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ENTRY	nt06214
Name	PI3K signaling (cancer)
Category	Disease view; Cancer signaling
Display	drug-target relation   disease type

N00033        EGF → EGFR → PI3K → PIP3 → AKT ⊣ BAD N00281        EGF* → EGFR → PI3K → PIP3 → AKT N00231        TGFA → EGFR → PI3K → PIP3 → AKT → MTOR N00232        TGFA* → EGFR → PI3K → PIP3 → AKT N00282        EREG → EGFR → PI3K → PIP3 → AKT → MTOR → S6K N00283        EREG* → EGFR → PI3K → PIP3 → AKT → S6K N00284        AREG → EGFR → PI3K → PIP3 → AKT → MTOR → S6K N00285        AREG* → EGFR → PI3K → PIP3 → AKT → S6K N01355        Arsenic → EGFR → PI3K → PIP3 → AKT → MTOR → S6K N00036            EGFR* → PI3K → PIP3 → AKT ⊣ BAD N00514            EGFR* → PI3K → PIP3 → AKT ⊣ BAD N00035            EGFR* → PI3K → PIP3 → AKT → MTOR N00042            EGFR* → PI3K → PIP3 → AKT → MTOR → S6K N00034        EGF → (ERBB2*+EGFR) → PI3K → PIP3 → AKT → MTOR → S6K N00253        EGF → (ERBB2*+EGFR) → PI3K → PIP3 → AKT → MTOR → S6K N00039        PDGF → PDGFR → PI3K → PIP3 → AKT → MTOR → S6K N00040            PDGFR* → PI3K → PIP3 → AKT → MTOR N00045        KITLG → KIT → PI3K → PIP3 → AKT → MTOR → S6K N00046            KIT* → PI3K → PIP3 → AKT ⊣ BAD N00037        FGF → FGFR → PI3K → PIP3 → AKT → MTOR → S6K N00038            FGFR* → PI3K → PIP3 → AKT → MTOR N00234        IGF2 → IGF1R → PI3K → PIP3 → AKT → MTOR → S6K N00236        IGF2* → IGF1R → PI3K → PIP3 → AKT → MTOR → S6K N00238        IGF2 → IGF1R* → PI3K → PIP3 → AKT → MTOR → S6K N00043    HGF → MET → GAB1 → PI3K → PIP3 → AKT ⊣ BAD N00247    HGF* → MET → GAB1 → PI3K → PIP3 → AKT ⊣ BAD N00044        MET* → GAB1 → PI3K → PIP3 → AKT ⊣ BAD N00260        MET* → GAB1 → PI3K → PIP3 → AKT → MTOR N00249        MET* → GAB1 → PI3K → PIP3 → AKT ⊣ BAD N01063        MET* → GAB1 → PI3K → PIP3 → AKT → MTOR N00048        BCR-ABL → (CRKL+CBL+CRK) → PI3K → PIP3 → AKT ⊣ BAD N01065            RET* → PI3K → PIP3 → AKT → MTOR N00047            EML4-ALK → PI3K → PIP3 → AKT ⊣ BAD N00159            K1 → PI3K N00267            X → PI3K N00272            NS5A → PI3K N00049                PI3K* → PIP3 → AKT → MTOR → S6K N00050                PI3K* → PIP3 → AKT → MTOR → S6K N00390        EGF → EGFR → PI3K → PIP3 → AKT → IKK → NFKBIA → NFKB N00182        IGF1 → IGF1R → PI3K → PIP3 → AKT → IKK → NFKBIA → NFKB N00179            K1 → PI3K N00501            TAX → PI3K   N00220                PTEN ⊣ PIP3 → AKT N01409        Metals → ROS ⊣ PTEN ⊣ PIP3 → AKT N00051                PTEN* ⌿ PIP3 → AKT N00052                PTEN* ⌿ PIP3 → AKT N00082                    NKX3-1* ⌿ AKT ⊣ BAD N00502        TAX ⊣ DLG1 → PTEN   N01356        P4 → mPR → PI3K → PIP3 → AKT N01357        (P4,MPA) → mPR → PI3K → PIP3 → AKT N01358        P4 → (PGR+SRC) → PI3K → PIP3 → AKT N01359        (P4,MPA) → (PGR+SRC) → PI3K → PIP3 → AKT   N01347    (EP,NE) → ADRB2 → GNAI → PI3K → PIP3 → AKT N01348    (Nicotine,NNK) → ADRB2 → GNAI → PI3K → PIP3 → AKT ⊣ BAD   N01338    ACh → CHRNA7 → Ca2+ → PI3K → PIP3 → AKT N01339    (NNK,NNN) → CHRNA7 → Ca2+ → PI3K → PIP3 → AKT → (MTOR,NFKB,BIRC5) N01349        ACh → CHRNA7 → PI3K → PIP3 → AKT                           D1  |     N01350        (NNK,NNN) → CHRNA9 → PI3K → PIP3 → AKT → (ESR1/2,AP1) ⇒ (CHRNA9,CCND3)   N00030    EGF → EGFR → GRB2 → SOS → RAS → PI3K → PIP3 → AKT ⊣ BAD N00218    FLT3LG → FLT3 → GRB2 → SOS → RAS → PI3K → PIP3 → AKT → MTOR N00031        FLT3* → GRB2 → SOS → RAS → PI3K → PIP3 → AKT ⊣ BAD N00032                    (KRAS*,NRAS*) → PI3K → PIP3 → AKT ⊣ BAD

		Drug name
D1	D12217	Imlunestrant tosylate (USAN)