KEGG   PATHWAY: mcal04024
Entry
mcal04024                   Pathway                                
Name
cAMP signaling pathway - Mus caroli (Ryukyu mouse)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
mcal04024  cAMP signaling pathway
mcal04024

Other DBs
GO: 0019933
Organism
Mus caroli (Ryukyu mouse) [GN:mcal]
Gene
110304053  Vip; VIP peptides isoform X1 [KO:K05264]
110292023  Crh; corticoliberin [KO:K05256]
110293638  Cga; glycoprotein hormones alpha chain [KO:K08522]
110299308  lutropin subunit beta [KO:K08521]
110285302  Gpha2; glycoprotein hormone alpha-2 [KO:K25483]
110307439  Gphb5; glycoprotein hormone beta-5 [KO:K25484]
110291669  Tshb; thyrotropin subunit beta isoform X1 [KO:K05251]
110307137  Pomc; pro-opiomelanocortin [KO:K05228]
110290210  Gcg; glucagon [KO:K05259]
110306054  Gip; gastric inhibitory polypeptide [KO:K05258]
110290424  Fshb; follitropin subunit beta [KO:K05250]
110293754  Nppa; natriuretic peptides A [KO:K12334]
110284144  Adcyap1; pituitary adenylate cyclase-activating polypeptide isoform X3 [KO:K05262]
110285631  Adrb1; beta-1 adrenergic receptor [KO:K04141]
110285060  Adrb2; beta-2 adrenergic receptor [KO:K04142]
110308359  Drd1; D(1A) dopamine receptor [KO:K04144]
110295343  Drd5; D(1B) dopamine receptor [KO:K05840]
110303741  Adora2a; adenosine receptor A2a [KO:K04266]
110284712  Htr4; 5-hydroxytryptamine receptor 4 isoform X2 [KO:K04160]
110293622  Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
110309863  Ptger2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
110296177  Adcyap1r1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
110307070  Vipr2; vasoactive intestinal polypeptide receptor 2 [KO:K04590]
110304426  Crhr1; corticotropin-releasing factor receptor 1 [KO:K04578]
110296052  Crhr2; corticotropin-releasing factor receptor 2 isoform X1 [KO:K04579]
110283830  Lhcgr; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
110306948  Tshr; thyrotropin receptor isoform X1 [KO:K04249]
110285054  Mc2r; adrenocorticotropic hormone receptor [KO:K04200]
110284015  Glp1r; glucagon-like peptide 1 receptor [KO:K04581]
110298884  Gipr; gastric inhibitory polypeptide receptor [KO:K04580]
110286150  Gpr119; glucose-dependent insulinotropic receptor [KO:K08424]
110312650  Fshr; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
110291324  Npr1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
110308282  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
110308334  neuroendocrine secretory protein 55 [KO:K04632]
110308576  Edn1; endothelin-1 [KO:K16366]
110293743  Edn2; endothelin-2 [KO:K16367]
110290123  Edn3; endothelin-3 [KO:K05227]
110312102  Sst; somatostatin [KO:K05237]
110296960  Npy; pro-neuropeptide Y [KO:K05232]
110296730  Ghrl; appetite-regulating hormone [KO:K05254]
110289944  Oxt; oxytocin-neurophysin 1 [KO:K05243]
110311770  Htr1f; 5-hydroxytryptamine receptor 1F [KO:K04153]
110302239  Htr1b; 5-hydroxytryptamine receptor 1B [KO:K04153]
110293220  Htr1d; 5-hydroxytryptamine receptor 1D [KO:K04153]
110308360  Htr1a; 5-hydroxytryptamine receptor 1A [KO:K04153]
110285542  Chrm1; muscarinic acetylcholine receptor M1 [KO:K04129]
110296617  Chrm2; muscarinic acetylcholine receptor M2 [KO:K04130]
110301511  Drd2; D(2) dopamine receptor isoform X2 [KO:K04145]
110292406  Gabbr2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
110284231  Gabbr1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
110290054  Adora1; adenosine receptor A1 [KO:K04265]
110299998  Ednra; endothelin-1 receptor isoform X1 [KO:K04197]
110300513  Npy1r; neuropeptide Y receptor type 1 [KO:K04204]
110307493  Sstr1; somatostatin receptor type 1 [KO:K04217]
110304417  Sstr2; somatostatin receptor type 2 [KO:K04218]
110284120  Sstr5; somatostatin receptor type 5 [KO:K04221]
110295319  Hcar1; hydroxycarboxylic acid receptor 1 [KO:K08401]
110295351  hydroxycarboxylic acid receptor 2 [KO:K08402]
110297703  Ffar2; free fatty acid receptor 2 [KO:K04328]
110291463  Sucnr1; succinate receptor 1 [KO:K10042]
110291650  Ptger3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
110296925  Oxtr; oxytocin receptor [KO:K04229]
110291654  Ghsr; growth hormone secretagogue receptor type 1 [KO:K04284]
110290775  Gnai3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
110294623  Gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
110301809  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
110305998  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
110307661  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
110306494  Adcy3; adenylate cyclase type 3 isoform X2 [KO:K08043] [EC:4.6.1.1]
110309267  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
110311373  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
110310126  Adcy6; adenylate cyclase type 6 isoform X5 [KO:K08046] [EC:4.6.1.1]
110299719  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
110310371  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
110311555  Adcy9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
110284653  Adcy10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
110294778  Cnga1; cGMP-gated cation channel alpha-1 [KO:K04948]
110287256  Cnga2; cyclic nucleotide-gated olfactory channel [KO:K04949]
110302480  Cnga3; cyclic nucleotide-gated cation channel alpha-3 isoform X1 [KO:K04950]
