KEGG   Homo sapiens (human): 57522
Entry
57522             CDS       T01001                                 
Symbol
SRGAP1, ARHGAP13, NMTC2
Name
(RefSeq) SLIT-ROBO Rho GTPase-activating protein 1 isoform 1
  KO
K07526  SLIT-ROBO Rho GTPase activating protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
hsa04517  IgSF CAM signaling
Network
nt06546  IgSF CAM signaling
  Element
N01942  SLIT-ROBO signaling in neuron
N01944  SLIT-ROBO-SRGAP1 signaling in podocyte
Disease
H00032  Thyroid cancer
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    57522 (SRGAP1)
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    57522 (SRGAP1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    57522 (SRGAP1)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Bin/Amphiphysin/Rvs (BAR) family proteins
   F-BAR proteins
    57522 (SRGAP1)
 Others
  Rho GTPase associated proteins
   Rho GTPase-activating proteins
    57522 (SRGAP1)
SSDB
Motif
Pfam: RhoGAP FCH SH3_1 SH3_9 SH3_2 FTZ FlaC_arch DUF8168_C
Other DBs
NCBI-GeneID: 57522
NCBI-ProteinID: NP_065813
OMIM: 606523
HGNC: 17382
Ensembl: ENSP00000347198.3
UniProt: Q7Z6B7
LinkDB
Position
12:63844700..64162217
AA seq 1085 aa
MSTPSRFKKDKEIIAEYESQVKEIRAQLVEQQKCLEQQTEMRVQLLQDLQDFFRKKAEIE
TEYSRNLEKLAERFMAKTRSTKDHQQYKKDQNLLSPVNCWYLLLNQVRRESKDHATLSDI
YLNNVIMRFMQISEDSTRMFKKSKEIAFQLHEDLMKVLNELYTVMKTYHMYHAESISAES
KLKEAEKQEEKQIGRSGDPVFHIRLEERHQRRSSVKKIEKMKEKRQAKYSENKLKSIKAR
NEYLLTLEATNASVFKYYIHDLSDLIDCCDLGYHASLNRALRTYLSAEYNLETSRHEGLD
IIENAVDNLEPRSDKQRFMEMYPAAFCPPMKFEFQSHMGDEVCQVSAQQPVQAELMLRYQ
QLQSRLATLKIENEEVKKTTEATLQTIQDMVTIEDYDVSECFQHSRSTESVKSTVSETYL
SKPSIAKRRANQQETEQFYFMKLREYLEGSNLITKLQAKHDLLQRTLGEGHRAEYMTTRP
PNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVKDSGQVIPLIVESCIRFINLYGLQHQGI
FRVSGSQVEVNDIKNSFERGENPLADDQSNHDINSVAGVLKLYFRGLENPLFPKERFNDL
ISCIRIDNLYERALHIRKLLLTLPRSVLIVMRYLFAFLNHLSQYSDENMMDPYNLAICFG
PTLMPVPEIQDQVSCQAHVNEIIKTIIIHHETIFPDAKELDGPVYEKCMAGDDYCDSPYS
EHGTLEEVDQDAGTEPHTSEDECEPIEAIAKFDYVGRSARELSFKKGASLLLYHRASEDW
WEGRHNGIDGLVPHQYIVVQDMDDTFSDTLSQKADSEASSGPVTEDKSSSKDMNSPTDRH
PDGYLARQRKRGEPPPPVRRPGRTSDGHCPLHPPHALSNSSVDLGSPSLASHPRGLLQNR
GLNNDSPERRRRPGHGSLTNISRHDSLKKIDSPPIRRSTSSGQYTGFNDHKPLDPETIAQ
DIEETMNTALNELRELERQSTAKHAPDVVLDTLEQVKNSPTPATSTESLSPLHNVALRSS
EPQIRRSTSSSSDTMSTFKPMVAPRMGVQLKPPALRPKPAVLPKTNPTIGPAPPPQGPTD
KSCTM
NT seq 3258 nt   +upstreamnt  +downstreamnt
atgtccaccccgagccgattcaagaaggacaaagagatcatagccgagtatgaaagtcaa
gtcaaagaaattcgagctcaactggtagaacaacaaaaatgcctggagcagcaaacggag
atgcgagttcagcttctccaggatctgcaagatttcttccgaaaaaaagctgaaattgag
acggaatattcccggaatctagagaagttagcagaaaggttcatggcaaaaacaagaagc
actaaggatcatcaacaatacaagaaagaccagaacctgttgtctccagtgaactgctgg
tatttgctcctgaaccaagtaaggagagaaagcaaagaccatgcaaccttgagtgacatc
tatctgaacaatgtgattatgcggttcatgcagataagtgaggattctaccaggatgttt
aaaaagagcaaagagattgcattccaacttcatgaggatttaatgaaggttcttaatgag
ctttatacggtgatgaaaacataccatatgtatcatgcagagagcatcagtgcagagagc
aagctgaaagaggccgaaaaacaagaggaaaagcaaattgggagatctggtgatccagtc
ttccatattcgactagaggagagacatcaacggcgaagctctgtaaagaaaattgaaaaa
atgaaagaaaaaagacaagcaaaatattcagaaaataagctaaaatcaattaaggcacgg
aacgaatatctcctaacacttgaagccaccaatgcctcagttttcaagtactatattcat
gatctttctgatttaattgattgctgtgatcttggctaccatgcaagtctgaacagagcc
ctaagaacatatctgtctgcggagtacaaccttgaaacctccagacatgagggcttagac
attattgagaatgcagttgataatttagagcccaggagcgataagcagagattcatggag
atgtaccctgctgcgttctgtccaccaatgaagtttgagtttcagtctcacatgggtgat
gaggtgtgccaggtcagtgcccagcagccagtccaggcagagctcatgctcaggtaccaa
cagttgcagtcccgccttgccacgctcaaaatcgagaatgaagaggttaagaaaacgact
gaagccaccttgcagacgatacaagatatggtcaccatcgaggactatgatgtttctgaa
tgcttccagcacagtcgttccacagaatcagtgaagtccactgtctctgaaacctacctg
agtaaacccagcatcgccaagagaagagccaaccagcaggaaactgaacagttctacttc
atgaaactcagagaatatttggaaggcagtaatctcatcacaaaacttcaagccaaacat
gacttgctgcagaggaccctgggagaaggtcatagagctgaatatatgactacaaggcct
ccaaatgttccccctaagccccagaaacacaggaagtccaggccccgctcacagtataat
actaagttgtttaatggggatttggaaacattcgtcaaggactcaggacaggttattccc
ctcattgtggaaagctgtattcggttcatcaatctctatggtcttcagcatcaggggatt
ttcagagtgtctggttcccaggtggaagtcaatgatattaaaaattcatttgagagaggt
gaaaatcctttggctgatgaccagagtaaccatgatattaactcagttgctggcgttctg
aagctctatttccgtgggctggaaaaccccctctttcctaaggaaagatttaacgatctg
atttcttgtatcagaatagataatctctatgagagggcgcttcacatccgcaaactcctc
ctgactttgcccaggtcggtccttatagtgatgaggtacctctttgccttcctcaatcat
ctatcacagtacagcgatgagaatatgatggacccttataacctggccatttgctttggc
ccaacattgatgcctgtcccagaaatacaggatcaagtgtcttgccaggcacatgtgaat
gaaattatcaaaaccatcatcatccaccatgagactattttcccagatgctaaagagctg
gatggccctgtttatgagaaatgtatggctggagatgactattgcgacagcccatacagt
gagcacggtacattggaggaagtggaccaagatgctggtacagagccccacacaagtgaa
gatgaatgtgagccaatagaagcaatagccaagtttgactatgttgggcggtctgccaga
gaactatccttcaagaagggtgcctccctgctgctgtatcaccgtgcatctgaggactgg
tgggaaggcaggcacaacgggattgacgggctggtgcctcaccagtatatagtggtgcag
gatatggatgatacgttttcagacactctgagccaaaaagccgacagtgaggccagcagt
gggccagtcacggaagacaagtcctcatccaaggacatgaactccccgacagaccgtcat
cctgacggctatttagccaggcaacgaaaaagaggagagccaccccctccagtaaggcgt
cctggcaggaccagtgatggccattgcccgctccaccctccacatgccctttctaactcc
tcagttgacctagggtccccaagccttgccagtcacccccggggcctgctgcagaaccgt
ggcctcaacaatgacagtcctgagcggaggcgcaggcctggccatggcagcctgaccaac
atcagccggcacgactccctcaagaagatcgacagccctcccattagaaggtccacgtca
tcagggcaatacacgggcttcaatgaccacaagccactggacccagagacaattgctcag
gatattgaagaaacgatgaacacagctttgaatgaactccgagaactggagagacagagc
acagcaaagcatgcccctgatgtggtgctggataccctggagcaagtgaaaaactctccc
acccctgccacttccacggaatctctcagccctttgcacaacgttgccctcaggagctcc
gagcctcagattcgacgtagcacgagctcctccagtgacacaatgagtactttcaagcct
atggtggcacccagaatgggcgtgcagctgaagcctccagcccttaggccaaaacctgct
gttcttccaaaaacaaatcctaccataggacctgccccacctccccagggtccaacagac
aagtcatgcacaatgtaa

KEGG   Homo sapiens (human): 23380
Entry
23380             CDS       T01001                                 
Symbol
SRGAP2, ARHGAP34, FNBP2, SRGAP2A, SRGAP3
Name
(RefSeq) SLIT-ROBO Rho GTPase-activating protein 2 isoform a
  KO
K07526  SLIT-ROBO Rho GTPase activating protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
hsa04517  IgSF CAM signaling
Network
nt06546  IgSF CAM signaling
  Element
N01942  SLIT-ROBO signaling in neuron
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    23380 (SRGAP2)
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    23380 (SRGAP2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    23380 (SRGAP2)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Bin/Amphiphysin/Rvs (BAR) family proteins
   F-BAR proteins
    23380 (SRGAP2)
 Others
  Rho GTPase associated proteins
   Rho GTPase-activating proteins
    23380 (SRGAP2)
SSDB
Motif
Pfam: RhoGAP FCH SH3_1 SH3_2 SH3_9 MM_CoA_mutase
Other DBs
NCBI-GeneID: 23380
NCBI-ProteinID: NP_056141
OMIM: 606524
HGNC: 19751
Ensembl: ENSP00000459615.2
UniProt: O75044 B4DFE5
Structure
LinkDB
Position
1:206203541..206464436
AA seq 1071 aa
MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIE
MDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIY
LNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSK
LKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYT
ENKLKAIKARNEYLLALEATNASVFKYYIHDLSDLIDQCCDLGYHASLNRALRTFLSAEL
NLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQ
PVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSME
SVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGE
SQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKN
AFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLMACVTMDNLQERALH
IRKVLLVLPKTTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSC
QAHVNELIKTIIIQHENIFPSPRELEGPVYSRGGSMEDYCDSPHGETTSVEDSTQDVTAE
HHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQ
YIVVQDTEDGVVERSSPKSEIEVISEPPEEKVTARAGASCPSGGHVADIYLANINKQRKR
PESGSIRKTFRSDSHGLSSSLTDSSSPGVGASCRPSSQPIMSQSLPKEGPDKCSISGHGS
LNSISRHSSLKNRLDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELREL
ERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIAC
AFRPVKSVKMAAPVKPPATRPKPTVFPKTNATSPGVNSSTSPQSTDKSCTV
NT seq 3216 nt   +upstreamnt  +downstreamnt
atgacgtctccagccaaattcaaaaaggataaggagatcatagcagagtacgatactcag
gtcaaagagatccgtgctcagctcacagagcagatgaaatgcctggaccagcagtgtgag
cttcgggtgcaactgttgcaggacctccaggacttcttccgaaagaaggcagagattgag
atggactactcccgcaacctggagaagctggcagaacgcttcctggccaagacacgcagc
accaaggaccagcaattcaagaaggatcagaatgttctctctccagtcaactgctggaat
ctcctcttaaaccaggtgaagcgggaaagcagggaccataccaccctgagtgacatctac
ctgaataatatcattcctcgatttgtacaagtcagcgaggactcaggaagactctttaaa
aagagtaaagaagtcggccagcagctccaagatgatttgatgaaggtcctgaacgagctc
tactcggtgatgaagacatatcacatgtacaatgccgacagcatcagtgctcagagcaaa
ctaaaggaggcggagaagcaggaggagaagcaaattggtaaatcggtaaagcaggaggac
cggcagaccccacgctcccctgactccacggccaacgttcgcattgaggagaaacatgtc
cggaggagctcagtgaagaagattgagaagatgaaggagaagcgtcaagccaagtacacg
gagaataagctgaaggccatcaaagcccggaatgagtacttgctggctttggaggcaacc
aatgcatctgtcttcaagtactacatccatgacctatctgaccttattgatcagtgttgt
gacttaggctaccatgcaagtctgaaccgggctctacgcaccttcctctctgctgagtta
aacctggaacagtcgaagcatgagggtctggatgccatcgagaatgcagtagaaaacctg
gatgccaccagtgacaagcagcgcctcatggagatgtacaacaacgtcttctgcccccct
atgaagtttgagtttcagccccacatgggggatatggcttcccagctctgtgcccagcag
cctgtccagagtgagctggtacagagatgccaacaactgcagtctcgcttatccactcta
aagattgaaaacgaagaggtaaagaagacaatggaggccaccctgcaaaccatccaggac
