KEGG   PATHWAY: mdt04014
Entry
mdt04014                    Pathway                                
Name
Ras signaling pathway - Myotis daubentonii (Daubenton's bat)
Description
The Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras proteins transduce signals from extracellular growth factors by cycling between inactive GDP-bound and active GTP-bound states. The exchange of GTP for GDP on RAS is regulated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Activated RAS (RAS-GTP) regulates multiple cellular functions through effectors including Raf, phosphatidylinositol 3-kinase (PI3K) and Ral guanine nucleotide-dissociation stimulator (RALGDS).
Class
Environmental Information Processing; Signal transduction
Pathway map
mdt04014  Ras signaling pathway
mdt04014

Other DBs
GO: 0032318
Organism
Myotis daubentonii (Daubenton's bat) [GN:mdt]
Gene
132211146  RALA; ras-related protein Ral-A [KO:K07834]
132211195  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
132211419  [KO:K02183]
132211802  SHC3; SHC-transforming protein 3 [KO:K17448]
132211847  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
132212039  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
132212489  ABL1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
132212522  RALGDS; ral guanine nucleotide dissociation stimulator isoform X1 [KO:K08732]
132212602  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
132212761  [KO:K04542]
132213040  [KO:K07360] [EC:2.7.10.2]
132213237  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
132213329  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
132213391  CALM2; calmodulin-2 [KO:K02183]
132213451  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
132213481  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
132214156  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
132214229  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
132214329  SHOC2; leucine-rich repeat protein SHOC-2 isoform X1 [KO:K19613]
132214489  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
132214561  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
132214715  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
132214821  PLA2G12A; group XIIA secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
132214840  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
132214841  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
132214990  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
132215288  CALML5; calmodulin-like protein 5 [KO:K02183]
132215294  [KO:K02183]
132215436  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
132215483  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
132215517  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
132215521  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
132215601  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
132215694  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
132215824  RASSF1; ras association domain-containing protein 1 isoform X1 [KO:K09850]
132215861  RHOA; transforming protein RhoA [KO:K04513]
132216059  [KO:K04513]
132216217  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
132216226  RRAS; ras-related protein R-Ras [KO:K07829]
132216318  FGF21; fibroblast growth factor 21 [KO:K22429]
132216323  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
132216549  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
132216614  NTF4; neurotrophin-4 [KO:K12457]
132216698  CALM3; calmodulin-3 [KO:K02183]
132216708  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
132216889  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132216915  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
132216939  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
132217017  [KO:K04392]
132217029  [KO:K04542]
132217215  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
132218137  PLD2; LOW QUALITY PROTEIN: phospholipase D2 [KO:K01115] [EC:3.1.4.4]
132218330  NF1; neurofibromin isoform X1 [KO:K08052]
132218334  KSR1; kinase suppressor of Ras 1 isoform X1 [KO:K14958]
132218608  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
132218645  RAB5C; ras-related protein Rab-5C isoform X1 [KO:K07889]
132218853  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
132218872  GNGT2; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
132218985  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
132219013  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
132219042  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
132219091  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
132219231  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
132219614  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
132219953  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
132220296  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
132220304  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
132220343  NGF; beta-nerve growth factor [KO:K02582]
132220415  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
132220566  RGL1; ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [KO:K17635]
132220603  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
132220634  RASSF5; ras association domain-containing protein 5 isoform X1 [KO:K08015]
132220639  RASAL2; ras GTPase-activating protein nGAP isoform X1 [KO:K17633]
132220680  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
132220725  ABL2; tyrosine-protein kinase ABL2 isoform X1 [KO:K08887] [EC:2.7.10.2]
132220747  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
132220792  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
132220794  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
132220796  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
132221210  NRAS; GTPase NRas [KO:K07828]
132221586  RASAL1; rasGAP-activating-like protein 1 [KO:K17632]
132221767  PLA2G1B; phospholipase A2 [KO:K01047] [EC:3.1.1.4]
132221796  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
132221833  KSR2; kinase suppressor of Ras 2 [KO:K18529] [EC:2.7.11.1]