110299160  Cnga4; cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
110299820  Cngb1; cyclic nucleotide-gated cation channel beta-1 isoform X1 [KO:K04952]
110292413  Cngb3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
110286675  calmodulin-alpha-like [KO:K02183]
110308577  Calml3; calmodulin-like protein 3 [KO:K02183]
110308601  calmodulin-4 [KO:K02183]
110286582  calmodulin [KO:K02183]
110306434  Calm1; calmodulin-1 [KO:K02183]
110302040  Calml4; calmodulin-like protein 4 isoform X2 [KO:K02183]
110297869  Calm3; calmodulin-3 [KO:K02183]
110294847  calmodulin-like [KO:K02183]
110312637  Calm2; calmodulin-2 [KO:K02183]
110309790  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X5 [KO:K04515] [EC:2.7.11.17]
110305925  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X5 [KO:K04515] [EC:2.7.11.17]
110290827  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3 [KO:K04515] [EC:2.7.11.17]
110284502  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
110284636  Camk4; calcium/calmodulin-dependent protein kinase type IV isoform X2 [KO:K05869] [EC:2.7.11.17]
110303903  Bves; blood vessel epicardial substance [KO:K21108]
110311447  Popdc2; popeye domain-containing protein 2 isoform X1 [KO:K26206]
110303827  Popdc3; popeye domain-containing protein 3 isoform X1 [KO:K26207]
110292906  Kcnk2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
110303031  Hcn2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
110301840  Hcn4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
110309097  Abcc4; multidrug resistance-associated protein 4 [KO:K05673]
110310170  Rapgef3; rap guanine nucleotide exchange factor 3 isoform X2 [KO:K08014]
110289761  Rapgef4; rap guanine nucleotide exchange factor 4 isoform X3 [KO:K04351]
110298333  Rras; ras-related protein R-Ras [KO:K07829]
110297889  Rras2; ras-related protein R-Ras2 [KO:K07830]
110304819  Pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
110290757  Pld1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
110285551  Plce1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5 [KO:K05860] [EC:3.1.4.11]
110294148  Mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110308920  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110304169  Mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110290796  Rap1a; ras-related protein Rap-1A [KO:K04353]
110303320  Rap1b; ras-related protein Rap-1b [KO:K07836]
110311394  Tiam1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
110310431  Vav2; guanine nucleotide exchange factor VAV2 isoform X2 [KO:K05730]
110312346  Vav1; proto-oncogene vav isoform X1 [KO:K05730]
110290661  Vav3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
110293965  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
110310226  Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110305163  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
110298300  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
110284610  Arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X4 [KO:K12490]
110292411  transforming protein RhoA [KO:K04513]
110302438  Rhoa; transforming protein RhoA [KO:K04513]
110284326  Afdn; afadin isoform X17 [KO:K05702]
110290798  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110292183  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110301355  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
110308009  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110299855  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
110292624  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110297609  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110294471  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110307022  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110295945  Braf; serine/threonine-protein kinase B-raf isoform X5 [KO:K04365] [EC:2.7.11.1]
110296919  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110301502  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110303196  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
110297836  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110311382  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110290795  Prkacb; cAMP-dependent protein kinase catalytic subunit beta isoform X2 [KO:K04345] [EC:2.7.11.11]
110300173  Prkaca; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
110305717  Ppp1r1b; protein phosphatase 1 regulatory subunit 1B [KO:K15494]
110285541  Ppp1ca; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
110294013  Ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
110294931  Ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
110288037  serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
110285614  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
110291408  Creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
110303337  Creb3l3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
110292754  Creb3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
110289497  Creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X2 [KO:K09048]
110296066  Creb3l2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
110296203  Creb5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
110310313  Ep300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