attgtgactgtcgaggactttgatgtgtctgactgcttccagtacagcaactccatggag
tccgtcaagtccacggtctctgaaaccttcatgagcaagcccagcattgctaagaggaga
gccaaccagcaagagacagagcagttttatttcacaaaaatgaaagagtacctggagggc
aggaacctcatcaccaagttacaagccaagcatgaccttctgcagaaaaccctgggagaa
agtcagcggacagattgcagtctagccaggcgcagctcaactgtgaggaaacaggactcc
agccaggcaattcctctggtggtggaaagctgtatccggtttatcagcagacacggacta
cagcatgaaggaattttccgggtgtcaggatcccaggtggaagtgaatgacatcaaaaat
gcctttgagagaggagaggaccccctggctggggaccagaacgaccatgacatggattcc
atagctggtgtcctgaagctttacttccgggggctggaacaccctctcttccccaaggac
atctttcatgacctgatggcctgcgtcacaatggacaacctgcaggagagagctctgcac
atccggaaagtcctcctagtcctgcccaaaaccactctgattatcatgagatacctcttt
gccttcctcaatcatttatcacagttcagtgaagagaacatgatggacccctacaacctc
gccatctgcttcgggccctcgctaatgtcagtgccagagggccacgaccaggtgtcctgc
caagcccacgtgaatgagctgatcaaaaccatcatcatccagcatgagaacatcttccca
agccccagggagctggagggccctgtctacagcagaggaggaagcatggaggattactgt
gatagccctcatggagagactacctcggttgaagactcaacccaggatgtgaccgcagag
caccacacgagcgatgacgaatgtgagcccatcgaggccattgccaagtttgactacgtg
ggccggacagcccgagagctatcctttaagaagggagcatccctgctgctttaccagcgg
gcttccgacgactggtgggaaggccggcacaatggcatcgacggactcatcccccatcag
tacatcgtggtccaagacaccgaggacggtgtcgtggagaggtccagccccaagtctgag
attgaggtcatttctgagccacctgaagaaaaggtgacagccagagcgggggccagctgt
cccagtgggggtcatgtagccgatatttatcttgcaaacatcaacaagcaaaggaagcgt
ccagaatctgggagcatccggaaaacttttcggagtgacagccatgggctgagcagttcc
ctgactgactcctcctccccaggggtgggggctagctgccgcccatcctcccagcccatc
atgagccagagcctccccaaagaagggccagataagtgttccatcagtgggcacgggagc
ctcaactccatcagccgccactcatccctgaagaatcggctggatagtccacagatccgg
aagactgccacagcgggaaggtcaaaaagcttcaataaccatcggcccatggaccctgag
gtcattgctcaggatattgaggcaacaatgaactcggccctgaatgagctacgggaacta
gaacggcagagcagtgtcaaacacacccctgacgtggttctggacaccttggagcccctc
aaaacctccccagtggtggcccccacgtcagagccctccagccctctgcacacccagctc
ctcaaggaccccgagcccgccttccagcgcagcgccagtactgctggggacatcgcctgc
gccttccggcctgtcaagtctgtcaagatggctgccccggtcaaaccaccagccacacgg
cccaagcccactgtcttccccaaaacaaatgccactagccctggtgtcaactcatcaact
tccccacagtctactgacaagtcttgtactgtctga

KEGG   Homo sapiens (human): 9901
Entry
9901              CDS       T01001                                 
Symbol
SRGAP3, ARHGAP14, MEGAP, SRGAP2, WRP
Name
(RefSeq) SLIT-ROBO Rho GTPase-activating protein 3 isoform a
  KO
K07526  SLIT-ROBO Rho GTPase activating protein
Organism
hsa  Homo sapiens (human)
Pathway
hsa04360  Axon guidance
hsa04517  IgSF CAM signaling
Network
nt06546  IgSF CAM signaling
  Element
N01942  SLIT-ROBO signaling in neuron
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    9901 (SRGAP3)
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    9901 (SRGAP3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    9901 (SRGAP3)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Bin/Amphiphysin/Rvs (BAR) family proteins
   F-BAR proteins
    9901 (SRGAP3)
 Others
  Rho GTPase associated proteins
   Rho GTPase-activating proteins
    9901 (SRGAP3)
SSDB
Motif
Pfam: RhoGAP FCH SH3_1 SH3_2 SH3_9 Flg_hook CNOT10_TPR FlaC_arch
Other DBs
NCBI-GeneID: 9901
NCBI-ProteinID: NP_055665
OMIM: 606525
HGNC: 19744
Ensembl: ENSP00000373347.3
UniProt: O43295
LinkDB
Position
3:complement(8980591..9363027)
AA seq 1099 aa
MSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE
LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIF
MNNVIVRLSQISEDVIRLFKKSKEIGLQMHEELLKVTNELYTVMKTYHMYHAESISAESK
LKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR
NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLD
VIENAVDNLDSRSDKHTVMDMCNQVFCPPLKFEFQPHMGDEVCQVSAQQPVQTELLMRYH
QLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM
SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRP
PCLPPKPQKMRRPRPLSVYSHKLFNGSMEAFIKDSGQAIPLVVESCIRYINLYGLQQQGI
FRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAGVLKLYFRGLENPLFPKERFQDL
ISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFLNHLSQYSDENMMDPYNLAICFG
PTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPRELEGPVYEKCMAGGEEYCDSPH
SEPGAIDEVDHDNGTEPHTSDEEVEQIEAIAKFDYMGRSPRELSFKKGASLLLYHRASED
WWEGRHNGVDGLIPHQYIVVQDMDDAFSDSLSQKADSEASSGPLLDDKASSKNDLQSPTE
HISDYGFGGVMGRVRLRSDGAAIPRRRSGGDTHSPPRGLGPSIDTPPRAAACPSSPHKIP
LTRGRIESPEKRRMATFGSAGSINYPDKKALSEGHSMRSTCGSTRHSSLGDHKSLEAEAL
AEDIEKTMSTALHELRELERQNTVKQAPDVVLDTLEPLKNPPGPVSSEPASPLHTIVIRD
PDAAMRRSSSSSTEMMTTFKPALSARLAGAQLRPPPMRPVRPVVQHRSSSSSSSGVGSPA
VTPTEKMFPNSSADKSGTM
NT seq 3300 nt   +upstreamnt  +downstreamnt
atgtcatctcaaactaagttcaagaaagacaaagagatcattgctgaatatgaagcccaa
ataaaagagatccgcacgcagctggtggagcagttcaaatgtctggagcagcaatcagag
tcgcgactgcagctgcttcaagacctccaggagtttttccgccggaaagctgagattgag
ctcgagtactcccgcagcctggagaagctggctgagcgcttctcctccaaaatccgcagc
tcccgggagcaccagttcaagaaggaccagtacctcctctcgcctgtgaactgttggtat
ctggttctgcatcagacccggcgggagagccgagaccatgccaccctcaatgacatcttc
atgaacaatgtcatcgtccgcctctcccagatcagtgaggatgtcatcagactcttcaaa
aagagcaaggagattggcctgcagatgcacgaggagctcctgaaggtgaccaatgagctc
tacacagtcatgaaaacctaccacatgtaccatgcagagagcatcagtgcggaaagcaag
ctgaaggaggctgagaagcaggaggagaagcagttcaataagtcaggagacctcagcatg
aacctgctccggcacgaggaccggccccagcgccgcagctctgtgaagaagattgagaag
atgaaggagaagaggcaggccaagtactctgagaacaagctgaaatgcacaaaggcccgg
aatgactacttgctcaatctggcagccaccaacgcagctataagcaaatactacatccat
gatgtctctgatctgatcgattgctgtgatttgggcttccatgccagcctggcccgcacc
ttccggacctatctctcagctgaatacaacctggagacctctcgccacgaagggctggat
gtcattgagaatgcagtggacaacctggattcccgaagtgacaagcacacagtcatggac
atgtgcaatcaagtcttctgccctccactcaagttcgagttccagccccacatgggggat
gaggtctgccaggtcagcgctcagcagcccgtccagacagaactgctcatgcgttatcac
cagctgcagtccagactggccaccctcaagatagagaatgaggaggttaggaaaaccctg
gatgccaccatgcagacattacaggacatgctgactgtggaggactttgatgtctccgat
gccttccaacacagtcgatcgacagagtccgtcaagtcggctgcctctgagacctacatg
agcaagatcaacattgccaagaggagagccaaccagcaggaaacagaaatgttttatttt
acaaaatttaaagagtatgtgaatggcagtaacctcatcaccaagctgcaggccaagcac
gatttactcaagcagaccctgggcgaaggggaaagagcagaatgcggcaccaccaggccc
ccctgtcttccccctaaaccacagaaaatgaggagacctaggcctctctcagtgtatagc
cataaactctttaacggcagtatggaagcattcattaaggattcaggacaagctataccg
cttgtagtcgagagctgcatccgttacatcaatttatatggactccagcagcaggggatc
ttcagagtgccaggatctcaggtggaagtcaatgacatcaaaaattcctttgagagaggt
gaagacccccttgtggacgatcaaaatgaacgagatatcaattcagtcgctggtgtttta
aaactgtatttccgaggactggaaaacccactctttcctaaggaaaggtttcaagatttg
atatctactattaaactggagaacccagccgagagggtgcaccagatccaacaaatcctc
gtcacccttccccgcgtggtcattgtggtcatgagatacctcttcgctttcctcaaccac
ctctcccagtatagcgacgagaacatgatggatccctacaacctggccatctgcttcggg
cctaccctcatgcacatccctgatgggcaggaccctgtgtcctgccaggcacacatcaat
gaagtcatcaaaaccatcatcatccatcatgaagccatcttccccagcccccgggagcta
gagggacctgtgtatgaaaaatgcatggctggaggggaagaatattgtgacagcccacac
agcgagccaggggccatcgatgaagttgaccatgacaatggcactgagcctcataccagc
gatgaagaagtggagcagatcgaggctattgccaagtttgactacatggggcggtccccg
cgtgagctatccttcaagaagggggcctcgctgctcctgtaccaccgcgcctcggaggac
tggtgggagggccggcacaacggcgtggatggactcatcccccatcagtacatagttgta
caggacatggatgatgccttctccgacagcctgagccagaaggctgacagcgaggccagc
agtgggccattgctggatgacaaggcctcttccaaaaacgacctccagtcccccacggag
cacatctcggattacggctttgggggggtgatgggccgagtgcggttacgatctgatgga
gcagccatccccagacgccgaagcgggggcgacacacacagcccgccccggggcctgggc
cccagcatagacacaccaccccgggctgctgcctgccccagcagcccccacaaaatcccc
ctcacccgggggaggatcgagagccctgagaagcggaggatggcgacgttcgggagcgct
ggcagcatcaactaccctgacaagaaggcgctctccgaagggcactcgatgaggtcgacc
tgcggttccaccaggcacagcagcctaggggaccacaagtccctggaggccgaggccctg
gcagaagacatcgagaagaccatgagcacggctctgcacgagttgcgggaactcgagagg
cagaacacggtcaagcaggcgccagatgtggtgctggacaccctggagcccctgaagaac
ccgccaggccccgtcagctcggagcccgccagtccccttcacaccatcgtcatccgcgac
cccgatgccgccatgcgccgcagcagcagctcctccaccgagatgatgaccaccttcaag
ccagccctgtccgcccgcctggctggcgcccagctccgcccgccccccatgcggcccgtg
cggccggtggtccagcaccggtccagcagcagcagcagctcgggcgtgggcagcccggcc
gtgacgcccaccgagaagatgttccccaacagctcagcggacaagtcgggcaccatgtga

KEGG   Homo sapiens (human): 393
Entry
393               CDS       T01001                                 
Symbol
ARHGAP4, C1, RGC1, RhoGAP4, SrGAP4, p115
Name
(RefSeq) rho GTPase-activating protein 4 isoform 2
  KO
K20122  Rho GTPase-activating protein 4
Organism
hsa  Homo sapiens (human)
Network
nt06546  IgSF CAM signaling
  Element
N01942  SLIT-ROBO signaling in neuron
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    393 (ARHGAP4)
Membrane trafficking [BR:hsa04131]
 Endocytosis
  Bin/Amphiphysin/Rvs (BAR) family proteins
   F-BAR proteins
    393 (ARHGAP4)
 Others
  Rho GTPase associated proteins
   Rho GTPase-activating proteins
    393 (ARHGAP4)
SSDB
Motif
Pfam: RhoGAP SH3_9 SH3_1 SH3_2 FCH
Other DBs
NCBI-GeneID: 393
NCBI-ProteinID: NP_001657
OMIM: 300023
HGNC: 674
Ensembl: ENSP00000203786.8
UniProt: P98171
Structure
LinkDB
Position
X:complement(153907378..153926264)
AA seq 946 aa
MAAHGKLRRERGLQAEYETQVKEMRWQLSEQLRCLELQGELRRELLQELAEFMRRRAEVE
LEYSRGLEKLAERFSSRGGRLGSSREHQSFRKEPSLLSPLHCWAVLLQHTRQQSRESAAL
SEVLAGPLAQRLSHIAEDVGRLVKKSRDLEQQLQDELLEVVSELQTAKKTYQAYHMESVN
AEAKLREAERQEEKRAGRSVPTTTAGATEAGPLRKSSLKKGGRLVEKRQAKFMEHKLKCT
KARNEYLLSLASVNAAVSNYYLHDVLDLMDCCDTGFHLALGQVLRSYTAAESRTQASQVQ
GLGSLEEAVEALDPPGDKAKVLEVHATVFCPPLRFDYHPHDGDEVAEICVEMELRDEILP
RAQNIQSRLDRQTIETEEVNKTLKATLQALLEVVASDDGDVLDSFQTSPSTESLKSTSSD
PGSRQAGRRRGQQQETETFYLTKLQEYLSGRSILAKLQAKHEKLQEALQRGDKEEQEVSW
