KEGG   PATHWAY: mdt04015
Entry
mdt04015                    Pathway                                
Name
Rap1 signaling pathway - Myotis daubentonii (Daubenton's bat)
Description
Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types.
Class
Environmental Information Processing; Signal transduction
Pathway map
mdt04015  Rap1 signaling pathway
mdt04015

Other DBs
GO: 0007264
Organism
Myotis daubentonii (Daubenton's bat) [GN:mdt]
Gene
132211126  PARD3; partitioning defective 3 homolog isoform X1 [KO:K04237]
132211146  RALA; ras-related protein Ral-A [KO:K07834]
132211191  DOCK4; dedicator of cytokinesis protein 4 isoform X1 [KO:K17697]
132211195  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
132211234  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
132211419  [KO:K02183]
132211847  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
132212019  [KO:K04634]
132212126  TLN1; talin-1 isoform X1 [KO:K06271]
132212258  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
132212498  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
132212522  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
132212530  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
132212602  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
132213391  CALM2; calmodulin-2 [KO:K02183]
132213472  PRKD3; serine/threonine-protein kinase D3 isoform X1 [KO:K06070] [EC:2.7.11.13]
132213481  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
132213586  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
132213834  PFN4; profilin-4 [KO:K05759]
132214156  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
132214332  APBB1IP; amyloid beta A4 precursor protein-binding family B member 1-interacting protein [KO:K17704]
132214489  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
132214561  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
132214841  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
132215221  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
132215288  CALML5; calmodulin-like protein 5 [KO:K02183]
132215294  [KO:K02183]
132215436  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
132215517  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
132215521  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
132215742  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
132215835  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
132215861  RHOA; transforming protein RhoA [KO:K04513]
132216059  [KO:K04513]
132216226  RRAS; ras-related protein R-Ras [KO:K07829]
132216318  FGF21; fibroblast growth factor 21 [KO:K22429]
132216549  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
132216692  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
132216698  CALM3; calmodulin-3 [KO:K02183]
132216730  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
132216889  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132216945  SIPA1L3; signal-induced proliferation-associated 1-like protein 3 isoform X1 [KO:K17703]
132217017  [KO:K04392]
132217325  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
132217424  CDH1; cadherin-1 isoform X1 [KO:K05689]
132217462  PARD6A; partitioning defective 6 homolog alpha [KO:K06093]
132217569  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
132217592  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
132217892  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
132217963  ADORA2B; adenosine receptor A2b [KO:K04267]
132218151  PFN1; profilin-1 [KO:K05759]
132218258  CRK; adapter molecule crk isoform X1 [KO:K04438]
132218548  ITGB3; integrin beta-3 [KO:K06493]
132218608  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
132218743  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
132218853  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
132218888  SKAP1; src kinase-associated phosphoprotein 1 [KO:K17699]
132218985  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
132219013  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
132219031  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
132219042  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
132219202  ACTG1; actin, cytoplasmic 2 [KO:K05692]
132219231  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
132219614  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
132219755  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
132220343  NGF; beta-nerve growth factor [KO:K02582]
132220478  MAGI3; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 isoform X1 [KO:K06112]
132220508  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
132220634  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
132220680  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
132220747  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
132220792  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
132220794  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
132220796  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
132220881  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
132221210  NRAS; GTPase NRas [KO:K07828]
132221757  ADORA2A; adenosine receptor A2a [KO:K04266]
132221880  CRKL; crk-like protein [KO:K04438]
132222289  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132222378  ENAH; protein enabled homolog isoform X1 [KO:K05746]
132222407  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
132222491  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
132222553  SIPA1L2; signal-induced proliferation-associated 1-like protein 2 isoform X1 [KO:K17702]
132222850  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
132223251  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
132224380  FGF16; fibroblast growth factor 16 [KO:K04358]
132224466  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
132225132  [KO:K05096] [EC:2.7.10.1]
132225178  [KO:K07836]
132226467  FGF20; fibroblast growth factor 20 [KO:K04358]
132226843  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
132226858  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
132226946  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
132227006  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
132227107  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
132227184  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
132227195  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
132227322  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
132227384  KRAS; GTPase KRas isoform X1 [KO:K07827]
132227498  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
132227516  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
132227892  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
132227995  KITLG; kit ligand isoform X1 [KO:K05461]
132228039  FGF23; fibroblast growth factor 23 [KO:K22428]
132228044  FGF6; fibroblast growth factor 6 [KO:K04358]
132228126  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
132228208  FGF9; fibroblast growth factor 9 [KO:K04358]
132228444  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132228629  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
