  Authors
Yang P, Maguire JJ, Davenport AP
  Title
Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system.
  Journal
Trends Pharmacol Sci 36:560-7 (2015)
DOI:10.1016/j.tips.2015.06.002
Reference
PMID:22140623
  Authors
Andersen CU, Hilberg O, Mellemkjaer S, Nielsen-Kudsk JE, Simonsen U
  Title
Apelin and pulmonary hypertension.
  Journal
Pulm Circ 1:334-46 (2011)
DOI:10.4103/2045-8932.87299
Reference
PMID:25275559
  Authors
Chapman NA, Dupre DJ, Rainey JK
  Title
The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR.
  Journal
Biochem Cell Biol 92:431-40 (2014)
DOI:10.1139/bcb-2014-0072
Reference
PMID:18272138
  Authors
Japp AG, Newby DE
  Title
The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential.
  Journal
Biochem Pharmacol 75:1882-92 (2008)
DOI:10.1016/j.bcp.2007.12.015
Reference
PMID:25652330
  Authors
Folino A, Montarolo PG, Samaja M, Rastaldo R
  Title
Effects of apelin on the cardiovascular system.
  Journal
Heart Fail Rev 20:505-18 (2015)
DOI:10.1007/s10741-015-9475-x
Reference
PMID:23943882
  Authors
O'Carroll AM, Lolait SJ, Harris LE, Pope GR
  Title
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.
  Journal
J Endocrinol 219:R13-35 (2013)
DOI:10.1530/JOE-13-0227
Reference
PMID:23973488
  Authors
Liu QF, Yu HW, You L, Liu MX, Li KY, Tao GZ
  Title
Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1.
  Journal
Biochem Biophys Res Commun 439:235-40 (2013)
DOI:10.1016/j.bbrc.2013.08.051
Reference
PMID:26254105
  Authors
Novakova V, Sandhu GS, Dragomir-Daescu D, Klabusay M
  Title
Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia.
  Journal
Vascul Pharmacol 76:1-10 (2016)
DOI:10.1016/j.vph.2015.08.005
Reference
PMID:21725702
  Authors
Castan-Laurell I, Dray C, Attane C, Duparc T, Knauf C, Valet P
  Title
Apelin, diabetes, and obesity.
  Journal
Endocrine 40:1-9 (2011)
DOI:10.1007/s12020-011-9507-9
Reference
PMID:23924696
  Authors
Li L, Li L, Xie F, Zhang Z, Guo Y, Tang G, Lv D, Lu Q, Chen L, Li J
  Title
Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation.
  Journal
Acta Biochim Biophys Sin (Shanghai) 45:875-81 (2013)
DOI:10.1093/abbs/gmt085
Reference
PMID:24990699
  Authors
Wu D, He L, Chen L
  Title
Apelin/APJ system: a promising therapy target for hypertension.
  Journal
Mol Biol Rep 41:6691-703 (2014)
DOI:10.1007/s11033-014-3552-4
Reference
PMID:20539939
  Authors
Liu C, Su T, Li F, Li L, Qin X, Pan W, Feng F, Chen F, Liao D, Chen L
  Title
PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13.
  Journal
Acta Biochim Biophys Sin (Shanghai) 42:396-402 (2010)
DOI:10.1093/abbs/gmq035
Reference
PMID:26607438
  Authors
Xie F, Liu W, Feng F, Li X, He L, Lv D, Qin X, Li L, Li L, Chen L
  Title
Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy.
  Journal
Acta Biochim Biophys Sin (Shanghai) 47:969-80 (2015)
DOI:10.1093/abbs/gmv111
Reference
PMID:27979574
  Authors
Lu L, Wu D, Li L, Chen L
  Title
Apelin/APJ system: A bifunctional target for cardiac hypertrophy.
  Journal
Int J Cardiol 230:164-170 (2017)
DOI:10.1016/j.ijcard.2016.11.215
Reference
PMID:16182514
  Authors
Carmen GY, Victor SM
  Title
Signalling mechanisms regulating lipolysis.
  Journal
Cell Signal 18:401-8 (2006)
DOI:10.1016/j.cellsig.2005.08.009
Reference
PMID:27650065
  Authors
Hu H, He L, Li L, Chen L
  Title
Apelin/APJ system as a therapeutic target in diabetes and its complications.
  Journal
Mol Genet Metab 119:20-7 (2016)
DOI:10.1016/j.ymgme.2016.07.012
Reference
PMID:25914650
  Authors
Bertrand C, Valet P, Castan-Laurell I
  Title
Apelin and energy metabolism.