110311224  Crebbp; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
110285237  Bdnf; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
110307063  Fos; proto-oncogene c-Fos [KO:K04379]
110292423  Jun; transcription factor AP-1 [KO:K04448]
110308037  Gli3; transcriptional activator GLI3 [KO:K06230]
110303011  Gli1; zinc finger protein GLI1 [KO:K16797]
110307775  Ptch1; protein patched homolog 1 isoform X1 [KO:K06225]
110300050  Hhip; hedgehog-interacting protein isoform X1 [KO:K06231]
110306864  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
110291231  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
110285703  Rela; transcription factor p65 [KO:K04735]
110304811  Sox9; transcription factor SOX-9 [KO:K18435]
110303725  Amh; muellerian-inhibiting factor [KO:K04665]
110310427  Ppara; peroxisome proliferator-activated receptor alpha [KO:K07294]
110304682  Acox1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
110294025  Acox3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
110284760  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
110308051  F2r; proteinase-activated receptor 1 [KO:K03914]
110285481  Bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
110298158  Lipe; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
110284478  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
110306686  Rock2; rho-associated protein kinase 2 isoform X2 [KO:K17388] [EC:2.7.11.1]
110302933  Ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X4 [KO:K06270]
110285279  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
110298605  Tnni3; troponin I, cardiac muscle [KO:K12044]
110303164  Pln; cardiac phospholamban [KO:K05852]
110295033  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
110304358  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2 [KO:K05853] [EC:7.2.2.10]
110299270  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
110308440  Ryr2; ryanodine receptor 2 isoform X1 [KO:K04962]
110285719  Grin1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
110311574  Grin2a; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
110296148  Grin2b; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
110305122  Grin2c; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
110298186  Grin2d; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
110293036  Grin3a; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
110303636  Grin3b; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
110306195  Gria1; glutamate receptor 1 isoform X2 [KO:K05197]
110292004  Gria2; glutamate receptor 2 isoform X5 [KO:K05198]
110286203  Gria3; glutamate receptor 3 isoform X1 [KO:K05199]
110302259  Gria4; glutamate receptor 4 isoform X1 [KO:K05200]
110296314  Cftr; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
110291780  sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
110290752  Atp1a1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
110297290  Atp1a3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
110296540  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
110290643  Atp1b1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
110287115  Atp1b4; protein ATP1B4 [KO:K01540]
110301197  Atp1b3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
110304973  Atp1b2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
110302161  Fxyd2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
110297729  Fxyd1; phospholemman isoform X1 [KO:K13360]
110292287  Slc9a1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
110294733  Orai1; calcium release-activated calcium channel protein 1 [KO:K16056]
110295976  Atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
110286561  Atp2b3; plasma membrane calcium-transporting ATPase 3 isoform X3 [KO:K05850] [EC:7.2.2.10]
110299202  Atp2b4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
110302903  Atp2b1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
110295755  voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
110309492  Cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
110286673  Cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
110296075  Cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
110296609  Pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
110297913  Pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
110292147  Pde4b; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
110301167  Pde4a; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X3 [KO:K13293] [EC:3.1.4.53]
110300097  Pde4c; cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
110307957  Pde4d; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
110312509  Pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X5 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
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Related
pathway
mcal00071  Fatty acid degradation
mcal04015  Rap1 signaling pathway
mcal04020  Calcium signaling pathway
mcal04151  PI3K-Akt signaling pathway
mcal04210  Apoptosis
mcal04260  Cardiac muscle contraction
mcal04340  Hedgehog signaling pathway
mcal04720  Long-term potentiation
mcal04740  Olfactory transduction
mcal04972  Pancreatic secretion
mcal04976  Bile secretion
KO pathway
ko04024   
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