132228769  VEGFC; vascular endothelial growth factor C [KO:K05449]
132228794  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
132229704  EVL; ena/VASP-like protein isoform X1 [KO:K23487]
132229824  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
132229971  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
132230026  P2RY1; P2Y purinoceptor 1 [KO:K04270]
132230097  PRKCI; protein kinase C iota type isoform X1 [KO:K06069] [EC:2.7.11.13]
132230128  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
132230329  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
132230553  PFN2; profilin-2 isoform X1 [KO:K05759]
132230575  CALM1; calmodulin-1 [KO:K02183]
132230890  LPAR3; lysophosphatidic acid receptor 3 isoform X1 [KO:K04294]
132231104  [KO:K02183]
132231240  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
132231353  PGF; placenta growth factor isoform X1 [KO:K16859]
132231564  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
132231567  RAP1GAP; LOW QUALITY PROTEIN: rap1 GTPase-activating protein 1 [KO:K17700]
132231587  [KO:K04393]
132231637  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
132231710  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
132231774  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
132231779  CALML6; calmodulin-like protein 6 [KO:K02183]
132232115  SIPA1L1; signal-induced proliferation-associated 1-like protein 1 isoform X1 [KO:K17701]
132232585  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
132232673  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
132232699  [KO:K06461]
132232700  [KO:K06461]
132232747  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
132232782  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
132232811  LAT; linker for activation of T-cells family member 1 [KO:K07362]
132233026  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
132233377  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
132233511  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
132233575  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
132233655  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
132233699  FGF10; fibroblast growth factor 10 [KO:K04358]
132233742  FYB1; FYN-binding protein 1 isoform X1 [KO:K17698]
132234095  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
132234313  PFN3; profilin-3 [KO:K05759]
132234588  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
132234607  [KO:K04456] [EC:2.7.11.1]
132234623  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
132234761  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
132234815  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
132234863  F2RL3; proteinase-activated receptor 4 [KO:K04236]
132235106  VAV1; proto-oncogene vav [KO:K05730]
132235183  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
132235203  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
132235276  EFNA2; ephrin-A2 [KO:K05462]
132235309  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
132235370  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
132235407  PDGFC; platelet-derived growth factor C [KO:K05450]
132235421  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
132235554  FGF2; fibroblast growth factor 2 [KO:K18497]
132235579  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
132235586  RGS14; regulator of G-protein signaling 14 [KO:K17706]
132235614  RAPGEF6; rap guanine nucleotide exchange factor 6 isoform X1 [KO:K08020]
132235777  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
132235794  FGF1; fibroblast growth factor 1 [KO:K18496]
132235845  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
132235846  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
132235951  LCP2; lymphocyte cytosolic protein 2 isoform X1 [KO:K07361]
132235958  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
132236015  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
132236028  ACTB; actin, cytoplasmic 1 [KO:K05692]
132236071  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
132236077  TLN2; talin-2 isoform X1 [KO:K06271]
132236697  AFDN; afadin isoform X1 [KO:K05702]
132237091  CNR1; cannabinoid receptor 1 [KO:K04277]
132237283  VEGFA; vascular endothelial growth factor A, long form [KO:K05448]
132237395  FGF7; fibroblast growth factor 7 [KO:K04358]
132237408  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
132237411  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
132238441  FARP2; FERM, ARHGEF and pleckstrin domain-containing protein 2 isoform X1 [KO:K06082]
132238527  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
132238716  RALB; ras-related protein Ral-B isoform X1 [KO:K07835]
132239051  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
132239155  THBS1; thrombospondin-1 [KO:K16857]
132239194  [KO:K04632]
132239196  [KO:K04632]
132239243  PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093]
132239361  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
132239363  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
132239461  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
132239488  ID1; DNA-binding protein inhibitor ID-1 [KO:K04680]
132239597  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
132239720  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
132239948  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
132240130  [KO:K04632]
132240565  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
132240569  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
132240692  [KO:K04513]
132241024  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
132241137  CTNND1; catenin delta-1 isoform X1 [KO:K05690]
132241265  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
132241300  FGF19; fibroblast growth factor 19 isoform X1 [KO:K22603]
132241411  SIPA1; signal-induced proliferation-associated protein 1 isoform X1 [KO:K08013]
132241461  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
132241471  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
132241479  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
132241561  [KO:K08732]
132241616  [KO:K04526]
132241831  HRAS; GTPase HRas isoform X1 [KO:K02833]
132241847  [KO:K04526]
132241978  [KO:K04526]
132241979  [KO:K04526]
132242328  FGF3; fibroblast growth factor 3 [KO:K04358]
132242329  FGF4; fibroblast growth factor 4 [KO:K04358]
132242351  [KO:K04526]
132242352  [KO:K04526]
132242672  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
132242840  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
132242888  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
132242928  KRIT1; krev interaction trapped protein 1 isoform X1 [KO:K17705]
132243027  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
132243106  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
132243107  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
132243125  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
Reference
PMID:17182900
  Authors
Kooistra MR, Dube N, Bos JL
  Title
Rap1: a key regulator in cell-cell junction formation.