TQYTQRKFQKSRQPRPSSQYNQRLFGGDMEKFIQSSGQPVPLVVESCIRFINLNGLQHEG
IFRVSGAQLRVSEIRDAFERGEDPLVEGCTAHDLDSVAGVLKLYFRSLEPPLFPPDLFGE
LLASSELEATAERVEHVSRLLWRLPAPVLVVLRYLFTFLNHLAQYSDENMMDPYNLAVCF
GPTLLPVPAGQDPVALQGRVNQLVQTLIVQPDRVFPPLTSLPGPVYEKCMAPPSASCLGD
AQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFAYTGRTAQELSFRRGDVLRLHERAS
SDWWRGEHNGMRGLIPHKYITLPAGTEKQVVGAGLQTAGESGSSPEGLLASELVHRPEPC
TSPEAMGPSGHRRRCLVPASPEQHVEVDKAVAQNMDSVFKELLGKTSVRQGLGPASTTSP
SPGPRSPKAPPSSRLGRNKGFSRGPGAPASPSASHPQGLDTTPKPH
NT seq 2841 nt   +upstreamnt  +downstreamnt
atggccgctcacgggaagctgcggcgggagcgggggctgcaggctgagtatgagacgcaa
gtcaaagagatgcgctggcagctgagcgagcagctgcgctgcctggagctgcagggcgag
ctgcggcgggagttgctgcaggagctggcagagttcatgcggcgccgcgctgaggtggag
ctggaatactcccggggcctggaaaagctggccgagcgcttctccagccgtggaggccgc
ctggggagcagccgggagcaccaaagcttccggaaggagccgtccctcctgtcgcccttg
cactgctgggcggtgctgctgcagcacacgcggcagcagagccgggagagcgcggccctg
agtgaggtgctggccgggcccctggcccagcgcctgagtcacattgcagaggacgtgggg
cgcctggtcaagaagagcagggatctggagcagcagctgcaggatgagctcctggaggtg
gtctcagagctccagacggccaagaagacgtaccaggcatatcacatggagagcgtgaat
gccgaggccaagctccgggaggccgagcggcaggaggagaagcgggcaggccggagtgtc
cccaccaccaccgctggtgccactgaggcagggcccctccgcaagagctccctcaagaag
ggagggaggctggtggagaagcggcaggccaagttcatggagcacaaactcaagtgcaca
aaggcgcgcaacgagtacctgcttagcctggctagtgtcaacgctgctgtcagtaactac
tacctgcatgacgtcttggacctcatggactgctgtgacacagggttccacctggccctg
gggcaggtgctccggagctacacggccgctgagagccgcacccaagcctcccaagtgcag
ggcctgggcagcctggaagaagctgtggaggccctggatcctccaggggacaaagccaag
gttctcgaggtgcatgctaccgtcttctgtcccccgctgcgctttgactaccacccccat
gatggggatgaggtggctgagatctgcgttgaaatggagctgcgggacgagattctgccc
agagcccagaacatccagagccgcctggaccgacagaccattgagacagaggaggtgaac
aagactctgaaggcgacactgcaggccctgctggaggtggtggcctcggatgacggggat
gtgcttgattccttccagaccagcccctccaccgagtccctcaagtccaccagctcagac
ccaggcagccggcaggcgggccggaggcgcggccagcagcaggagaccgaaaccttctac
ctcacgaagctccaggagtatctgagtggacggagcatcctcgccaagctgcaggccaag
cacgagaagctgcaggaggcccttcagcgaggtgacaaggaggagcaggaggtgtcttgg
acccagtacacacagagaaaattccagaagagccgccagccccgccccagctcccagtat
aaccagagactctttgggggagacatggagaagtttatccagagctcaggccagcctgtg
cccctggtggtggagagctgcattcgcttcatcaacctcaatggcctgcagcatgaaggc
atcttccgggtatcgggtgcccagctccgggtctcagagatccgtgatgccttcgagaga
ggggaggacccactggtggagggctgcactgcccatgacctggactcggtggccggggtg
ctgaagctctacttccggagcctggagcccccactcttccccccagacctgttcggcgag
ctgctggcttcttcggagctggaggccacagcggagagggtggagcacgtgagccgcctg
ctgtggcggctgcccgcgccggtgctggtggttctgcgctacctcttcaccttcctcaac
cacctggcccagtacagcgatgagaacatgatggacccctacaacctggccgtgtgcttc
gggcccacgctgctaccggtgcccgctgggcaggacccggtggcgctgcagggccgggtg
aaccagctggtgcagacgctcatagtgcagcccgatcgggtcttcccgcccctgacctcg
ctgcctggccccgtctacgagaagtgcatggcaccgccttccgccagctgcctgggggac
gcccagctggagagcctgggggcggacaatgagccggagctggaagccgagatgcccgca
caggaggatgacctggagggggtcgtggaggctgtggcctgctttgcctacacgggccgc
acagcccaggagctgagcttccggcggggggacgtactgcggctgcacgagagggcctcg
agcgactggtggcggggggagcacaacggcatgcggggcctcatcccccacaagtatatc
acgctgcccgccgggacggagaagcaggtggtgggcgcagggctgcagactgcaggggag
tctgggagcagtcccgagggcctcctggcatcggagctggtccaccggccagagccatgc
acctcacctgaggccatgggaccctctggacacagacgacgctgcttggtcccagcctcc
ccagagcaacacgtggaggtggataaggctgtggcacagaacatggactctgtgtttaag
gagctcttgggaaagacctctgtccgccagggccttgggccagcatctaccacctctccc
agtcctgggccccgaagcccaaaggccccgcccagcagccgcctgggcaggaacaaaggc
ttctcccggggccctggggccccagcctcaccctcagcttcccacccccagggcctagac
acgacccccaagccacactga

KEGG   Homo sapiens (human): 25
Entry
25                CDS       T01001                                 
Symbol
ABL1, ABL, BCR-ABL, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl
Name
(RefSeq) tyrosine-protein kinase ABL1 isoform a
  KO
K06619  abelson tyrosine-protein kinase 1 [EC:2.7.10.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04110  Cell cycle
hsa04360  Axon guidance
hsa04517  IgSF CAM signaling
hsa04722  Neurotrophin signaling pathway
hsa05130  Pathogenic Escherichia coli infection
hsa05200  Pathways in cancer
hsa05206  MicroRNAs in cancer
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05220  Chronic myeloid leukemia
hsa05416  Viral myocarditis
Network
nt06180  Pathogenic Escherichia coli
nt06210  ERK signaling (cancer)
nt06214  PI3K signaling (cancer)
nt06219  JAK-STAT signaling (cancer)
nt06223  TNF signaling (cancer)
nt06276  Chronic myeloid leukemia
nt06546  IgSF CAM signaling
  Element
N00002  BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00048  BCR-ABL fusion kinase to PI3K signaling pathway
N00055  BCR-ABL fusion kinase to Jak-STAT signaling pathway
N01093  Escherichia EspJ/Tir to Actin signaling pathway
N01411  Metals to NFKB signaling pathway
N01942  SLIT-ROBO signaling in neuron
Disease
H00001  B-cell acute lymphoblastic leukemia
H00004  Chronic myeloid leukemia
H02982  Congenital heart defects and skeletal malformations syndrome
Drug target
Asciminib (DG03004): D11403 D11404<JP/US>
Bafetinib: D10202
Bosutinib (DG00718): D03252<US> D09728<JP/US>
Dasatinib (DG00714): D03658<JP> D06414<JP/US> D12609
Imatinib (DG00710): D01441<JP/US> D08066
Nilotinib (DG00716): D06413<JP/US> D08953 D12444<JP/US> D12854 D13008<US> D13308
Olverembatinib: D12175
Ponatinib (DG00722): D09950 D09951<JP/US>
Rebastinib (DG01368): D10334 D10399
Risvodetinib (DG03300): D12828 D12829
Saracatinib (DG01418): D09664 D09665
Tozasertib (DG01365): D08279 D08344
Vodobatinib: D11786
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    25 (ABL1)
   04014 Ras signaling pathway
    25 (ABL1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    25 (ABL1)
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    25 (ABL1)
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    25 (ABL1)
  09158 Development and regeneration
   04360 Axon guidance
    25 (ABL1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    25 (ABL1)
   05206 MicroRNAs in cancer
    25 (ABL1)
   05208 Chemical carcinogenesis - reactive oxygen species
    25 (ABL1)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    25 (ABL1)
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    25 (ABL1)
  09166 Cardiovascular disease
   05416 Viral myocarditis
    25 (ABL1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    25 (ABL1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     25 (ABL1)
Protein kinases [BR:hsa01001]
 Non-receptor tyrosine kinases
  ABL family
   25 (ABL1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase F_actin_bind SH2 SH3_1 SH3_2 SH3_9 Haspin_kinase Kinase-like SH3_6 ABC1
Other DBs
NCBI-GeneID: 25
NCBI-ProteinID: NP_005148
OMIM: 189980
HGNC: 76
Ensembl: ENSP00000323315.5
UniProt: P00519 Q59FK4
Structure
LinkDB
Position
9:130713043..130887675
AA seq 1130 aa
MLEICLKLVGCKSKKGLSSSSSCYLEEALQRPVASDFEPQGLSEAARWNSKENLLAGPSE
NDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVN
SLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS
DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERT
DITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQ
LLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFI
HRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKS
DVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNP
SDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAE
HRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLLPKDKKTNLF
SALIKKKKKTAPTPPKRSSSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSP
KPSNGAGVPNGALRESGGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSAS
CVPHGAKDTEWRSVTLPRDLQSTGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTV
TPPPRLVKKNEEAADEVFKDIMESSPGSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGS
ALGTPAAAEPVTPTSKAGSGAPGGTSKGPAEESRVRRHKHSSESPGRDKGKLSRLKPAPP
PPPAASAGKAGGKPSQSPSQEAAGEAVLGAKTKATSLVDAVNSDAAKPSQPGEGLKKPVL
PATPKPQSAKPSGTPISPAPVPSTLPSASSALAGDQPSSTAFIPLISTRVSLRKTRQPPE
RIASGAITKGVVLDSTEALCLAISRNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNK
FAFREAINKLENNLRELQICPATAGSGPAATQDFSKLLSSVKEISDIVQR
NT seq 3393 nt   +upstreamnt  +downstreamnt
atgttggagatctgcctgaagctggtgggctgcaaatccaagaaggggctgtcctcgtcc
tccagctgttatctggaagaagcccttcagcggccagtagcatctgactttgagcctcag
ggtctgagtgaagccgctcgttggaactccaaggaaaaccttctcgctggacccagtgaa
aatgaccccaaccttttcgttgcactgtatgattttgtggccagtggagataacactcta
agcataactaaaggtgaaaagctccgggtcttaggctataatcacaatggggaatggtgt
gaagcccaaaccaaaaatggccaaggctgggtcccaagcaactacatcacgccagtcaac
agtctggagaaacactcctggtaccatgggcctgtgtcccgcaatgccgctgagtatctg
ctgagcagcgggatcaatggcagcttcttggtgcgtgagagtgagagcagtcctggccag
aggtccatctcgctgagatacgaagggagggtgtaccattacaggatcaacactgcttct
gatggcaagctctacgtctcctccgagagccgcttcaacaccctggccgagttggttcat
catcattcaacggtggccgacgggctcatcaccacgctccattatccagccccaaagcgc
aacaagcccactgtctatggtgtgtcccccaactacgacaagtgggagatggaacgcacg
gacatcaccatgaagcacaagctgggcgggggccagtacggggaggtgtacgagggcgtg
tggaagaaatacagcctgacggtggccgtgaagaccttgaaggaggacaccatggaggtg
gaagagttcttgaaagaagctgcagtcatgaaagagatcaaacaccctaacctggtgcag
ctccttggggtctgcacccgggagcccccgttctatatcatcactgagttcatgacctac
gggaacctcctggactacctgagggagtgcaaccggcaggaggtgaacgccgtggtgctg
ctgtacatggccactcagatctcgtcagccatggagtacctggagaagaaaaacttcatc
cacagagatcttgctgcccgaaactgcctggtaggggagaaccacttggtgaaggtagct
gattttggcctgagcaggttgatgacaggggacacctacacagcccatgctggagccaag