  Journal
Front Physiol 6:115 (2015)
DOI:10.3389/fphys.2015.00115
Reference
PMID:26385179
  Authors
Yao F, Lv YC, Zhang M, Xie W, Tan YL, Gong D, Cheng HP, Liu D, Li L, Liu XY, Zheng XL, Tang CK
  Title
Apelin-13 impedes foam cell formation by activating Class III PI3K/Beclin-1-mediated autophagic pathway.
  Journal
Biochem Biophys Res Commun 466:637-43 (2015)
DOI:10.1016/j.bbrc.2015.09.045
Reference
PMID:22842084
  Authors
Than A, Cheng Y, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen P
  Title
Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.
  Journal
Mol Cell Endocrinol 362:227-41 (2012)
DOI:10.1016/j.mce.2012.07.002
Reference
PMID:24055369
  Authors
Yu XH, Tang ZB, Liu LJ, Qian H, Tang SL, Zhang DW, Tian GP, Tang CK
  Title
Apelin and its receptor APJ in cardiovascular diseases.
  Journal
Clin Chim Acta 428:1-8 (2014)
DOI:10.1016/j.cca.2013.09.001
Reference
PMID:25931124
  Authors
Than A, He HL, Chua SH, Xu D, Sun L, Leow MK, Chen P
  Title
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes.
  Journal
J Biol Chem 290:14679-91 (2015)
DOI:10.1074/jbc.M115.643817
Reference
PMID:25139773
  Authors
Fu J, Li Z, Zhang H, Mao Y, Wang A, Wang X, Zou Z, Zhang X
  Title
Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue.
  Journal
Diabetes Metab Res Rev 31:433-52 (2015)
DOI:10.1002/dmrr.2600
Reference
PMID:21464822
  Authors
Aharoni-Simon M, Hann-Obercyger M, Pen S, Madar Z, Tirosh O
  Title
Fatty liver is associated with impaired activity of PPARgamma-coactivator 1alpha (PGC1alpha) and mitochondrial biogenesis in mice.
  Journal
Lab Invest 91:1018-28 (2011)
DOI:10.1038/labinvest.2011.55
Reference
PMID:22995518
  Authors
McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK, Chun HJ
  Title
Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.
  Journal
Arterioscler Thromb Vasc Biol 32:2640-3 (2012)
DOI:10.1161/ATVBAHA.112.300317
Reference
PMID:22028387
  Authors
Pchejetski D, Foussal C, Alfarano C, Lairez O, Calise D, Guilbeau-Frugier C, Schaak S, Seguelas MH, Wanecq E, Valet P, Parini A, Kunduzova O
  Title
Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1.
  Journal
Eur Heart J 33:2360-9 (2012)
DOI:10.1093/eurheartj/ehr389
Reference
PMID:26944568
  Authors
Huang S, Chen L, Lu L, Li L
  Title
The apelin-APJ axis: A novel potential therapeutic target for organ fibrosis.
  Journal
Clin Chim Acta 456:81-8 (2016)
DOI:10.1016/j.cca.2016.02.025
Reference
PMID:19093215
  Authors
Liu G, Han J, Profirovic J, Strekalova E, Voyno-Yasenetskaya TA
  Title
Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis.
  Journal
Angiogenesis 12:1-15 (2009)
DOI:10.1007/s10456-008-9123-3
Reference
PMID:23603510
  Authors
Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ
  Title
Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
  Journal
Circ Res 113:22-31 (2013)
DOI:10.1161/CIRCRESAHA.113.301324
Reference
PMID:25164121
  Authors
Wang LY, Diao ZL, Zhang DL, Zheng JF, Zhang QD, Ding JX, Liu WH
  Title
The regulatory peptide apelin: a novel inhibitor of renal interstitial fibrosis.
  Journal
Amino Acids 46:2693-704 (2014)
DOI:10.1007/s00726-014-1826-8
Reference
PMID:26756969
  Authors
Zhou Y, Deng L, Zhao D, Chen L, Yao Z, Guo X, Liu X, Lv L, Leng B, Xu W, Qiao G, Shan H
  Title
MicroRNA-503 promotes angiotensin II-induced cardiac fibrosis by targeting Apelin-13.
  Journal
J Cell Mol Med 20:495-505 (2016)
DOI:10.1111/jcmm.12754
Reference
PMID:27825851
  Authors
Zhong JC, Zhang ZZ, Wang W, McKinnie SM, Vederas JC, Oudit GY
  Title
Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.
  Journal
Biochim Biophys Acta 1863:1942-1950 (2017)
DOI:10.1016/j.bbadis.2016.11.007
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pathway
cclu04010  MAPK signaling pathway
cclu04020  Calcium signaling pathway
cclu04140  Autophagy - animal
cclu04150  mTOR signaling pathway
cclu04270  Vascular smooth muscle contraction
cclu04530  Tight junction
KO pathway
ko04371   

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