  Journal
J Cell Sci 120:17-22 (2007)
DOI:10.1242/jcs.03306
Reference
PMID:11331911
  Authors
Bos JL, de Rooij J, Reedquist KA
  Title
Rap1 signalling: adhering to new models.
  Journal
Nat Rev Mol Cell Biol 2:369-77 (2001)
DOI:10.1038/35073073
Reference
PMID:17383543
  Authors
Minato N, Kometani K, Hattori M
  Title
Regulation of immune responses and hematopoiesis by the Rap1 signal.
  Journal
Adv Immunol 93:229-64 (2007)
DOI:10.1016/S0065-2776(06)93006-5
Reference
PMID:15780587
  Authors
Bos JL
  Title
Linking Rap to cell adhesion.
  Journal
Curr Opin Cell Biol 17:123-8 (2005)
DOI:10.1016/j.ceb.2005.02.009
Reference
PMID:12508104
  Authors
Caron E
  Title
Cellular functions of the Rap1 GTP-binding protein: a pattern emerges.
  Journal
J Cell Sci 116:435-40 (2003)
DOI:10.1242/jcs.00238
Reference
PMID:10579920
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:14607972
  Authors
Hattori M, Minato N
  Title
Rap1 GTPase: functions, regulation, and malignancy.
  Journal
J Biochem 134:479-84 (2003)
DOI:10.1093/jb/mvg180
Reference
PMID:19159611
  Authors
Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL
  Title
Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1788:790-6 (2009)
DOI:10.1016/j.bbamem.2008.12.010
Reference
PMID:19615876
  Authors
Boettner B, Van Aelst L
  Title
Control of cell adhesion dynamics by Rap1 signaling.
  Journal
Curr Opin Cell Biol 21:684-93 (2009)
DOI:10.1016/j.ceb.2009.06.004
Reference
PMID:15803158
  Authors
Xia Z, Storm DR.
  Title
The role of calmodulin as a signal integrator for synaptic plasticity.
  Journal
Nat Rev Neurosci 6:267-76 (2005)
DOI:10.1038/nrn1647
Reference
PMID:17624948
  Authors
Mor A, Dustin ML, Philips MR
  Title
Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
  Journal
Immunol Rev 218:114-25 (2007)
DOI:10.1111/j.1600-065X.2007.00538.x
Reference
PMID:17624944
  Authors
Burbach BJ, Medeiros RB, Mueller KL, Shimizu Y
  Title
T-cell receptor signaling to integrins.
  Journal
Immunol Rev 218:65-81 (2007)
DOI:10.1111/j.1600-065X.2007.00527.x
Reference
PMID:12765839
  Authors
Stork PJ
  Title
Does Rap1 deserve a bad Rap?
  Journal
Trends Biochem Sci 28:267-75 (2003)
DOI:10.1016/S0968-0004(03)00087-2
Reference
PMID:12351703
  Authors
Banihashemi B, Albert PR
  Title
Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements.
  Journal
Mol Endocrinol 16:2393-404 (2002)
DOI:10.1210/me.2001-0220
Reference
PMID:18363565
  Authors
Banno A, Ginsberg MH
  Title
Integrin activation.
  Journal
Biochem Soc Trans 36:229-34 (2008)
DOI:10.1042/BST0360229
Reference
PMID:19710505
  Authors
Doebele RC, Schulze-Hoepfner FT, Hong J, Chlenski A, Zeitlin BD, Goel K, Gomes S, Liu Y, Abe MK, Nor JE, Lingen MW, Rosner MR
  Title
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis.
  Journal
Blood 114:4592-600 (2009)
DOI:10.1182/blood-2009-04-217042
Reference
PMID:21402149
  Authors
Breckler M, Berthouze M, Laurent AC, Crozatier B, Morel E, Lezoualc'h F
  Title
Rap-linked cAMP signaling Epac proteins: compartmentation, functioning and disease implications.
  Journal
Cell Signal 23:1257-66 (2011)
DOI:10.1016/j.cellsig.2011.03.007
Related
pathway
mdt04010  MAPK signaling pathway
mdt04014  Ras signaling pathway
mdt04020  Calcium signaling pathway
mdt04151  PI3K-Akt signaling pathway
mdt04510  Focal adhesion
mdt04520  Adherens junction
mdt04660  T cell receptor signaling pathway
mdt04810  Regulation of actin cytoskeleton
KO pathway
ko04015   

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