ttccccatcaaatggactgcacccgagagcctggcctacaacaagttctccatcaagtcc
gacgtctgggcatttggagtattgctttgggaaattgctacctatggcatgtccccttac
ccgggaattgacctgtcccaggtgtatgagctgctagagaaggactaccgcatggagcgc
ccagaaggctgcccagagaaggtctatgaactcatgcgagcatgttggcagtggaatccc
tctgaccggccctcctttgctgaaatccaccaagcctttgaaacaatgttccaggaatcc
agtatctcagacgaagtggaaaaggagctggggaaacaaggcgtccgtggggctgtgagt
accttgctgcaggccccagagctgcccaccaagacgaggacctccaggagagctgcagag
cacagagacaccactgacgtgcctgagatgcctcactccaagggccagggagagagcgat
cctctggaccatgagcctgccgtgtctccattgctccctcgaaaagagcgaggtcccccg
gagggcggcctgaatgaagatgagcgccttctccccaaagacaaaaagaccaacttgttc
agcgccttgatcaagaagaagaagaagacagccccaacccctcccaaacgcagcagctcc
ttccgggagatggacggccagccggagcgcagaggggccggcgaggaagagggccgagac
atcagcaacggggcactggctttcacccccttggacacagctgacccagccaagtcccca
aagcccagcaatggggctggggtccccaatggagccctccgggagtccgggggctcaggc
ttccggtctccccacctgtggaagaagtccagcacgctgaccagcagccgcctagccacc
ggcgaggaggagggcggtggcagctccagcaagcgcttcctgcgctcttgctccgcctcc
tgcgttccccatggggccaaggacacggagtggaggtcagtcacgctgcctcgggacttg
cagtccacgggaagacagtttgactcgtccacatttggagggcacaaaagtgagaagccg
gctctgcctcggaagagggcaggggagaacaggtctgaccaggtgacccgaggcacagta
acgcctccccccaggctggtgaaaaagaatgaggaagctgctgatgaggtcttcaaagac
atcatggagtccagcccgggctccagcccgcccaacctgactccaaaacccctccggcgg
caggtcaccgtggcccctgcctcgggcctcccccacaaggaagaagctggaaagggcagt
gccttagggacccctgctgcagctgagccagtgacccccaccagcaaagcaggctcaggt
gcaccagggggcaccagcaagggccccgccgaggagtccagagtgaggaggcacaagcac
tcctctgagtcgccagggagggacaaggggaaattgtccaggctcaaacctgccccgccg
cccccaccagcagcctctgcagggaaggctggaggaaagccctcgcagagcccgagccag
gaggcggccggggaggcagtcctgggcgcaaagacaaaagccacgagtctggttgatgct
gtgaacagtgacgctgccaagcccagccagccgggagagggcctcaaaaagcccgtgctc
ccggccactccaaagccacagtccgccaagccgtcggggacccccatcagcccagccccc
gttccctccacgttgccatcagcatcctcggccctggcaggggaccagccgtcttccacc
gccttcatccctctcatatcaacccgagtgtctcttcggaaaacccgccagcctccagag
cggatcgccagcggcgccatcaccaagggcgtggtcctggacagcaccgaggcgctgtgc
ctcgccatctctaggaactccgagcagatggccagccacagcgcagtgctggaggccggc
aaaaacctctacacgttctgcgtgagctatgtggattccatccagcaaatgaggaacaag
tttgccttccgagaggccatcaacaaactggagaataatctccgggagcttcagatctgc
ccggcgacagcaggcagtggtccagcggccactcaggacttcagcaagctcctcagttcg
gtgaaggaaatcagtgacatagtgcagaggtag

KEGG   Homo sapiens (human): 207
Entry
207               CDS       T01001                                 
Symbol
AKT1, AKT, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
Name
(RefSeq) RAC-alpha serine/threonine-protein kinase
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04370  VEGF signaling pathway
hsa04371  Apelin signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04517  IgSF CAM signaling
hsa04518  Integrin signaling
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa04620  Toll-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagosome formation
hsa04668  TNF signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04922  Glucagon signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04926  Relaxin signaling pathway
hsa04929  GnRH secretion
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04935  Growth hormone synthesis, secretion and action
hsa04936  Alcoholic liver disease
hsa04973  Carbohydrate digestion and absorption
hsa05010  Alzheimer disease
hsa05017  Spinocerebellar ataxia
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06214  PI3K signaling (cancer)
nt06224  CXCR signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06272  Prostate cancer
nt06273  Glioma
nt06275  Acute myeloid leukemia
nt06276  Chronic myeloid leukemia
nt06462  Spinocerebellar ataxia
nt06464  Amyotrophic lateral sclerosis
nt06530  PI3K signaling
nt06537  TCR/BCR signaling
nt06541  Cytoskeleton in neurons
nt06543  NRG-ERBB signaling
nt06546  IgSF CAM signaling
  Element
N00030  EGF-EGFR-RAS-PI3K signaling pathway
N00031  Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00032  Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00033  EGF-EGFR-PI3K signaling pathway
N00034  ERBB2-overexpression to PI3K signaling pathway
N00035  Amplified EGFR to PI3K signaling pathway
N00036  Mutation-activated EGFR to PI3K signaling pathway
N00037  FGF-FGFR-PI3K signaling pathway
N00038  Amplified FGFR to PI3K signaling pathway
N00039  PDGF-PDGFR-PI3K signaling pathway
N00040  Amplified PDGFR to PI3K signaling pathway
N00042  EGFR-overexpression to PI3K signaling pathway
N00043  HGF-MET-PI3K signaling pathway
N00044  Mutation-activated MET to PI3K signaling pathway
N00045  KITLG-KIT-PI3K signaling pathway
N00046  Mutation-activated KIT to PI3K signaling pathway
N00047  EML4-ALK fusion kinase to PI3K signaling pathway
N00048  BCR-ABL fusion kinase to PI3K signaling pathway
N00049  Mutation-activated PI3K to PI3K signaling pathway
N00050  Amplified PI3K to PI3K signaling pathway
N00051  Deleted PTEN to PI3K signaling pathway
N00052  Mutation-inactivated PTEN to PI3K signaling pathway
N00082  Loss of NKX3-1 to PI3K signaling pathway
N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
N00182  IGF-IGFR-PI3K-NFKB signaling pathway
N00218  FLT3LG-FLT3-RAS-PI3K signaling pathway
N00220  PTEN-PIP3-AKT signaling pathway
N00231  TGFA-EGFR-PI3K signaling pathway
N00232  TGFA-overexpression to PI3K signaling pathway
N00234  IGF2-IGF1R-PI3K signaling pathway
N00236  IGF2-overexpression to PI3K signaling pathway
N00238  IGF1R-overexpression to PI3K signaling pathway
N00247  HGF-overexpression to PI3K signaling pathway
N00249  MET-overexpression to PI3K signaling pathway
N00253  Amplified ERBB2 to PI3K signaling pathway
N00260  Amplified MET to PI3K signaling pathway
N00281  EGF-overexpression to PI3K signaling pathway
N00282  EREG-EGFR-PI3K signaling pathway
N00283  EREG-overexpression to PI3K signaling pathway
N00284  AREG-EGFR-PI3K signaling pathway
N00285  AREG-overexpression to PI3K signaling pathway
N00342  MAGI-PTEN signaling pathway
N00355  PP2A-AKT signaling pathway
N00390  EGF-EGFR-PI3K-NFKB signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00430  CXCR4-GNAI-PI3K-BAD signaling pathway
N00514  Mutation-activated EGFR to PI3K signaling pathway
N00582  IGF-IGF1R-PI3K signaling pathway
N00683  CD80/CD86-CD28-PI3K signaling pathway
N00963  RELN-VLDLR-PI3K signaling pathway
N00964  DAB1-overexpression to RELN-VLDLR-PI3K signaling pathway
N01063  Mutation-activated MET to PI3K signaling pathway
N01065  Mutation-activated RET to PI3K signaling pathway
N01163  NRG-ERBB4-PI3K signaling pathway
N01338  ACH-CHRN-PI3K signaling pathway
N01339  NNK/NNN to PI3K signaling pathway
N01347  EP/NE-ADRB-PI3K signaling pathway
N01348  Nicotine/NNK to PI3K signaling pathway
N01349  ACH-CHRN-PI3K signaling pathway
N01350  NNK/NNN to PI3K signaling pathway
N01355  Arsenic to PI3K signaling pathway
N01356  Membrane-initiated progesterone signaling pathway
N01357  P4/MPA to membrane-initiated progesterone signaling pathway
N01358  P4-PR-PI3K signaling pathway
N01359  P4/MPA to PR-PI3K signaling pathway
N01409  Metals to PI3K signaling pathway
N01579  CD80/CD86-CTLA4-PP2A signaling pathway
N01656  GF-RTK-PI3K signaling pathway
N01657  GPCR-PI3K signaling pathway
N01658  GF-RTK-RAS-PI3K signaling pathway
N01695  BCR-BCAP/CD19-PI3K signaling pathway
N01696  ICOSLG/ICOS-PI3K signaling pathway
N01833  DRAXIN-MAP1B axon guidance signaling
N01858  EFNB1-MAPT axon guidance signaling
N01875  NRG-ERBB2/ERBB3 pathway (P13K signaling)
N01942  SLIT-ROBO signaling in neuron
Disease
H00020  Colorectal cancer
H00027  Ovarian cancer
H01222  Cowden syndrome
H01556  Meningioma
H01649  Schizophrenia
H02119  Proteus syndrome
Drug target
Afuresertib (DG01408): D10381 D10382
Capivasertib: D11371<JP/US>
Ipatasertib (DG02851): D10641 D11074
Miransertib (DG03026): D11409 D11508
Triciribine phosphate: D06221
Uprosertib: D10674
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    207 (AKT1)
   04012 ErbB signaling pathway
    207 (AKT1)
   04014 Ras signaling pathway
    207 (AKT1)
   04015 Rap1 signaling pathway
    207 (AKT1)
   04370 VEGF signaling pathway
    207 (AKT1)
   04371 Apelin signaling pathway
    207 (AKT1)
   04630 JAK-STAT signaling pathway
    207 (AKT1)
   04668 TNF signaling pathway
    207 (AKT1)
   04066 HIF-1 signaling pathway
    207 (AKT1)
   04068 FoxO signaling pathway
    207 (AKT1)
   04072 Phospholipase D signaling pathway
    207 (AKT1)
   04071 Sphingolipid signaling pathway
    207 (AKT1)
   04024 cAMP signaling pathway
    207 (AKT1)
   04022 cGMP-PKG signaling pathway
    207 (AKT1)
   04151 PI3K-Akt signaling pathway
    207 (AKT1)
   04152 AMPK signaling pathway
    207 (AKT1)
   04150 mTOR signaling pathway
    207 (AKT1)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    207 (AKT1)
   04518 Integrin signaling
    207 (AKT1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    207 (AKT1)
  09143 Cell growth and death
   04210 Apoptosis
    207 (AKT1)
   04218 Cellular senescence
    207 (AKT1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    207 (AKT1)
   04550 Signaling pathways regulating pluripotency of stem cells
    207 (AKT1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    207 (AKT1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    207 (AKT1)
   04613 Neutrophil extracellular trap formation