132221847  BRAP; BRCA1-associated protein isoform X1 [KO:K10632] [EC:2.3.2.27]
132221950  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
132222154  PLA2G3; group 3 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
132222289  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
132222400  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
132222407  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
132222491  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
132222752  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
132222850  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
132223870  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
132224109  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
132224380  FGF16; fibroblast growth factor 16 [KO:K04358]
132224466  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
132224555  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
132224649  [KO:K04542]
132224989  FOXO4; forkhead box protein O4 [KO:K12358]
132225132  [KO:K05096] [EC:2.7.10.1]
132225178  [KO:K07836]
132226467  FGF20; fibroblast growth factor 20 [KO:K04358]
132226827  [KO:K04545]
132226855  [KO:K04542]
132226946  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
132226975  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
132227006  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
132227107  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
132227172  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
132227184  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
132227213  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
132227322  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
132227384  KRAS; GTPase KRas isoform X1 [KO:K07827]
132227738  RAB5B; ras-related protein Rab-5B isoform X1 [KO:K07888]
132227867  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
132227892  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
132227995  KITLG; kit ligand isoform X1 [KO:K05461]
132228039  FGF23; fibroblast growth factor 23 [KO:K22428]
132228044  FGF6; fibroblast growth factor 6 [KO:K04358]
132228126  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
132228127  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
132228208  FGF9; fibroblast growth factor 9 [KO:K04358]
132228444  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
132228576  RASA3; ras GTPase-activating protein 3 [KO:K12380]
132228611  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
132228629  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
132228769  VEGFC; vascular endothelial growth factor C [KO:K05449]
132228794  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
132229461  [KO:K04542]
132229545  PLA2G2F; group IIF secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
132229546  PLA2G2D; group IID secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
132229547  PLA2G5; phospholipase A2 group V [KO:K01047] [EC:3.1.1.4]
132229794  PLA2G2E; group IIE secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
132229824  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
132229880  ETS2; protein C-ets-2 isoform X1 [KO:K21932]
132230108  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
132230128  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
132230132  GNB4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
132230275  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
132230386  PLA1A; phospholipase A1 member A isoform X1 [KO:K13618] [EC:3.1.1.111]
132230575  CALM1; calmodulin-1 [KO:K02183]
132230640  EXOC2; exocyst complex component 2 isoform X1 [KO:K17637]
132230897  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
132230901  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
132230958  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
132231104  [KO:K02183]
132231240  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
132231353  PGF; placenta growth factor isoform X1 [KO:K16859]
132231564  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
132231586  PLA2G2C; putative inactive group IIC secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
132231587  [KO:K04393]
132231588  [KO:K01047] [EC:3.1.1.4]
132231589  [KO:K01047] [EC:3.1.1.4]
132231590  [KO:K01047] [EC:3.1.1.4]
132231592  [KO:K01047] [EC:3.1.1.4]
132231593  PLA2G2A; phospholipase A2, membrane associated [KO:K01047] [EC:3.1.1.4]
132231637  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
132231710  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
132231779  CALML6; calmodulin-like protein 6 [KO:K02183]
132231780  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
132232585  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
132232673  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
132232782  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
132232811  LAT; linker for activation of T-cells family member 1 [KO:K07362]
132232875  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
132233109  [KO:K01047] [EC:3.1.1.4]
132233221  RASA4B; ras GTPase-activating protein 4B isoform X1 [KO:K17630]
132233258  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
132233377  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
132233445  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
132233465  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
132233575  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
132233699  FGF10; fibroblast growth factor 10 [KO:K04358]
132234095  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
132234588  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
132234601  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
132234607  [KO:K04456] [EC:2.7.11.1]
132234623  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
132234732  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
132234815  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
132234889  RASAL3; RAS protein activator like-3 isoform X1 [KO:K17634]
132234916  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
132234959  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
