KEGG   PATHWAY: nnt04010
Entry
nnt04010                    Pathway                                
Name
MAPK signaling pathway - Nestor notabilis (Kea)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
nnt04010  MAPK signaling pathway
nnt04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Nestor notabilis (Kea) [GN:nnt]
Gene
104398986  [KO:K04372] [EC:2.7.11.1]
104399059  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
104399076  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
104399199  [KO:K04424] [EC:2.7.11.25]
104399262  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
104399345  FGF20; fibroblast growth factor 20 [KO:K04358]
104399465  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104399489  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
104399565  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
104399643  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
104399835  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
104400028  HSPA8; heat shock cognate 71 kDa protein isoform X1 [KO:K03283]
104400190  [KO:K16342] [EC:3.1.1.4]
104400218  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
104400257  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
104400334  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
104400634  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
104400645  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
104400662  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
104400669  AREG; amphiregulin [KO:K09782]
104400700  [KO:K04441] [EC:2.7.11.24]
104400737  VEGFC; vascular endothelial growth factor C [KO:K05449]
104400851  [KO:K04392]
104400866  DUSP3; LOW QUALITY PROTEIN: dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
104400882  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
104401002  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
104401121  PGF; placenta growth factor [KO:K16859]
104401234  [KO:K16342] [EC:3.1.1.4]
104401254  [KO:K18497]
104401293  CRK; adapter molecule crk [KO:K04438]
104401387  [KO:K04358]
104401428  JUN; transcription factor AP-1 [KO:K04448]
104401498  [KO:K03158]
104401514  CACNG4; LOW QUALITY PROTEIN: voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
104401645  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
104401663  NRAS; GTPase NRas [KO:K07828]
104401714  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
104401729  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
104401977  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
104402000  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
104402014  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
104402051  STK4; serine/threonine-protein kinase 4 [KO:K04411]
104402070  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
104402074  TRAF2; LOW QUALITY PROTEIN: TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
104402110  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
104402159  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
104402190  STMN1; stathmin [KO:K04381]
104402195  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
104402233  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
104402341  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
104402362  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104402400  [KO:K04421] [EC:2.7.11.25]
104402506  NGF; beta-nerve growth factor [KO:K02582]
104402542  MAX; protein max [KO:K04453]
104402574  TGFA; protransforming growth factor alpha [KO:K08774]
104402580  [KO:K04348] [EC:3.1.3.16]
104402582  FIGF; vascular endothelial growth factor D [KO:K05449]
104402600  FGF8; fibroblast growth factor 8 [KO:K04358]
104402611  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
104402628  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
104402726  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
104402745  MECOM; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
104402756  MAPT; microtubule-associated protein tau [KO:K04380]
104402957  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
104403122  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
104403452  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
104403914  [KO:K04519]
104403918  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
104403920  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
104404031  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
104404202  [KO:K04348] [EC:3.1.3.16]
104404355  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
104404365  RASA2; ras GTPase-activating protein 2 [KO:K08053]
104404444  CRKL; crk-like protein [KO:K04438]
104404453  KITLG; kit ligand [KO:K05461]
104404511  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
104404513  [KO:K04388] [EC:2.7.11.30]
104404578  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
104404672  VEGFA; vascular endothelial growth factor A [KO:K05448]
104404787  [KO:K04852]
104404822  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
104404848  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
104404855  GNA12; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
104404908  [KO:K04456] [EC:2.7.11.1]
104404911  PDGFB; LOW QUALITY PROTEIN: platelet-derived growth factor subunit B [KO:K17386]
104404923  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
104404938  [KO:K04373] [EC:2.7.11.1]
104404955  INS; insulin [KO:K04526]
104405060  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
104405178  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
104405182  [KO:K04456] [EC:2.7.11.1]
104405191  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
104405205  [KO:K04358]
104405310  SRF; serum response factor [KO:K04378]
104405440  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
104405753  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
104405779  [KO:K19662] [EC:2.7.11.13]
104405836  RRAS2; ras-related protein R-Ras2 [KO:K07830]
104406104  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
104406140  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
104406161  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
104406443  [KO:K16342] [EC:3.1.1.4]
104406772  [KO:K16342] [EC:3.1.1.4]
104406773  [KO:K16342] [EC:3.1.1.4]
104406784  TEK; LOW QUALITY PROTEIN: angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
104406789  [KO:K04849]
104406818  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104406866  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