    207 (AKT1)
   04620 Toll-like receptor signaling pathway
    207 (AKT1)
   04625 C-type lectin receptor signaling pathway
    207 (AKT1)
   04660 T cell receptor signaling pathway
    207 (AKT1)
   04662 B cell receptor signaling pathway
    207 (AKT1)
   04664 Fc epsilon RI signaling pathway
    207 (AKT1)
   04666 Fc gamma R-mediated phagosome formation
    207 (AKT1)
   04062 Chemokine signaling pathway
    207 (AKT1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    207 (AKT1)
   04922 Glucagon signaling pathway
    207 (AKT1)
   04923 Regulation of lipolysis in adipocytes
    207 (AKT1)
   04920 Adipocytokine signaling pathway
    207 (AKT1)
   04929 GnRH secretion
    207 (AKT1)
   04915 Estrogen signaling pathway
    207 (AKT1)
   04914 Progesterone-mediated oocyte maturation
    207 (AKT1)
   04917 Prolactin signaling pathway
    207 (AKT1)
   04926 Relaxin signaling pathway
    207 (AKT1)
   04935 Growth hormone synthesis, secretion and action
    207 (AKT1)
   04919 Thyroid hormone signaling pathway
    207 (AKT1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    207 (AKT1)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    207 (AKT1)
  09156 Nervous system
   04725 Cholinergic synapse
    207 (AKT1)
   04728 Dopaminergic synapse
    207 (AKT1)
   04722 Neurotrophin signaling pathway
    207 (AKT1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    207 (AKT1)
  09149 Aging
   04211 Longevity regulating pathway
    207 (AKT1)
   04213 Longevity regulating pathway - multiple species
    207 (AKT1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    207 (AKT1)
   05205 Proteoglycans in cancer
    207 (AKT1)
   05207 Chemical carcinogenesis - receptor activation
    207 (AKT1)
   05208 Chemical carcinogenesis - reactive oxygen species
    207 (AKT1)
   05230 Central carbon metabolism in cancer
    207 (AKT1)
   05231 Choline metabolism in cancer
    207 (AKT1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    207 (AKT1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    207 (AKT1)
   05212 Pancreatic cancer
    207 (AKT1)
   05225 Hepatocellular carcinoma
    207 (AKT1)
   05226 Gastric cancer
    207 (AKT1)
   05214 Glioma
    207 (AKT1)
   05221 Acute myeloid leukemia
    207 (AKT1)
   05220 Chronic myeloid leukemia
    207 (AKT1)
   05218 Melanoma
    207 (AKT1)
   05211 Renal cell carcinoma
    207 (AKT1)
   05215 Prostate cancer
    207 (AKT1)
   05213 Endometrial cancer
    207 (AKT1)
   05224 Breast cancer
    207 (AKT1)
   05222 Small cell lung cancer
    207 (AKT1)
   05223 Non-small cell lung cancer
    207 (AKT1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    207 (AKT1)
   05170 Human immunodeficiency virus 1 infection
    207 (AKT1)
   05161 Hepatitis B
    207 (AKT1)
   05160 Hepatitis C
    207 (AKT1)
   05164 Influenza A
    207 (AKT1)
   05162 Measles
    207 (AKT1)
   05168 Herpes simplex virus 1 infection
    207 (AKT1)
   05163 Human cytomegalovirus infection
    207 (AKT1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    207 (AKT1)
   05169 Epstein-Barr virus infection
    207 (AKT1)
   05165 Human papillomavirus infection
    207 (AKT1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    207 (AKT1)
   05131 Shigellosis
    207 (AKT1)
   05135 Yersinia infection
    207 (AKT1)
   05152 Tuberculosis
    207 (AKT1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    207 (AKT1)
   05142 Chagas disease
    207 (AKT1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    207 (AKT1)
   05017 Spinocerebellar ataxia
    207 (AKT1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    207 (AKT1)
   05418 Fluid shear stress and atherosclerosis
    207 (AKT1)
   05415 Diabetic cardiomyopathy
    207 (AKT1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    207 (AKT1)
   04932 Non-alcoholic fatty liver disease
    207 (AKT1)
   04931 Insulin resistance
    207 (AKT1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    207 (AKT1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    207 (AKT1)
   01524 Platinum drug resistance
    207 (AKT1)
   01522 Endocrine resistance
    207 (AKT1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    207 (AKT1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     207 (AKT1)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   207 (AKT1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 Seadorna_VP7 ABC1
Other DBs
NCBI-GeneID: 207
NCBI-ProteinID: NP_001014431
OMIM: 164730
HGNC: 391
UniProt: P31749 B0LPE5
Structure
LinkDB
Position
14:complement(104769349..104795748)
AA seq 480 aa
MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGI
KDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
NT seq 1443 nt   +upstreamnt  +downstreamnt
atgagcgacgtggctattgtgaaggagggttggctgcacaaacgaggggagtacatcaag
acctggcggccacgctacttcctcctcaagaatgatggcaccttcattggctacaaggag
cggccgcaggatgtggaccaacgtgaggctcccctcaacaacttctctgtggcgcagtgc
cagctgatgaagacggagcggccccggcccaacaccttcatcatccgctgcctgcagtgg
accactgtcatcgaacgcaccttccatgtggagactcctgaggagcgggaggagtggaca
accgccatccagactgtggctgacggcctcaagaagcaggaggaggaggagatggacttc
cggtcgggctcacccagtgacaactcaggggctgaagagatggaggtgtccctggccaag
cccaagcaccgcgtgaccatgaacgagtttgagtacctgaagctgctgggcaagggcact
ttcggcaaggtgatcctggtgaaggagaaggccacaggccgctactacgccatgaagatc
ctcaagaaggaagtcatcgtggccaaggacgaggtggcccacacactcaccgagaaccgc
gtcctgcagaactccaggcaccccttcctcacagccctgaagtactctttccagacccac
gaccgcctctgctttgtcatggagtacgccaacgggggcgagctgttcttccacctgtcc
cgggagcgtgtgttctccgaggaccgggcccgcttctatggcgctgagattgtgtcagcc
ctggactacctgcactcggagaagaacgtggtgtaccgggacctcaagctggagaacctc
atgctggacaaggacgggcacattaagatcacagacttcgggctgtgcaaggaggggatc
aaggacggtgccaccatgaagaccttttgcggcacacctgagtacctggcccccgaggtg
ctggaggacaatgactacggccgtgcagtggactggtgggggctgggcgtggtcatgtac
gagatgatgtgcggtcgcctgcccttctacaaccaggaccatgagaagctttttgagctc
atcctcatggaggagatccgcttcccgcgcacgcttggtcccgaggccaagtccttgctt
tcagggctgctcaagaaggaccccaagcagaggcttggcgggggctccgaggacgccaag
gagatcatgcagcatcgcttctttgccggtatcgtgtggcagcacgtgtacgagaagaag
ctcagcccacccttcaagccccaggtcacgtcggagactgacaccaggtattttgatgag
gagttcacggcccagatgatcaccatcacaccacctgaccaagatgacagcatggagtgt
gtggacagcgagcgcaggccccacttcccccagttctcctactcggccagcggcacggcc
tga

KEGG   Homo sapiens (human): 208
Entry
208               CDS       T01001                                 
Symbol
AKT2, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA
Name
(RefSeq) RAC-beta serine/threonine-protein kinase isoform 1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04370  VEGF signaling pathway
hsa04371  Apelin signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04517  IgSF CAM signaling
hsa04518  Integrin signaling
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa04620  Toll-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagosome formation
hsa04668  TNF signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04922  Glucagon signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04926  Relaxin signaling pathway
hsa04929  GnRH secretion
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04935  Growth hormone synthesis, secretion and action
hsa04936  Alcoholic liver disease
hsa04973  Carbohydrate digestion and absorption
hsa05010  Alzheimer disease
hsa05017  Spinocerebellar ataxia
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06214  PI3K signaling (cancer)
nt06224  CXCR signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06272  Prostate cancer
nt06273  Glioma
nt06275  Acute myeloid leukemia
nt06276  Chronic myeloid leukemia
nt06462  Spinocerebellar ataxia
nt06464  Amyotrophic lateral sclerosis
nt06530  PI3K signaling
nt06537  TCR/BCR signaling
nt06541  Cytoskeleton in neurons
nt06543  NRG-ERBB signaling
nt06546  IgSF CAM signaling
  Element
N00030  EGF-EGFR-RAS-PI3K signaling pathway
N00031  Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00032  Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00033  EGF-EGFR-PI3K signaling pathway
N00034  ERBB2-overexpression to PI3K signaling pathway
N00035  Amplified EGFR to PI3K signaling pathway
N00036  Mutation-activated EGFR to PI3K signaling pathway
N00037  FGF-FGFR-PI3K signaling pathway
N00038  Amplified FGFR to PI3K signaling pathway
N00039  PDGF-PDGFR-PI3K signaling pathway
N00040  Amplified PDGFR to PI3K signaling pathway
N00042  EGFR-overexpression to PI3K signaling pathway
N00043  HGF-MET-PI3K signaling pathway
N00044  Mutation-activated MET to PI3K signaling pathway
N00045  KITLG-KIT-PI3K signaling pathway
N00046  Mutation-activated KIT to PI3K signaling pathway
N00047  EML4-ALK fusion kinase to PI3K signaling pathway
N00048  BCR-ABL fusion kinase to PI3K signaling pathway
N00049  Mutation-activated PI3K to PI3K signaling pathway
N00050  Amplified PI3K to PI3K signaling pathway
N00051  Deleted PTEN to PI3K signaling pathway
N00052  Mutation-inactivated PTEN to PI3K signaling pathway
N00082  Loss of NKX3-1 to PI3K signaling pathway
N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
N00182  IGF-IGFR-PI3K-NFKB signaling pathway
N00218  FLT3LG-FLT3-RAS-PI3K signaling pathway
N00220  PTEN-PIP3-AKT signaling pathway
N00231  TGFA-EGFR-PI3K signaling pathway