132234986  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
132235101  ARF6; ADP-ribosylation factor 6 [KO:K07941]
132235183  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
132235203  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
132235228  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
132235276  EFNA2; ephrin-A2 [KO:K05462]
132235309  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
132235316  SHC2; SHC-transforming protein 2 [KO:K17447]
132235370  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
132235407  PDGFC; platelet-derived growth factor C [KO:K05450]
132235497  GAB1; GRB2-associated-binding protein 1 isoform X1 [KO:K09593]
132235554  FGF2; fibroblast growth factor 2 [KO:K18497]
132235579  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
132235794  FGF1; fibroblast growth factor 1 [KO:K18496]
132235845  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
132235846  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
132235958  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
132236015  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
132236071  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
132236697  AFDN; afadin isoform X1 [KO:K05702]
132237121  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
132237283  VEGFA; vascular endothelial growth factor A, long form [KO:K05448]
132237395  FGF7; fibroblast growth factor 7 [KO:K04358]
132237461  SYNGAP1; ras/Rap GTPase-activating protein SynGAP isoform X1 [KO:K17631]
132237468  RGL2; ral guanine nucleotide dissociation stimulator-like 2 isoform X1 [KO:K17636]
132237519  SHC4; SHC-transforming protein 4 [KO:K17449]
132238004  [KO:K04542]
132238642  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
132238656  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
132238716  RALB; ras-related protein Ral-B isoform X1 [KO:K07835]
132239073  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
132239164  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
132239300  RALGAPA2; ral GTPase-activating protein subunit alpha-2 isoform X1 [KO:K25768]
132239362  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
132239461  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
132239491  BCL2L1; bcl-2-like protein 1 [KO:K04570]
132239782  RALBP1; ralA-binding protein 1 [KO:K08773]
132239912  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
132239948  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
132239962  RALGAPB; ral GTPase-activating protein subunit beta isoform X1 [KO:K25769]
132240569  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
132240692  [KO:K04513]
132240747  GAB2; GRB2-associated-binding protein 2 isoform X1 [KO:K08091]
132240766  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
132240997  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
132241082  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
132241300  FGF19; fibroblast growth factor 19 isoform X1 [KO:K22603]
132241379  RIN1; LOW QUALITY PROTEIN: ras and Rab interactor 1 [KO:K17638]
132241412  RELA; transcription factor p65 isoform X1 [KO:K04735]
132241461  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
132241476  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
132241479  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
132241510  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
132241511  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
132241512  PLAAT3; phospholipase A and acyltransferase 3 isoform X1 [KO:K16817] [EC:3.1.1.32 3.1.1.4]
132241514  [KO:K16817] [EC:3.1.1.32 3.1.1.4]
132241536  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
132241561  [KO:K08732]
132241616  [KO:K04526]
132241786  RALGAPA1; ral GTPase-activating protein subunit alpha-1 isoform X1 [KO:K25768]
132241831  HRAS; GTPase HRas isoform X1 [KO:K02833]
132241832  IGF2; insulin-like growth factor II [KO:K13769]
132241847  [KO:K04526]
132241978  [KO:K04526]
132241979  [KO:K04526]
132242328  FGF3; fibroblast growth factor 3 [KO:K04358]
132242329  FGF4; fibroblast growth factor 4 [KO:K04358]
132242351  [KO:K04526]
132242352  [KO:K04526]
132242672  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
132242888  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
132242948  [KO:K04548]
132242949  [KO:K04546]
132243027  RAPGEF5; rap guanine nucleotide exchange factor 5 isoform X1 [KO:K08019]
Compound
C00035  GDP
C00044  GTP
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:18568040
  Authors
Karnoub AE, Weinberg RA
  Title
Ras oncogenes: split personalities.
  Journal
Nat Rev Mol Cell Biol 9:517-31 (2008)
DOI:10.1038/nrm2438
Reference
PMID:12778136
  Authors
Malumbres M, Barbacid M
  Title
RAS oncogenes: the first 30 years.
  Journal
Nat Rev Cancer 3:459-65 (2003)
DOI:10.1038/nrc1097
Reference
PMID:21686117
  Authors
Cox AD, Der CJ
  Title
Ras history: The saga continues.
  Journal
Small GTPases 1:2-27 (2010)
DOI:10.4161/sgtp.1.1.12178
Reference
PMID:12642680
  Authors
Cox AD, Der CJ
  Title
Ras family signaling: therapeutic targeting.
  Journal
Cancer Biol Ther 1:599-606 (2002)
DOI:10.4161/cbt.306
Reference
PMID:17428555
  Authors
Rajalingam K, Schreck R, Rapp UR, Albert S
  Title
Ras oncogenes and their downstream targets.
  Journal
Biochim Biophys Acta 1773:1177-95 (2007)
DOI:10.1016/j.bbamcr.2007.01.012
Reference
PMID:17384584
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
PMID:22233291
  Authors
Poulogiannis G, Luo F, Arends MJ
  Title
RAS signalling in the colorectum in health and disease.
  Journal
Cell Commun Adhes 19:1-9 (2012)
DOI:10.3109/15419061.2011.649380
Reference
PMID:22020205
  Authors
Berndt N, Hamilton AD, Sebti SM
  Title
Targeting protein prenylation for cancer therapy.
  Journal
Nat Rev Cancer 11:775-91 (2011)
DOI:10.1038/nrc3151
Reference
PMID:21196257
  Authors
Overmeyer JH, Maltese WA
  Title
Death pathways triggered by activated Ras in cancer cells.
  Journal
Front Biosci (Landmark Ed) 16:1693-713 (2011)
DOI:10.2741/3814
Reference
PMID:16869784
  Authors
Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F
  Title
Cancer targets in the Ras pathway.