104406980  [KO:K04389]
104407006  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
104407043  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
104407080  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
104407115  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
104407224  RASGRP3; ras guanyl-releasing protein 3 [KO:K12362]
104407365  NF1; neurofibromin [KO:K08052]
104407376  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
104407420  [KO:K05096] [EC:2.7.10.1]
104407632  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
104407792  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
104407830  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
104407859  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
104407879  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
104408030  [KO:K04371] [EC:2.7.11.24]
104408091  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
104408101  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
104408125  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
104408146  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
104408148  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
104408199  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
104408229  [KO:K04456] [EC:2.7.11.1]
104408251  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
104408256  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
104408300  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
104408426  EFNA5; ephrin-A5 [KO:K05462]
104408442  [KO:K02677] [EC:2.7.11.13]
104408603  MRAS; ras-related protein M-Ras [KO:K07831]
104408630  RASA1; ras GTPase-activating protein 1 [KO:K04352]
104408794  PLA2G4F; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
104408796  [KO:K16342] [EC:3.1.1.4]
104408823  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
104408827  [KO:K16342] [EC:3.1.1.4]
104408848  PDGFD; platelet-derived growth factor D [KO:K05450]
104409001  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
104409010  FGF16; fibroblast growth factor 16 [KO:K04358]
104409139  MEF2C; myocyte-specific enhancer factor 2C [KO:K04454]
104409207  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
104409217  BDNF; brain-derived neurotrophic factor [KO:K04355]
104409260  FGF6; fibroblast growth factor 6 [KO:K04358]
104409282  DUSP4; LOW QUALITY PROTEIN: dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104409287  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
104409455  FGF23; fibroblast growth factor 23 [KO:K22428]
104409457  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
104409459  [KO:K05460]
104409530  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
104409649  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
104409697  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
104409733  KRAS; GTPase KRas isoform X1 [KO:K07827]
104409789  [KO:K04345] [EC:2.7.11.11]
104409804  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
104409828  [KO:K04388] [EC:2.7.11.30]
104409913  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
104410007  RAP1A; ras-related protein Rap-1A [KO:K04353]
104410066  EFNA2; ephrin-A2 [KO:K05462]
104410125  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
104410165  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
104410211  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
104410244  [KO:K04373] [EC:2.7.11.1]
104410334  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
104410372  PDGFC; platelet-derived growth factor C [KO:K05450]
104410404  [KO:K05095] [EC:2.7.10.1]
104410411  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
104410465  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
104410534  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
104410675  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
104410749  [KO:K04850]
104410776  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
104410846  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
104410862  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
104410927  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
104411015  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
104411019  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
104411056  TGFB3; transforming growth factor beta-3 [KO:K13377]
104411282  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
104411368  [KO:K04441] [EC:2.7.11.24]
104411369  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
104411430  IGF2; insulin-like growth factor II [KO:K13769]
104411483  [KO:K04867]
104411495  [KO:K04441] [EC:2.7.11.24]
104411647  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
104411674  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
104411708  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
104411737  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
104411811  [KO:K17534] [EC:2.7.11.25]
104411934  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
104411965  [KO:K07836]
104412008  MAP3K4; mitogen-activated protein kinase kinase kinase 4 [KO:K04428] [EC:2.7.11.25]
104412069  [KO:K04407] [EC:2.7.11.1]
104412405  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
104412481  FGF3; fibroblast growth factor 3 [KO:K04358]
104412612  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
104412813  IGF1; LOW QUALITY PROTEIN: insulin-like growth factor I [KO:K05459]
104412858  HRAS; GTPase HRas [KO:K02833]
104412934  [KO:K04469]
104412979  RAPGEF2; rap guanine nucleotide exchange factor 2 [KO:K08018]
104413057  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
104413058  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
104413238  [KO:K04868]
104413377  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
104413389  [KO:K04439]
104413443  FAS; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 6 [KO:K04390]
104413454  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
104413471  EREG; proepiregulin [KO:K09784]
104413692  [KO:K04855]
104413830  FLT4; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
104413853  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
104413858  [KO:K04865]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
nnt04070  Phosphatidylinositol signaling system
nnt04110  Cell cycle
nnt04115  p53 signaling pathway
nnt04210  Apoptosis
nnt04310  Wnt signaling pathway
KO pathway
ko04010   

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