N00232  TGFA-overexpression to PI3K signaling pathway
N00234  IGF2-IGF1R-PI3K signaling pathway
N00236  IGF2-overexpression to PI3K signaling pathway
N00238  IGF1R-overexpression to PI3K signaling pathway
N00247  HGF-overexpression to PI3K signaling pathway
N00249  MET-overexpression to PI3K signaling pathway
N00253  Amplified ERBB2 to PI3K signaling pathway
N00260  Amplified MET to PI3K signaling pathway
N00281  EGF-overexpression to PI3K signaling pathway
N00282  EREG-EGFR-PI3K signaling pathway
N00283  EREG-overexpression to PI3K signaling pathway
N00284  AREG-EGFR-PI3K signaling pathway
N00285  AREG-overexpression to PI3K signaling pathway
N00342  MAGI-PTEN signaling pathway
N00355  PP2A-AKT signaling pathway
N00390  EGF-EGFR-PI3K-NFKB signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00430  CXCR4-GNAI-PI3K-BAD signaling pathway
N00514  Mutation-activated EGFR to PI3K signaling pathway
N00582  IGF-IGF1R-PI3K signaling pathway
N00683  CD80/CD86-CD28-PI3K signaling pathway
N00963  RELN-VLDLR-PI3K signaling pathway
N00964  DAB1-overexpression to RELN-VLDLR-PI3K signaling pathway
N01063  Mutation-activated MET to PI3K signaling pathway
N01065  Mutation-activated RET to PI3K signaling pathway
N01163  NRG-ERBB4-PI3K signaling pathway
N01338  ACH-CHRN-PI3K signaling pathway
N01339  NNK/NNN to PI3K signaling pathway
N01347  EP/NE-ADRB-PI3K signaling pathway
N01348  Nicotine/NNK to PI3K signaling pathway
N01349  ACH-CHRN-PI3K signaling pathway
N01350  NNK/NNN to PI3K signaling pathway
N01355  Arsenic to PI3K signaling pathway
N01356  Membrane-initiated progesterone signaling pathway
N01357  P4/MPA to membrane-initiated progesterone signaling pathway
N01358  P4-PR-PI3K signaling pathway
N01359  P4/MPA to PR-PI3K signaling pathway
N01409  Metals to PI3K signaling pathway
N01579  CD80/CD86-CTLA4-PP2A signaling pathway
N01656  GF-RTK-PI3K signaling pathway
N01657  GPCR-PI3K signaling pathway
N01658  GF-RTK-RAS-PI3K signaling pathway
N01695  BCR-BCAP/CD19-PI3K signaling pathway
N01696  ICOSLG/ICOS-PI3K signaling pathway
N01833  DRAXIN-MAP1B axon guidance signaling
N01858  EFNB1-MAPT axon guidance signaling
N01875  NRG-ERBB2/ERBB3 pathway (P13K signaling)
N01942  SLIT-ROBO signaling in neuron
Disease
H00027  Ovarian cancer
H00409  Type 2 diabetes mellitus
H00420  Familial partial lipodystrophy
H01909  Hypoinsulinemic hypoglycemia with hemihypertrophy
Drug target
Afuresertib (DG01408): D10381 D10382
Capivasertib: D11371<JP/US>
Ipatasertib (DG02851): D10641 D11074
Miransertib (DG03026): D11409 D11508
Triciribine phosphate: D06221
Uprosertib: D10674
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    208 (AKT2)
   04012 ErbB signaling pathway
    208 (AKT2)
   04014 Ras signaling pathway
    208 (AKT2)
   04015 Rap1 signaling pathway
    208 (AKT2)
   04370 VEGF signaling pathway
    208 (AKT2)
   04371 Apelin signaling pathway
    208 (AKT2)
   04630 JAK-STAT signaling pathway
    208 (AKT2)
   04668 TNF signaling pathway
    208 (AKT2)
   04066 HIF-1 signaling pathway
    208 (AKT2)
   04068 FoxO signaling pathway
    208 (AKT2)
   04072 Phospholipase D signaling pathway
    208 (AKT2)
   04071 Sphingolipid signaling pathway
    208 (AKT2)
   04024 cAMP signaling pathway
    208 (AKT2)
   04022 cGMP-PKG signaling pathway
    208 (AKT2)
   04151 PI3K-Akt signaling pathway
    208 (AKT2)
   04152 AMPK signaling pathway
    208 (AKT2)
   04150 mTOR signaling pathway
    208 (AKT2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    208 (AKT2)
   04518 Integrin signaling
    208 (AKT2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    208 (AKT2)
  09143 Cell growth and death
   04210 Apoptosis
    208 (AKT2)
   04218 Cellular senescence
    208 (AKT2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    208 (AKT2)
   04550 Signaling pathways regulating pluripotency of stem cells
    208 (AKT2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    208 (AKT2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    208 (AKT2)
   04613 Neutrophil extracellular trap formation
    208 (AKT2)
   04620 Toll-like receptor signaling pathway
    208 (AKT2)
   04625 C-type lectin receptor signaling pathway
    208 (AKT2)
   04660 T cell receptor signaling pathway
    208 (AKT2)
   04662 B cell receptor signaling pathway
    208 (AKT2)
   04664 Fc epsilon RI signaling pathway
    208 (AKT2)
   04666 Fc gamma R-mediated phagosome formation
    208 (AKT2)
   04062 Chemokine signaling pathway
    208 (AKT2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    208 (AKT2)
   04922 Glucagon signaling pathway
    208 (AKT2)
   04923 Regulation of lipolysis in adipocytes
    208 (AKT2)
   04920 Adipocytokine signaling pathway
    208 (AKT2)
   04929 GnRH secretion
    208 (AKT2)
   04915 Estrogen signaling pathway
    208 (AKT2)
   04914 Progesterone-mediated oocyte maturation
    208 (AKT2)
   04917 Prolactin signaling pathway
    208 (AKT2)
   04926 Relaxin signaling pathway
    208 (AKT2)
   04935 Growth hormone synthesis, secretion and action
    208 (AKT2)
   04919 Thyroid hormone signaling pathway
    208 (AKT2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    208 (AKT2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    208 (AKT2)
  09156 Nervous system
   04725 Cholinergic synapse
    208 (AKT2)
   04728 Dopaminergic synapse
    208 (AKT2)
   04722 Neurotrophin signaling pathway
    208 (AKT2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    208 (AKT2)
  09149 Aging
   04211 Longevity regulating pathway
    208 (AKT2)
   04213 Longevity regulating pathway - multiple species
    208 (AKT2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    208 (AKT2)
   05205 Proteoglycans in cancer
    208 (AKT2)
   05207 Chemical carcinogenesis - receptor activation
    208 (AKT2)
   05208 Chemical carcinogenesis - reactive oxygen species
    208 (AKT2)
   05230 Central carbon metabolism in cancer
    208 (AKT2)
   05231 Choline metabolism in cancer
    208 (AKT2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    208 (AKT2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    208 (AKT2)
   05212 Pancreatic cancer
    208 (AKT2)
   05225 Hepatocellular carcinoma
    208 (AKT2)
   05226 Gastric cancer
    208 (AKT2)
   05214 Glioma
    208 (AKT2)
   05221 Acute myeloid leukemia
    208 (AKT2)
   05220 Chronic myeloid leukemia
    208 (AKT2)
   05218 Melanoma
    208 (AKT2)
   05211 Renal cell carcinoma
    208 (AKT2)
   05215 Prostate cancer
    208 (AKT2)
   05213 Endometrial cancer
    208 (AKT2)
   05224 Breast cancer
    208 (AKT2)
   05222 Small cell lung cancer
    208 (AKT2)
   05223 Non-small cell lung cancer
    208 (AKT2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    208 (AKT2)
   05170 Human immunodeficiency virus 1 infection
    208 (AKT2)
   05161 Hepatitis B
    208 (AKT2)
   05160 Hepatitis C
    208 (AKT2)
   05164 Influenza A
    208 (AKT2)
   05162 Measles
    208 (AKT2)
   05168 Herpes simplex virus 1 infection
    208 (AKT2)
   05163 Human cytomegalovirus infection
    208 (AKT2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    208 (AKT2)
   05169 Epstein-Barr virus infection
    208 (AKT2)
   05165 Human papillomavirus infection
    208 (AKT2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    208 (AKT2)
   05131 Shigellosis
    208 (AKT2)
   05135 Yersinia infection
    208 (AKT2)
   05152 Tuberculosis
    208 (AKT2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    208 (AKT2)
   05142 Chagas disease
    208 (AKT2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    208 (AKT2)
   05017 Spinocerebellar ataxia
    208 (AKT2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    208 (AKT2)
   05418 Fluid shear stress and atherosclerosis
    208 (AKT2)
   05415 Diabetic cardiomyopathy
    208 (AKT2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    208 (AKT2)
   04932 Non-alcoholic fatty liver disease
    208 (AKT2)
   04931 Insulin resistance
    208 (AKT2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    208 (AKT2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    208 (AKT2)
   01524 Platinum drug resistance
    208 (AKT2)
   01522 Endocrine resistance
    208 (AKT2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    208 (AKT2)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     208 (AKT2)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   208 (AKT2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 Seadorna_VP7
Other DBs
NCBI-GeneID: 208
NCBI-ProteinID: NP_001617
OMIM: 164731
HGNC: 392
Ensembl: ENSP00000375892.2
UniProt: P31751
Structure
LinkDB
Position
19:complement(40230317..40285345)
AA seq 481 aa
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
NT seq 1446 nt   +upstreamnt  +downstreamnt
atgaatgaggtgtctgtcatcaaagaaggctggctccacaagcgtggtgaatacatcaag
acctggaggccacggtacttcctgctgaagagcgacggctccttcattgggtacaaggag
aggcccgaggcccctgatcagactctaccccccttaaacaacttctccgtagcagaatgc
cagctgatgaagaccgagaggccgcgacccaacacctttgtcatacgctgcctgcagtgg
accacagtcatcgagaggaccttccacgtggattctccagacgagagggaggagtggatg
cgggccatccagatggtcgccaacagcctcaagcagcgggccccaggcgaggaccccatg
gactacaagtgtggctcccccagtgactcctccacgactgaggagatggaagtggcggtc