  Journal
Cold Spring Harb Symp Quant Biol 70:461-7 (2005)
DOI:10.1101/sqb.2005.70.044
Reference
PMID:14663478
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
PMID:18413813
  Authors
Braun BS, Shannon K
  Title
Targeting Ras in myeloid leukemias.
  Journal
Clin Cancer Res 14:2249-52 (2008)
DOI:10.1158/1078-0432.CCR-07-1005
Reference
PMID:20420946
  Authors
Pino MS, Chung DC
  Title
The chromosomal instability pathway in colon cancer.
  Journal
Gastroenterology 138:2059-72 (2010)
DOI:10.1053/j.gastro.2009.12.065
Reference
PMID:12217381
  Authors
Schrader JW, Schallhorn A, Grill B, Guo X
  Title
Activation of small GTPases of the Ras and Rho family by growth factors active on mast cells.
  Journal
Mol Immunol 38:1181-6 (2002)
DOI:10.1016/S0161-5890(02)00060-3
Reference
PMID:22189424
  Authors
Ahearn IM, Haigis K, Bar-Sagi D, Philips MR
  Title
Regulating the regulator: post-translational modification of RAS.
  Journal
Nat Rev Mol Cell Biol 13:39-51 (2012)
DOI:10.1038/nrm3255
Reference
PMID:11313946
  Authors
Ehrhardt GR, Korherr C, Wieler JS, Knaus M, Schrader JW
  Title
A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth.
  Journal
Oncogene 20:188-97 (2001)
DOI:10.1038/sj.onc.1204053
Reference
PMID:16966426
  Authors
Goldfinger LE, Ptak C, Jeffery ED, Shabanowitz J, Hunt DF, Ginsberg MH
  Title
RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration.
  Journal
J Cell Biol 174:877-88 (2006)
DOI:10.1083/jcb.200603111
Reference
PMID:23506953
  Authors
Kortum RL, Rouquette-Jazdanian AK, Samelson LE
  Title
Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
  Journal
Trends Immunol 34:259-68 (2013)
DOI:10.1016/j.it.2013.02.004
Reference
PMID:15572660
  Authors
Roberts DM, Anderson AL, Hidaka M, Swetenburg RL, Patterson C, Stanford WL, Bautch VL
  Title
A vascular gene trap screen defines RasGRP3 as an angiogenesis-regulated gene required for the endothelial response to phorbol esters.
  Journal
Mol Cell Biol 24:10515-28 (2004)
DOI:10.1128/MCB.24.24.10515-10528.2004
Reference
PMID:10712923
  Authors
Reuther GW, Der CJ
  Title
The Ras branch of small GTPases: Ras family members don't fall far from the tree.
  Journal
Curr Opin Cell Biol 12:157-65 (2000)
DOI:10.1016/S0955-0674(99)00071-X
Reference
PMID:21111786
  Authors
Fernandez-Medarde A, Santos E
  Title
The RasGrf family of mammalian guanine nucleotide exchange factors.
  Journal
Biochim Biophys Acta 1815:170-88 (2011)
DOI:10.1016/j.bbcan.2010.11.001
Reference
PMID:18437264
  Authors
Iwashita S, Song SY
  Title
RasGAPs: a crucial regulator of extracellular stimuli for homeostasis of cellular functions.
  Journal
Mol Biosyst 4:213-22 (2008)
DOI:10.1039/b716357f
Reference
PMID:15062121
  Authors
Ory S, Morrison DK
  Title
Signal transduction: implications for Ras-dependent ERK signaling.
  Journal
Curr Biol 14:R277-8 (2004)
DOI:10.1016/j.cub.2004.03.023
Reference
PMID:19091743
  Authors
Matheny SA, White MA
  Title
Signaling threshold regulation by the Ras effector IMP.
  Journal
J Biol Chem 284:11007-11 (2009)
DOI:10.1074/jbc.R800082200
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:34074494
  Authors
Apken LH, Oeckinghaus A
  Title
The RAL signaling network: Cancer and beyond.
  Journal
Int Rev Cell Mol Biol 361:21-105 (2021)
DOI:10.1016/bs.ircmb.2020.10.005
Related
pathway
mdt04010  MAPK signaling pathway
mdt04015  Rap1 signaling pathway
mdt04020  Calcium signaling pathway
mdt04144  Endocytosis
mdt04151  PI3K-Akt signaling pathway
mdt04660  T cell receptor signaling pathway
mdt04720  Long-term potentiation
mdt04810  Regulation of actin cytoskeleton
KO pathway
ko04014   

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