agcaaggcacgggctaaagtgaccatgaatgacttcgactatctcaaactccttggcaag
ggaacctttggcaaagtcatcctggtgcgggagaaggccactggccgctactacgccatg
aagatcctgcggaaggaagtcatcattgccaaggatgaagtcgctcacacagtcaccgag
agccgggtcctccagaacaccaggcacccgttcctcactgcgctgaagtatgccttccag
acccacgaccgcctgtgctttgtgatggagtatgccaacgggggtgagctgttcttccac
ctgtcccgggagcgtgtcttcacagaggagcgggcccggttttatggtgcagagattgtc
tcggctcttgagtacttgcactcgcgggacgtggtataccgcgacatcaagctggaaaac
ctcatgctggacaaagatggccacatcaagatcactgactttggcctctgcaaagagggc
atcagtgacggggccaccatgaaaaccttctgtgggaccccggagtacctggcgcctgag
gtgctggaggacaatgactatggccgggccgtggactggtgggggctgggtgtggtcatg
tacgagatgatgtgcggccgcctgcccttctacaaccaggaccacgagcgcctcttcgag
ctcatcctcatggaagagatccgcttcccgcgcacgctcagccccgaggccaagtccctg
cttgctgggctgcttaagaaggaccccaagcagaggcttggtggggggcccagcgatgcc
aaggaggtcatggagcacaggttcttcctcagcatcaactggcaggacgtggtccagaag
aagctcctgccacccttcaaacctcaggtcacgtccgaggtcgacacaaggtacttcgat
gatgaatttaccgcccagtccatcacaatcacaccccctgaccgctatgacagcctgggc
ttactggagctggaccagcggacccacttcccccagttctcctactcggccagcatccgc
gagtga

KEGG   Homo sapiens (human): 10000
Entry
10000             CDS       T01001                                 
Symbol
AKT3, MPPH, MPPH2, PKB-GAMMA, PKBG, PRKBG, RAC-PK-gamma, RAC-gamma, STK-2
Name
(RefSeq) RAC-gamma serine/threonine-protein kinase isoform 1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
hsa  Homo sapiens (human)
Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa01522  Endocrine resistance
hsa01524  Platinum drug resistance
hsa04010  MAPK signaling pathway
hsa04012  ErbB signaling pathway
hsa04014  Ras signaling pathway
hsa04015  Rap1 signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04062  Chemokine signaling pathway
hsa04066  HIF-1 signaling pathway
hsa04068  FoxO signaling pathway
hsa04071  Sphingolipid signaling pathway
hsa04072  Phospholipase D signaling pathway
hsa04140  Autophagy - animal
hsa04150  mTOR signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04152  AMPK signaling pathway
hsa04210  Apoptosis
hsa04211  Longevity regulating pathway
hsa04213  Longevity regulating pathway - multiple species
hsa04218  Cellular senescence
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04370  VEGF signaling pathway
hsa04371  Apelin signaling pathway
hsa04380  Osteoclast differentiation
hsa04510  Focal adhesion
hsa04517  IgSF CAM signaling
hsa04518  Integrin signaling
hsa04550  Signaling pathways regulating pluripotency of stem cells
hsa04611  Platelet activation
hsa04613  Neutrophil extracellular trap formation
hsa04620  Toll-like receptor signaling pathway
hsa04625  C-type lectin receptor signaling pathway
hsa04630  JAK-STAT signaling pathway
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagosome formation
hsa04668  TNF signaling pathway
hsa04722  Neurotrophin signaling pathway
hsa04725  Cholinergic synapse
hsa04728  Dopaminergic synapse
hsa04810  Regulation of actin cytoskeleton
hsa04910  Insulin signaling pathway
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
hsa04917  Prolactin signaling pathway
hsa04919  Thyroid hormone signaling pathway
hsa04920  Adipocytokine signaling pathway
hsa04922  Glucagon signaling pathway
hsa04923  Regulation of lipolysis in adipocytes
hsa04926  Relaxin signaling pathway
hsa04929  GnRH secretion
hsa04931  Insulin resistance
hsa04932  Non-alcoholic fatty liver disease
hsa04933  AGE-RAGE signaling pathway in diabetic complications
hsa04935  Growth hormone synthesis, secretion and action
hsa04936  Alcoholic liver disease
hsa04973  Carbohydrate digestion and absorption
hsa05010  Alzheimer disease
hsa05017  Spinocerebellar ataxia
hsa05131  Shigellosis
hsa05132  Salmonella infection
hsa05135  Yersinia infection
hsa05142  Chagas disease
hsa05145  Toxoplasmosis
hsa05152  Tuberculosis
hsa05160  Hepatitis C
hsa05161  Hepatitis B
hsa05162  Measles
hsa05163  Human cytomegalovirus infection
hsa05164  Influenza A
hsa05165  Human papillomavirus infection
hsa05166  Human T-cell leukemia virus 1 infection
hsa05167  Kaposi sarcoma-associated herpesvirus infection
hsa05168  Herpes simplex virus 1 infection
hsa05169  Epstein-Barr virus infection
hsa05170  Human immunodeficiency virus 1 infection
hsa05200  Pathways in cancer
hsa05205  Proteoglycans in cancer
hsa05207  Chemical carcinogenesis - receptor activation
hsa05208  Chemical carcinogenesis - reactive oxygen species
hsa05210  Colorectal cancer
hsa05211  Renal cell carcinoma
hsa05212  Pancreatic cancer
hsa05213  Endometrial cancer
hsa05214  Glioma
hsa05215  Prostate cancer
hsa05218  Melanoma
hsa05220  Chronic myeloid leukemia
hsa05221  Acute myeloid leukemia
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05224  Breast cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05230  Central carbon metabolism in cancer
hsa05231  Choline metabolism in cancer
hsa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
hsa05415  Diabetic cardiomyopathy
hsa05417  Lipid and atherosclerosis
hsa05418  Fluid shear stress and atherosclerosis
Network
nt06160  Human T-cell leukemia virus 1 (HTLV-1)
nt06161  Human immunodeficiency virus 1 (HIV-1)
nt06162  Hepatitis B virus (HBV)
nt06163  Hepatitis C virus (HCV)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06165  Epstein-Barr virus (EBV)
nt06166  Human papillomavirus (HPV)
nt06167  Human cytomegalovirus (HCMV)
nt06168  Herpes simplex virus 1 (HSV-1)
nt06169  Measles virus (MV)
nt06170  Influenza A virus (IAV)
nt06214  PI3K signaling (cancer)
nt06224  CXCR signaling (cancer)
nt06260  Colorectal cancer
nt06261  Gastric cancer
nt06262  Pancreatic cancer
nt06263  Hepatocellular carcinoma
nt06264  Renal cell carcinoma
nt06266  Non-small cell lung cancer
nt06267  Small cell lung cancer
nt06268  Melanoma
nt06270  Breast cancer
nt06271  Endometrial cancer
nt06272  Prostate cancer
nt06273  Glioma
nt06275  Acute myeloid leukemia
nt06276  Chronic myeloid leukemia
nt06462  Spinocerebellar ataxia
nt06464  Amyotrophic lateral sclerosis
nt06530  PI3K signaling
nt06537  TCR/BCR signaling
nt06541  Cytoskeleton in neurons
nt06543  NRG-ERBB signaling
nt06546  IgSF CAM signaling
  Element
N00030  EGF-EGFR-RAS-PI3K signaling pathway
N00031  Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway
N00032  Mutation-activated KRAS/NRAS to PI3K signaling pathway
N00033  EGF-EGFR-PI3K signaling pathway
N00034  ERBB2-overexpression to PI3K signaling pathway
N00035  Amplified EGFR to PI3K signaling pathway
N00036  Mutation-activated EGFR to PI3K signaling pathway
N00037  FGF-FGFR-PI3K signaling pathway
N00038  Amplified FGFR to PI3K signaling pathway
N00039  PDGF-PDGFR-PI3K signaling pathway
N00040  Amplified PDGFR to PI3K signaling pathway
N00042  EGFR-overexpression to PI3K signaling pathway
N00043  HGF-MET-PI3K signaling pathway
N00044  Mutation-activated MET to PI3K signaling pathway
N00045  KITLG-KIT-PI3K signaling pathway
N00046  Mutation-activated KIT to PI3K signaling pathway
N00047  EML4-ALK fusion kinase to PI3K signaling pathway
N00048  BCR-ABL fusion kinase to PI3K signaling pathway
N00049  Mutation-activated PI3K to PI3K signaling pathway
N00050  Amplified PI3K to PI3K signaling pathway
N00051  Deleted PTEN to PI3K signaling pathway
N00052  Mutation-inactivated PTEN to PI3K signaling pathway
N00082  Loss of NKX3-1 to PI3K signaling pathway
N00154  CXCR-GNB/G-PI3K-AKT signaling pathway
N00182  IGF-IGFR-PI3K-NFKB signaling pathway
N00218  FLT3LG-FLT3-RAS-PI3K signaling pathway
N00220  PTEN-PIP3-AKT signaling pathway
N00231  TGFA-EGFR-PI3K signaling pathway
N00232  TGFA-overexpression to PI3K signaling pathway
N00234  IGF2-IGF1R-PI3K signaling pathway
N00236  IGF2-overexpression to PI3K signaling pathway
N00238  IGF1R-overexpression to PI3K signaling pathway
N00247  HGF-overexpression to PI3K signaling pathway
N00249  MET-overexpression to PI3K signaling pathway
N00253  Amplified ERBB2 to PI3K signaling pathway
N00260  Amplified MET to PI3K signaling pathway
N00281  EGF-overexpression to PI3K signaling pathway
N00282  EREG-EGFR-PI3K signaling pathway
N00283  EREG-overexpression to PI3K signaling pathway
N00284  AREG-EGFR-PI3K signaling pathway
N00285  AREG-overexpression to PI3K signaling pathway
N00342  MAGI-PTEN signaling pathway
N00355  PP2A-AKT signaling pathway
N00390  EGF-EGFR-PI3K-NFKB signaling pathway
N00399  CCR2-GNB/G-PI3K-NFKB signaling pathway
N00430  CXCR4-GNAI-PI3K-BAD signaling pathway
N00514  Mutation-activated EGFR to PI3K signaling pathway
N00582  IGF-IGF1R-PI3K signaling pathway
N00683  CD80/CD86-CD28-PI3K signaling pathway
N00963  RELN-VLDLR-PI3K signaling pathway
N00964  DAB1-overexpression to RELN-VLDLR-PI3K signaling pathway
N01063  Mutation-activated MET to PI3K signaling pathway
N01065  Mutation-activated RET to PI3K signaling pathway
N01163  NRG-ERBB4-PI3K signaling pathway
N01338  ACH-CHRN-PI3K signaling pathway
N01339  NNK/NNN to PI3K signaling pathway
N01347  EP/NE-ADRB-PI3K signaling pathway
N01348  Nicotine/NNK to PI3K signaling pathway
N01349  ACH-CHRN-PI3K signaling pathway
N01350  NNK/NNN to PI3K signaling pathway
N01355  Arsenic to PI3K signaling pathway
N01356  Membrane-initiated progesterone signaling pathway
N01357  P4/MPA to membrane-initiated progesterone signaling pathway
N01358  P4-PR-PI3K signaling pathway
N01359  P4/MPA to PR-PI3K signaling pathway
N01409  Metals to PI3K signaling pathway
N01579  CD80/CD86-CTLA4-PP2A signaling pathway
N01656  GF-RTK-PI3K signaling pathway
N01657  GPCR-PI3K signaling pathway
N01658  GF-RTK-RAS-PI3K signaling pathway
N01695  BCR-BCAP/CD19-PI3K signaling pathway
N01696  ICOSLG/ICOS-PI3K signaling pathway
N01833  DRAXIN-MAP1B axon guidance signaling
N01858  EFNB1-MAPT axon guidance signaling
N01875  NRG-ERBB2/ERBB3 pathway (P13K signaling)
N01942  SLIT-ROBO signaling in neuron
Disease
H01885  Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
Drug target
Afuresertib (DG01408): D10381 D10382
Capivasertib: D11371<JP/US>
Ipatasertib (DG02851): D10641 D11074
Miransertib (DG03026): D11409 D11508
Triciribine phosphate: D06221
Uprosertib: D10674
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    10000 (AKT3)
   04012 ErbB signaling pathway
    10000 (AKT3)
   04014 Ras signaling pathway
    10000 (AKT3)
   04015 Rap1 signaling pathway
    10000 (AKT3)
   04370 VEGF signaling pathway
    10000 (AKT3)
   04371 Apelin signaling pathway
    10000 (AKT3)
   04630 JAK-STAT signaling pathway
    10000 (AKT3)
   04668 TNF signaling pathway
    10000 (AKT3)
   04066 HIF-1 signaling pathway
    10000 (AKT3)
   04068 FoxO signaling pathway
    10000 (AKT3)
   04072 Phospholipase D signaling pathway
    10000 (AKT3)
   04071 Sphingolipid signaling pathway
    10000 (AKT3)
   04024 cAMP signaling pathway
    10000 (AKT3)
   04022 cGMP-PKG signaling pathway
    10000 (AKT3)
   04151 PI3K-Akt signaling pathway
    10000 (AKT3)
   04152 AMPK signaling pathway
    10000 (AKT3)
   04150 mTOR signaling pathway
    10000 (AKT3)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    10000 (AKT3)
   04518 Integrin signaling
    10000 (AKT3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    10000 (AKT3)
  09143 Cell growth and death
   04210 Apoptosis
    10000 (AKT3)
   04218 Cellular senescence
    10000 (AKT3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    10000 (AKT3)
   04550 Signaling pathways regulating pluripotency of stem cells
    10000 (AKT3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    10000 (AKT3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    10000 (AKT3)
   04613 Neutrophil extracellular trap formation
    10000 (AKT3)
   04620 Toll-like receptor signaling pathway
    10000 (AKT3)
   04625 C-type lectin receptor signaling pathway
    10000 (AKT3)
   04660 T cell receptor signaling pathway
    10000 (AKT3)
   04662 B cell receptor signaling pathway
    10000 (AKT3)
   04664 Fc epsilon RI signaling pathway
    10000 (AKT3)
   04666 Fc gamma R-mediated phagosome formation
    10000 (AKT3)
   04062 Chemokine signaling pathway
    10000 (AKT3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    10000 (AKT3)
   04922 Glucagon signaling pathway
    10000 (AKT3)
   04923 Regulation of lipolysis in adipocytes
    10000 (AKT3)
   04920 Adipocytokine signaling pathway
    10000 (AKT3)
   04929 GnRH secretion
    10000 (AKT3)
   04915 Estrogen signaling pathway
    10000 (AKT3)
   04914 Progesterone-mediated oocyte maturation
    10000 (AKT3)
   04917 Prolactin signaling pathway
    10000 (AKT3)
   04926 Relaxin signaling pathway
    10000 (AKT3)
   04935 Growth hormone synthesis, secretion and action
    10000 (AKT3)
   04919 Thyroid hormone signaling pathway
    10000 (AKT3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    10000 (AKT3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    10000 (AKT3)
  09156 Nervous system
   04725 Cholinergic synapse
    10000 (AKT3)
   04728 Dopaminergic synapse
    10000 (AKT3)
   04722 Neurotrophin signaling pathway
    10000 (AKT3)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    10000 (AKT3)
  09149 Aging
   04211 Longevity regulating pathway
    10000 (AKT3)
   04213 Longevity regulating pathway - multiple species
    10000 (AKT3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    10000 (AKT3)
   05205 Proteoglycans in cancer
    10000 (AKT3)
   05207 Chemical carcinogenesis - receptor activation
    10000 (AKT3)
   05208 Chemical carcinogenesis - reactive oxygen species
    10000 (AKT3)
   05230 Central carbon metabolism in cancer
    10000 (AKT3)
   05231 Choline metabolism in cancer
    10000 (AKT3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    10000 (AKT3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    10000 (AKT3)
   05212 Pancreatic cancer
    10000 (AKT3)
   05225 Hepatocellular carcinoma
    10000 (AKT3)
   05226 Gastric cancer
    10000 (AKT3)
   05214 Glioma
    10000 (AKT3)
   05221 Acute myeloid leukemia
    10000 (AKT3)
   05220 Chronic myeloid leukemia
    10000 (AKT3)
   05218 Melanoma
    10000 (AKT3)
   05211 Renal cell carcinoma
    10000 (AKT3)
   05215 Prostate cancer
    10000 (AKT3)
   05213 Endometrial cancer
    10000 (AKT3)
   05224 Breast cancer
    10000 (AKT3)
   05222 Small cell lung cancer
    10000 (AKT3)
   05223 Non-small cell lung cancer
    10000 (AKT3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    10000 (AKT3)
   05170 Human immunodeficiency virus 1 infection
    10000 (AKT3)
   05161 Hepatitis B
    10000 (AKT3)
   05160 Hepatitis C
    10000 (AKT3)
   05164 Influenza A
    10000 (AKT3)
   05162 Measles
    10000 (AKT3)
   05168 Herpes simplex virus 1 infection
    10000 (AKT3)
   05163 Human cytomegalovirus infection
    10000 (AKT3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    10000 (AKT3)
   05169 Epstein-Barr virus infection
    10000 (AKT3)
   05165 Human papillomavirus infection
    10000 (AKT3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    10000 (AKT3)
   05131 Shigellosis
    10000 (AKT3)
   05135 Yersinia infection
    10000 (AKT3)
   05152 Tuberculosis
    10000 (AKT3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    10000 (AKT3)
   05142 Chagas disease
    10000 (AKT3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    10000 (AKT3)
   05017 Spinocerebellar ataxia
    10000 (AKT3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    10000 (AKT3)
   05418 Fluid shear stress and atherosclerosis
    10000 (AKT3)
   05415 Diabetic cardiomyopathy
    10000 (AKT3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    10000 (AKT3)
   04932 Non-alcoholic fatty liver disease
    10000 (AKT3)
   04931 Insulin resistance
    10000 (AKT3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    10000 (AKT3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    10000 (AKT3)
   01524 Platinum drug resistance
    10000 (AKT3)
   01522 Endocrine resistance
    10000 (AKT3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    10000 (AKT3)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     10000 (AKT3)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   10000 (AKT3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr PH Pkinase_C Kinase-like PH_20 ABC1
Other DBs
NCBI-GeneID: 10000
NCBI-ProteinID: NP_001357003
OMIM: 611223
HGNC: 393
UniProt: Q9Y243
Structure
LinkDB
Position
1:complement(243488233..243851079)
AA seq 479 aa
MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQDVDLPYPLNNFSVAKCQ
LMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCS
PTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILK
KEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRE
RVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDA
ATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILM
EDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVP
PFKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCMDNERRPHFPQFSYSASGRE
NT seq 1440 nt   +upstreamnt  +downstreamnt
atgagcgatgttaccattgtgaaagaaggttgggttcagaagaggggagaatatataaaa
aactggaggccaagatacttccttttgaagacagatggctcattcataggatataaagag
aaacctcaagatgtggatttaccttatcccctcaacaacttttcagtggcaaaatgccag
ttaatgaaaacagaacgaccaaagccaaacacatttataatcagatgtctccagtggact
actgttatagagagaacatttcatgtagatactccagaggaaagggaagaatggacagaa
gctatccaggctgtagcagacagactgcagaggcaagaagaggagagaatgaattgtagt
ccaacttcacaaattgataatataggagaggaagagatggatgcctctacaacccatcat
aaaagaaagacaatgaatgattttgactatttgaaactactaggtaaaggcacttttggg
aaagttattttggttcgagagaaggcaagtggaaaatactatgctatgaagattctgaag
aaagaagtcattattgcaaaggatgaagtggcacacactctaactgaaagcagagtatta
aagaacactagacatccctttttaacatccttgaaatattccttccagacaaaagaccgt
ttgtgttttgtgatggaatatgttaatgggggcgagctgtttttccatttgtcgagagag
cgggtgttctctgaggaccgcacacgtttctatggtgcagaaattgtctctgccttggac
tatctacattccggaaagattgtgtaccgtgatctcaagttggagaatctaatgctggac
aaagatggccacataaaaattacagattttggactttgcaaagaagggatcacagatgca
gccaccatgaagacattctgtggcactccagaatatctggcaccagaggtgttagaagat
aatgactatggccgagcagtagactggtggggcctaggggttgtcatgtatgaaatgatg
tgtgggaggttacctttctacaaccaggaccatgagaaactttttgaattaatattaatg
gaagacattaaatttcctcgaacactctcttcagatgcaaaatcattgctttcagggctc
ttgataaaggatccaaataaacgccttggtggaggaccagatgatgcaaaagaaattatg
agacacagtttcttctctggagtaaactggcaagatgtatatgataaaaagcttgtacct
ccttttaaacctcaagtaacatctgagacagatactagatattttgatgaagaatttaca
gctcagactattacaataacaccacctgaaaaatatgatgaggatggtatggactgcatg
gacaatgagaggcggccgcatttccctcaattttcctactctgcaagtggacgagaataa

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